Tag: 100-200

Hashimoto, K.; Yanagida, M.; Horikawa, M.; Shirahama, H. published an article in 1989, the title of the article was Syntheses and neuroexcitatory activity of kainoids.Category: alcohols-buliding-blocks And the article contains the following content:

Kainoids, such as kainic acid, domoic acid, acromelic acids A and B, cause marked depolarization against L-glutamate receptor in vertebrates and invertebrates. To find the more potent kainoids and to reveal the structure-activity relationship, efforts were made toward the syntheses of kainoids and related compounds The most rational synthesis of kainoid, i.e., introduction of various substituents to a common intermediate, was achieved by the use of diaryl copper lithium reagent for the substitution reaction of trans-4-tosyloxyproline with retention of configuration. Neuroexcitatory activity of the synthetic compounds was also examined Among the 6 acyclic analogs of kainoid, only the (2S,3R)-isomers, which have π-electrons on the β-substituent, showed neuroexcitatory activity. In the newly synthesized kainoids, the Ph derivative (I) showed comparable activity to kainic acid, the phenol derivative (II) exhibited more potent activity than acromelic acid B or domoic acid, and the methoxyphenyl derivative (III) was 3- to 5-fold more potent than acromelic acid A, and the most potent excitatory reagent known so far. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Category: alcohols-buliding-blocks

The Article related to kainoid preparation neuroexcitatory, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 28, 1998, Hikima, Toshio published a patent.COA of Formula: C3H10ClNO The title of the patent was skin cosmetics containing biphenyl compounds. And the patent contained the following:

Skin cosmetics showing excellent skin-lightening, antiaging and rough skin-preventing effects contain: [A] ascorbic acid or derivatives and/or fibroblast collagen formation promoters and [B] biphenyl compounds(I)[R1 = Me, Et, Pr, CH2OH, C3H6OH, CH2CH:CH2] or (II) [R2 = H, C1-8 hydrocarbons]. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).COA of Formula: C3H10ClNO

The Article related to skin cosmetic biphenyl compound, ascorbate collagen formation promoter skin cosmetic, Essential Oils and Cosmetics: Skin Preparations and other aspects.COA of Formula: C3H10ClNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 30, 2021, Liang, Zhi; Lin, Wenfeng; Shi, Ruijun; Liu, Xun published a patent.COA of Formula: C6H10O3 The title of the patent was Method for preparation and purification of antibody-drug conjugates having improved plasma stability and therapeutic effect for cancer therapy. And the patent contained the following:

Disclosed is a preparation method for an antibody medicament conjugate, comprising steps for synthesizing and purifying same. The experimental process involved the reaction of 3-Cyclopropyl-2-hydroxypropanoic acid(cas: 1599840-16-0).COA of Formula: C6H10O3

The Article related to sequence antibody drug conjugate improved stability effect cancer immunotherapy, Immunochemistry: Antibodies and Immunoglobulins and other aspects.COA of Formula: C6H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 18, 2013, Chen, Longdi published a patent.Synthetic Route of 62640-03-3 The title of the patent was Synergistic hair conditioner containing Camellia sinensis leaf oil. And the patent contained the following:

The invention discloses a hair conditioner containing (by weight) Camellia sinensis leaf oil 0.2-0.6%, dihydrogenated tallowamidoethyl hydroxyethylmoniumchloride 2-5%, cetearyl phosphate 3-6%, L-glucitol 1-3%, and water in balance. The hair conditioner also contains zinc pyrithione, eugenol and ammothamnine. The hair conditioner has antifungal effect and anti-dandruff effect, and improves hair loss and tinea capitis. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Synthetic Route of 62640-03-3

The Article related to synergistic hair conditioner camellia leaf oil fungicide tinea capitis, Essential Oils and Cosmetics: Hair Preparations and other aspects.Synthetic Route of 62640-03-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 20, 2018, Botto, Anna; Suleiman, Azizah; Mahadeshwar, Anand; Naiberk, Emma; Decarlo, Vanessa published a patent.Name: 2-Methyl-2-propylpropane-1,3-diol The title of the patent was Leave-on hair styling compositions comprising calcium carbonate and sugar alcohols. And the patent contained the following:

The present disclosure relates to leave-on hair styling compositions comprising: (a) calcium carbonate: (b) one or more sugar alcs.; (c) one or more thickening polymers; and (d) water. The leave-on hair styling compositions do not require synthetic film-forming polymers nor do they require silicones. The leave-on hair styling compositions are particularly useful in methods for imparting durable styling or shaping benefits, providing volume and fullness, and imparting frizz control to hair. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Name: 2-Methyl-2-propylpropane-1,3-diol

The Article related to leave on hair styling calcium carbonate sugar alc, Essential Oils and Cosmetics: Hair Preparations and other aspects.Name: 2-Methyl-2-propylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 11, 2017, Zheng, Hao published a patent.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol The title of the patent was A nose mask for sleeping. And the patent contained the following:

The invention discloses a nose mask for sleeping, belonging to medical instruments field. The nose mask for sleeping of the present invention, consists support. The two ends of the support are resp. fixedly connected with rhinarium. The rhinarium is provided with breather pipe, and the breather pipe surface is covered with filter membrane. The filter membrane is composed of polyallylacrylamide sodium 22, activated carbon 8, ethylparaben 3 and anhydrous calcium chloride 23 weight parts. The middle of the support is provided with connecting through hole which is connected with gas pipe. The gas pipe is disposed on the upper surface of the support, and is connected with gasket via the connecting through hole. The gasket is made from flexible material, and comprises adsorption layer, sustained-release layer and air-permeable layer from top to bottom. The adsorption layer is composed of nano indium oxide 27, polyoxypropylene diol 13, butenoate-grafted starch 41 and sodium dodecyl benzene sulfonate 16 weight parts. The sustained-release layer is composed of ephedrine derivative 6, Camellia oleifera extract 12, wood fiber 8, 2-acrylamide-2-methylpropanesulfonic acid 19, guar gum-g-poly(alginic acid-co-styrene) 21, Artemisia argyi leaf extract 4 and Abrus cantoniensis extract 8 weight parts. The air-permeable layer is composed of polyimide 30, Polycaprolactone 5, polylactic acid 19, sodium o-formylbenzene sulfonate isonicotinylhydrazone 22 and lignin fiber 13 weight parts. The inside of the rhinarium and support is hollow. The breather pipe is connected with rhinarium and support inside. The support is made up of flexible material, and the inside of the support is provided with iron wire for setting shape. The nose mask for sleeping of the present invention has the features of novel structure, reducing the mask size to a large extent, while ensuring the good ventilation of mouth and nasal airflow of the patient; it can achieve comfortable sleep, simultaneously ensures the mask not displace because of rolling in bed etc. . The experimental process involved the reaction of 1-(5-Chloro-2-methylphenyl)ethanol(cas: 58966-31-7).Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

The Article related to sleeping nose mask natural pharmaceutical, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Quality Control of 1-(5-Chloro-2-methylphenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 25, 2020, Li, Xiao’Ou; Cheng, Jiahan; Shen, Yongchun; Chen, Jun; Wang, Tao; Wen, Fuqiang; Chen, Lei published an article.Application of 32462-30-9 The title of the article was Metabolomic analysis of lung cancer patients with chronic obstructive pulmonary disease using gas chromatography-mass spectrometry. And the article contained the following:

Chronic obstructive pulmonary disease (COPD), characterized by intermittent exacerbations and clin. subphenotypes like emphysema and chronic bronchitis, poses a significant risk of lung cancer (LC) development. Metabolomic studies of COPD are scarce, and those of LC patients with COPD subphenotypes have not been investigated. To study metabolite profile alteration in LC patients with different COPD subphenotypes, lung paracancer tissue from 10 LC (CON) patients, 10 LC patients with emphysema (E), and 9 LC patients with chronic bronchitis (CB) were analyzed using gas chromatog.-mass spectrometry. Multivariate anal. indicated a distinct separation between LC patients with COPD subphenotypes and LC patients. Overall, 60, 55, 33 and 63 differential metabolites (DM) were identified in comparisons between CB vs. CON, E vs. CON, CB vs. E, and CB + E vs. CON, resp., and of these, 8 DM were shared in all comparisons. Among the high altered metabolites, E samples showed higher ‘acetol’ than CON samples, and lower ‘azelaic acid’, ‘3-methylglutaric acid’ and ‘allose’. CB samples showed higher ‘turanose’ and ‘o-phosphoserine’ and lower ‘anandamide’ than CON and E samples. In CB and E samples, ‘galactonic acid’, ‘2-mercaptoethanesulfonic acid’, ‘D-alanyl-D-alanine’ ‘3-methylglutaric acid’, ‘glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ had common alteration trends compared with those of CON samples. ‘Glycine’, ‘L-4-Hydroxyphenylglycine’ and ‘O-phosphonothreonine’ were significantly enriched in glycine, serine and threonine metabolism pathways. The total differential metabolites detected were remarkably altered in pyrimidine, beta-alanine and purine metabolism Our study provided altered DM patterns of lung paracancer tissue, the key metabolites and their enriched metabolic pathways in LC patients with different COPD subphenotypes. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to metabolomic lung cancer obstructive disease, chronic obstructive pulmonary disease, gas chromatography-mass spectrometry, lung cancer, metabolite, Mammalian Pathological Biochemistry: Oncology and other aspects.Application of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 1, 2022, Apriyanto, Ardha; Compart, Julia; Zimmermann, Vincent; Alseekh, Saleh; Fernie, Alisdair R.; Fettke, Joerg published an article.Computed Properties of 473-81-4 The title of the article was Indication that starch and sucrose are biomarkers for oil yield in oil palm (Elaeis guineensis Jacq.). And the article contained the following:

Oil palm (Elaeis guineensis Jacq.) is the most productive oil-producing crop per ha of land. The oil that accumulates in the mesocarp tissue of the fruit is the highest observed among fruit-producing plants. A comparative anal. between high-, medium-, and low-yielding oil palms, particularly during fruit development, revealed unique characteristics. Metabolomics anal. was able to distinguish accumulation patterns defining of the various developmental stages and oil yield. Interestingly, high- and medium-yielding oil palms exhibited substantially increased sucrose levels compared to low-yielding palms. In addition, parameters such as starch granule morphol., granule size, total starch content, and starch chain length distribution (CLD) differed significantly among the oil yield categories with a clear correlation between oil yield and various starch parameters. These results provide new insights into carbohydrate and starch metabolism for biosynthesis of oil palm fruits, indicating that starch and sucrose can be used as novel, easy-to-analyze, and reliable biomarker for oil yield. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Computed Properties of 473-81-4

The Article related to starch sucrose biomarker oil palm elaeis metabolism, carbohydrate, mesocarp, metabolites, oil palm, oil yield, starch, sucrose, Food and Feed Chemistry: Fats, Oils, and Margarine and other aspects.Computed Properties of 473-81-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 7, 2010, Lan, Hong-Qiao; Ruan, Yuan-Ping; Huang, Pei-Qiang published an article.Safety of H-Phg(4-OH)-OH The title of the article was The first enantioselective synthesis of cytotoxic marine natural product palau’imide and assignment of its C-20 stereochemistry. And the article contained the following:

Me tetramate derivative I has been developed as a new building block for the flexible and racemization-free synthesis of Me 5-benzyl-3-methyltetramate via alkylation, and used in the first asym. synthesis of palau’imide (II). This allowed the establishment of the hitherto unknown stereochem. at the C-20 of palau’imide as S. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to enantioselective synthesis palau’imide alkylation chiral auxiliary, mol structure absolute configuration palau’imide, Alkaloids: Alkaloids Containing Two Nitrogen Atoms and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2022, Ji, Jiacheng; Zhang, Shuo; Tang, Li; Zhang, Min; Yuan, Minyan; Wang, Pengjiao; Gao, Xiuli published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Integrative analysis of fecal metabolome and gut microbiota in high-fat diet-induced hyperlipidemic rats treated with Rosa Roxburghii Tratt juice. And the article contained the following:

The fruit of Rosa Roxburghii Tratt (RRT) is edible and has been considered as a medicinal fruit with a lipid-lowering effect, but the mechanism is still unclear. In this study, we integrated the results of 16S rRNA gene sequence and fecal metabolome to explore the potential mechanisms of RRTJ treatment in hyperlipidemia. The result suggests the useful effects of RRT juice (RRTJ) in hyperlipidemic rats. The 12 wk of RRT juice (RRTJ) treatment decreased serum lipids, fat accumulation, body weight and liver weight RRTJ treatment reversed the HFD-induced gut dysbiosis by lowering Dorea, Coprobacillus abundance and enriching Bifidobacterium, Roseburia abundance. Also, we conducted a targeted metabolic profile anal. of 160 metabolites in feces and 19 feces metabolites have significant changes. Correlation analyzes suggest that the reductions in serum lipids by RRTJ are associated with the gut microbial community (Dorea, Coprobacillus and Roseburia, Bifidobacterium) and their associated metabolites (palmitoleic acid, succinic acid, propionic acid, Glyceric acid). In conclusion, the 12 wk of treatment with RRT juice (RRTJ) can regulate dyslipidemia by improving intestinal microbiota disorders and related metabolites disorders. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to fecal metabolome gut microbiota high fat diet hyperlipidemic rat, rosa roxburghii tratt juice, Animal Nutrition: Carbohydrates, Fiber, and Energy and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts