Tag: 100-200

On November 24, 2009, Mereacre, Valeriu; Ako, Ayuk M.; Akhtar, Muhammad Nadeem; Lindemann, Anja; Anson, Christopher E.; Powell, Annie K. published an article.Electric Literature of 2160-93-2 The title of the article was Homo- and Heterovalent Polynuclear Cerium and Cerium/Manganese Aggregates. And the article contained the following:

Reactions of CeIII(NO3)3·6H2O or (NH4)2[CeIV(NO3)6] with Mn-containing starting materials result in seven novel polynuclear Ce or Ce/Mn complexes with pivalato (tBuCO2-) and, in most cases, auxiliary N,O- or N,O,O-donor ligands. With nuclearities from 6-14, the compounds present aesthetically pleasing structures. [CeIV6(μ3-O)4(μ3-OH)4(μ-O2CtBu)12] (1), [CeIV6MnIII4(μ4-O)4(μ3-O)4(O2CtBu)12(ea)4(OAc)4]·4H2O·4MeCN (ea- = 2-aminoethanolato; 2), [CeIV6MnIII8(μ4-O)4(μ3-O)8(pye)4(O2CtBu)18]2[CeIV6(μ3-O)4(μ3-OH)4(O2CtBu)10(NO3)4] [CeIII(NO3)5(H2O)]·21 MeCN (pye- = pyridine-2-ethanolato; 3), and [CeIV6CeIII2MnIII2(μ4-O)4(μ3-O)4(tbdea)2(O2CtBu)12(NO3)2(OAc)2]·4 CH2Cl2 (tbdea2- = 2,2′-[tert-butylimino]bis[ethanolato]; 4) all contain structures based on an octahedral {CeIV6(μ3-O)8} core, in which many of the O-atoms are either protonated to give (μ3-OH)- hydroxo ligands or coordinate to further metal centers (MnIII or CeIII) to give interstitial (μ4-O)2- oxo bridges. Decanuclear [CeIV8CeIIIMnIII(μ4-O)3(μ3-O)3(μ3-OH)2(μ-OH)(bdea)4(O2CtBu)9.5(NO3)3.5(OAc)2]·1.5 MeCN (bdea2- = 2,2′-[butylimino]bis[ethanolato]; 5) contains a rather compact CeIV7 core with the CeIII and MnIII centers well-separated from each other on the periphery. The aggregate in [CeIV4MnIV2(μ3-O)4(bdea)2(O2CtBu)10(NO3)2]·4 MeCN (6) is based on a quasi-planar {MnIV2CeIV4(μ3-O)4} core made up of four edge-sharing {MnIVCeIV2(μ3-O)} or {CeIV3(μ3-O)} triangles. The structure of [CeIV3MnIV4MnIII(μ4-O)2(μ3-O)7(O2CtBu)12(NO3)(furan)]·6 H2O (7·6 H2O) can be considered as {MnIV2CeIV2O4} and distorted {MnIV2MnIIICeIVO4} cubane units linked through a central (μ4-O) bridge. The Ce6Mn8 is the highest nuclearity yet reported for a heterometallic Ce/Mn aggregate. In contrast to most of the previously reported heterometallic Ce/Mn systems, which contain only CeIV and either MnIV or MnIII, some of the aggregates presented here show mixed valency, either MnIV/MnIII (see 7) or CeIV/CeIII (see 4 and 5). Some of the compounds, including the heterovalent CeIV/CeIII 4, could be obtained from either CeIII(NO3)3·6 H2O or (NH4)2[CeIV(NO3)6] as starting material. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Electric Literature of 2160-93-2

The Article related to cluster cerium manganese oxo preparation mixed valent, crystal structure cerium manganese oxo cluster, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Electric Literature of 2160-93-2

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On May 5, 2022, Li, Si-nong; Cao, Meng-ru; Li, Yi-qi; Yang, Jia-xin; Zhao, Mei-hong; Song, Hui-Hua published an article.Product Details of 32462-30-9 The title of the article was Three pairs of Pb(II), Cd(II) and Cu(II) enantiomeric coordination compounds based on D-(-)- and L-(+) -4-Hydroxyphenylglycine: Synthesis, structures and properties. And the article contained the following:

Three pairs of stable chiral coordination compounds [Pb(D-hpg)2(bpe)2]·(NO3)2 (1), [Pb(L-hpg)2(bpe)2]·(NO3)2 (2); {[Cd (D-hpg)(bpe)(H2O)]·(NO3)·(H2O)}n (3), {[Cd(L-hpg)(bpe)(H2O)]·(NO3)·(H2O)}n (4); {[Cu2(D-hpg)2(bpe)(H2O)2]·(NO3)2·H2O}n (5), {[Cu2(L-hpg)2(bpe)(H2O)2]·(NO3)2·H2O}n (6) (D-Hhpg = D-(-)-4-Hydroxyphenylglycine, L-Hhpg = L-(+)-4-Hydroxyphenylglycine, bpe = 1,2-bis(4-pyridyl)ethane) have been successfully synthesized. Their structures were determined by single-crystal X-ray diffraction anal. and characterized by elemental anal., IR spectroscopy, thermogravimetric anal., powder X-ray diffraction and CD. Compounds 1 and 2 feature 0D mol. structures, compounds 3 and 4 are 2D rectangular grid networks and compounds 5 and 6 exhibit 2D hexagonal grid networks with an ABAB stacking sequence. Compounds 1-6 are further extended into 3D supramol. architectures through hydrogen-bonding interactions. Our results highlight that the modulation of coordination polymers with different structures can be accomplish by selecting the center metal of different electronic structures. Luminescent properties of compounds 1 and 2 were investigated at room temperature 1 and 2 show similar selectivity toward Fe3+ions through luminescent quenching in aqueous solution Moreover, the electrochem. behaviors of compounds 5 and 6 were further studied by cyclic voltammetry, indicating a surface-controlled electrochem. process. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9

The Article related to lead cadmium copper hydroxyphenylglycine bispyridylethane complex preparation structure luminescence, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Product Details of 32462-30-9

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On April 30, 2011, Grabau, Mathias; Forster, Johannes; Heussner, Kirsten; Streb, Carsten published an article.Formula: C8H19NO2 The title of the article was Synthesis and Theoretical Hirshfeld Analysis of a Supramolecular Heteropolyoxovanadate Architecture. And the article contained the following:

A supramol. heteropolyoxovanadate structure was synthesized and characterized using single-crystal XRD, powder XRD and a range of spectroscopic methods. The new compound, [tBuNH(C2H4OH)2]4[H5P1V14O42]·12H2O (1) was obtained using a 1-pot strategy starting from a simple inorganic V oxide precursor and an amphiphilic cation in acidic aqueous solution The cluster anion [H5P1V14O42]4- is based on the known Keggin structure but in addition features two capping vanadyl [V=O]3+ units. In the crystal lattice, the clusters are arranged in linear 1-dimensional chains where neighboring clusters are directly linked by one H bond. The assembly is stabilized by lattice H2O mols. and organic counterions which aggregate to form hydrophobic cavities with diameters of 0.6 nm. To analyze the supramol. interactions leading to the cluster formation, the authors used a combination of traditional structural anal., theor. bond valence sum (BVS) calculations and computational Hirshfeld surface analyses which allow the rapid determination of short- and long-range intermol. contacts. The applicability of the Hirshfeld anal. tool for complex ionic compounds is evaluated and the advantages as well as the limitations of the method are discussed. The combination of these techniques allowed the authors to assess the dominating intermol. interactions and showed that the crystal packing is not only controlled by electrostatic interactions, but also by distinctive sets of H bonds and hydrophobic interactions between adjacent organic counterions. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Formula: C8H19NO2

The Article related to phosphovanadate preparation theroretical hirshfeld analysis, crystal structure phosphovanadate, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Formula: C8H19NO2

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On March 31, 2014, Takenaka, Shinji; Yoshida, Kenji; Tanaka, Kosei; Yoshida, Ken-ichi published an article.Reference of H-Phg(4-OH)-OH The title of the article was Molecular characterization of a novel N-acetyltransferase from Chryseobacterium sp.. And the article contained the following:

N-Acetyltransferase from Chryseobacterium sp. strain 5-3B is an acetyl CoA (acetyl-CoA)-dependent enzyme that catalyzes the enantioselective transfer of an acetyl group from acetyl-CoA to the amino group of L-2-phenylglycine to produce (2S)-2-acetylamino-2-phenylacetic acid. We purified the enzyme from strain 5-3 B and deduced the N-terminal amino acid sequence. The gene, designated natA, was cloned with two other hypothetical protein genes; the three genes probably form a 2.5-kb operon. The deduced amino acid sequence of NatA showed high levels of identity to sequences of putative N-acetyltransferases of Chryseobacterium spp. but not to other known arylamine and arylalkylamine N-acetyltransferases. Phylogenetic anal. indicated that NatA forms a distinct lineage from known N-acetyltransferases. We heterologously expressed recombinant NatA (rNatA) in Escherichia coli and purified it. RNatA showed high activity for L-2-phenylglycine and its chloro- and hydroxyl-derivatives The Km and Vmax values for L-2-phenylglycine were 0.145 ± 0.026 mM and 43.6 ± 2.39 μmol·min-1·mg protein-1, resp. The enzyme showed low activity for 5-aminosalicylic acid and 5-hydroxytryptamine, which are reported as good substrates of a known arylamine N-acetyltransferase and an arylalkylamine N-acetyltransferase. RNatA had a comparatively broad acyl donor specificity, transferring acyl groups to L-2-phenylglycine and producing the corresponding 2-acetylamino-2-phenylacetic acids (relative activity with acetyl donors acetyl-CoA, propanoyl-CoA, butanoyl-CoA, pentanoyl-CoA, and hexanoyl-CoA, 100:108:122:10:<1). The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Reference of H-Phg(4-OH)-OH

The Article related to acetyltransferase chryseobacterium aminosalicylate protein sequence phenylglycine phylogeny, Enzymes: Separation-Purification-General Characterization and other aspects.Reference of H-Phg(4-OH)-OH

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On November 25, 2020, Davaritouchaee, Maryam; Chen, Shulin; Mancini, Rock J. published an article.Category: alcohols-buliding-blocks The title of the article was Delignification and Enzyme-Diffusion Kinetics of Radical Systems Treating Wheat Straw. And the article contained the following:

Biomass pretreatment is often evaluated based on the degree of delignification and the yield of enzymic hydrolysis. Thus, the phase delignification and enzyme diffusion kinetics models were utilized to describe the deconstruction mechanism of wheat straw treated with two-step radical oxidation The oxidation started with a superoxide radical anion, followed by a second radical treatment that synergizes the advantages of both radical systems. Two-step superoxide radical anion and two-step superoxide-hydroxyl radical pretreatments were the most effective pretreatment based on the degree of lignin removal and sugar release. These treatments resulted in 65 and 46% decrease in lignin content and 85.75 and 73.96% increase in glucan recovery, resp. The delignification kinetics constants, k1, k2, and k3, were found to be 1.950, 1.085, and 1.085 min-1, resp., for two-step pretreatment with superoxide radicals and 1.094, 0.717, and 0.717 min-1 with superoxide-hydroxyl radical pretreatment, whereas the kinetics constants were 0.485, 0.390, and 0.390 min-1 for the control. The structural diffusion resistance constant, n, was 0.205-0.359 for the control and 0.185-0.305 for the one-step superoxide treatment, 0.114-0.304 for two-step superoxide treatment, and 0.179-0.249 for two-step superoxide-hydroxyl radical treatment. These results justify that high lignin removal does not always contribute to a better enzymic hydrolysis rate, likely because oxidized lignin products on the surface of biomass can restrict enzyme accessibility. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Category: alcohols-buliding-blocks

The Article related to delignification enzyme diffusion kinetics radical system treating wheat straw, Cellulose, Lignin, Paper, and Other Wood Products: Lignin and other aspects.Category: alcohols-buliding-blocks

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On September 7, 2012, James, Kenneth Duke, Jr.; Laudeman, Christopher Patrick; Malkar, Navdeep Balkrishna; Radhakrishnan, Balasingham published a patent.Product Details of 62640-03-3 The title of the patent was Antifungal agents and uses thereof. And the patent contained the following:

The invention features echinocandin class compounds The compounds can be useful for the treatment of fungal infections. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Product Details of 62640-03-3

The Article related to antifungal anidulafungin derivative preparation fungal infection therapy, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Product Details of 62640-03-3

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Shimojima, Masayuki; Fukushi, Shuetsu; Tani, Hideki; Yoshikawa, Tomoki; Fukuma, Aiko; Taniguchi, Satoshi; Suda, Yuto; Maeda, Ken; Takahashi, Toru; Morikawa, Shigeru; Saijo, Masayuki published an article in 2014, the title of the article was Effects of ribavirin on severe fever with thrombocytopenia syndrome virus in vitro.COA of Formula: C7H16O2 And the article contains the following content:

Severe fever with thrombocytopenia syndrome (SFTS) is a disease with a high case fatality rate that is caused by infection with the recently identified tick-borne SFTS virus (SFTSV), for which there are no specific countermeasures. We examined the effects of ribavirin and mizoribine, which are nucleoside analog drugs with broad antiviral activities, on SFTSV proliferation in vitro. When 3 cell lines were treated with these drugs before and during infection with a Chinese SFTSV strain, the 99% effective concentrations (EC99) of ribavirin were 19-64 μg/mL (78-262 μM); in contrast, the EC99 of mizoribine was >500 μg/mL (1,929 μM). Similar levels of inhibitory effects of ribavirin were observed with 4 Japanese SFTSV strains. However, when Vero cells were treated with ribavirin 3 days after inoculation, the inhibitory effect was dramatically decreased, indicating that ribavirin did not effectively reduce virus production in pre-infected cells. These results suggest that ribavirin could be used as postexposure prophylaxis for the prevention of SFTS. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).COA of Formula: C7H16O2

The Article related to severe fever thrombocytopenia syndrome antiviral ribavirin mizoribine, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.COA of Formula: C7H16O2

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On May 31, 2020, Hayashi, Mikihiro; Obara, Haruna; Shibata, Keisuke; Sugimoto, Kanta; Takasu, Akinori published an article.Synthetic Route of 111-29-5 The title of the article was Glass transition analysis of model metallosupramolecular polyesters bearing pendant pyridine ligands with a controlled ligand-ligand distance. And the article contained the following:

Supramol. materials formed via metal-ligand coordination, so-called metallosupramol. materials, have attracted attention due to their ability to modify a broad range of phys. properties depending on the association strength at the coordination bond. Here, we demonstrate the correlation between the glass transition properties and the ligand distance by utilizing amorphous polyesters (denoted as PE-Py) with pendant pyridine ligands arranged homogeneously along the chain. The ligand distance is treated as the pyridine group equivalent mol. weight (MPy) and takes values of 900, 750, 550, and 420. The metal salt ZnCl2 forms coordination bonds with the pyridine ligands, generating a metallosupramol. network. The fraction of coordinated pyridine is finely tuned by the mole ratio between the pyridine ligand and ZnCl2 ([Zn2+]/[Py]) while adhering to the stoichiometric rule. DSC measurements reveal that the variation in the glass transition temperature (Tg) with increasing [Zn2+]/[Py] is closely correlated with 1/MPy. Temperature-ramp rheol. measurements are also performed, revealing that the apparent activation energy (Ea) of segmental motion has a quasi-linear relationship with 1/MPy. Thus, the present study demonstrates that the degree of restriction for segmental motion is very systematically strengthened as the ligand distance decreases, highlighting the importance of ligand distance in phys. property control of metallosupramol. materials. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Synthetic Route of 111-29-5

The Article related to polyester bearing zinc pyridine complex preparation glass transition, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Synthetic Route of 111-29-5

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On August 13, 2020, Kuehl, Nikos; Graf, Dominik; Bock, Josephine; Behnam, Mira A. M.; Leuthold, Mila-Mareen; Klein, Christian D. published an article.Application of 32462-30-9 The title of the article was A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays. And the article contained the following:

Dengue and West Nile virus are rapidly spreading global pathogens for which no specific therapeutic treatments are available. One of the promising targets for drug discovery against dengue and other flaviviruses is the viral serine protease NS2B-NS3. We present the design, synthesis, and in vitro and cellular characterization of a novel chemotype of potent small-mol. non-peptidic dengue protease inhibitors derived from 4-benzyloxyphenylglycine. A newly developed luciferase-based DENV-2 protease reporter system in HeLa cells (DENV2proHeLa) was employed to determine the activity of the compounds in a cellular environment. Specificity and selectivity of the DENV2proHeLa system were confirmed by viral titer reduction assays. The compounds reach low micromolar to upper nanomolar inhibitory potency in cell-based assays, are selective against other serine proteases, and do not show relevant cytotoxicity. An extensive structure-activity relationship study provides a perspective for further drug development against flaviviral infections. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to dengue west nile virus protease inhibitors sar flaviviral infections, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Application of 32462-30-9

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On February 25, 2021, Le Manach, Claire; Dam, Jean; Woodland, John G.; Kaur, Gurminder; Khonde, Lutete P.; Brunschwig, Christel; Njoroge, Mathew; Wicht, Kathryn J.; Horatscheck, Andre; Paquet, Tanya; Boyle, Grant A.; Gibhard, Liezl; Taylor, Dale; Lawrence, Nina; Yeo, Tomas; Mok, Sachel; Eastman, Richard T.; Dorjsuren, Dorjbal; Talley, Daniel C.; Guo, Hui; Simeonov, Anton; Reader, Janette; van der Watt, Mariette; Erlank, Erica; Venter, Nelius; Zawada, Jacek W.; Aswat, Ayesha; Nardini, Luisa; Coetzer, Theresa L.; Lauterbach, Sonja B.; Bezuidenhout, Belinda C.; Theron, Anjo; Mancama, Dalu; Koekemoer, Lizette L.; Birkholtz, Lyn-Marie; Wittlin, Sergio; Delves, Michael; Ottilie, Sabine; Winzeler, Elizabeth A.; von Geldern, Thomas W.; Smith, Dennis; Fidock, David A.; Street, Leslie J.; Basarab, Gregory S.; Duffy, James; Chibale, Kelly published an article.Electric Literature of 32462-30-9 The title of the article was Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts. And the article contained the following:

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to malaria antimalarial plasmodium diazaspirooctane pharmacokinetic, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Electric Literature of 32462-30-9

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