Tag: 100-200

On April 30, 1978, Perchonock, Carl D.; Loev, Bernard published an article.Synthetic Route of 42900-89-0 The title of the article was Synthesis of some aromatic prostaglandin analogs. And the article contained the following:

Some aromatic prostaglandin analogs, with a benzene (I) (R = H, Me) or a dimethoxybenzene ring (II) in place of the cyclopentane moiety, were synthesized. The key intermediates in the syntheses were lactols III and IV, which were elaborated to the final products via two olefination reactions. I (R = H) was twice as potent as phenylbutazone and nine times as potent as aspirin in inhibiting prostaglandin synthetase activity. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Synthetic Route of 42900-89-0

The Article related to aromatic prostaglandin analog, benzene prostaglandin analog, Alicyclic Compounds: Cyclopentanes, Including Fulvenes and Fulvalenes and other aspects.Synthetic Route of 42900-89-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salerno, Anna; Fragasso, Gabriele; Montanaro, Claudia; Cera, Michela; Torlasco, Camilla; Maranta, Francesco; Margonato, Alberto published an article in 2010, the title of the article was Role of metabolic modulation in the management of chronic ischemic heart disease.SDS of cas: 32462-30-9 And the article contains the following content:

Abstract: Coronary artery disease (CAD) is a major cause of morbidity and mortality in the world. Therapy for stable CAD is currently based on conventional medical therapy, including nitrates, β-blockers and calcium-channels antagonists and, more recently, metabolic therapy, of which a pivotal therapeutic role is increasingly recognized. Under normoxic condition, the healthy heart derives 2/3 of its energy from the free fatty acid (FFA) pathway, the other source of energy being derived from glucose oxidation However, glycolysis requires less O2 per mol of ATP generated compared with FFA oxidation On this basis, shifting energy substrate utilization from fatty acid metabolism to glucose metabolism can be more efficient in terms of ATP production per mol of oxygen utilized. A number of different approaches have been used to manipulate energy metabolism in the heart. These approaches include direct agents, such as dichloroacetate, -carnitine, ribose or lipoic acid which directly increase glucose oxidation, or indirect methods, through the inhibition of free fatty acids oxidation Among these, the most important are carnitil-palmitoyl-transpherase I (CPT-I) inhibitors, which inhibit FFA mitochondrial uptake (e.g. etomoxir, perhexiline, oxphenicine), or 3-ketoacyl-coenzyme-A thiolase (3-KAT) inhibitors, such as trimetazidine, which inhibits the last enzyme involved in β-oxidation In most patients with ischemic heart disease metabolic abnormalities, if not adequately treated, will heavily contribute to the occurrence of complications, of whom severe left ventricular dysfunction is at present one of the most frequent and insidious. In this paper, all possible metabolic approaches to ischemic heart disease are reviewed and discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to metabolic therapy ischemic heart disease cardioprotectant, Pharmacology: Effects Of Cardiovascular, Hematologic, and Renal Drugs and other aspects.SDS of cas: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huangfu, Xinlei; Wang, Yueqiao; Lu, Guozhang; Cao, Yinwei; Tang, Guo; Zhao, Yufen published an article in 2020, the title of the article was Direct synthesis of phosphorotrithioites and phosphorotrithioates from white phosphorus and thiols.Synthetic Route of 143-10-2 And the article contains the following content:

White phosphorus (P4) is still the major com. P-atom source for the production of organophosphorus compounds Conventionally, C-S-P bonds were constructed from environmentally questionable P(O)X directly or indirectly. From the green chem. point of view, formation of C-S-P bonds from inorganic mol. P4 in an easy-to-operate and atom-economical way is essential because it will avoid the hazardous chlorination process. Only five methods for the formation of C-S-P bonds from P4 have been developed over the past 70 years. Here, the first general and high-yielding synthesis of P(SR)3 and P(O)(SR)3 involving P4 and thiols is presented. With the use of KOH or K2CO3 as a base and DMSO-toluene as a solvent, both arythiols and alkylthiols are tolerant in this transformation. The reaction is characterized by a complete conversion of white phosphorus. This operationally simple and environmentally sound reaction shows a broad scope of substrates and good functional group tolerance. Moreover, this method can be easily adapted to large-scale preparation The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to phosphorotrithioate phosphorotrithioite green chem preparation occupational safety, green chem white phosphorus thiol reactivity occupational safety, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Synthetic Route of 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 1984, Osman, Fayez H.; Gawad, Mahfouz M. Abdel; Abbasi, Mohamed M. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was The behavior of N-tert-butyl-2,2′-iminodiethanol towards some trivalent phosphorus compounds. And the article contained the following:

Treating (HOCH2CH2)2NCMe3 (I) with PCl3 or HMPT in C6H6 gave the 2:3 adduct II, which was hydrolyzed by H2O to give the dioxazaphosphocane oxide III (R = H) (IV) and I. Treating IV with o-chloranil gave a crystalline product which in solution gave an equilibrium mixture of V (R = OH) and III (R = OC6Cl4OH-2). PhPCl2 or (Me2N)2PPh reacted with I to give dioxazaphosphocane VI, which added o-chloranil to give an equilibrium mixture of VII and V (R = Ph). Treating VI with PhN3 gave the imine VIII. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to dioxazaphosphocane derivative, iminodiethanol cyclization phosphorus compound, butyliminodiethanol cyclization phosphorus compound, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 30, 1994, Houalla, Douraid; Bounja, Zouhair; Skouta, Said; Wolf, Robert; Jaud, Joel published an article.SDS of cas: 2160-93-2 The title of the article was Macrocycles containing bicyclophosphorane moieties. And the article contained the following:

The first stable macrocycles, e.g. I (R = CMe3, Ph), containing pentacovalent phosphorus have been obtained by an Atherton-Todd reaction between the bis(hydridobicyclophosphoranes) with the corresponding binucleophile HO(CH2)2X(CH2)2OH. The tricyclic monophosphoranes II (X = O, NBu, NCMe3, NPh) as well as the noncyclic derivative III have also been isolated. A pathway that accounts for the formation of all these compounds is proposed. The x-ray crystal study of 2 16-membered rings, I (R = CMe3, Ph), confirms the diequatorial placement of the macrocyclic frame on the trigonal bipyramidal phosphorus which retains the most favorable axial-equatorial-axial annelation of the bicyclic moiety. Comparison of these 2 mol. structures points out the effect of the nature of X on the conformation of the macrocycle. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).SDS of cas: 2160-93-2

The Article related to macrocycle bicyclophosphorane preparation conformation, crystal mol structure bicyclophosphorane containing macrocycle, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.SDS of cas: 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Osman, F. H.; El-Hamouly, W. S.; Abdel-Gawad, M. M.; Abbasi, M. M. published an article in 1982, the title of the article was The behavior of 2,2′-(tert-butylimino)diethanol toward five-membered heterocycles containing phosphorus(III).Safety of 2,2′-(tert-Butylazanediyl)diethanol And the article contains the following content:

The reaction of 2,2′-(tert-butylimino)diethanol Me3CN(CH2CH2OH)2 (I) with dioxaphospholanes II (X = Cl, NMe2) gave III. Thermal reaction of III with I gives a complete rearrangement yielding a mixture of spirophosphorane IV, V, and traces of another product. III reacts with Ph azide to give a mixture of penta- and tetracoordinated phosphorus structures VI and VII, resp. Biacetyl condenses with III to give VIII. Reaction of dioxaphospholane IX (X = Cl) with I yields a mixture of the biphosphite V and another product believed to be either triethylammonium tris(o-phenylenedioxy) phosphate or spirobenzodioxaphospholane X. Similarly, dioxaphospholane IX (X = NMe2) reacts with I forming a mixture of XI and XII. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Safety of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to iminodiethanol reaction dioxaphospholane, ethylene bisphosphite reaction, spirophosphorane, tetraoxaphosphaspirononene, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Safety of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 1994, Houalla, Douraid; Moureau, Loeticia; Skouta, Said; Wolf, Robert published an article.Electric Literature of 2160-93-2 The title of the article was New bicyclophosphoranic macrocycles. II. Mixed macrocycles derived from 3-oxa-, 3-amino- and 3-thia-1,5-pentanediols. And the article contained the following:

New bis- (1-5; shown as I; X = S, O, NPh, NMe; Y = NCMe3, S, O, NPh), tris- (6,7) and tetrakis(bicyclophosphoranes) (8-10) containing macrocycles were obtained by a Todd reaction between the corresponding bis(hydridobicyclophosphoranes) (II) and four 1,5-pentanediols HO(CH2)2Y(CH2)2OH (Y = O, S, NCMe3, NPh). I were formed in moderate (29-45%) yields. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Electric Literature of 2160-93-2

The Article related to macrocycle bicyclophosphorane, pentanediol atherton todd reaction hydridobicyclophosphorane, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.Electric Literature of 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 1987, Robert, Dominique; Gawad, Hoda Abdel; Riess, Jean G. published an article.SDS of cas: 2160-93-2 The title of the article was Fluorophosphoranes as Lewis acids. The conditions of access to hexacoordinated neutral adducts via the intramolecular addition of an electron donor. And the article contained the following:

The preparation of bicyclic neutral hexacoordinated fluorophosphorus adducts (I) from RPF4 (R = F, Me, Ph) and (Me3SiOCH2CH2)2X (X = O, S, NH, NMe, NCMe3, NPh) was examined Adduct I was formed predominantly only in the case where R = F and X = S. In all the other cases there was a strong tendency to form ionic species. The 8-membered dialkoxyfluorophosphorane model precursor II (X = CH2) does not form easily, and the driving force towards the formation of the very stable RPF5- anions and of tetracoordinated phosphorylated species leads to its easy decomposition The monocyclic adducts of type III and IV are not easier to prepare: compound V only could be obtained where X = NH2 and R = F, while the spirophosphorane VI was isolated when R = Ph. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).SDS of cas: 2160-93-2

The Article related to hexacoordinated fluorophosphorus adduct, fluorophosphorane lewis acid reaction, Organometallic and Organometalloidal Compounds: Phosphorus Compounds and other aspects.SDS of cas: 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 5, 2021, Li, Na; Mao, Weimin; Gao, Yun; Wang, Ding; Song, Zhengbo; Chen, Zhongjian published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Liquid chromatography-mass spectrometry based metabolic characterization of pleural effusion in patients with acquired EGFR-TKI resistance. And the article contained the following:

Epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) acquired resistance remains a major barrier in the clin. treatment of lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutations. Despite extensive efforts, mechanism of acquired resistance has not yet been elucidated clearly. The subject of this study was to characterize the metabolic signatures relevant to acquired EGFR-TKI resistance in pleural effusion (PE), and identify potential biomarkers in PE of patients with acquired EGFR-TKI resistance. PE from EGFR-TKI untreated group (n = 30) and EGFR-TKI resistant group (n = 18) was analyzed using liquid chromatog.-mass spectrometry (LC-MS) based metabolomic. Multivariate statistical anal. revealed distinctive diff ;erences between the groups. A total of 34 significantly differential metabolites in PE were identified, among which, the acquired EGFR-TKI resistant group had higher levels of L-lysine, taurine, ornithine and citrulline, and lower levels of L-tryptophan, kynurenine, L-phenylalanine, L-leucine, N-formyl-L-methionine, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine in PE than that of the EGFR-TKI untreated group. These metabolites are mainly involved in six amino acid metabolic pathways. In addition, 3-hydroxyphenylacetic acid and N-acetyl-D-phenylalanine showed the highest AUC values of 0.934 and 0.929 in receiver operating characteristic anal. Through LC-MS metabolomics, our study identified potential biomarkers in PE, differentiating EGFR-TKI resistant patients from untreated patients, as well as the mechanisms underlying acquired EGFR-TKI resistance; thus, providing novel insights into acquired EGFR-TKI resistance. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to egfr tki resistance liquid chromatog mass spectrometry pleural effusion, biomarker, egfr-tki, lung cancer, metabolomics, pleural effusion, resistance, Mammalian Pathological Biochemistry: Respiratory Diseases and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 7, 2012, Manos, Manolis J.; Moushi, Eleni E.; Papaefstathiou, Giannis S.; Tasiopoulos, Anastasios J. published an article.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was New Zn2+ Metal Organic Frameworks with Unique Network Topologies from the Combination of Trimesic Acid and Amino-Alcohols. And the article contained the following:

New Zn2+-trimesate (btc3-) metal organic frameworks (MOFs) were isolated in the presence of various amino-alcs. under solvothermal conditions. Thus, the reaction of ZnCl2 with trimesic acid (H3btc) and the amino alcs. triethanolamine (teoa), 2-(hydroxymethyl)piperidine (hmpip), N-tert-butyldiethanolamine (tbdeoa), 1,4-bis(2-hydroxyethyl)piperazine (bhep), N-methyldiethanolamine (mdeoa), or 4-(2-hydroxyethyl)morpholine (hem) in a 1.6:1:5.6 molar ratio in DMF afforded compounds (teoaH)2[Zn(btc)1.33] (MOAAF-1) (MOAAF = metal organic amino-alc. framework), (NH2Me2)2(hmpipH)[Zn3(btc)3] (MOAAF-2), (NH2Me2)(tbdmaH)2[Zn3(btc)3] (MOAAF-3) (tbdma = N-tert-butyl-dimethylamine), (NH2Me2)(bhepH2)[Zn3(btc)3] (MOAAF-4), (NH2Me2)[Zn4(btc)3(mdeoa)2] (MOAAF-5), and (NH2Me2)[Zn4(btc)3(hem)2] (MOAAF-6), resp. The compounds display 3-dimensional structures with relatively large cavities (4-10 Å) and high potential solvent-accessible areas (38-68% of the unit cell volumes). A number of novel structural features are revealed in the reported MOFs, such as unprecedented dinuclear [Zn2(COO)5]-1 secondary building units (SBUs) and unique network topologies (e.g., in compounds MOAAF-2, MOAAF-3, MOAAF-5, and MOAAF-6). The amino-alcs. employed played a key role for the appearance of such novel structural features in MOAAF 1-6 since they act as bases responsible for the deprotonation of H3btc, templates, and chelating ligands. Specifically, most of the compounds synthesized are templated by protonated amino-alcs. that are involved in H bonding interactions with the frameworks, whereas in two cases (compounds MOAAF-5 and MOAAF-6) the amino-alcs. acted as chelating ligands affecting significantly the underline topol. of the MOFs. The thermal stability and photoluminescence properties of the MOFs are also discussed. This work represents the initial systematic study on the use of combination of amino-alcs. and polycarboxylate ligands for the synthesis of new MOFs, demonstrating it as a powerful synthetic strategy for the isolation of novel MOFs. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to zinc trimesate amino mof preparation thermal stability photoluminescence, crystal structure zinc trimesate amino alc metal organic framework, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Application In Synthesis of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts