Tag: 100-200

On July 31, 2011, Marina Prendes, M. G.; Hermann, R.; Torresin, M. E.; Souto, P.; Tallis, S.; Savino, E. A.; Varela, A.; Jaitovich, M. M. published an article.Product Details of 32462-30-9 The title of the article was Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats. And the article contained the following:

The effects of ischemic-postconditioning (IPOC) on functional recovery and cell viability of ischemic-reperfused hearts from fed and fasted rats were studied in relation to triacylglycerol and glycogen mobilization, ATP content, glucose-6-phosphate dehydrogenase activity and reduced/oxidized glutathione (GSH/GSSG). Oxidative damage was estimated by measuring thiobarbituric acid reactive substances (TBARS). IPOC improved contractile recovery and cell viability in the fed but attenuated them in the fasted hearts. In both groups ischemia lowered glycogen. IPOC further reduced it. Triacylglycerol remained unchanged during ischemia-reperfusion in both groups, but triacylglycerol mobilization was activated by IPOC in the fasted group. ATP was increased by IPOC in the fed hearts, but lowered in the fasted ones, which appeared to be associated with the rates of ATP synthesis in isolated mitochondria. In the fed hearts IPOC raised glucose-6-phosphate dehydrogenase activity and GSH/GSSG, and lowered TBARS. These results suggest that IPOC effects are associated with changes in the ATP supply, mobilization of energy sources and glutathione antioxidant ratio. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9

The Article related to energy metabolism ischemic postconditioning reperfusion fed fasting heart, Mammalian Pathological Biochemistry: Cardiovascular Diseases and other aspects.Product Details of 32462-30-9

Referemce:
Alcohol – Wikipedia,
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On October 15, 2020, Zhong, Wenge; Guo, Wei published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Benzimidazole derivatives as Glp-1R agonists and their preparation, pharmaceutical compositions and use in the treatment of diseases. And the patent contained the following:

Provided herein are benzimidazole compounds of formula I and pharmaceutical compositions thereof, for use in, e.g. treating type 2 diabetes mellitus, pre-diabetes, obesity, non-alc. fatty liver disease, non-alc. steatohepatitis, and cardiovascular disease. Compounds of formula I wherein dashed double bond is either as single bond or a double bond; EE is COOH, -COCF3, -CH(OH)CF3, -CO-NH-CN, -CO-NH-OH, etc.; X1-X5 are independently N, CH; W is O, S, (un)substituted CH, NH and derivatives; ring B is 6-membered heteroaryl, 6-membered monocyclic ring, Ph; Y1 and Y3-Y4 are independently N, CH; T6-T8 are independently N, (un)substituted VH; ring C is cyclohexyl, Ph, pyridinyl; L is (un)substituted CH2, S, O, NH and derivatives; ring D is bicyclic heteroaryl; EE is COOH, -COCF3, -CH(OH)CF3, -CONH-CN, -CONH-OH, -CO-NH-OMe, etc.; Rb is H, C1-6 alkyl, C1-6 alkoxy, etc.; R1 is H, halo, CN, OH, C1-6 alkyl, C1-6 alkoxy, etc.; R2 is H, D, halo, CN, OH, oxo, C1-6 alkyl, etc.; R3 is H, D, CN, OH, oxo, C1-6 alkyl, C1-6 alkoxy, etc.; and their pharmaceutically acceptable salts, stereoisomers, solvates, hydrates as Glp-1R agonists in the treatment of diseases thereof, are claimed. Example compound II was prepared starting from 4-bromo-3-fluorobenzeneacetonitrile by using alcoholysis, heterocyclization, cross-coupling, and hydrolysis as the key steps. All the invention compounds were evaluated for their Glp-1R agonistic activity. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to benzimidazole derivative preparation glp1r agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On June 16, 2022, Li, Zhi; Sundara Sekar, Balaji; Lukito, Benedict Ryan published a patent.SDS of cas: 926292-63-9 The title of the patent was Bioproduction of enantiopure (R)- and (S)-2-phenylglycinol from styrene and renewable feedstocks via artificial enzyme cascade. And the patent contained the following:

The present invention relates to methods of bioprodn. of enantiomerically pure or enantiomerically enriched 2- phenylglycinol or a derivative thereof by multiple enzyme-catalyzed chem. transformations in a one-pot reaction system. In a specific embodiment, at least one multiple enzyme is located on one or more plasmids or integrated in the chromosome of each of the one or more recombinant microbial cells. In a further embodiment, one or more recombinant microbial cells are genetically engineered to overexpress multiple enzymes, including styrene monooxygenase, epoxide hydrolase, alc. dehydrogenase, transaminase, phenylalanine ammonia lyase, and phenylacrylic acid decarboxylase. The experimental process involved the reaction of (R)-2-Amino-2-(m-tolyl)ethanol(cas: 926292-63-9).SDS of cas: 926292-63-9

The Article related to styrene artificial enzyme cascade phenylglycinol enantiopure, Fermentation and Bioindustrial Chemistry: Industrial Chemicals and other aspects.SDS of cas: 926292-63-9

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On September 18, 2014, Desroy, Nicolas; Heckmann, Bertrand; Brys, Reginald Christophe Xavier; Joncour, Agnes; Peixoto, Christophe; Bock, Xavier published a patent.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of imidazo[1,2-a]pyridine derivatives for treatment of inflammatory disorders. And the patent contained the following:

Disclosed are the title imidazo[1,2-a]pyridine derivatives I [R1a = H, halo, C1-C4 alkyl; R1b = halo, halo-(un)substituted C1-C4 alkyl, halo-(un)substituted C1-C4 alkoxy; X = S, O, N:CH, CH:CH; W = N, CR3; R4 = C1-C4 alkyl; R5 = (un)substituted C1-C4 alkyl with CN, OH, halo, C(:O)NH2; one of R6a or R6b = H, Me, halo, and the other is H; Cy = C4-C10 cycloalkyl, 41̃0 membered mono.bicyclic heterocycloalkyl, 47̃ membered heterocycloalkenyl; R7 = independently OH, oxo, halo, etc.; subscript a = 0, 1, 2; R8 = (L1-W1)m-L2-G1 wherein L1 = absent, O, C(:O), SO2, etc.; W1 = C1-C4 alkylene; subscript m = 0, 1; L2 = absent, O, C(:O), OC(:O), etc.; G1 = H, CN, (un)substituted C1-C4 alkyl, etc.; a pharmaceutically acceptable salt, or a solvate, or a pharmaceutically acceptable salt of a solvate thereof; or a biol. active metabolite thereof] for treatment of inflammatory disorders. For example, II was prepared in a multistep synthesis. The present invention relates to compounds I inhibiting autotaxin (NPP2 or ENPP2), methods for their production, pharmaceutical compositions, and methods of treatment using I, for the prophylaxis and/or treatment of diseases involving fibrotic diseases, proliferative diseases, inflammatory diseases, autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatol. disorders, and/or abnormal angiogenesis associated diseases by administering I. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation imidazopyridine treatment inflammatory disorder, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2022, Indrati, Niken; Sumpavapol, Punnanee; Samakradhamrongthai, Rajnibhas Sukeaw; Phonsatta, Natthaporn; Poungsombat, Patcha; Khoomrung, Sakda; Panya, Atikorn published an article.Application In Synthesis of 2,3-Dihydroxypropanoic acid The title of the article was Volatile and non-volatile compound profiles of commercial sweet pickled mango and its correlation with consumer preference. And the article contained the following:

Summary : Sweet pickled mango named Ma-Muang Bao Chae-Im is a traditional preserved mango from Hat Yai, Thailand. This study investigated (I) volatile and non-volatile compound profiles of com. Ma-Muang Bao Chae-Im and (II) their relationship to consumer preference. Untargeted metabolomics profiling was performed by gas chromatog.-mass quadrupole-time of flight anal. There were 117 volatile and 44 non-volatile compounds annotated in six com. brands of Ma-Muang Bao Chae-Im. Furthermore, 46 volatile and 19 non-volatile compounds discriminant markers were found by Partial least square discriminant anal. Among those markers, sorbic and benzoic acid were observed in several brands; moreover, the combination of both compounds altered the volatile profile, especially the ester group. Partial least square regression revealed that overall consumer liking is correlated to 1-heptanol; 1-octanol; acetoin; acetic acid, 2-phenylethyl ester; D-manitol; terpenes and terpenoids, while firmness to sucrose and L-(-)-sorbofuranose. On the other hand, most ester compounds were not related to consumer preference. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to sweet pickled mango 1heptanol 1octanol acetoin acetic acid, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 8, 2011, Barnes, Michael Christopher Stratton; Flack, Stephen Sean; Fraser, Ian; Lumley, James Andrew; Pang, Pui Shan; Spencer, Keith Charles; Tiberghien, Nathalie Anne Laure; Tomkinson, Gary Peter published a patent.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of benzodiazepine compounds useful for the treatment of hepatitis C. And the patent contained the following:

The invention concerns benzodiazepine derivatives of Formula I (L1 is O or NR8, wherein R8 is H, C1-6 alkyl, etc.; L2 is -(CR9R10)n-, wherein n = 1-6 and R9 and R10 independently are H, C1-6 alkyl, or cyclopropyl; A is aryl, a 5-6 membered monocyclic heteroaryl ring, etc.; R1 is H or fluoro; R2 is H, halo, C1-6 alkyl, etc.; R3 is H, C1-6 alkyl or halo; R4 is H, halo, C1-6 alkyl, etc.; R5 is H, halo, or C1-6 alkyl; R6 is H, halo, C1-6 alkyl, etc.; and R7 is H, C1-6 alkyl, halo, etc.; X is CH or N). The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection. Example compound II was prepared by reacting 3-amino-5-(2,4,6-trichlorophenyl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one hydrochloride and 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chlorobenzoic acid. When tested in assays that measured HCV polymerase inhibitory activity and/or reduction of HCV replicon levels, all of the exemplified compounds of the invention had IC50 values < 10 μM, indicating that they are expected to possess useful therapeutic properties. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to benzodiazepine compound preparation treatment hepatitis c, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Beyoglu, Diren; Park, Eun-Jung; Quinones-Lombrana, Adolfo; Dave, Asim; Parande, Falguni; Pezzuto, John M.; Idle, Jeffrey R. published an article in 2022, the title of the article was Addition of grapes to both a standard and a high-fat Western pattern diet modifies hepatic and urinary metabolite profiles in the mouse.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:

The benefits of fruit and vegetable dietary consumption are largely defined in epidemiol. terms. Relatively little is known about the discrete effects on metabolic pathways elicited by individual dietary fruits and vegetables. To address this, grape powder was added to both a standard and a high-fat Western pattern diet given to 10-wk-old female C57BL/6J mice for a period of 91 days, whereupon 24 h urines were collected and the mice euthanized after a 12 h fast for the collection of liver tissue. Alterations in hepatic and urinary metabolite patterns were determined by gas chromatog.-mass spectrometry-based metabolomics. Urinary excretion of the gut microbiota metabolites 4-hydroxyphenylacetic acid, 5-hydroxyindole, glyceric acid, gluconic acid and myo-inositol was attenuated when grape was added to the standard diet but the gut microbiota metabolites gluconic acid, scyllo-inositol, mannitol, xylitol, 5-hydroxyindole and 2-deoxyribonic acid were increased in urine when grape was added to the high-fat diet. Increased hepatic ascorbic acid and 5-oxoproline levels indicated the anti-oxidant effect of grape powder on the liver. Pathway enrichment anal. demonstrated that for both standard and high-fat diets, grape addition significantly upregulated the malate-aspartate shuttle indicating enhanced hepatic utilization of glucose via cytosolic glycolysis for mitochondrial ATP production It is concluded that a grape diet reprogrammes gut microbiota metabolism, attenuates the hepatic oxidative stress of a high-fat diet and increases the efficiency of glucose utilization by the liver for energy production The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to glyceric acid myoinositol liver urine grape high fat diet, Food and Feed Chemistry: Fruits, Vegetables, Legumes, and Nuts and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 19, 2022, Feng, Haichao; Lv, Yu; Krell, Tino; Fu, Ruixin; Liu, Yunpeng; Xu, Zhihui; Du, Wenbin; Shen, Qirong; Zhang, Nan; Zhang, Ruifu published an article.Computed Properties of 473-81-4 The title of the article was Signal binding at both modules of its dCache domain enables the McpA chemoreceptor of Bacillus velezensis to sense different ligands. And the article contained the following:

Bacteria have evolved multiple signal transduction systems that permit an adaptation to changing environmental conditions. Chemoreceptor-based signaling cascades are very abundant in bacteria and are among the most complex signaling systems. Currently, our knowledge on the mol. features that determine signal recognition at chemoreceptors is limited. Chemoreceptor McpA of Bacillus velezensis SQR9 has been shown to mediate chemotaxis to a broad range of different ligands. Here we show that its ligand binding domain binds directly 13 chemoattractants. We provide support that organic acids and amino acids bind to the membrane-distal and membrane-proximal module of the dCache domain, resp., whereas binding of sugars/sugar alcs. occurred at both modules. Structural biol. studies combined with site-directed mutagenesis experiments have permitted to identify 10 amino acid residues that play key roles in the recognition of multiple ligands. Residues in membrane-distal and membrane-proximal regions were central for sensing organic acids and amimo acids, resp., whereas all residues participated in sugars/sugar alc. sensing. Most characterized chemoreceptors possess a narrow and well-defined ligand spectrum. We propose here a sensing mechanism involving both dCache modules that allows the integration of very diverse signals by a single chemoreceptor. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to bacillus mcpa chemoreceptor dcache domain signal ligand binding chemoattractant, chemoreceptor, chemotaxis, dcache sensor domain, ligand recognition, signal transduction, Microbial, Algal, and Fungal Biochemistry: Classical Genetics and other aspects.Computed Properties of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2021, He, Zhen; Wu, Jinjie; Gong, Junli; Ke, Jia; Ding, Tao; Zhao, Wenjing; Cheng, Wai Ming; Luo, Zhanhao; He, Qilang; Zeng, Wanyi; Yu, Jing; Jiao, Na; Liu, Yanmin; Zheng, Bin; Dai, Lei; Zhi, Min; Wu, Xiaojian; Jobin, Christian; Lan, Ping published an article.HPLC of Formula: 621-37-4 The title of the article was Microbiota in mesenteric adipose tissue from Crohns disease promote colitis in mice. And the article contained the following:

Mesenteric adipose tissue (mAT) hyperplasia, known as creeping fat is a pathol. characteristic of Crohns disease (CD). The reserve of creeping fat in surgery is associated with poor prognosis of CD patients, but the mechanism remains unknown. Mesenteric microbiome, metabolome, and host transcriptome were characterized using a cohort of 48 patients with CD and 16 non-CD controls. Multidimensional data including 16S rRNA gene sequencing (16S rRNA), host RNA sequencing, and metabolome were integrated to reveal network interaction. Mesenteric resident bacteria were isolated from mAT and functionally investigated both in the dextran sulfate sodium (DSS) model and in the Il10 gene-deficient (Il10-/-) mouse colitis model to validate their pro-inflammatory roles. Mesenteric microbiota contributed to aberrant metabolites production and transcripts in mATs from patients with CD. The presence of mAT resident microbiota was associated with the development of CD. Achromobacter pulmonis (A. pulmonis) isolated from CD mAT could translocate to mAT and exacerbate both DSS-induced and Il10 gene-deficient (Il10-/-) spontaneous colitis in mice. The levels of A. pulmonis in both mAT and mucous layer from CD patients were higher compared to those from the non-CD group. This study suggests that the mesenteric microbiota from patients with CD sculpt a detrimental microenvironment and promote intestinal inflammation. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to microbiota mesenteric adipose tissue crohns disease promote colitis mice, bacterial translocation, crohn’s disease, mesenteric adipose tissue, microbiota, Mammalian Pathological Biochemistry: Digestive Tract Diseases and other aspects.HPLC of Formula: 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2022, Sun, Xiaowei; Dey, Priyankar; Bruno, Richard S.; Zhu, Jiangjiang published an article.Product Details of 621-37-4 The title of the article was EGCG and catechin relative to green tea extract differentially modulate the gut microbial metabolome and liver metabolome to prevent obesity in mice fed a high-fat diet. And the article contained the following:

Green tea extract (GTE) alleviates obesity, in part, by modulating gut microbial composition and metabolism However, direct evidence regarding the catechin-specific bioactivities that are responsible for these benefits remain unclear. The present study therefore investigated dietary supplementation of GTE, epigallocatechin gallate (EGCG), or (+)-catechin (CAT) in male C57BL6/J mice that were fed a high-fat (HF) diet to establish the independent contributions of EGCG and CAT relative to GTE to restore microbial and host metabolism We hypothesized that EGCG would regulate the gut microbial metabolome and host liver metabolome more similar to GTE than CAT to explain their previously observed differential effects on cardiometabolic health. To test this, we assessed metabolic and phenolic shifts in liver and fecal samples during dietary HF-induced obesity. Ten fecal metabolites and ten liver metabolites (VIP > 2) primarily contributed to the differences in the metabolome among different interventions. In fecal samples, nine metabolic pathways (e.g., tricarboxcylic acid cycle and tyrosine metabolism) were differentially altered between the GTE and CAT interventions, whereas three pathways differed between GTE and EGCG interventions, suggesting differential benefits of GTE and its distinctive bioactive components on gut microbial metabolism Likewise, hepatic glycolysis / gluconeogenesis metabolic pathways were significantly altered between GTE and EGCG interventions, while only hepatic tyrosine metabolism was altered between CAT and GTE interventions. Thus, our findings support that purified catechins relative to GTE uniquely contribute to regulating host and microbial metabolic pathways such as central energy metabolism to protect against metabolic dysfunction leading to obesity. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Product Details of 621-37-4

The Article related to epigallocatechin gallate catechin green tea extract liver microbial metabolome, cat, egcg, gte intervention, metabolic regulation, metabolomics, obesity, Animal Nutrition: Nonnutrient Growth and Metabolic Stimulants and other aspects.Product Details of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts