Tag: 100-200

On July 31, 2022, Li, Yangfan; Yao, Weijie; Gao, Yanbin published an article.COA of Formula: C3H6O4 The title of the article was Effects of Tang Luo Ning on diabetic peripheral neuropathy in rats revealed by LC-MS metabolomics approach. And the article contained the following:

Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes with limited therapies. Tang Luo Ning (TLN), a traditional Chinese medicine compound, has been proved to be effective in the treatment of DPN in clin. and exptl. studies. However, the potential metabolic mechanism of TLN for the treatment of DPN is still unclear. Here the therapeutic effect of TLN on DPN was studied, and HPLC-IT-TOF/MS was used to explore the metabolic changes related to DPN and to explore the mechanism of TLN on DPN induced by high glucose. Furthermore, metabolic pathway anal. was used to explore the metabolic changes induced by DPN and TLN. As a result, TLN could improve the peripheral nerve function of DPN rats, and TLN could reduce the demyelination of the sciatic nerve in DPN rats. Metabolomics anal. showed that 14 potential biomarkers (citrate, creatine, fumarate, glyceric acid, glycine, succinate, etc.) of both DPN and TLN treatment were identified. Pathway anal. showed that the changes in these metabolites were mainly related to the citrate cycle (TCA cycle); glycine, serine, and threonine metabolism; and glyoxylate and dicarboxylate metabolism The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).COA of Formula: C3H6O4

The Article related to tang luo ning antidiabetic agent metabolome diabetic peripheral neuropathy, tang luo ning, diabetic peripheral neuropathy, metabolomics, pathway analysis, Placeholder for records without volume info and other aspects.COA of Formula: C3H6O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Manting; Cai, Bolin; Kong, Shaofen; Zhou, Zhen; Zhang, Jing; Zhang, Xiquan; Nie, Qinghua published an article in 2022, the title of the article was PPARGC1A Is a Moderator of Skeletal Muscle Development Regulated by miR-193b-3p.Application In Synthesis of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Meat production performance is one of the most important factors in determining the economic value of poultry. Myofiber is the basic unit of skeletal muscle, and its phys. and chem. properties determine the meat quality of livestock and poultry to a certain extent. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) as a transcriptional coactivator has been found to be widely involved in a series of biol. processes. However, PPARGC1A is still poorly understood in chickens. In this manuscript, we reported that PPARGC1A was highly expressed in slow-twitch myofibers. PPARGC1A facilitated mitochondrial biogenesis and regulated skeletal muscle metabolism by mediating the flux of glycolysis and the TCA cycle. Gain- and loss-of-function analyses revealed that PPARGC1A promoted i.m. fatty acid oxidation, drove the transformation of fast-twitch to slow-twitch myofibers, and increased chicken skeletal muscle mass. Mechanistically, the expression level of PPARGC1A is regulated by miR-193b-3p. Our findings help to understand the genetic regulation of skeletal muscle development and provide a mol. basis for further research on the antagonism of skeletal muscle development and fat deposition in chickens. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Application In Synthesis of 2,3-Dihydroxypropanoic acid

The Article related to skeletal muscle development microrna genetic regulation, ppargc1a, mir-193b-3p, mitochondrial biogenesis, muscle metabolism, skeletal muscle development, Placeholder for records without volume info and other aspects.Application In Synthesis of 2,3-Dihydroxypropanoic acid

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Alcohol – Wikipedia,
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On August 9, 2021, Nagumo, Ryo; Matsuoka, Takumi; Iwata, Shuichi published an article.Application of 111-29-5 The title of the article was Interactions between Acrylate/Methacrylate Biomaterials and Organic Foulants Evaluated by Molecular Dynamics Simulations of Simplified Binary Mixtures. And the article contained the following:

Improving hydrophilicity is a key factor for enhancing the biocompatibility of polymer surfaces. Nevertheless, previous studies have reported that poly(2-methoxyethyl acrylate) (PMEA) surfaces demonstrate markedly better biocompatibility than more hydrophilic poly(2-hydroxyethyl methacrylate) (PHEMA) surfaces. In this work, the origins of the excellent biocompatibility of the PMEA surface are investigated using mol. dynamics (MD) simulations of simplified binary mixtures of acrylate/methacrylate trimers and organic solvents, with n-nonane, 1,5-pentanediol, or 1-octanol serving as the probe organic foulants. The interactions between the acrylate/methacrylate trimers and solvent mols. were evaluated by calculating the radial distribution function (RDF), with the resulting curves indicating that the 2-methoxyethyl acrylate (MEA) trimer has a lower affinity for n-nonane mols. than the 2-hydroxyethyl methacrylate (HEMA) trimer. This result agrees with the exptl. consensus that the biocompatibility of PMEA surfaces is better than that of PHEMA surfaces, supporting the hypothesis that the affinity between an acrylate/methacrylate trimer and a foulant mol. in a simplified binary mixture is a significant factor in determining a surfaces antifouling properties. The RDF curves obtained for the other two solvent systems exhibited behavior that further highlighted the advantages of the PMEA surfaces as biocompatible polymers. In addition, the validity of employing the second virial coefficient (B2) as a predictor of antifouling properties was explored. The order of the B2 values of different binary mixtures indicated that the MEA trimers have the lowest affinities with n-nonane mols., which confirms that although PMEA is more hydrophobic than PHEMA, it exhibits better biocompatibility. This anal. demonstrates that the MEAs weaker miscibility with nonpolar foulants contributes to the excellent biocompatibility of PMEA. Thus, B2 is a promising criterion for assessing the miscibility between acrylate/methacrylate materials and nonpolar organic foulants, which indicates the potential for predicting the antifouling properties of acrylate/methacrylate polymer materials by evaluating the value of B2. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application of 111-29-5

The Article related to methoxyethyl acrylate biomaterial binary mixture mol dynamic simulation, phema, pmea, biocompatibility, fouling, miscibility, second virial coefficient, Placeholder for records without volume info and other aspects.Application of 111-29-5

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Alcohol – Wikipedia,
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On July 31, 2022, Lee, Jang-Eun; Yun, Jeong-Hyun; Lee, Eunjung; Hong, Sang Pil published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Untargeted Metabolomics reveals Doenjang metabolites affected by manufacturing process and microorganisms. And the article contained the following:

Doenjang is a traditional Korean fermented soybean-based food that is now produced industrially as traditional Doenjang and modernized Doenjang, depending on the conditions of the manufacturing process. In this study, the effect of the production process on Doenjang metabolites was analyzed using untargeted capillary electrophoresis time-of-flight mass spectrometry (CE-TOF/MS). Of the 247 metabolites detected in 19 traditional and three modernized Doenjang samples, the level of 55 metabolites were significantly different between the two production groups. The S-plot of the orthogonal projection to latent structures-discriminant anal. (OPLS-DA) revealed that nine compounds (tryptamine, 2-phenylethylamine, citrulline, gamma-aminobutyric acid, putrescine, tyramine, 2-aminoisobutyric acid, stachydrine, and N5-ethylglutamine) were highly distributed in the traditional group, and six compounds (arginine, citric acid, choline, cytidine, hypoxanthine, and glucaric acid) were considered distinguishable metabolites of the modernized group. Microbial community anal. indicated that the levels of these metabolites were significantly altered by the presence of Bacillus spp., Enterococcus faecium, Tetragenococcus halophilus, Aspergillus oryzae, Penicillium spp., and Saccharomyces cerevisiae. These findings will give better understanding of the influence of the manufacturing process on Doenjang production in terms of both microbial activity and metabolite profiles. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to doenjang metabolite manufacturing process microorganism metabolomics, ce-tof/ms, doenjang, metabolite, microbial community, untargeted metabolomics, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
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On August 21, 2020, Foth, Paul J.; Malig, Thomas C.; Yu, Hao; Bolduc, Trevor G.; Hein, Jason E.; Sammis, Glenn M. published an article.Synthetic Route of 143-10-2 The title of the article was Halide-Accelerated Acyl Fluoride Formation Using Sulfuryl Fluoride. And the article contained the following:

Herein, we report a new one-pot sequential method for SO2F2-mediated nucleophilic acyl substitution reactions starting from carboxylic acids. A mechanistic study revealed that SO2F2-mediated acid activation proceeds via the anhydride, which is then converted to the corresponding acyl fluoride. Tetrabutylammonium chloride or bromide accelerate the formation of acyl fluoride. Optimized halide-accelerated conditions were used to synthesize acyl fluorides in 30-80% yields, and esters, amides, and thioesters in 72-96% yields without reoptimization for each nucleophile. Safety: toxic SO2F2. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to halide accelerated acyl fluoride formation sulfuryl fluoride, safety toxic sulfuryl fluoride, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 143-10-2

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Alcohol – Wikipedia,
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Miesen, Thomas J.; Engstrom, Arek M.; Frost, Dane C.; Ajjarapu, Ramya; Ajjarapu, Rohan; Lira, Citlali Nieves; Mackiewicz, Marilyn R. published an article in 2020, the title of the article was A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution.Recommanded Product: 143-10-2 And the article contains the following content:

The controlled synthesis of stable silver nanoparticles (AgNPs), that do not undergo surface oxidation and Ag+ ion dissolution, continues to be a major challenge. Here the synthesis of robust hybrid lipid-coated AgNPs, comprised of L-α-phosphatidylcholine (PC) membranes anchored by a stoichiometric amount of long-chained hydrophobic thiols and sodium oleate (SOA) as hydrophobic binding partners, that do not undergo surface oxidation and Ag+ ion dissolution, is described. UV-Visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), and inductively coupled plasma mass spectrometry (ICP-MS) demonstrate that in the presence of strong oxidants, such as potassium cyanide (KCN), the hybrid lipid-coated AgNPs are stable and do not undergo surface oxidation even in the presence of membrane destabilizing surfactants. UV-Vis studies show that the stability of hybrid lipid-coated AgNPs of various sizes and shapes is dependent on the length of the thiol hydrocarbon chain and can be ranked in the order of increasing stability as follows: propanethiol (PT) < hexanethiol (HT) ≤ decanethiol (DT). UV-Vis and ICP-MS studies show that the hybrid lipid-coated AgNPs do not change in size or shape confirming that the AgNPs do not undergo surface oxidation and Ag+ ion dissolution when placed in the presence of strong oxidants, chlorides, thiols, and low pH. Long-term stability studies, over 21 days, show that the hybrid lipid-coated AgNPs do not release Ag+ ions and are more stable. Overall, these studies demonstrate hybrid membrane encapsulation of nanomaterials is a viable method for stabilizing AgNPs in a "shape-locked" form that is unable to undergo surface oxidation, Ag+ ion release, aging, or shape conversion. More importantly, this design strategy is a simple approach to the synthesis and stabilization of AgNPs for a variety of biomedical and com. applications where Ag+ ion release and toxicity is a concern. With robust and shielded AgNPs, investigators can now evaluate and correlate how the phys. features of AgNPs influence toxicity without the confounding factor of Ag+ ions present in samples. This design strategy also provides an opportunity where the membrane composition can be tuned to control the release rate of Ag+ ions for optimizing antimicrobial activity. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 143-10-2

The Article related to lipid membrane silver nanoparticle surface oxidation ion dissolution prevention, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 143-10-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 6, 2022, Romano, Ciro; Talavera, Laura; Gomez-Bengoa, Enrique; Martin, Ruben published an article.Application In Synthesis of Pentane-1,5-diol The title of the article was Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp3 C-O Bonds in Cyclic Acetals. And the article contained the following:

A dual catalytic manifold that enables site-selective functionalization of unactivated sp3 C-O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*-p orbital overlap prior to sp3 C-O cleavage, thus highlighting the importance of conformational flexibility in both reactivity and site selectivity. The protocol is characterized by its excellent chemoselectivity profile, thus offering new vistas for activating strong σ sp3 C-O linkages. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Application In Synthesis of Pentane-1,5-diol

The Article related to cyclic acetal regioselective alkylation arylation conformational flexibility, General Organic Chemistry: Synthetic Methods and other aspects.Application In Synthesis of Pentane-1,5-diol

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Alcohol – Wikipedia,
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On May 20, 2022, Yu, Yi; Wu, Shao-Fen; Zhu, Xiao-Bin; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article.Safety of 1-Decanethiol The title of the article was Electrochemical Sulfoxidation of Thiols and Alkyl Halides. And the article contained the following:

A green and efficient electrochem. sulfoxidation via the use of readily available materials, i.e., thiols and alkyl halides was reported. The simple operation, mild conditions and broad substrate scope render this protocol potentially applicable for the preparation of diverse synthetically significant sulfoxides RSOCH2R1 [R = i-Pr, 4-FC6H4, 4-ClC6H4, etc.; R1 = (CH2)2CH3, Ph, 3-MeOC6H4, etc.]. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Safety of 1-Decanethiol

The Article related to sulfoxide green preparation, alkyl halide thiol electrochem sulfoxidation, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 1-Decanethiol

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Alcohol – Wikipedia,
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Malviya, Bhanwar Kumar; Verma, Ved Prakash; Sharma, Siddharth published an article in 2021, the title of the article was Electrochemical metal- and oxidant-free synthesis of S-thiocarbamates.Recommanded Product: 1-Decanethiol And the article contains the following content:

An expeditious synthetic strategy to access functionalized S-thiocarbamates was developed in good to excellent yields and with high current efficiencies. Readily available isocyanides and thiols were used as the starting materials under simple metal- and oxidant-free reaction conditions avoiding an inert atm. The practical application of the present methodol. was achieved by electrochem. synthesis of the herbicides prosulfocarb and pebulate. Furthermore, continuous electrochem. flow conditions using a graphite/Pt flow cell were used to obtain S-thiocarbamate compounds on a gram scale within a residence time of 35 min. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 1-Decanethiol

The Article related to isocyanide thiol electrochem cross coupling, thiocarbamate preparation, General Organic Chemistry: Synthetic Methods and other aspects.Recommanded Product: 1-Decanethiol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 25, 2020, Gao, Zhisheng; Dance, Smruti A.; Taggi, Andrew E.; Bair, Joseph S. published a patent.Application of 78-26-2 The title of the patent was Low viscosity heat transfer fluids with increasing flash point and thermal conductivity. And the patent contained the following:

This disclosure relates to a heat transfer fluid having at least one first ester that is partially esterified, and at least one second ester that is fully esterified. The heat transfer fluid has a flash point from about 125°C to about 225°C as determined by ASTM D-93, and a kinematic viscosity (KV100) from about 1 to about 5 at 100°C as determined by ASTM D-445. The at least one first ester and the at least one second ester are present in an amount such that, as the flash point and thermal conductivity of the heat transfer fluid are increased, the kinematic viscosity (KV100) of the heat transfer fluid is decreased or essentially maintained. This disclosure also relates to a method for increasing flash point and thermal conductivity, while decreasing or essentially maintaining viscosity, of a heat transfer fluid by using the heat transfer fluid. The experimental process involved the reaction of 2-Methyl-2-propylpropane-1,3-diol(cas: 78-26-2).Application of 78-26-2

The Article related to low viscosity heat transfer fluid flash point thermal conductivity, Unit Operations and Processes: Heat Transfer and other aspects.Application of 78-26-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts