Tag: 100-200

On February 8, 2022, Jeong, Jaeyoung; Fujita, Ken-ichi published an article.Computed Properties of 111-29-5 The title of the article was Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway. And the article contained the following:

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Computed Properties of 111-29-5

The Article related to bisdimethylamine green preparation, diol aqueous dimethylamine bisdimethylamination iridium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Computed Properties of 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guo, Wusheng; Laserna, Victor; Rintjema, Jeroen; Kleij, Arjan W. published an article in 2016, the title of the article was Catalytic One-Pot Oxetane to Carbamate Conversions: Formal Synthesis of Drug Relevant Molecules.SDS of cas: 78-26-2 And the article contains the following content:

Oxetanes are versatile building blocks in drug-related synthesis to induce property-modulating effects. Whereas related oxiranes are widely used in coupling chem. with CO2 to afford value-added commodity chems., oxetane/CO2 couplings remain extremely limited despite the recent advances in the synthesis of these four-membered heterocycles. Here we report an effective one-pot three-component reaction (3CR) strategy for the coupling of (substituted) oxetanes, amines, and CO2 to afford a variety of functionalized carbamates with excellent chemoselectivity and good yields. The process is mediated by an aluminum-based catalyst under relatively mild conditions and the developed catalytic methodol. can be applied to the formal synthesis of two pharmaceutically relevant carbamates with the 3CR being a key step. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).SDS of cas: 78-26-2

The Article related to carbamate preparation, three component reaction carbon dioxide oxetane amine aluminum catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 78-26-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 16, 2020, Bhattacharya, Soumya; Yothers, Mitchell P.; Huang, Liangliang; Bumm, Lloyd A. published an article.Quality Control of 1-Decanethiol The title of the article was Interaction of the (2√3 x 3)rect. Adsorption-Site Basis and Alkyl-Chain Close Packing in Alkanethiol Self-Assembled Monolayers on Au(111): A Molecular Dynamics Study of Alkyl-Chain Conformation. And the article contained the following:

We show that the adsorption site basis of the (2√3 x 3)rect. phase of n-alkanethiol self-assembled monolayers plays a key role in determining the mol. conformation of the close-packed alkyl chains. Ten proposed reconstructed Au-S interfaces are used to explore the minimized energy alkyl-chain packing of n-decanethiol mols. using mol. dynamics with the all-atom description. In this comparative study, all models have the same alkyl-chain surface d. of four mols. per unit cell; thus, differences are due to the headgroup spacing within the 4-mol. basis as opposed to the average surface d. We demonstrate for the first time the 4-mol.-basis twist structure driven by the packing of alkanethiol mols. in a large simulation box (100 mols., 25 unit cells) using mol. dynamics. Our results validate the prediction put forward by Mar and Klein that to achieve the 4-mol.-basis twist symmetry observed by the experiment, the headgroups must deviate from the high-symmetry (√3 x √3)R30° sites. The key structural parameters: tilt, twist, and end-group height, as well as their spatial order, are compared with exptl. results, which we show is a highly sensitive approach that can be used to vet proposed Au-S interfacial models. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Quality Control of 1-Decanethiol

The Article related to alkanethiol self assembly monolayer gold, Surface Chemistry and Colloids: Solid-Gas Systems and other aspects.Quality Control of 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 18, 1997, Leung, Hon-Wing; Ballantyne, Bryan published an article.Related Products of 2160-93-2 The title of the article was Evaluation of the genotoxic potential of alkylalkanolamines. And the article contained the following:

Three alkylalkanolamines, N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine, were evaluated for potential genotoxic activity using the Salmonella/microsome reverse gene mutation test, the CHO/HGPRT forward gene mutation test, a sister chromatid exchange test in cultured CHO cells, and an in vivo peripheral blood micronucleus test in Swiss-Webster mice. None of the three alkylalkanolamines produced any significant or dose-related increases in the frequencies of mutations, sister chromatid exchanges or micronuclei. These results indicate that N,N-dimethylethanolamine, N-methyldiethanolamine, and tert-butyldiethanolamine are not genotoxic in the tests conducted. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Related Products of 2160-93-2

The Article related to genotoxic potential alkylalkanolamine, Toxicology: Carcinogens, Mutagens, and Teratogens and other aspects.Related Products of 2160-93-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 10, 2020, Nakamura, Sho; Sayama, Misa; Uwamizu, Akiharu; Jung, Sejin; Ikubo, Masaya; Otani, Yuko; Kano, Kuniyuki; Omi, Jumpei; Inoue, Asuka; Aoki, Junken; Ohwada, Tomohiko published an article.Name: Pentane-1,5-diol The title of the article was Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors. And the article contained the following:

Lysophosphatidylserine (LysoPS), an endogenous ligand of G protein-coupled receptors, consists of L-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages, resp. An ester linkage of phosphatidylserine can be hydrolyzed at the 1-position or at the 2-position to give 2-acyl lysophospholipid or 1-acyl lysophospholipid, resp. 2-Acyl lysophospholipid is in nonenzymic equilibrium with 1-acyl lysophospholipid in vivo. On the other hand, 3-acyl lysophospholipid is not found, at least in mammals, raising the question of whether the reason for this might be that the 3-acyl isomer lacks the biol. activities of the other isomers. Here, to test this idea, we designed and synthesized a series of new 3-acyl lysophospholipids. Structure-activity relationship studies of more than 100 “glycol surrogate” derivatives led to the identification of potent and selective agonists for LysoPS receptors GPR34 and P2Y10. Thus, the non-natural 3-acyl compounds are indeed active and appear to be biol. orthogonal with respect to the physiol. relevant 1- and 2-acyl lysophospholipids. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Name: Pentane-1,5-diol

The Article related to structure activity agonist lysops receptor lysophospholipid phosphatidylserine glycol surrogate, human calcium mobilization agonist amino acid lysophospholipid glycerol, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Name: Pentane-1,5-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 19, 1990, Hashimoto, Kimiko; Horikawa, Manabu; Shirahama, Haruhisa published an article.Recommanded Product: Isochroman-3-ol The title of the article was Simple analogs of acromelic acid, which are highly active agonists of kainate type neuroexcitant. And the article contained the following:

The highly stereoselective synthesis of acromelic acid analogs I (R = H, Me) was achieved. The new kainoid I (R = Me) was the strongest neuroexcitant among the kainoids known so far. The experimental process involved the reaction of Isochroman-3-ol(cas: 42900-89-0).Recommanded Product: Isochroman-3-ol

The Article related to neurotransmitter agonist acromelic acid analog, kainate neuroexitant carboxymethylhydroxyphenylproline, proline hydroxyphenyl carboxymethyl kainate neuroexitant, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: Isochroman-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2010, Berkecz, Robert; Hyyrylaeinen, Anna R. M.; Fueloep, Ferenc; Peter, Antal; Janaky, Tamas; Vainiotalo, Pirjo; Pakarinen, Jaana M. H. published an article.Recommanded Product: 32462-30-9 The title of the article was Chiral discrimination of β-3-homo-amino acids using the kinetic method. And the article contained the following:

Chiral discrimination of seven enantiomeric pairs of β-3-homo-amino acids was studied by using the kinetic method and trimeric metal-bound complexes, with natural and unnatural α-amino acids as chiral reference compounds and divalent metal ions (Cu2+ and Ni2+) as the center ions. The β-3-homo-amino acids were selected for this study because, first of all, chiral discrimination of β-amino acids has not been extensively studied by mass spectrometry. Moreover, these β-3-homo-amino acids studied have different aromatic side chains. Thus, the emphasis was to study the effect of the side chain (electron d. of the Ph ring, as well as the difference between Ph and benzyl side chains) for the chiral discrimination. The results showed that by the proper choice of a metal ion and a chiral reference compound, all seven enantiomeric pairs of β-3-homo-amino acids could be differentiated. Moreover, it was noted that the β-3-homo-amino acids with benzyl side chains provided higher enantioselectivity than the corresponding Ph ones. However, increasing or decreasing the electron d. of the aromatic ring by different substituents in both the Ph and benzyl side chains had practically no role for chiral discrimination of β-3-homo-amino acids studied. When copper was used as the central metal, the Ph side chain containing reference mols. (S)-2-amino-2-phenylacetic acid (L-Phg) and (S)-2-amino-2-(4-hydroxyphenyl)-acetic acid (L-4′-OHPhg) gave rise to an addnl. copper-reduced dimeric fragment ion, [CuI(ref)(A)]+. The inclusion of this ion improved noticeably the enantioselectivity values obtained. Copyright © 2010 John Wiley & Sons, Ltd. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: 32462-30-9

The Article related to chiral discrimination homo amino acid kinetic method copper nickel, Amino Acids, Peptides, and Proteins: Amino Acids and other aspects.Recommanded Product: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 28, 2018, Din Belle, David; Makela, Mikko; Passiniemi, Mikko; Pietikainen, Pekka; Rummakko, Petteri; Tiainen, Eija; Vaismaa, Matti; Wohlfahrt, Gerd published a patent.Safety of 2-(Methylamino)ethan-1-ol hydrochloride The title of the patent was Preparation of the pyran derivatives as cyp11a1 (cytochrome p450 monooxygenase 11a1) inhibitors. And the patent contained the following:

The invention is related to the preparation of the pyran derivatives as cyp11a1 (cytochrome P 450 monooxygenase 11a1) inhibitors I. The invention compounds I , wherein ring B is a 4-10 membered monocyclic or bicyclic ring containing 0-4 heteroatoms independently selected form N, O or S; A is 2-tetrahydroindenyl, 2-tetrahydroisoquinolinyl, etc; L is absent, CH2, CH2CH2, etc.; R1 is hydrogen, C1-7 alkyl, C1-7 alkoxy, etc.; R2 is H, halo, OH, etc.; R3 is H, halo, NO2, etc.; R4 is H, halo, OH, etc.; R5 is H, halo, C1-7 alkyl; R23 is H or oxo; R24 is H or C1-7 alkyl; and their pharmaceutically acceptable salts are claimed. Compound I was prepared by multi-step procedure (procedure given). The compounds of formula I possess utility as cytochrome P 450 monooxygenase 11A1(CYP11A1) inhibitors. The compounds are useful as medicaments in the treatment of steroidreceptor, particularly androgen receptor,dependent diseases and conditions, such asprostate cancer. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Safety of 2-(Methylamino)ethan-1-ol hydrochloride

The Article related to preparation pyran cyp11a1 cytochrome p450 monooxygenase inhibitor, Heterocyclic Compounds (One Hetero Atom): Pyrans and other aspects.Safety of 2-(Methylamino)ethan-1-ol hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 21, 2020, Tang, Yidan; Meador, Rowan I. L.; Malinchak, Casina T.; Harrison, Emily E.; McCaskey, Kimberly A.; Hempel, Melanie C.; Funk, Timothy W. published an article.Electric Literature of 111-29-5 The title of the article was (Cyclopentadienone)iron-Catalyzed Transfer Dehydrogenation of Symmetrical and Unsymmetrical Diols to Lactones. And the article contained the following:

Air-stable iron carbonyl compounds bearing cyclopentadienone ligands with varying substitution were explored as catalysts in dehydrogenative diol lactonization reactions using acetone as both the solvent and hydrogen acceptor. Two catalysts with trimethylsilyl groups in the 2- and 5-positions, [2,5-(SiMe3)2-3,4-(CH2)4(η4-C4C=O)]Fe(CO)3 and [2,5-(SiMe3)2-3,4-(CH2)3(η4-C4C=O)]Fe(CO)3, were found to be the most active, with 2 being the most selective in the lactonization of diols containing both primary and secondary alcs. Lactones containing five-, six-, and seven-membered rings were successfully synthesized, and no over-oxidations to carboxylic acids were detected. The lactonization of unsym. diols containing two primary alcs. occurred with catalyst 1, but selectivity was low based on alc. electronics and modest based on alc. sterics. Evidence for a transfer dehydrogenation mechanism was found, and insight into the origin of selectivity in the lactonization of 1°/2° diols was obtained. Addnl., spectroscopic evidence for a trimethylamine-ligated iron species formed in solution during the reaction was discovered. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Electric Literature of 111-29-5

The Article related to lactone preparation, diol transfer dehydrogenation iron catalyst, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Electric Literature of 111-29-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 15, 2006, Bharate, Sandip B.; Bhutani, Kamlesh K.; Khan, Shabana I.; Tekwani, Babu L.; Jacob, Melissa R.; Khan, Ikhlas A.; Singh, Inder Pal published an article.Recommanded Product: 55743-13-0 The title of the article was Biomimetic synthesis, antimicrobial, antileishmanial and antimalarial activities of euglobals and their analogues. And the article contained the following:

In the present communication, naturally occurring phloroglucinol-monoterpene adducts, euglobals G1-G4 (3b/a and 4a/b) and 16 new analogs (13a/b-18a/b and 19-22) were synthesized by biomimetic approach. These synthetic compounds differ from natural euglobals in the nature of monoterpene and acyl functionality. All of these compounds were evaluated for their antibacterial, antifungal, antileishmanial and antimalarial activities. Analog 17b possessed good antibacterial activity against methicillin-resistant Staphylococcus aureus, while analogs 19-22 possessed potent antifungal activity against Candida glabrata with IC50s ranging from 1.5 to 2.5 μg/mL. Euglobals along with all synthesized analogs exhibited antileishmanial activity. Amongst these, euglobal G2 (3a), G3 (4a) and analogs 13a and 14a showed potent antileishmanial activity with IC50s ranging from 2.8 to 3.9 μg/mL. Analog 16a possessed antimalarial activity against chloroquine sensitive D6 clone of Plasmodium falciparum. None of the compounds showed toxicity against mammalian kidney fibroblasts (vero cells) up to the concentration of 4.76 μg/mL. The experimental process involved the reaction of 2,4,6-Trihydroxy-3-methylbenzaldehyde(cas: 55743-13-0).Recommanded Product: 55743-13-0

The Article related to antimicrobial antileishmanial antimalarial euglobal analog, Microbial, Algal, and Fungal Biochemistry: Other and other aspects.Recommanded Product: 55743-13-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts