Tag: 100-200

On May 13, 2022, Shang, Rui; Liu, Can published a patent.Related Products of 386704-04-7 The title of the patent was Application method of thiophenol photocatalyst in defluorination alkylation or defluorination protonation reaction. And the patent contained the following:

The title method includes (1) mixing a trifluoromethyl compound (with a formula I as shown in Claim 2, such as trifluoromethyl (hetero)alkyl compounds, trifluoroacetamide compounds, etc.) and/or polyfluoroalkyl compound (with a formula II, such as pentafluoroacetamide compounds, etc.), thiophenol photocatalyst (4-methoxythiophenol, 4-methylthiophenol, etc.), formate salt (sodium formate, calcium formate, etc.) and organic solvent (DMF, THF, etc.) to form a reaction mixture. (2) Irradiating under the protection of inert gas for a defluorination reaction to obtain a difluoromethyl free radical and/or polyfluoroalkyl free radical intermediate product. (3) Reacting with unsaturated olefin (with formula III as shown in Claim 5, such as dimethyl(phenyl)(vinyl)silane, but-3-en-1-ol, etc.) to obtain a defluorination alkylation product (6-(3-(dimethyl(phenyl)silyl)-1,1-difluoropropyl)pyridin-2-amine, 5-(6-aminopyridin-2-yl)-5,5-difluoropentan-1-ol, etc.). (4) Or reacting the intermediate product as hydrogen donor with formate salt to obtain a defluorination protonation product. In formulas I-III, R is amido, ester group, aryl or heteroaryl; and R’ is or cycloalkyl. The thiophenol photocatalyst has the advantages of low cost and environment friendliness. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to thiophenol photocatalyst alkylsilane preparation defluorination alkylation, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Related Products of 386704-04-7

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On December 31, 2020, Ma, Yibao; Wang, Wei; Devarakonda, Teja; Zhou, Huiping; Wang, Xiang-Yang; Salloum, Fadi N.; Spiegel, Sarah; Fang, Xianjun published an article.SDS of cas: 32462-30-9 The title of the article was Functional analysis of molecular and pharmacological modulators of mitochondrial fatty acid oxidation. And the article contained the following:

Abstract: Fatty acid oxidation (FAO) is a key bioenergetic pathway often dysregulated in diseases. The current knowledge on FAO regulators in mammalian cells is limited and sometimes controversial. Previous FAO analyses involve nonphysiol. culture conditions or lack adequate quantification. We herein described a convenient and quant. assay to monitor dynamic FAO activities of mammalian cells in physiol. relevant settings. The method enabled us to assess various mol. and pharmacol. modulators of the FAO pathway in established cell lines, primary cells and mice. Surprisingly, many previously proposed FAO inhibitors such as ranolazine and trimetazidine lacked FAO-interfering activity. In comparison, etomoxir at low micromolar concentrations was sufficient to saturate its target proteins and to block cellular FAO function. Oxfenicine, on the other hand, acted as a partial inhibitor of FAO. As another class of FAO inhibitors that transcriptionally repress FAO genes, antagonists of peroxisome proliferator-activated receptors (PPARs), particularly that of PPARa, significantly decreased cellular FAO activity. Our assay also had sufficient sensitivity to monitor upregulation of FAO in response to environmental glucose depletion and other energy-demanding cues. Altogether this study provided a reliable FAO assay and a clear picture of biol. properties of potential FAO modulators in the mammalian system. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to monocytic lymphoma breast carcinoma fatty acid oxidation mitochondria, Pharmacology: Effects Of Neoplasm Inhibitors and Cytotoxic Agents and other aspects.SDS of cas: 32462-30-9

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On January 15, 2007, Roy, Chandra D.; Brown, Herbert C. published an article.Electric Literature of 2160-93-2 The title of the article was Stability of boronic esters – Structural effects on the relative rates of transesterification of 2-(phenyl)-1,3,2-dioxaborolane. And the article contained the following:

Relative rates of reaction of the achiral cyclic phenylboronic ester 2-(phenyl)-1,3,2-dioxaborolane with a wide variety of structurally modified diols, have been studied to understand the factors influencing the relative stabilities of boronic esters. It is found that the alkyl substituents on the α-carbons of diols slow down the transesterification, but produce thermodynamically more stable boronic ester. Six-membered boronic esters are thermodynamically more stable than their corresponding five-membered analogs. Amongst cyclic 1,2-diols, cis-1,2-cyclopentanediol displaces ethylene glycol instantaneously whereas trans-1,2-cyclopentanediol is totally unreactive, which suggests that the cis-stereochem. of the 1,2-diol is a prerequisite for transesterification. Among the 1,5-diols, diethanolamine displaces ethylene glycol quite rapidly forming a more stable bicyclic chelate in which nitrogen is attached to boron by a coordinating bond (as evident by 11B NMR spectroscopy). The oxygen atom of di(ethylene glycol) and the sulfur atom of 2,2′-thiodiethanol do not assist in displacing the ethylene glycol from their boronic esters. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Electric Literature of 2160-93-2

The Article related to phenyl dioxaborolane preparation transesterification kinetics diol, cyclic phenylboronic ester preparation transesterification kinetics diol substituent effect, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Electric Literature of 2160-93-2

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On September 30, 2009, Durka, Krzysztof; Kurach, Pawel; Lulinski, Sergiusz; Serwatowski, Janusz published an article.Product Details of 2160-93-2 The title of the article was Functionalization of Dihalophenylboronic Acids by Deprotonation of Their N-Butyldiethanolamine Esters. And the article contained the following:

Deprotonative lithiation of twelve 6-butyl-2-(dihalophenyl)-(N-B)-1,3,6,2-dioxazaborocines (N-butyldiethanolamine esters of dihalophenylboronic acids) was studied. Selective transformations can be best achieved using LDA as the lithiating reagent. The reactivities of these compounds vary significantly, depending on the natures and positions of the halogen atoms. The resultant B-Li bimetallic intermediates were subjected to reactions with electrophiles to afford functionalized halogenated arylboronic acids. Nineteen functionalized halogenated arylboronic acid derivatives were prepared in 8%-95% yield. E.g., lithiation of 6-butyl-2-(3′,4′-difluorophenyl)(N-B)-1,3,6,2-1,3,6,2-dioxazaborocine followed by reaction with TMSCl gave 3,4-difluoro-5-(trimethylsilyl)phenylboronic acid in 90% yield. (© Wiley-VCH Verlag GmbH and Co. KGaA, 69451 Weinheim, Germany, 2009). The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Product Details of 2160-93-2

The Article related to dihalophenyl dioxazaborocane dioxazaborocine preparation, lithiation dihalophenyl dioxazaborocine reaction electrophile preparation dihalophenylboronic acid, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Product Details of 2160-93-2

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On March 31, 2022, Ho, Angel; Pounder, Austin; Koh, Samuel; Macleod, Matthew P.; Carlson, Emily; Tam, William published an article.Recommanded Product: Pentane-1,5-diol The title of the article was Acid-Catalyzed Intramolecular Ring-Opening Reactions of Cyclopropanated Oxabenzonorbornadienes with Carboxylic Acid Nucleophiles. And the article contained the following:

The present work demonstrates the ability of carboxylic acid tethered cyclopropanated oxabenzonorbornadienes (CPOBDs) to undergo ring-opening reactions in mild acidic conditions. The optimized reaction conditions involve the use of pTsOH in DCE at 90°C. Two regioisomers are formed but the reactions are highly regioselective towards type 3 ring-opened products. It was observed that substitution at the C5 and aryl positions of CPOBD significantly hinders the ring-opening reactions leading to decreased yields of ring-opened products, although high regioselectivity for the Type 3 ring-opened products is still maintained. Herein, the first examples of acid-catalyzed intramol. ring-opening reactions of CPOBD with carboxylic acid nucleophiles are reported. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: Pentane-1,5-diol

The Article related to fused heterocyclic compound preparation regioselective, carboxy oxatetracyclododecatriene preparation intramol ring opening acid catalyst, Heterocyclic Compounds (One Hetero Atom): Higher-Membered Rings and other aspects.Recommanded Product: Pentane-1,5-diol

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Roy, Chandra D.; Brown, Herbert C. published an article in 2007, the title of the article was A Comparative Study of the Relative Stability of Representative Chiral and Achiral Boronic Esters Employing Transesterification.Category: alcohols-buliding-blocks And the article contains the following content:

A comparative study of the transesterification of five representative chiral and achiral boronic esters with various structurally modified diols was undertaken to qual. understand the factors influencing the relative stability of these boronic esters. Several factors such as chelation, conformation, steric bulk of the substituents, size of the heterocycle, and entropy influence the relative rate of transesterification as well as the stability of the boronic esters. Amongst these boronic esters, pinanediol phenylboronic ester is the most stable boronic ester whereas DIPT boronic ester appeared to be thermodynamically the least stable one. The transesterification with sterically hindered diols is relatively slow, but afforded thermodynamically more stable boronic esters. Boronic esters derived from cis-cyclopentanediols and the bicyclo[2.2.1]heptane-exo,exo-2,3-diols are relatively more stable. This study not only presents the qual. picture of relative stability of various boronic esters, but also provides helpful hints regarding the possible recovery of chiral auxiliaries. Many C 2-sym. chiral auxiliaries, such as 2,3-butanediol, 2,4-pentanediol, DIPT, and cis-cyclohexane-1,2-diol, can be retrieved by simple transesterification of the corresponding boronic esters with com. inexpensive diols, such as pinacol, 1,3-propanediol, and neopentyl glycol. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Category: alcohols-buliding-blocks

The Article related to transesterification chiral achiral boronic ester structurally modified diol, boronic ester preparation stability factor, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Category: alcohols-buliding-blocks

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On March 1, 2022, Pitcher, Noel P.; Harjani, Jitendra R.; Zhao, Yichao; Jin, Jianwen; Knight, Daniel R.; Li, Lucy; Putsathit, Papanin; Riley, Thomas V.; Carter, Glen P.; Baell, Jonathan B. published an article.Related Products of 621-37-4 The title of the article was Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract. And the article contained the following:

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Related Products of 621-37-4

The Article related to gastrointestinal tract antimicrobial quaternary ammonium clostridioides mdr enterococcus oxadiazole, Pharmacology: Effects Of Gastrointestinal and Respiratory Drugs and other aspects.Related Products of 621-37-4

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On August 20, 1999, Brown, Herbert C.; Kanth, Josyula V. B.; Dalvi, Pramod V.; Zaidlewicz, Marek published an article.Formula: C8H19NO2 The title of the article was Molecular Addition Compounds. 15. Synthesis, Hydroboration, and Reduction Studies of New, Highly Reactive tert-Butyldialkylamine-Borane Adducts. And the article contained the following:

Two series of tert-butyldialkylamines have been prepared and examined for borane complexation. The complexing ability of each amine in the two series examined decreases in the order shown. First series: t-BuN(CH2CH2)2O 1a > t-BuNEt2 1b > t-BuNPrn2 1c > t-BuN(CH2CH2OMe)2 1d ≫ t-BuNBui2 1e. Second series: t-BuNBuiMe 2a > t-BuNPriMe 2b > t-BuNBuiEt 2c > t-BuNBuiPrn 2d ≫ t-BuNPriEt 2e. The reactivity of the corresponding borane adducts toward 1-octene increases in the reverse order. The following amines form highly reactive liquid borane adducts hydroborating 1-octene in THF at room temperature in less than 1h: t-BuN(CH2CH2OMe)2, t-BuNBuiEt, and t-BuNPriMe. The limit of borane complexation among the amines examined is reached for t-BuNBui2 exchanging borane neither with BMS nor with BH3-THF. Among the various borane adducts prepared, the more promising borane adducts, t-Bu(CH3OCH2CH2)2N-BH3 (7), t-BuMePriN-BH3 (8), and t-BuEtBuiN-BH3 (9), were selected for complete hydroboration and reduction studies. Hydroboration studies with the new, highly reactive trialkylamine-borane adducts 7-9 and representative olefins, such as 1-hexene, styrene, β-pinene, cyclopentene, norbornene, cyclohexene, 2-methyl-2-butene, α-pinene, and 2,3-dimethyl-2-butene, in THF, dioxane, tert-Bu Me ether, n-pentane, and dichloromethane, at room temperature (22 ± 3°) were carried out. The reactions are faster in dioxane, requiring 1-2 h for the hydroboration of simple, unhindered olefins to the trialkylborane stage. Moderately hindered olefins, such as cyclohexene and 2-methyl-2-butene, give the corresponding dialkylboranes rapidly, with further slow hydroboration. However, the more hindered olefins, α-pinene and 2,3-dimethyl-2-butene, give stable monoalkylboranes very rapidly, with further hydroboration proceeding relatively slowly. The hydroborations can also be carried out conveniently in other solvents, such as THF, tert-Bu Me ether, and n-pentane. A significant rate retardation is observed in dichloromethane. Regioselectivity studies of 1-hexene and styrene using these amine-borane adducts show selectivities similar to that of BH3-THF. The rates and stoichiometry of the reaction of t-BuMePriN-BH3 in THF with selected organic compounds containing representative functional groups were also examined at room temperature The reductions of esters, amides, and nitriles, which exhibit a sluggish reaction at room temperature, proceed readily under reflux conditions in THF and dioxane and without solvent (at 85-90°). The carrier amines can be recovered by simple acid-base manipulations in good yield and readily recycled to make the borane adducts. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Formula: C8H19NO2

The Article related to butyldialkylamine borane adduct preparation hydroboration reduction reagent, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Formula: C8H19NO2

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On November 16, 2017, Akama, Tsutomu; Carter, David Scott; Halladay, Jason S.; Jacobs, Robert T.; Liu, Yang; Plattner, Jacob J.; Zhang, Yong-Kang; Witty, Michael John published a patent.Category: alcohols-buliding-blocks The title of the patent was Oxaborole esters and uses thereof. And the patent contained the following:

The present invention provides oxaborole ester compounds, e.g. I, and compositions thereof which are useful to treat diseases associated with parasites, such as Chagas Disease and African Animal Trypanosomosis. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks

The Article related to oxaborole ester preparation treatment parasite disease trypanosomosis, Organometallic and Organometalloidal Compounds: Boron Compounds and other aspects.Category: alcohols-buliding-blocks

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On August 29, 2022, Fu, Qiang; Shofner, Meisha L.; Sinquefield, Scott A.; Nair, Sankar published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was Recovery and Enrichment of Organic Acids from Kraft Black Liquor by an Adsorption-Based Process. And the article contained the following:

Kraft black liquor (BL) is a complex multicomponent byproduct from wood pulping processes. After lignin, carbohydrate-derived carboxylic acids are the second most abundant class of organics in kraft BL and comprise a potential biomass-derived feedstock of more than 50 million tons/yr globally. These acids can be valorized in biofuels and biobased chems. production or further fractionated to produce specific high-value carboxylic acids from the mixture However, both of these routes require a viable process to sep. carboxylic acids from BL. In this work, an adsorption-based process was developed to address this challenging issue. The kraft BL stream was first pretreated to remove most of the lignin by membrane nanofiltration (NF) combined with lignin-selective adsorption. To sep. organic acids from this pretreated BL, organophilic/hydrophobic granulated activated carbon (GAC) was identified as a promising adsorbent with excellent organic/inorganic selectivity and adsorption capacity (>100 mg/g GAC). We present comprehensive adsorption measurements and anal. to characterize the adsorbent and develop a viable cyclic operation scheme for the adsorption process. The GAC adsorbents show robust separation performance over 20+ cycles. We have successfully obtained concentrated aqueous organic acid mixtures with ~95% purity from kraft BL. We propose a modified kraft process with energy-efficient BL dewatering by NF and organic acids recovery for valorization. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to enrichment organate kraft black liquor adsorption, Cellulose, Lignin, Paper, and Other Wood Products: Pulp and Liquors and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

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