Tag: 100-200

On October 8, 2021, Wang, Bingzhi; Yang, Xingxing; Yan, Yiyong; Xu, Wenjian; Fu, Hui; Zeng, Chuyi; Huang, Yongjian; Liu, Yunwang; Wang, Shuishu published a patent.Category: alcohols-buliding-blocks The title of the patent was Preparation of sulfoxaflor hapten, artificial antigen and antibody for immunodetection of sulfoxaflor. And the patent contained the following:

The present invention relates to the preparation of sulfoxaflor hapten, artificial antigen and antibody for immunodetection of sulfoxaflor. In particular, the sulfoxaflor hapten I (wherein, n = 1, 2, 3, 4, or 5) was prepared The inventive hapten is coupled with the carrier protein to prepare artificial antigens, and the artificial antigens are used to immunize animals to obtain sulfoxaflor antibodies, the sulfoxaflor hapten, antigen, and antibody is used in immunol. detection, the inventive method provides a gold chromatog. detection device which can quickly and accurately detect sulfoxaflor residue content in vegetables or fruits, can meet regulators, on-site supervision and law enforcement detection mechanism needs, uses easily available chem. reagents, has simple operation process, high reaction yield and low detection cost.; the inventive detection method has high degree, high specificity, low cost, simple operation, short detection time and long shelf life. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Category: alcohols-buliding-blocks

The Article related to sulfoxaflor hapten preparation artificial antigen antibody immunodetection, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
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Chaudhari, Shivshankar; Shin, HyeonTae; Choi, SeoungYong; Cho, KieYong; Shon, MinYoung; Nam, SeungEun; Park, YouIn published an article in 2021, the title of the article was Hydrophilic and organophilic pervaporation of industrially important α,β and α,ω-diols.Recommanded Product: 111-29-5 And the article contains the following content:

The distillation-based purification of α,β and α,ω-diols is energy and resource intensive, as well as time consuming. Pervaporation separation is considered to be a remarkable energy efficient membrane technol. for purification of diols. Thus, as a core pervaporation process, hydrophilic polyvinyl alc. (PVA) membranes for the removal of water from 1,2-hexanediol (1,2-HDO) and organophilic polydimethylsiloxane-polysulfone (PDMS-PSF) membranes for the removal of isopropanol from 1,5 pentanediol (1,5-PDO) were employed. For 1,2-HDO/water separation using a feed having a 1 : 4 weight ratio of 1,2-HDO/water, the membrane prepared using 4 vol% glutaraldehyde (GA4) showed the best performance, yielding a flux of 0.59 kg m-2 h-1 and a separation factor of 175 at 40°C. In the organophilic pervaporation separation of the 1,5-PDO/IPA feed having a 9 : 1 weight ratio of components, the PDMS membrane prepared with a molar ratio of TEOS alkoxy groups to PDMS hydroxyl groups of 70 yielded a flux of 0.12 kg m-2 h-1 and separation factor of 17 638 at 40°C. Long term stability anal. found that both hydrophilic (PVA) and organophilic (PDMS) membranes retained excellent pervaporation output over 18 days’ continuous exposure to the feed. Both the hydrophilic and organophilic membranes exhibited promising separation performance at elevated operating conditions, showing their great potential for purification of α,β and α,ω-diols. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Recommanded Product: 111-29-5

The Article related to pva pdms polysulfone membrane diol hydrophilic organophilic pervaporation, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.Recommanded Product: 111-29-5

Referemce:
Alcohol – Wikipedia,
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On April 5, 2012, Bae, Sung Jin; Yi, Han Ju; Hwang, Sun Gwan; Jeong, Mo Ses; Yoon, Yeo Jin; Chae, Sang Mi; Park, Joo Young; Ryu, Eun Ju published a patent.Application of 386704-04-7 The title of the patent was Cyclohexane derivatives as NO production inhibitors and their preparation and use for the treatment of pain. And the patent contained the following:

The invention relates to cyclohexane derivatives of formula I, which are inhibitors of nitric oxide production and which are useful in the treatment of pain. Compounds of formula I wherein Ar is (un)substituted Ph, (un)substituted pyridine and (un)substituted pyridine N-oxide; X is O, C(O)O, NH, etc.; Y is CH2, O and NH and derivatives; A is O and NH; Q is CH and N; m is 0 to 2; n is 0 and 1; and pharmaceutically acceptable salts, isomers, solvates and hydrates thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). All the invention compounds were evaluated for their NO production inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range 7.5 – 9.9 μM. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to cyclohexane preparation nitric oxide production inhibitor treatment pain, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

Referemce:
Alcohol – Wikipedia,
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On September 2, 2014, Bae, Sung Jin; Yi, Han Ju; Hwang, Sun Gwan; Jeong, Mo Ses; Yoon, Yeo Jin; Chae, Sang Mi; Park, Joo Young; Ryu, Eun Ju published a patent.Formula: C7H6F3NO The title of the patent was Methylcyclohexane derivatives and uses thereof. And the patent contained the following:

A novel methylcyclohexane derivative, and a pharmaceutical composition including the same that is effective for the prevention or treatment of pain. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to cyclohexane preparation nitric oxide production inhibitor treatment pain, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H6F3NO

Referemce:
Alcohol – Wikipedia,
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On August 14, 2014, Fox, William Alan published a patent.Synthetic Route of 78-26-2 The title of the patent was Cytological staining compositions containing a cationic dye and a hygroscopic polyol and uses thereof. And the patent contained the following:

The present subject matter is directed to a composition for staining cytol. material comprising a cationic dye component, a hygroscopic polyol and optionally a water-soluble solvent, water or water-miscible solvent, methods of use of the compositions Advantageously, the present compositions do not require the use of a cover slide as is required in known staining fixatives. The compositions are able to retain cell morphol. for a period of time such that a cover slide is not required. Further, the compositions do not contain hazardous levels of organic components. Preferably, the compositions consist essentially of Azure C, glycerol and optionally water. In another aspect, the present subject matter is directed to a method of characterizing a cell sample comprising contacting the cell sample with a composition comprising a dye component and a hygroscopic polyol and subjecting the sample to anal. to determine the presence or absence of abnormal cells. The cytol. staining composition composition comprises 0.004% w/v Azure C and 3% volume/volume glycerol. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Synthetic Route of 78-26-2

The Article related to cytol staining composition cationic dye hygroscopic polyol water solvent, Biochemical Methods: Cytochemical and Histochemical and other aspects.Synthetic Route of 78-26-2

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Alcohol – Wikipedia,
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On June 14, 2019, Desi Reddy, Srinivas Reddy; Peri, Seetharamasarma; Rane, Dnyandev Ragho; Donta, Suresh published a patent.Related Products of 386704-04-7 The title of the patent was A process for the preparation 6-trifluoromethylnicotinaldehyde. And the patent contained the following:

The present application provides a process for preparation of 6-trifluoromethylnicotinaldehyde, which is useful as an intermediate for the preparation of Pexidartinib. This process comprises: (a) reacting 5-bromo-2-(trifluoromethyl)pyridine with RMgX [R = Et, Me, Pr and butyl; and X = Cl, F, Br and I] in presence of organic solvent and further treated with paraformaldehyde to produce (6-(trifluoromethyl)pyridin-3-yl)methanol; and (b) oxidizing the latter with MnO2 in presence of organic solvent to produce 6-trifluoromethylnicotinaldehyde. A process for the preparation of 6-trifluoromethylnicotinaldehyde which comprises: (a) reacting 5-bromo-2-(trifluoromethyl)pyridine with RMgX [R and X are as defined above] in presence of organic solvent to produce in-situ of formula I; and (b) reacting I with formylating agent to produce 6-trifluoromethylnicotinaldehyde, is also provided. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to trifluoromethylnicotinaldehyde preparation intermediate pexidartinib, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Related Products of 386704-04-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2021, Ghorbani, Fatemah; Tirgir, Farhang; Jafari, Abbas published an article.SDS of cas: 32462-30-9 The title of the article was Construction and characterization of the novel polymer/Ag nanocomposite coated on glass bead as filter for inactivation of E. coli in water. And the article contained the following:

Abstract: In this project, pseudo-poly(amino acid)s (PAAs) containing different amino acids in main chain were synthesized by direct polyesterification of N,N-(pyromellitoyl)-bis-D-4-hydroxyphenylglycine di-Me ester as biol. active diol with diacid monomer derived from different amino acids was carried by tosyl chloride/pyridine/DMF as condensing agent. All biol. properties of the polymers were determined by biol. evaluation in bacterial media. PAAs containing silver nanoparticles were fabricated by in- situ method using dimethylformaide (DMF) as a solvent which leads to a spontaneous reduce in room temperature Furthermore, these biopolymer nanocomposite/Ag thin films were immobilized on glass microbeads. The chem. structures of synthesized PAAs and PAA/Ag nanocomposite (NC) were considered by FTIR, 1H-NMR spectroscopy, transmission electron microscopy (TEM), elemental anal., differential scanning calorimetry (DSC), thermogravimetric anal. (TGA), SEM, and energy dispersive X-ray (EDAX). The results of EDAX and TEM anal. of PAAs/Ag NC showed that silver particles have homogeneous dispersion and uniformity in nano-dimensions about 50 nm in PAAs matrix. The micro glass beads were coated with PAA/Ag nanocomposite thin film and placed in a column through for the disinfecting effect of Escherichia coli in water was evaluated very well. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to filter silver polyester polyimide nanocomposite preparation thermal, Plastics Fabrication and Uses: Plastic Product Uses and other aspects.SDS of cas: 32462-30-9

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Alcohol – Wikipedia,
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On April 22, 2004, Lowe, John A.; Volkmann, Robert A. published a patent.Formula: C3H10ClNO The title of the patent was Preparation of 2-amino-6-(2,4,5-substituted-phenyl)pyridines as nitrous oxide synthase (NOS) inhibitors. And the patent contained the following:

Title compounds I [R1 = Me, Et, Pr, etc.; R2 = H, Me, Et, Pr, etc.; m = 1-3; R3-4 = Ph, 5-6-membered heteroaryl containing from 1 to 4 heteroatoms, etc.] are prepared For instance, 4-benzyloxy-5-ethyl-2-methoxyphenylboronic acid (preparation given) is reacted with 2-bromo-6-(2,5-dimethylpyrrol-1-yl)pyridine (EtOHaq, Na2CO3, (PPh3)4Pd, reflux, 64 h) and the resulting adduct debenzylated (MeOH, NH4O2CH, Pd(OH)2, reflux, 45 min), the amino residue unmasked (EtOHaq, NH2OH, reflux, 16 h), alkylated with 3-((methanesulfonyl)oxy)azetidine-1-carboxylic acid tert-Bu ester (DMSO, t-BuOK) and finally converted to II (THF, LAH). Example compounds exhibit IC50 < 1 μM for inhibition of NOS. I are useful for the treatment of treatment and prevention of central nervous system and other disorders. I are also used for inhibiting neurol. damage caused by impairment of glucose and/or oxygen to the brain; in one embodiment, the NOS inhibitor is administered to the mammal prior to surgery, e.g., prior to cardiac surgery, angioplasty, or angiog. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amino phenyl pyridine nitric oxide synthase inhibitor preparation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C3H10ClNO

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Alcohol – Wikipedia,
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On September 22, 2016, Conn, P. Jeffrey; Lindsley, Craig W.; Emmitte, Kyle A.; Felts, Andrew S.; Bollinger, Katrina A. published a patent.Formula: C7H6F3NO The title of the patent was Pyridine derivatives as negative allosteric modulators of metabotropic glutamate receptor 2 and their preparation. And the patent contained the following:

Described are pyridine derivatives of formula I as neg. allosteric modulators of metabotropic glutamate receptor 2 (mGlu2), pharmaceutical compositions including the compounds, and methods of using the compounds and compositions for treating depression, anxiety, obsessive-compulsive disorder, cognitive disorders, Alzheimer’s disease, or autism spectrum disorders in a subject. Compounds of formula I wherein R1 is aryl, heteroaryl, heterocyclyl and cycloalkyl; R2a and R2b are independently H, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl and C1-4 haloalkoxy; R3 is X-(C(R5)2)0-2-Z-(C(R5)2)0-2-N(R6)2, X-(C(R5)2)0-2-Z-(C(R5)2)0-2-Y-A, A’-X-(C(R5)2)0-2-Z-(C(R5)2)0-2-N(R6)2, etc.; X, Y and Z are independently C(R5)2, O, S, CO, OCO, etc.; each R5 are independently H, F, C1-4 alkyl, C1-4 alkoxy, etc.; each R6 are independently C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, C1-6 heteroalkyl and heterocyclyl; N(R6)2 may be taken together form heterocyclyl; A and A’ are independently (un)substituted aryl, (un)substituted heteroaryl, (un)substituted cycloalkyl and (un)substituted heterocyclyl; R4 is CONH2 and CN; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their mGlu2 receptor modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 6850 nM and a maximum response of 5.12 %. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to pyridine preparation mglu2 receptor neg allosteric modulator, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Formula: C7H6F3NO

Referemce:
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On September 16, 2022, Scaini, Denis; Biscarini, Fabio; Casalis, Loredana; Albonetti, Cristiano published an article.HPLC of Formula: 143-10-2 The title of the article was Substrate roughness influence on the order of nanografted Self-Assembled Monolayers. And the article contained the following:

Adjacent patches of alkanethiol mols. whose chain lengths range from 11 to 15 carbon atoms are fabricated by nanografting within a Self-Assembled Monolayer matrix. Atomic Force Microscopy and Electrostatic Force Microscopy are employed to investigate their structural and electronic properties, highlighting the key role of the substrate roughness. In particular, the topog. phase signal allows to establish an odd-even dependence of the local stiffness vs. the alkyl chain length, while the electrostatic force signal provides evidence that the conformational order vs. the alkyl chain length follows an asym. parabolic trend induced by the substrate roughness. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).HPLC of Formula: 143-10-2

The Article related to gold substrate roughness nanograft self assembled monolayer, Surface Chemistry and Colloids: Solid-Solid Systems and other aspects.HPLC of Formula: 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts