Tag: 100-200

On January 31, 2020, Rigane, Ghayth; Ben Salem, Ridha published an article.Formula: C8H8O3 The title of the article was Microwave-assisted extraction of hydroxytyrosol from alperujo and its impact on the stability of mayonnaise. And the article contained the following:

Extraction is one of the crucial steps for research and development of plant secondary metabolites. Microwave power and extraction time were selected as extraction parameters of hydroxytyrosol from alperujo. To achieve this goal, the optimization of phys. parameters was carried out by analyzing the obtained extracts using GC-MS apparatus Optimum conditions of microwave-assisted extraction based on maximum levels of responses were medium microwave power with 15 min of alperujo treatment. Maximum levels of hydroxytyrosol were obtained under these conditions (~1.9 g of hydroxytyrosol/kg of alperujo). Furthermore, we have studied the stability of mayonnaise after addition of hydroxytyrosol extract ranging between 65 and195μg by following the changes on free acidity, peroxide value, conjugated dienes as well as content of polyphenols and squalene. This study was conducted for 4 wk and the mayonnaise samples were stored protected from light at room temperature These results showed that 195μg of hydroxytyrosol rich extract may be of great benefit to improve the stability of the mayonnaise against oxidation The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to hydroxytyrosol alperujo mayonnaise microwave assisted extraction, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C8H8O3

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On March 31, 2016, Cai, Jiaqiang; Colandrea, Vincent; Crespo, Alejandro; Debenham, John; Du, Xiaoxing; Guiadeen, Deodialsingh; Liu, Ping; Liu, Rongqiang; Madsen-Duggan, Cristina B.; McCoy, Joshua G.; Quan, Weiguo; Sinz, Christopher; Wang, Liping published a patent.Related Products of 386704-04-7 The title of the patent was Inhibitors of HIF prolyl hydroxylase for use in enhancing erythropoietin production and treatment of anemia. And the patent contained the following:

The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Related Products of 386704-04-7

The Article related to inhibitor hif prolyl hydroxylase erythropoietin anemia therapy, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 386704-04-7

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Alcohol – Wikipedia,
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On December 31, 2010, Kumar, K. Ashok; Setty, S. Ramachandra; Narsu, Laxmi published an article.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol The title of the article was Pharmacognostic and phytochemical investigations of roots of Hibiscus micranthus Linn. And the article contained the following:

The objective of the present investigation was determine the Pharmacognostical, physicochem. and phytochem. parameters as standardization markers for Hibiscus micranthus Linn. The macroscopic and microscopic characters, phys. constant values, extractive values, ash values, micro chem. anal. and fluorescence anal. were performed. The presence of lignified, thick wall, libiform type of fibers with pointed tips & vessel elements with oblique perforations plates having short, pointed tails, calcium oxalate druses are abundant in the phloem and periderm as seen in the powder/transverse sections of root were the distinguishing microscopic features and can be used as anatomical markers. Chemomicroscopic characters present included lignin, starch, suberin, mucilage, cellulose, protein bodies and calcium oxalate crystals. Phys. constants performed were loss on drying, ash content, acid insoluble ash and water soluble ash. Extractive values in pet. ether (60-80°C), chloroform, alc. and hydroalcoholic were determined Fluorescence studies of the powder were carried in ordinary light and UV light with various solvents. Phytochem. screening of successive extracts showed pos. reactions for steroids, flavonoids, carbohydrates, phenols and tannins. The fingerprints of the hydroalcoholic extract were obtained by HPTLC technique in three best mobile phase solvent systems. The flavonoid content of hydroalcoholic extract was determined by colorimetric method. Chem. profiling of hydroalcoholic extract was also performed by GC-MS anal. Further a HPLC method with photodiode array detector was followed to quantify rutin in hydroalcoholic extract of Hibiscus micranthus (HEHM). The present study provides details to characterize the Pharmacognostical, physicochem. and phytochem. parameters. An accurate and rapid HPLC quantification method has also been developed for quality control determination of rutin from Hibiscus micranthus roots. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

The Article related to hibiscus root pharmacognosy physicochem phytochem, Plant Biochemistry: Composition and Products and other aspects.Application In Synthesis of 2-Methyl-2-propylpropane-1,3-diol

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On December 31, 2020, Ahmadi, Delaram; Mahmoudi, Najet; Li, Peixun; Ma, Kun; Doutch, James; Foglia, Fabrizia; Heenan, Richard K.; Barlow, David; Lawrence, M. Jayne published an article.Application of 111-29-5 The title of the article was Revealing the Hidden Details of Nanostructure in a Pharmaceutical Cream. And the article contained the following:

Creams are multi-component semi-solid emulsions that find widespread utility across a wide range of pharmaceutical, cosmetic, and personal care products, and they also feature prominently in veterinary preparations and processed foodstuffs. The internal architectures of these systems, however, have to date been inferred largely through macroscopic and/or indirect exptl. observations and so they are not well-characterized at the mol. level. Moreover, while their long-term stability and shelf-life, and their aesthetics and functional utility are critically dependent upon their mol. structure, there is no real understanding yet of the structural mechanisms that underlie the potential destabilizing effects of additives like drugs, anti-oxidants or preservatives, and no structure-based rationale to guide product formulation. In the research reported here we sought to address these deficiencies, making particular use of small-angle neutron scattering and exploiting the device of H/D contrast variation, with complementary studies also performed using bright-field and polarised light microscopy, small-angle and wide-angle X-ray scattering, and steady-state shear rheol. measurements. Through the convolved findings from these studies we have secured a finely detailed picture of the mol. structure of creams based on Aqueous Cream BP, and our findings reveal that the structure is quite different from the generic picture of cream structure that is widely accepted and reproduced in textbooks. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5

The Article related to cosmetics nanostructure pharmaceutical cream, Pharmaceuticals: Formulation and Compounding and other aspects.Application of 111-29-5

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On September 9, 2015, Wang, Lin; Tang, Lin; Chen, Zhiwu; Peng, Tao; Zhang, Shouguo; Wen, Xiaoxue; Yan, Haiyan; Wang, Gang; Liu, Shuchen; Sun, Yunbo; Li, Lu published a patent.Application In Synthesis of (2-Fluorophenyl)methanethiol The title of the patent was Substances having protein tyrosine kinase inhibiting activity, and preparation method and application thereof. And the patent contained the following:

The title substances are compounds represented by formula I, wherein X is sulfonyl (SO2) or sulfinyl (SO); R1 is selected from hydrogen, halogen, C1-C6 alkyl, and C1-C6 alkoxy; R is selected from substituted 2-indolinone-3-methylene or substituted 2-naphthyl. These compounds have better protein tyrosine kinase inhibiting activity than pilot compound (data given). ExRad, and can be used as candidate drugs for prevention and treatment of neoplastic diseases. The experimental process involved the reaction of (2-Fluorophenyl)methanethiol(cas: 72364-46-6).Application In Synthesis of (2-Fluorophenyl)methanethiol

The Article related to protein tyrosine kinase inhibitof antitumor, Aliphatic Compounds: Sulfoxides and Sulfones and other aspects.Application In Synthesis of (2-Fluorophenyl)methanethiol

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On December 31, 2021, Albozahid, Muayad; Naji, Haneen Zuhair; Alobad, Zoalfokkar Kareem; Saiani, Alberto published an article.Safety of Pentane-1,5-diol The title of the article was Effect of OMMT reinforcement on morphology and rheology properties of polyurethane copolymer nanocomposites. And the article contained the following:

The remarkable structural features of organic modified montmorillonite particles (OMMT) enable them to complete their important role in enhancing different properties of polyurethane copolymer with 75 weight% hard segments (PUC/75). Based on the melt intercalation approach, various amounts of OMMT were incorporated into PUC/75 solution followed by the injection molding process. It is essential to mention that the synthesized PUC/75 in this work relied on using 1,5-Pentanediol as a chain extender in order to produce a long-term and thermal-stable PUC successfully. The effect of incorporating various loading of OMMT on rheol. properties of neat PUC/75 and its nanocomposites was investigated. The structure of PUC/OMMT was studied using X-ray diffraction (XRD) and SEM. Addnl., differential scanning calorimetry (DSC) thermograms were utilized to investigate OMMT effect on the thermal transitions and crystallinity of resultant PUC nanocomposites. Interestingly, the dynamic rheol. anal. exhibited a remarkable increase in melt rheol. behavior with increasing OMMT loading compared to neat PUC/75. This could imply a good interaction between the functional group on the surface of OMMT and PUC/75 domains; particularly hard domains, herein the DSC results showed moderate improvement in melt temperature (Tm) of PUC/OMMT nanocomposite. However, a decline in crystalline temperature (Tc) was also seen due to aggregation of OMMT, especially at higher OMMT loading. While XRD results exhibited a slight shifting in crystalline peaks of PUC nanocomposites relative to neat PUC/75. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

The Article related to polyurethane copolymer nanocomposite rheol, Plastics Manufacture and Processing: General and other aspects.Safety of Pentane-1,5-diol

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Alcohol – Wikipedia,
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On April 2, 2020, Xu, Jianyan; Zhang, Ying; Cai, Xiaofeng; Qu, Bolei; Liang, Jindong; Zhang, Lianshan; He, Feng; Tao, Weikang published a patent.Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid The title of the patent was Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof. And the patent contained the following:

The present invention relates to a ligand-drug conjugate of an exatecan analog, a preparation method therefor and an application thereof. Specifically, the present invention provides a ligand-drug conjugate having a structure shown in formula (-D), a preparation method therefor, a pharmaceutical composition containing same, and use thereof in preparation of drugs for treating cancers by means of receptor regulation. The definition of each substituent in formula (-D) is the same as that in the description. The experimental process involved the reaction of 3-Cyclopropyl-2-hydroxypropanoic acid(cas: 1599840-16-0).Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid

The Article related to ligand drug conjugate exatecan analog, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 3-Cyclopropyl-2-hydroxypropanoic acid

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On September 30, 2021, Yue, Zhanlong; Yan, Zhen; Liu, Xun published a patent.Computed Properties of 1599840-16-0 The title of the patent was Pharmaceutical composition comprising antibody drug conjugate and use thereof. And the patent contained the following:

A pharmaceutical composition, comprising an antibody drug conjugate in a buffer solution The antibody drug conjugate has a structure represented by the general formula (Pc-L-Y-D). The pharmaceutical composition further comprises sugar and a surfactant. The experimental process involved the reaction of 3-Cyclopropyl-2-hydroxypropanoic acid(cas: 1599840-16-0).Computed Properties of 1599840-16-0

The Article related to antibody drug conjugate, Pharmaceuticals: Formulation and Compounding and other aspects.Computed Properties of 1599840-16-0

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Hagenbeek, Fiona A.; van Dongen, Jenny; Pool, Rene; Harms, Amy C.; Roetman, Peter J.; Fanos, Vassilios; van Keulen, Britt J.; Walker, Brian R.; Karu, Naama; Hulshoff Pol, Hilleke E.; Rotteveel, Joost; Finken, Martijn J. J.; Vermeiren, Robert R. J. M.; Kluft, Cornelis; Bartels, Meike; Hankemeier, Thomas; Boomsma, Dorret I. published an article in 2022, the title of the article was Heritability of Urinary Amines, Organic Acids, and Steroid Hormones in Children.Synthetic Route of 473-81-4 And the article contains the following content:

Variation in metabolite levels reflects individual differences in genetic and environmental factors. Here, we investigated the role of these factors in urinary metabolomics data in children. We examined the effects of sex and age on 86 metabolites, as measured on three metabolomics platforms that target amines, organic acids, and steroid hormones. Next, we estimated their heritability in a twin cohort of 1300 twins (age range: 5.7-12.9 years). We observed associations between age and 50 metabolites and between sex and 21 metabolites. The monozygotic (MZ) and dizygotic (DZ) correlations for the urinary metabolites indicated a role for non-additive genetic factors for 50 amines, 13 organic acids, and 6 steroids. The average broad-sense heritability for these amines, organic acids, and steroids was 0.49 (range: 0.25-0.64), 0.50 (range: 0.33-0.62), and 0.64 (range: 0.43-0.81), resp. For 6 amines, 7 organic acids, and 4 steroids the twin correlations indicated a role for shared environmental factors and the average narrow-sense heritability was 0.50 (range: 0.37-0.68), 0.50 (range; 0.23-0.61), and 0.47 (range: 0.32-0.70) for these amines, organic acids, and steroids. We conclude that urinary metabolites in children have substantial heritability, with similar estimates for amines and organic acids, and higher estimates for steroid hormones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to steroid hormone organic acids urinary amines metabolomics, amines, children, classical twin design, heritability, metabolites, organic acids, steroid hormones, urine, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4

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Alcohol – Wikipedia,
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Cabani, S.; Mollica, V.; Lepori, L.; Lobo, S. T. published an article in 1977, the title of the article was Volume changes in the proton ionization of amines in water. 2. Amino alcohols, amino ethers, and diamines.Formula: C3H10ClNO And the article contains the following content:

From d. measurements (25°) of aqueous solutions at various concentrations of solute, apparent molar volumes of some open-chain bifunctional primary, secondary and tertiary amines were determined; the compounds studied were X(CH2)nNH2 (X = HO, MeO, H2N; n = 2,3) and 2-XCH2CH2OH (X = MeNH, EtNH, Me2N, Et2N) and their mono- and dihydrochlorides, for which ΔV1° and ΔV2° for the 1st and 2nd steps of proton ionization were calculated from the limiting partial molar volumes Values ΔV1° for the above bifunctional amines are compared with the corresponding values for monofunctional amines, and the difference in ΔV1° caused by the introduction of the 2nd hydrophilic center is discussed. The volumes and entropies of ionization of the amines and carboxylic acids are compared, and the deviations of these functions from predictions based on simple electrostatic theories are considered. The experimental process involved the reaction of 2-(Methylamino)ethan-1-ol hydrochloride(cas: 62640-03-3).Formula: C3H10ClNO

The Article related to amine ionization molar volume, Physical Organic Chemistry: Structure Effects and other aspects.Formula: C3H10ClNO

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Alcohol – Wikipedia,
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