Tag: 100-200

On July 21, 2017, Huang, Qi; Zard, Samir Z. published an article.Computed Properties of 386704-04-7 The title of the article was Modular route to azaindanes. And the article contained the following:

A convergent radical based route to azaindanes, e.g., I, is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-Et dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Computed Properties of 386704-04-7

The Article related to xanthate ester radical cyclization, azaindane preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Computed Properties of 386704-04-7

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On September 20, 2007, Imogai, Hassan Julien; Cid-Nunez, Jose Maria; Andres-Gil, Jose Ignacio; Trabanco-Suarez, Andres Avelino; Oyarzabal Santamarina, Julen; Dautzenberg, Frank Matthias; MacDonald, Gregor James; Pullan, Shirley Elizabeth; Luetjens, Robert Johannes; Duvey, Guillaume Albert Jacques; Nhem, Vanthea; Finn, Terry Patrick; Melikyan, Gagik published a patent.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was 1,4-Disubstituted 3-cyanopyridone derivatives and their use as positive allosteric modulators of mGlu2-receptors and their preparation. And the patent contained the following:

The invention relates to compounds, in particular pyridinone derivatives according to formula I wherein all radicals are defined in the application and claims. Compounds of formula I wherein V1 is a covalent bond and bivalent (un)saturated (un)branched C1-6 hydrocarbon radical; M1 is H, C3-7 cycloalkyl, aryl, alkylcarbonyl, alkyloxy, aryloxy, arylcarbonyl, etc.; L is a covalent bond, O, OCH2, OCH2CH2, OCH2CH2O, OCH2CH2OCH2, S, NH and derivatives, etc.; R2 and R3 are independently H, halo and alkyl; A is (un)substituted Ph, (un)substituted piperazinyl, (un)substituted piperidinyl, (un)substituted thienyl, (un)substituted furanyl, etc.; R4 is halo, CN, OH, oxo, formyl, ethanoyl, carboxyl, NO2, etc.; n is 0, 1, 2, and 3; and their pharmaceutically acceptable acid and addition base salts, stereochem. isomeric forms, N-oxides, and quaternary ammonium salts thereof, are claimed. The compounds according to the invention are pos. allosteric modulators of metabotropic receptors – sub-type 2 (“”mGluR2″”) which are useful for the treatment or prevention of neurol. and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. In particular, such diseases are central nervous system disorders selected from the group of anxiety, schizophrenia, migraine, depression, and epilepsy. The invention is also directed to pharmaceutical compositions and processes to prepare such compounds and compositions, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR2 is involved. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their mGlu-2 receptor modulatory activity. From the assay, it was determined that compound II exhibited a pEC50 value of 6.2. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to disubstituted cyanopyridone preparation mglur2 modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On March 3, 2011, Gradl, Stefan; Laird, Ellen; Moreno, David; Ren, Li; Wenglowsky, Steven Mark published a patent.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Preparation of 1H-pyrazolo[3,4-b]pyridine compounds useful for inhibiting Raf kinase. And the patent contained the following:

Title compounds I [R1 = H, halo, CN, etc.; R2 and R3 independently = H, halo, alkyl or alkoxy; R4 and R5 independently = H, halo or alkyl; R6 = (un)substituted Ph, 5- to 6-membered heteroaryl, 9- to 10-membered bicyclic heterocyclyl or heteroaryl; R7 = H or methyl], and their stereoisomers, tautomers or pharmaceutically acceptable salts, are prepared Thus, e.g., II was prepared by cyclization of 5-methoxy-1H-pyrazol-3-amine with sodium nitromalonaldehyde monohydrate followed by reduction and acylation with 3-(benzyloxy)benzoic acid. Compounds of the invention were evaluated for their inhibitory activity of human recombinant B-Raf protein and were found to have an IC50 value of < 1 μM. Methods of using such compounds for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders including cancer in mammalian cells, or associated pathol. conditions are disclosed. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to pyrazolopyridine preparation raf kinase inhibitor cancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Name: (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On June 30, 2020, Honorato de Castro, Ana Cristina; Alves, Livia Maria; Siquieroli, Ana Carolina Silva; Madurro, Joao Marcos; Brito-Madurro, Ana Graci published an article.Formula: C8H8O3 The title of the article was Label-free electrochemical immunosensor for detection of oncomarker CA125 in serum. And the article contained the following:

This paper reports the construction of a new electrochem. immunosensor for detection of oncomarker CA125 for diagnosis and monitoring of ovarian cancer. The platform was developed using screen-printed carbon electrodes modified with poly(3-hydroxyphenylacetic acid) and anti-CA125 as probe for evaluate the biomol. interactions (anti-CA125:CA125) onto the solid surface. Current response of the system has a linear relationship of anti-CA125 concentration in the range of 5 to 80 U mL-1 with a limit of detection of 1.45 U mL-1, discriminating between neg. and pos. serum. The immunosensor was successfully applied to determination of CA-125 in real biol. samples using differential pulse voltammetry (DPV), surface plasmon resonance (SPR) and at. force microscopy (AFM). The results showed the developed immunosensor is versatile, easily integrated to the point of care applications, being an interesting platform to ovarian cancer diagnose in complex samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to ovarian cancer serum oncomarker electrochem immunosensor, Biochemical Methods: Cytochemical and Histochemical and other aspects.Formula: C8H8O3

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On February 17, 2005, Vanotti, Ermes; D’Alessio, Roberto; Tibolla, Marcellino; Varasi, Mario; Montagnoli, Alessia; Santocanale, Corrado; Martina, Katia; Menichincheri, Maria published a patent.COA of Formula: C7H8FNO The title of the patent was Preparation of pyridylpyrrole derivatives active as kinase inhibitors. And the patent contained the following:

Pyridylpyrrole derivatives of formula I [R1 = H, amino, etc.; R2, R’2 = H, halo, etc.; further detail on R1 and R’2 is given; R3, R’3, R4, R’4 = H, alkyl, etc.; R5 = H, halo, etc.] and pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer. Thus, 2-(2-cyclopentylaminopyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one was prepared from 2-(2-chloropyridin-4-yl)-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one and cyclopentylamine. Compounds of this invention in vitro showed IC50 values of 2 nM to 20 nM against Cdc7 kinase. The experimental process involved the reaction of 1-(3-Fluoropyridin-4-yl)ethanol(cas: 87674-15-5).COA of Formula: C7H8FNO

The Article related to pyridylpyrrole derivative preparation kinase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.COA of Formula: C7H8FNO

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On February 15, 2012, McConnell, Ivan; Benchikh, Elouard; Fitzgerald, Peter; Lowry, Philip published a patent.HPLC of Formula: 78-26-2 The title of the patent was Preparation and use of immunogens for development of meprobamate immunoassay with carisoprodol crossreactivity. And the patent contained the following:

Carisoprodol is a centrally-acting prescription drug of known abuse. Upon ingestion it is rapidly metabolized to meprobamate, also a prescription drug with abuse potential. Current immunoassays are specific for carisoprodol and therefore have a short window of detection and, furthermore, are ineffective at detecting meprobamate. The current invention, underpinned by an antibody specific for meprobamate, overcomes these deficiencies. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).HPLC of Formula: 78-26-2

The Article related to forensic meprobamate immunoassay carisoprodol test kit, Toxicology: Forensic Chemistry (Including Analysis) and other aspects.HPLC of Formula: 78-26-2

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On June 25, 2006, Yang, Dehong; Yang, Benyong; Li, Hui published an article.Category: alcohols-buliding-blocks The title of the article was Synthesis of 2-(methyl-2-pyridinylamino)ethanol. And the article contained the following:

The title compound [i.e., 2-[methyl(2-pyridinyl)amino]ethanol] is a key intermediate in the synthesis of rosiglitazone. A reaction of 2-chloropyridine with two equivalent 2-(methylamino)ethanol gave the target compound and 2-(methylamino)ethanol hydrochloride. To enhance the reaction yield, appropriately increasing reaction temperature and changing post-treatment can shorten reaction time to 7-8 h, simplify the operation and significantly improve the yield to 95%. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Category: alcohols-buliding-blocks

The Article related to rosiglitazone methylpyridinylamino ethanol preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: alcohols-buliding-blocks

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On July 4, 2013, Xiao, Dengming; Zhu, Li; Hu, Yuandong; Yu, Rong; Hu, Wei; Zhao, Na; Peng, Yong; Luo, Hong; Han, Yongxin published a patent.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of ethylene derivatives as selective estrogen receptor regulators. And the patent contained the following:

The invention relates to ethylene derivatives I [wherein R0 and R1 = independently H, halo, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl; A and B = independently aryl or heteroaryl; R2 and R3 = independently halo, hydroxy, amino, cyano, mercapto, carboxyl, alkyl, alkenyl, alkynyl, etc.; m and n = independently 0-3], pharmaceutically acceptable salts, stereoisomers, solvates, polymorphs, tautomers, or prodrugs thereof as selective estrogen receptor modulators (SERMs) for treating atrophic vaginitis, endometriosis, female sex dysfunction, mammary cancer, depression, diabetes mellitus, osteoporosis, etc. For example, II was prepared in a multi-step synthesis. II showed inhibitory activity with IC50 < 100 nM against MCF-7 human breast cancer cell lines. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation pyridine pyrimidine selective estrogen receptor regulator human, treatment vaginitis endometriosis mammary cancer depression diabetes osteoporosis, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 2-(Methylamino)ethan-1-ol hydrochloride

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On July 17, 2012, Hannam, Joanne Clare; Hartmann, Sascha; Madin, Andrew; Ridgill, Mark Peter published a patent.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol The title of the patent was Piperidines and related compounds for the treatment of dementia. And the patent contained the following:

Compounds of formula I: modulate the action of gamma secretase, and hence find use in treatment of Alzheimer’s disease and related conditions. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

The Article related to piperidineacetate preparation gamma secretase modulator, heteroarylmethyl pentenynyl piperidineacetate preparation amyloid beta disease treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of (6-(Trifluoromethyl)pyridin-3-yl)methanol

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On October 4, 2007, Hannam, Joanne Clare; Hartmann, Sascha; Madin, Andrew; Ridgill, Mark Peter published a patent.Application of 386704-04-7 The title of the patent was Preparation of piperidines and related compounds as γ-secretase modulators for treatment of diseases associated with amyloid beta deposition in the brain. And the patent contained the following:

Title compounds [I; p = 0, 1; q = 0-3; V = bond, C atom bound to H, R2, XZ; W = N, C bound to H, R2, XZ; X = bond, C(R1)2, CH2C(R1)2; Y = bond, CH2, CH2CH2; Z = CO2H, tetrazolyl; R1 = H, nonaromatic hydrocarbyl; R1R1 = atoms to form an alicyclic group; R3, R4 = H; when V, W = C, then R3R4 = CH2CH2; R5 = H, alkyl, fluoroalkyl, alkoxy, fluoroalkoxy, alkenyl; R6 = Het-A; A = bond, CH2, 1,4-phenylene; Het = (substituted) heterocyclyl; R7 = hydrocarbyl optionally bearing a CF3 group; with provisos], were prepared Thus, 6-trifluoromethylnicotinaldehyde (preparation given), 2-methyl-1-buten-3-yne, Me [2-[4-(trifluoromethyl)phenyl]piperidin-4-yl]acetate hydrochloride (preparation given), and AuBr3 were microwaved together in H2O to give 64% ester derivative, which was saponified with LiOH in THF/H2O to give 71% title compound (II). In a cell-based γ-secretase assay, I showed IC50 values for inhibition of Aβ(42) production that were at least 2-fold lower than for Aβ(40). The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to piperidineacetate preparation gamma secretase modulator, heteroarylmethyl pentenynyl piperidineacetate preparation amyloid beta disease treatment, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

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