Tag: 100-200

On May 1, 2020, Wang, Yanling; Berhow, Mark A.; Black, Molly; Jeffery, Elizabeth H. published an article.Application of 621-37-4 The title of the article was A comparison of the absorption and metabolism of the major quercetin in brassica, quercetin-3-O-sophoroside, to that of quercetin aglycone, in rats. And the article contained the following:

Although flavonoid sophorosides are common glycosides in brassica vegetables, red raspberries and other food plants, there is a lack of studies of absorption and metabolism of any sophoroside. The aim of this study was to characterize the absorption, phase II metabolism and microbial catabolism of quercetin-3-O-sophoroside, compared to that of quercetin aglycon. Quercetin-3-O-sophoroside was purified from Apocynum venetum and characterized by MS2, 1H and 13C NMR. Using an in situ rat gut model, we found intact, methylated, sulfated and both methylated and sulfated quercetin sophoroside in the plasma following jejunal introduction of the sophoroside; we found derivatives of benzoic acid, phenylacetic acid, and Ph propionic acid in the cecal contents following cecal introduction. This novel finding, that quercetin sophoroside was absorbed intact, without deglycosylation, points to a possible role for the terminal sugar and/or the type of linkage among glycosidic moieties in the mechanism of absorption of flavonoid glycosides. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

The Article related to quercetin sophoroside aglycon absorption metabolism intestine, flavonol absorption, metabolism, microbial catabolism, quercetin sophoroside, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Application of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 11, 2015, Kane, John L., Jr.; Matthews, Gloria; Metz, Markus; Kothe, Michael; Liu, Jinyu; Scholte, Andrew published a patent.Category: alcohols-buliding-blocks The title of the patent was Benzimidazole and imidazopyridine derivatives as tropomyosin-related kinase (Trk) inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:

The invention relates to benzimidazole and imidazopyridine derivatives of formula I, which are tropomyosin-related kinase (Trk) inhibitors and which are useful in the treatment of diseases. Compounds of formula I wherein Q1 is H, halo, (un)substituted C6-14 aryl, etc.; Q2 is (un)substituted C6-14 aryl, (un)substituted C2-9 heteroaryl, etc.; R1 is H, halo, C1-10 alkyl, etc.; R2 is H, halo, C1-10 alkyl, C1-10 alkoxy, etc.; L is (CR3R4)1-5; R3 and R4 are independently H, NH2, C1-10 alkyl, etc.; Z is (CR5R6)0-4; R5 and R6 are independently H, NH2, C1-10 alkyl, etc.; X is CH, halo, NH, etc.; and pharmaceutically acceptable salts thereof, are disclosed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their Trk inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values of 0.001 μM and 0.0005 μM towards TrkA and TrkB, resp. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks

The Article related to imidazopyridine preparation trk inhibitor treatment disease, benzimidazole preparation trk inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 5, 2007, Buettelmann, Bernd; Han, Bo; Knust, Henner; Thomas, Andrew published a patent.SDS of cas: 386704-04-7 The title of the patent was Preparation of arylisoxazolyl imidazoles as GABAA α5 receptor ligands for the treatment of cognitive disorder and Alzheimer’s disease. And the patent contained the following:

Title compounds I [wherein R1, R2, R3 = H or halo; R4 = H, alkyl, cycloalkyl, etc.; R5 = (un)substituted (CH2)m-(hetero)aryl; m = 0-1; R6 = H, CHO, cycloalkyl, etc.] and pharmaceutically acceptable acid addition salts thereof were prepared as GABAA α5 receptor ligands. For instance, II was synthesized in 43% yield by N-alkylation of the corresponding imidazole with 4-fluoroacetophenone. This compound has a Ki value of 4.7 nM for displacement of [3H]flumazenil from GABAA α5 subunits. I and their pharmaceutical compositions are useful for the treatment of diseases related to the GABAA a5 subunits, such as cognitive disorder and Alzheimer’s disease. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).SDS of cas: 386704-04-7

The Article related to arylisoxazolyl imidazole preparation gabaa receptor ligand cognitive enhancer antialzheimer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.SDS of cas: 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 23, 2020, Martin, Caterina; Trajkovic, Milos; Fraaije, Marco W. published an article.Safety of Pentane-1,5-diol The title of the article was Production of Hydroxy Acids: Selective Double Oxidation of Diols by Flavoprotein Alcohol Oxidase. And the article contained the following:

Flavoprotein oxidases can catalyze oxidations of alcs. and amines by merely using mol. oxygen as the oxidant, making this class of enzymes appealing for biocatalysis. The FAD-containing (FAD=FAD) alc. oxidase from P. chrysosporium facilitated double and triple oxidations for a range of aliphatic diols. Interestingly, depending on the diol substrate, these reactions result in formation of either lactones or hydroxy acids. For example, diethylene glycol could be selectively and fully converted into 2-(2-hydroxyethoxy)acetic acid. Such a facile cofactor-independent biocatalytic route towards hydroxy acids opens up new avenues for the preparation of polyester building blocks. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to alc oxidase diol double oxidation, biocatalysis, diols, enzymes, lactones, oxidation, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Safety of Pentane-1,5-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 23, 2017, Axten, Jeffrey Michael; Faucher, Nicolas Eric; Daugan, Alain Claude-Marie published a patent.Product Details of 386704-04-7 The title of the patent was Preparation of imidazolidinone derivatives as inhibitors of PERK. And the patent contained the following:

The title imidazolidinones I [R1 = (un)substituted bicycloheteroaryl, heteroaryl; R2 = alkyl, (un)substituted aryl, heteroaryl, etc.; R3 = H, NH2, NH(alkyl), etc.; R4 and R5 = (independently) H and alkyl; R4 and R5 taken together with the carbon atoms to which they are attached form 3-4 membered cycloalkyl, optionally substituted with 1-3 alkyl; R6 = H, alkyl, CF3, etc.; R7 = H, alkyl, CF3, etc.; X = N or (un)substituted CH; Y1 and Y2 = (independently) H, CF3, alkyl; or Y1 and Y2 are taken together with the carbon to which they are attached to form C3-6 cycloalkyl; z = 0-1] or salts thereof including a pharmaceutically acceptable salts thereof, which are inhibitors of PERK and can be useful in the treatment of cancer, pre-cancerous syndromes, Alzheimer’s disease, neuropathic pain, etc., were prepared and formulated. E.g., a multi-step synthesis of II, starting from 4-bromo-3-fluoroaniline and 1-chloro-2-isocyanatoethane, was described. Exemplified compounds I were tested for activity against PERK (data given). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound I. The invention is still further directed to methods of inhibiting PERK activity and treatment of disorders associated therewith using a compound I or a pharmaceutical composition comprising I. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Product Details of 386704-04-7

The Article related to imidazolidinone preparation perk inhibitor antitumor analgesic alzheimer’s disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 14, 2020, Zhang, Jiandong; Yang, Xiaoxiao; Dong, Rui; Gao, Lili; Li, Jing; Li, Xing; Huang, Shuangping; Zhang, Chaofeng; Chang, Honghong published an article.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol The title of the article was Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols. And the article contained the following:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

The Article related to cascade reaction stereoselective aminohydroxylation styrenyl olefin arylglycinol, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.Application In Synthesis of (R)-2-Amino-2-(m-tolyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 1, 2022, Yang, Xiaozhe; Hu, Wenzhong; Xiu, Zhilong; Ji, Yaru; Guan, Yuge published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Interactions between Leu. mesenteroides and L. plantarum in Chinese northeast sauerkraut. And the article contained the following:

LAB are mostly used microorganisms for traditional fermented foods, e.g. Chinese northeast sauerkraut. However, the interactions between these strains are little known in mixed culture. This study aimed to explore the interaction between Leu. mesenteroides and L. plantarum based on metabolomics and transcriptomics during single- and mix-cultured fermentation of Chinese northeast sauerkraut. Metabolomics anal. revealed that the mixed culture showed different metabolite profiles in comparison with single culture. Higher levels of 4-vinylphenol (4.51%), 2,6-diaminopimelic acid (4.47%), Et dodecanoate (5.53%) were observed in mix-cultured samples than that with Leu. mesenteroides. In addition, the levels of 4-isopropylbenzoic acid (3.54%), 2,3-butanediol (7.23%), 1-octadecene (5.15%), Et dodecanoate (5.53%) were higher than that with L. plantarum. The most influenced pathway was carbohydrate metabolism, which was mostly related to 116 genes considered as DEGs in C_30 vs. D_30 groups (CD), according to transcriptomics anal. Addnl., 69 genes were considered as significantly DEGs in C_30 vs. A_30 groups (CA) which were considerably mapped to amino acid metabolism These results provided integrated views into the adaptive responses of the two strains to mix-cultured fermentation, which was useful for the rational development of mixed cultures in sauerkraut industry. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to sauerkraut leuconostoc mesenteroides lactobacillus plantarum interaction, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 15, 2020, Zhong, Wenge; Guo, Wei published a patent.Application of 386704-04-7 The title of the patent was Benzimidazole derivatives as Glp-1R agonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Provided herein are benzimidazole compounds of formula I and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, non-alc. fatty liver disease, non-alc. steatohepatitis, and cardiovascular disease. Compounds of formula I wherein dashed double bond is either as single bond or a double bond; X1-X5 are independently N, CH; W is O, S, (un)substituted CH, NH and derivatives; ring B is 6-membered heteroaryl, 6-membered monocyclic ring, Ph; Y1 is N, NH, CH, CH2; ring C is cyclohexyl, Ph, pyridinyl; L is (un)substituted CH2, S, O, NH and derivatives; ring D is bicyclic heteroaryl; EE is COOH, -COCF3, -CH(OH)CF3, -CONH-CN, -CONH-OH, -CO-NH-OMe, etc.; T is -CH(RbRc); Ra, Rb and Rc are independently H, D, halo, CN, C1-6 alkyl, C1-6 alkoxy, etc.; R1 is H, D, halo, CN, OH, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is H, D, halo, CN, OH, oxo, C1-6 alkyl, etc.; R3 is H, D, CN, OH, oxo, C1-6 alkyl, C1-6 alkoxy, etc.; R4 is H, D, halo, OH, CN, C1-6 alkyl, C1-6 alkoxy, etc.; and their pharmaceutically acceptable salts, stereoisomers, solvates, hydrates as Glp-1R agonists in the treatment of diseases thereof, are claimed. Example compound II was prepared starting from 4-bromo-3-fluorobenzeneacetonitrile by using alcoholysis, heterocyclization, cross-coupling, and hydrolysis as the key steps. All the invention compounds were evaluated for their Glp-1R agonistic activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to benzimidazole derivative preparation glp1r agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 1979, Bennett, E. O. published an article.COA of Formula: C8H19NO2 The title of the article was Corrosion inhibitors as preservatives for metalworking fluids – ethanolamines. And the article contained the following:

Fifty-nine monoethanolamines, diethanolamines, and triethanolamines were studied for their antimicrobial properties in 13 cutting fluid products. 2-(N-Amyl) ethanolamine [35161-67-2] exhibited outstanding activity in all of the products. Other compounds producing significant inhibition of microbial growth included N-Me ethanolamine [109-83-1], N-Et ethanolamine [110-73-6], N-Bu ethanolamine [111-75-1], 2-N-methyl-N-heptyl) ethanolamine [71247-70-6], 2-cyclohexyl ethanolamine [2842-38-8], and N-benzyl ethanolamine [104-63-2]. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).COA of Formula: C8H19NO2

The Article related to ethanolamine derivative corrosion inhibitor bactericide, cutting fluid anticorrosion antimicrobial agent, Fossil Fuels, Derivatives, and Related Products: Lubricating Oils and other aspects.COA of Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 31, 1983, Liepins, E.; Birgele, I.; Zelcans, G.; Urtane, I.; Lukevics, E. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Nitrogen-containing organosilicon compounds. CXII. Carbon-13, silicon-29, and nitrogen-15 NMR spectra of a series of cyclic organosilicon esters of N-substituted diethanolamines and their methiodides. And the article contained the following:

The title NMR of 28 (I, R = Me, Ph, p-MeC6H4, 2-thienyl; R1 = Me, Ph, Pr, MeO, Cl, H, CH:CH2; RR1 = OCMe2CMe2O; X = NMe, NH, NCMe3, N+Me2 I-) were studied. The influence of N-substitution on N→Si interaction was also discussed. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to nmr dioxaazasilacyclooctane, azadioxasilacyclooctane nmr, siladioxaazacyclooctene nmr, Organometallic and Organometalloidal Compounds: Silicon Compounds and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts