Tag: 100-200

On March 31, 2022, Ji, Jiacheng; Zhang, Shuo; Tang, Li; Zhang, Min; Yuan, Minyan; Wang, Pengjiao; Gao, Xiuli published an article.Recommanded Product: 2,3-Dihydroxypropanoic acid The title of the article was Integrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice. And the article contained the following:

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to fecal metabolome gut microbiota high fat diet hyperlipidemic rat, rosa roxburghii tratt juice, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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On June 26, 2020, Ju, Jian; Hsieh, Chao-Mao; Tian, Yao; Kang, Jian; Chia, Ruining; Chang, Hao; Bai, Yanru; Xu, Chenjie; Wang, Xiaomeng; Liu, Quan published an article.Electric Literature of 143-10-2 The title of the article was Surface Enhanced Raman Spectroscopy Based Biosensor with a Microneedle Array for Minimally Invasive In Vivo Glucose Measurements. And the article contained the following:

To monitor blood glucose levels reliably, diabetic patients usually have to undergo frequent fingerstick tests to draw out fresh blood, which is painful and inconvenient with the potential risk of cross contamination especially when the lancet is reused or not properly sterilized. This work reports a novel surface-enhanced Raman spectroscopy (SERS) sensor for the in situ intradermal detection of glucose based on a low-cost poly(Me methacrylate) microneedle (PMMA MN) array. After incorporating 1-decanethiol (1-DT) onto the silver-coated array surface, the sensor was calibrated in the range of 0-20 mM in skin phantoms then tested for the in vivo quantification of glucose in a mouse model of streptozocin (STZ)-induced type I diabetes. The results showed that the functional poly(Me methacrylate) microneedle (F-PMMA MN) array was able to directly measure glucose in the interstitial fluid (ISF) in a few minutes and retain its structural integrity without swelling. The Clarke error grid anal. of measured data indicated that 93% of the data points lie in zones A and B. Moreover, the MN array exhibited minimal invasiveness to the skin as the skin recovered well without any noticeable adverse reaction in 10 min after measurements. With further improvement and proper validation, this polymeric MN array-based SERS biosensor has the potential to be used in painless glucose monitoring of diabetic patients in the future. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Electric Literature of 143-10-2

The Article related to sers biosensor glucose, glucose sensing, in vivo biosensor, microneedle array, minimally invasive intradermal measurements, surface enhanced raman scattering, Biochemical Methods: Spectral and Related Methods and other aspects.Electric Literature of 143-10-2

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On June 4, 2020, Kap, Oezlem; Kabanov, Nikolai; Tsvetanova, Martina; Varlikli, Canan; Klavsyuk, Andrey L.; Zandvliet, Harold J. W.; Sotthewes, Kai published an article.Product Details of 143-10-2 The title of the article was Structural Stability of Physisorbed Air-Oxidized Decanethiols on Au(111). And the article contained the following:

We have studied the dynamic behavior of decanethiol and air-oxidized decanethiol self-assembled monolayers (SAMs) on Au(111) using time-resolved scanning tunneling microscopy at room temperature The air-oxidized decanethiols arrange in a lamellae-like structure leaving the herringbone reconstruction of the Au(111) surface intact, indicating a rather weak interaction between the mols. and the surface. Successive STM images show that the air-oxidized mols. are structurally more stable as compared to the nonoxidized decanethiol mols. This is further confirmed by performing current-time traces with the feedback loop disabled at different locations and at different mol. phases. D. function theory calculations reveal that the diffusion barrier of the physisorbed oxidized decanethiol mol. on Au(111) is about 100 meV higher than the diffusion barrier of a chemisorbed Au-decanethiol complex on Au(111). A two-dimensional activity map of individual current-time traces performed on the air-oxidized decanethiol phase reveals that all the dynamic events take place within the vacancy lines between the air-oxidized decanethiols. These results reveal that the oxidation of thiols provides a pathway to produce more robust and stable self-assembled monolayers at ambient conditions. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Product Details of 143-10-2

The Article related to decanethiol gold stability surface oxidation self assembly monolayer, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Product Details of 143-10-2

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On April 28, 2022, Du, Chuanshen; Andino, Richard S.; Rotondaro, Matthew C.; Devlin, Shane W.; Erramilli, Shyamsunder; Ziegler, Lawrence D.; Thuo, Martin M. published an article.Formula: C10H22S The title of the article was Substrate Roughness and Tilt Angle Dependence of Sum-Frequency Generation Odd-Even Effects in Self-Assembled Monolayers. And the article contained the following:

Role of substrate type, gold or silver, and surface roughness on the parity odd-even effect in n-alkanethiolate (n = 10-16) self-assembled monolayers (SAMs), materials of potential importance to mol. scale electronics, is studied using vibrational sum-frequency generation (SFG) spectroscopy. An inverted odd-even effect is observed for SAMs on Ag substrates relative to SAMs on Au. The metal-specific SFG spectra in the Me and methylene stretching regions provide a sensitive probe of the in situ cant angle and mol. twist dependence of the interfacial group orientation. Within the precision of these measurements, disorder due to gauche defects is not evident in this spectral anal. SFG Me vibrational frequencies and line widths show parity and substrate dependence. Metal substrate roughness, an under-reported exptl. parameter, affects the extent of odd-even Me orientation anisotropy. Parity-dependent Me orientation effects are seen on Ag beyond the roughness limit established by hydrophobicity data on Au. The SFG anal. predicts an ~2.8 nm rms roughness limit for odd-even effects on Ag substrates. These SFG results further confirm the role competing pairwise short-range dispersive (∝1/r6) and longer range polar (∝1/r to 1/r4) interactions play in controlling the observed odd-even wetting behavior of SAMs on metal substrates as a function of surface roughness. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

The Article related to surface roughness wetting self assembly monolayer gold silver thiol, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Formula: C10H22S

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On March 22, 2022, Murthy, Palle Ramana; Selvam, Parasuraman published an article.Quality Control of 2,3-Dihydroxypropanoic acid The title of the article was Ordered Mesoporous Carbon-supported Morphologically-controlled Nano-Gold: Role of Support as well as the Shape and Size of Gold Nanoparticles on the Selective Oxidation of Glycerol. And the article contained the following:

Glyceric acid is one of the important intermediates of glycerol oxidation However, it is extremely difficult to achieve high glyceric acid selectively as the reaction follows a complex pathway with the formation of a variety of undesired products. In this context, periodic mesoporous carbon-supported gold catalysts show promise for selective formation of the targeted product. Therefore, in this investigation, an effort has made to study the effect of particle size and shape of a series of carbon supported with varied sized/shaped gold catalysts on the liquid-phase oxidation of glycerol. Further, the role played by the surface of gold-nanoparticles has prompted us to investigate in detail the isotropic (nanocube/nanosphere) and anisotropic (nanoslabs/nanorods) gold supported onto both activated/amorphous carbon (Au/AC) and ordered mesoporous carbon (Au/CMK-3) towards glycerol oxidation It was observed that the CMK-3 supported gold nanocube exhibited the highest yield towards glyceric acid with an excellent stability in terms of recyclability/reusability. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Quality Control of 2,3-Dihydroxypropanoic acid

The Article related to gold nanoparticle carbon glycerol selective oxidation morphol, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Quality Control of 2,3-Dihydroxypropanoic acid

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On April 21, 2020, Zhou, Guobing; Liu, Chang; Bumm, Lloyd A.; Huang, Liangliang published an article.Synthetic Route of 143-10-2 The title of the article was Force Field Parameter Development for the Thiolate/Defective Au(111) Interface. And the article contained the following:

A mol.-level understanding of the interplay between self-assembled monolayers (SAMs) of thiolates and gold surface is of great importance to a wide range of applications in surface science and nanotechnol. Despite theor. research progress of the past decade, an atomistic model, capable of describing key features of SAMs at reconstructed gold surfaces, is still missing. In this work, periodic ab initio d. functional theory (DFT) calculations were utilized to develop a new atomistic force field model for alkanethiolate (AT) SAMs on a reconstructed Au(111) surface. The new force field parameters were carefully trained to reproduce the key features, including vibrational spectra and torsion energy profiles of ethylthiolate (C2S) in the bridge or staple motif model on the Au(111) surface, wherein, the force constants of the bond and angle terms were trained by matching the vibrational spectra, while the torsion parameters of the dihedral angles were trained via fitting the torsion energy profiles from DFT calculations To validate the developed force field parameters, we performed classical mol. dynamics (MD) simulations for both pristine and reconstructed Au-S interface models with a (2√3 x 3) unit cell, which includes four dodecanethiolate (C10S) mols. on the Au(111) surface. The simulation results showed that the geometrical features of the investigated Au-S interface models and structural properties of the C10S SAMs are in good agreement with the ab initio MD studies. The newly developed atomistic force field model provides new fundamental insights into AT SAMs on the reconstructed Au(111) surface and adds advancement to the existing interface research knowledge. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to force field parameter thiolate gold interface surface defect, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Synthetic Route of 143-10-2

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On August 30, 2022, Tsvetanova, Martina; Syromyatnikov, Alexey G.; Zandvliet, Harold J. W.; Klavsyuk, Andrey L.; Sotthewes, Kai published an article.SDS of cas: 143-10-2 The title of the article was Low coverage disordered decanethiol monolayers on Au(001): A conjecture regarding the formation of Au-adatom-molecule complexes. And the article contained the following:

We present a scanning tunneling microscopy study of decanethiol on Au(001) in the low coverage regime. As expected, the hex reconstruction is lifted, however, no ordered decanethiol phases form. We observe large areas free of Au islands and covered with a disordered decanethiol phase. I(t) spectroscopy measurements suggest that this disordered phase is dynamic and most likely comprises diffusing Au adatoms, decanethiol mols., and/or Au-adatom-decanethiol mol. complexes. We have performed d. functional theory calculations and show that the activation barrier for diffusion is lower when Au-adatom-mol. complexes are considered in comparison to the case of bare mol. These findings suggest that although no vacancy pits form on Au(001), Au-adatoms expelled during the lifting of the hex reconstruction may be still important for the diffusion of thiol mols. on this surface. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).SDS of cas: 143-10-2

The Article related to gold decanethiol monolayer adatom mol conjecture formation, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.SDS of cas: 143-10-2

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On June 30, 2020, Truyens, Anne-Julie; Vekeman, Jelle; Tielens, Frederik published an article.Synthetic Route of 143-10-2 The title of the article was A subtle balance between interchain interactions and surface reconstruction at the origin of the alkylthiol/Au(111) self-assembled monolayer geometry. And the article contained the following:

In this paper we present a DFT investigation on the structure and energetics of (√3 × 2√3)R30° high coverage SAMs of n-alkanethiols up to twelve carbon atoms on a clean Au(111) surface. The surface was found to be more reconstructed for longer chains, although a surface reconstruction plateau was reached for decanethiol SAMs. The geometry was suggested to be dictated by steric effects and van der Waals interactions between the adsorbates resulting in a specific adsorption configuration. Furthermore, the increasing adsorption energy per thiol mol. is due to the increasing van der Waals forces between the adsorbates. In conclusion a more stable monolayer was obtained with increasing adsorbate chain length. In other words a subtle balance between interchain interactions and surface reconstruction is at the origin of the alkylthiol/Au(111) self-assembled monolayer geometry. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to surface reconstruction self assembly monolayer gold thiol, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Synthetic Route of 143-10-2

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On November 11, 2021, Brown, Sarah; Sayler, Jeffrey D.; Sibener, S. J. published an article.Category: alcohols-buliding-blocks The title of the article was Influence of Structural Dynamics on the Kinetics of Atomic Hydrogen Reactivity with Low-Temperature Alkanethiolate Self-Assembled Monolayers. And the article contained the following:

This study examines the impact of surface temperature on alkanethiolate self-assembled monolayer (SAM) reactivity with at. hydrogen (H) as well as how the combined effects of temperature and alkanethiol chain length alter the reaction outcome. This is achieved using ultrahigh vacuum scanning tunneling microscopy (UHV-STM) to monitor the spatiotemporal evolution of the monolayer throughout the reaction. We find that with decreasing temperature, the reaction rate of alkanethiol SAMs with at. H decreases monotonically. Furthermore, the kinetic profile of the low-temperature reaction differs from that at room temperature, indicating structural and dynamical fluctuations within the monolayer that influence reactivity. Chain length is also seen to significantly affect reactivity at reduced substrate temperature, with longer alkanethiols reacting more slowly than shorter ones. Finally, we observe a unique surface rearrangement of the SAM upon exposure to at. H, including changes in the organization of close-packed thiol domains and the evolution of gold adatom islands not observed at elevated temperatures Overall, this work provides both quant. and nanoscopic insight into how substrate temperature influences the structural dynamics of thiolate monolayers and how these fluctuations influence chem. reactivity. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Category: alcohols-buliding-blocks

The Article related to atomic hydrogen thiol self assembly monolayer reactivity, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Category: alcohols-buliding-blocks

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On May 2, 2013, Bayburt, Erol K.; Clapham, Bruce; Cox, Phil B.; Daanen, Jerome F.; Gomtsyan, Arthur; Kort, Michael E.; Kym, Philip R.; Voight, Eric A.; Schmidt, Robert G.; Dart, Michael J.; Gfesser, Gregory published a patent.Application of 386704-04-7 The title of the patent was Preparation of (cyclobutyl)(pyridinyl)methanol derivatives as TRPV3 modulators. And the patent contained the following:

Title compounds I [each occurrence of Ra and Rb independently = H, (un)substituted alkyl, haloalkyl, halogen, OH, O(alkyl), or phenyl; q = 0-2; X3 = O; X4 = bond or (CH2)m; X5 = (CH2)n; m and n are each 1; each Z1 = alkyl, oxo, halogen, haloalkyl, etc.; p = 1-4; X1 = OH; X2 = H; G1 = (un)substituted aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl; G2 = aryl, heteroaryl, cycloalkyl, heterocycle, or cycloalkenyl], and their pharmaceutically acceptable salts, are prepared Compounds of the invention were evaluated for ability to antagonize the activation of recombinant human TRPV3 using FLIPR Tetra cellular screening. Thus, e.g., II was prepared in a multi-step synthesis and had IC50 value of 0.19 nM as human TRPV3 antagonist. The invention compounds and combination with other therapeutic agent are useful for treating conditions such as pain and inflammation. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Application of 386704-04-7

The Article related to methanol cyclobutyl pyridinyl preparation trpv3 modulator pain inflammation, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 386704-04-7

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