Tag: 100-200

On March 1, 2021, Martinez-Hernandez, Gabriela Belen; Jimenez-Ferrer, Enrique; Roman-Ramos, Ruben; Zamilpa, Alejandro; Gonzalez-Cortazar, Manases; Leon-Rivera, Ismael; Vargas-Villa, Gabriela; Herrera-Ruiz, Maribel published an article.SDS of cas: 621-37-4 The title of the article was A mixture of quercetin 4′-O-rhamnoside and isoquercitrin from Tilia americana var. mexicana and its biotransformation products with antidepressant activity in mice. And the article contained the following:

The present study aims to focus on the evaluation of the antidepressant effect of the mixture of two flavonoids (FMix), and its interaction with serotonergic drugs. One of the fractions contained FMix wich is constituted of the mixture of quercetin 4′-O-rhamnoside y isoquercitrin. The mice were divided into the several following groups: FMix; FMix (1.0 mg/kg) and agonist DOI (2.0 mg/kg); FMix (1.0 mg/kg) and antagonist ketanserin (KET, 0.03 mg/kg) of 5-HT2A receptors; FMix (1.0 mg/kg) and selective agonist 8-OH-DPAT (8-OH, 0.01 mg/kg); FMix (1.0 mg/kg) and antagonist WAY100635 (WAY, 0.5 mg/kg) of 5HT1 receptors; PHL; DOPAC; p-HPAA; and m-HPAA were tested in FST or OFT. FMix induced dependent-dose antidepressant activity and, at the highest dose administered, a sedative effect was also observed The 8-OH-DPAT, or the DOI, or the KET combination with FMix (1.0 mg/kg) induced a higher antidepressant effect than compounds alone; there was no effect exerted with WAY. The activity on OFT increased only with the FMix and KET combination. At the same time, the products of the aglycon metabolism of quercetin, i.e., DOPAC and p-HPAA, decreased the immobility time of the mice in FST at 1.0 mg/kg, and a dose-curve was formed for these. The antidepressant effect of FMix could depend, at least in part, on the degradation products of quercetin and with a possible action mode through interaction with the serotoninergic system. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to tilia biotransformation antidepressant isoquercitrin, 5-ht, dopac, depression, isoquercitrin, phloroglucinol, quercetin 4′-o-rhamnoside, tilia americana, p-hpaa, Placeholder for records without volume info and other aspects.SDS of cas: 621-37-4

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On September 30, 2022, Xue, Guiren; Su, Shanshan; Yan, Pengfei; Shang, Jiawei; Wang, Jianxin; Yan, Chengye; Li, Jiaxi; Wang, Qiao; Xiong, Xue; Xu, Huijun published an article.Related Products of 473-81-4 The title of the article was Integrative analyses of widely targeted metabolomic profiling and derivatization-based LC-MS/MS reveals metabolic changes of Zingiberis Rhizoma and its processed products. And the article contained the following:

Zingiberis Rhizoma (ZR) has nutritional value and application potentiality, while Zingiberis Rhizoma Praeparatum (ZRP) and Carbonised Ginger (CG) are two main processed products of ZR based on different methods. Here, we performed a widely targeted metabolomics method with Sequential Windowed Acquisition of all Theor. fragment ions (SWATH) mode to analyze differential metabolites in ZR, ZRP and CG. Addnl., the chem. derivatization was applied to characterize different submetabolomes and improve the separation effect and MS response of metabolites. In total, 369 metabolites were identified and divided into 14 categories, 104 of which were differential metabolites. Our results suggest that carbohydrates, nucleotides, organic acids, vitamins, lipids, indoles, alkaloids, and terpenes contributed to a downward trend after processing, but the maximum content of flavanones, phenylpropanes and polyphenols appeared in ZRP, and that of alcs. appeared in CG. These findings serve as promising perspectives for developing functional food in ZR, ZRP and CG. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to metabolomic profiling zingiberis rhizoma, chemical derivatization, differentiate, processed products, widely targeted metabolomic analysis, zingiberis rhizoma, Placeholder for records without volume info and other aspects.Related Products of 473-81-4

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Zizmare, Laimdota; Boyle, Christina N.; Buss, Sabrina; Louis, Sandrine; Kuebler, Laura; Mulay, Ketki; Krueger, Ralf; Steinhauer, Lara; Mack, Isabelle; Rodriguez Gomez, Manuel; Herfert, Kristina; Ritze, Yvonne; Trautwein, Christoph published an article in 2022, the title of the article was Roux-En-Y Gastric Bypass (RYGB) Surgery during High Liquid Sucrose Diet Leads to Gut Microbiota-Related Systematic Alterations.Formula: C8H8O3 And the article contains the following content:

Roux-en-Y gastric bypass (RYGB) surgery has been proven successful in weight loss and improvement of co-morbidities associated with obesity. Chronic complications such as malabsorption of micronutrients in up to 50% of patients underline the need for addnl. therapeutic approaches. We investigated systemic RYGB surgery effects in a liquid sucrose diet-induced rat obesity model. After consuming a diet supplemented with high liquid sucrose for eight weeks, rats underwent RYGB or control sham surgery. RYGB, sham pair-fed, and sham ad libitum-fed groups further continued on the diet after recovery. Notable alterations were revealed in microbiota composition, inflammatory markers, feces, liver, and plasma metabolites, as well as in brain neuronal activity post-surgery. Higher fecal 4-aminobutyrate (GABA) correlated with higher Bacteroidota and Enterococcus abundances in RYGB animals, pointing towards the altered enteric nervous system (ENS) and gut signaling. Favorable C-reactive protein (CRP), serine, glycine, and 3-hydroxybutyrate plasma profiles in RYGB rats were suggestive of reverted obesity risk. The impact of liquid sucrose diet and caloric restriction mainly manifested in fatty acid changes in the liver. Our multi-modal approach reveals complex systemic changes after RYGB surgery and points towards potential therapeutic targets in the gut-brain system to mimic the surgery mode of action. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to obesity rygb surgery gut microbiota crp serine glycine hydroxybutyrate, 3-hydroxybutyrate, gaba, rygb, gut-brain axis, inflammation, metabolomics, microbiome, Placeholder for records without volume info and other aspects.Formula: C8H8O3

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On November 15, 2020, Kuznetsov, Ilya E.; Nikitenko, Sergey L.; Kuznetsov, Petr M.; Dremova, Nadezhda N.; Troshin, Pavel A.; Akkuratov, Alexander V. published an article.Product Details of 143-10-2 The title of the article was Solubilizing Side Chain Engineering: Efficient Strategy to Improve the Photovoltaic Performance of Novel Benzodithiophene-Based (X-DADAD)n Conjugated Polymers. And the article contained the following:

Conjugated polymers represent a promising family of semiconductor materials for thin-film organic solar cells (OSCs). An efficient approach to improve the photovoltaic performance of conjugated polymers is engineering the side chains attached to the polymer backbone. This work reports the impact of different alkyl substituents on the optoelectronic properties, charge carrier mobilities, thin film morphol., and photovoltaic performance of novel (X-DADAD)n conjugated polymers incorporating benzo[1,2-b:4,5-b]dithiophene moieties. It has been shown that loading conjugated polymers with appropriate alkyl side chains results in a spectacular performance improvement from 6.8% to 9% in OCSs using a model fullerene acceptor [6,6]-phenyl-C71-butyric acid Me ester. The obtained results feature side-chain engineering as a facile and efficient strategy for designing high-performance conjugated polymers for organic photovoltaics. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Product Details of 143-10-2

The Article related to benzothiopene conjugated polymer organic solar cell optical band gap, benzodithiophene, benzothiadiazole, conjugated polymers, organic solar cells, thiophene, Placeholder for records without volume info and other aspects.Product Details of 143-10-2

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On July 31, 2022, Zong, Shuai; Ye, Hongling; Ye, Ziyang; He, Yaling; Zhang, Xinmiao; Ye, Ming published an article.SDS of cas: 621-37-4 The title of the article was Polysaccharides from Lachnum sp. Inhibited colitis-associated colon tumorigenesis in mice by modulating fecal microbiota and metabolites. And the article contained the following:

It is still uncertain whether the consumption of Lachnum sp. polysaccharides (LEP) alleviates colorectal cancer (CRC) through the gut microbiota. In this study, our efforts are focused on the influence of LEP on CRC, intestinal barrier and inflammation, and fecal microbiota and the metabolites, in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CRC mice. Results showed that LEP inhibited CRC mouse colon shortening and weight loss, decreased tumor incidence, restored intestinal barrier integrity, and reduced excessive inflammation. LEP consumption significantly altered microbiota overall structure and community, with reduced pernicious bacteria (such as Parabacteroides, Escherichia_Shigella, Desulfovibrio and Helicobacter), and increased beneficial bacterium (such as Alistipes, Alloprevotella and Ruminiclostridium). Fecal-metabolome profile indicated that a total of 43 metabolites were clearly changed, with 10 down-regulated and 33 up-regulated metabolites. In addition, short-chain fatty acids (SCFAs), including acetic acid, propionic acid and n-butyric acid, were significantly increased after LEP administration. Moreover, a strong correlation between the fluctuant gut microbiota and metabolites was found. These findings provided not only deeper insights into the responsibility of LEP for CRC alleviation, and but also the potential of LEP as a promising candidate for CRC prevention and treatment. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).SDS of cas: 621-37-4

The Article related to lachnum polysaccharide mice colitis colon tumorigenesis fecal microbiota metabolite, aom/dss, colorectal cancer, gut microbiota, lachnum sp. polysaccharides, Placeholder for records without volume info and other aspects.SDS of cas: 621-37-4

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Yang, Hao; Wang, Zhenfei; Shi, Shujun; Yu, Qin; Liu, Meiling; Zhang, Zhelin published an article in 2022, the title of the article was Identification of cerebrospinal fluid metabolites as biomarkers for neurobrucellosis by liquid chromatography-mass spectrometry approach.Application of 32462-30-9 And the article contains the following content:

Neurobrucellosis is the most morbid form in brucellosis disease. Metabolomics is an emerging method which intends to explore the global alterations of various metabolites in samples. We aimed to identify metabolites in cerebrospinal fluid (CSF) as biomarkers that were potentially unique for neurobrucellosis. CSF samples from 25 neurobrucellosis patients and 25 normal controls (uninfected patients with hydrocephalus) were collected for metabolite detection using liquid chromatog.-mass spectrometry (LC-MS) approach. Inflammatory cytokines in CSF were measured with ELISA (ELISA). The base peak chromatogram in CSF samples showed that small-mol. metabolites were well separated Principal Component Anal. (PCA) anal. exhibited the examined samples were arranged in two main clusters in accordance with their group. Projection to Latent Structures Discriminant Anal. (PLS-DA) revealed there was a noticeable separation between neurobrucellosis and normal groups. Orthogonal Partial Least-Squares-Discriminant Anal. (OPLS-DA) could responsibly illuminate the differences between neurobrucellosis and normal controls. Neurobrucellosis showed a total of 155 differentiated metabolites. Prominent potential biomarkers including 30 metabolites were then selected out, regarded as more capable of distinguishing neurobrucellosis. TNF-α and IL-6 in CSF were remarkably increased in neurobrucellosis. We presented the heatmaps and correlation analyses among the identified 30 potential biomarkers. In conclusion, this study showed that CSF metabolomics based on LC-MS could distinguish neurobrucellosis patients from normal controls. Our data offered perspectives for diagnosis and treatment for neurobrucellosis. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to neurobrucellosis cerebrospinal fluid metabolite biomarker lcms, neurobrucellosis, cerebrospinal fluid, liquid chromatography-mass spectrometry, metabolomics, Placeholder for records without volume info and other aspects.Application of 32462-30-9

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Yang, Hao; Wang, Zhenfei; Shi, Shujun; Yu, Qin; Liu, Meiling; Zhang, Zhelin published an article in 2022, the title of the article was Identification of cerebrospinal fluid metabolites as biomarkers for neurobrucellosis by liquid chromatography-mass spectrometry approach.Formula: C8H8O3 And the article contains the following content:

Neurobrucellosis is the most morbid form in brucellosis disease. Metabolomics is an emerging method which intends to explore the global alterations of various metabolites in samples. We aimed to identify metabolites in cerebrospinal fluid (CSF) as biomarkers that were potentially unique for neurobrucellosis. CSF samples from 25 neurobrucellosis patients and 25 normal controls (uninfected patients with hydrocephalus) were collected for metabolite detection using liquid chromatog.-mass spectrometry (LC-MS) approach. Inflammatory cytokines in CSF were measured with ELISA (ELISA). The base peak chromatogram in CSF samples showed that small-mol. metabolites were well separated Principal Component Anal. (PCA) anal. exhibited the examined samples were arranged in two main clusters in accordance with their group. Projection to Latent Structures Discriminant Anal. (PLS-DA) revealed there was a noticeable separation between neurobrucellosis and normal groups. Orthogonal Partial Least-Squares-Discriminant Anal. (OPLS-DA) could responsibly illuminate the differences between neurobrucellosis and normal controls. Neurobrucellosis showed a total of 155 differentiated metabolites. Prominent potential biomarkers including 30 metabolites were then selected out, regarded as more capable of distinguishing neurobrucellosis. TNF-α and IL-6 in CSF were remarkably increased in neurobrucellosis. We presented the heatmaps and correlation analyses among the identified 30 potential biomarkers. In conclusion, this study showed that CSF metabolomics based on LC-MS could distinguish neurobrucellosis patients from normal controls. Our data offered perspectives for diagnosis and treatment for neurobrucellosis. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to neurobrucellosis cerebrospinal fluid metabolite biomarker lcms, neurobrucellosis, cerebrospinal fluid, liquid chromatography-mass spectrometry, metabolomics, Placeholder for records without volume info and other aspects.Formula: C8H8O3

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On December 31, 2021, Bagheri, Minoo; Shah, Rachana D.; Mosley, Jonathan D.; Ferguson, Jane F. published an article.Computed Properties of 621-37-4 The title of the article was A metabolome and microbiome wide association study of healthy eating index points to the mechanisms linking dietary pattern and metabolic status. And the article contained the following:

Healthy eating index (HEI), a measure of diet quality, associates with metabolic health outcomes; however, the mol. basis is unclear. We conducted a multi-omic study to examine whether HEI associates with the circulatory and gut metabolome and investigated the gut microbiome-HEI interaction on circulating and gut metabolites. Through a cross-sectional study, we evaluated diet quality in healthy individuals [the ABO Glycoproteomics in Platelets and Endothelial Cells (ABO) Study, n = 73], metabolites (measured at Metabolon Inc.) in plasma (n = 800) and gut (n = 767) and the gut microbiome at enterotype and microbial taxa (n = 296) levels. Pathway anal. was conducted using Metaboanalyst 4.0. We performed multi-variable linear regression to explore both the HEI-metabolites and HEI-microbiome associations and how metabolites were affected by the HEI-microbiome interaction. In the Fish oils and Adipose Inflammation Reduction (FAIR) Study (n = 25), analyses on HEI and plasma metabolites were replicated. Estimates of findings from both studies were pooled in random-effects meta-anal. The HEI-2015 was associated with 74 plasma and 73 gut metabolites (mostly lipids) and with 47 metabolites in the meta-anal. of the ABO and FAIR Studies. Compared to Enterotype-1 participants, those with Enterotype-2 had higher diet quality (p = 0.01). We also identified 9 microbial genera associated with HEI, and 35 plasma and 40 gut metabolites linked to the HEI-gut microbiome interaction. Pathways involved in the metabolism of polar lipids, amino acids and caffeine strongly associated with diet quality. However, the HEI-microbiome interaction not only influenced the pathways involved in the metabolism of branch-chain amino acids, it also affected upstream pathways including nucleotide metabolism and amino acids biosynthesis. Our multi-omic anal. demonstrated that changes in metabolism, measured by either circulatory/gut metabolites or metabolic pathways, are influenced by not only diet quality but also gut microbiome alterations shaped by the quality of diet consumed. Future work is needed to explore the causality in the interplay between HEI and gut-microbiome composition in metabolism The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to metabolome microbiome healthy eating index dietary pattern, diet quality, healthy eating index, metabolic pathway, metabolome, microbiome, multi-omic study, Placeholder for records without volume info and other aspects.Computed Properties of 621-37-4

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Zhou, Yumei; Zhao, Haihong; Wang, Tieshan; Zhao, Xiaoshan; Wang, Ji; Wang, Qi published an article in 2022, the title of the article was Anti-inflammatory and anti-asthmatic effects of TMDCT decoction in eosinophilic asthma through Treg/ Th17 balance.Category: alcohols-buliding-blocks And the article contains the following content:

Tuo-Min-Ding-Chuan decoction (TMDCT) is a Traditional Chinese Medicine (TCM) formula consisting of twelve herbs that can relieve the symptoms and treat allergic asthma. Yet, the underlying mechanism of action is still unclear. In this study, we investigated the effect of TMDCT in regulating Treg/Th17 cells immune balance and explored potential metabolic and gut biomarkers associated with Treg and Th17 cells in eosinophilic asthma mice treated by TMDCT. We found that TMDCT increases Treg cells percentage and decreases Th17 cells percentage in the ovalbumin (OVA) -induced eosinophilic asthma mice model. Furthermore, Imidazoleacetic acid, DL-glutamine, L-pyroglutamic acid, 2-deoxy-D-glucose were preliminary identified as biomarkers in plasma metabolites treated by TMDCT, meanwhile genus Desulfovibrio, genus Butyricimonas and genus Prevotella 9 were preliminary identified as gut microbiota biomarkers after TMDCT treatment. These results provide an exptl. foundation for the treatment of allergic asthma with Chinese herbal compounds The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to tmdct decoction antiinflammatory treg th17 allergic asthma, treg/th17, tuo-min-ding-chuan decoction, anti-asthmatic, anti-inflammatory, eosinophilic asthma, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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On May 31, 2022, van Drooge, Barend L.; Garatachea, Roger; Reche, Cristina; Titos, Gloria; Alastuey, Andres; Lyamani, Hassan; Alados-Arboledas, Lucas; Querol, Xavier; Grimalt, Joan O. published an article.HPLC of Formula: 473-81-4 The title of the article was Primary and secondary organic winter aerosols in Mediterranean cities under different mixing layer conditions (Barcelona and Granada). And the article contained the following:

PM10 was collected during an EMEP winter campaign of 2017-2018 in two urban background sites in Barcelona (BCN) and Granada (GRA), two Mediterranean cities in the coast and inland, resp. The concentrations of PM10, organic carbon (OC), elemental carbon (EC), and organic mol. tracer compounds such as hopanes, anhydro-saccharides, polycyclic aromatic hydrocarbon, and several biogenic and anthropogenic markers of secondary organic aerosols (SOA) were two times higher in GRA compared to BCN and related to the atm. mixing heights in the areas. Multivariate curve resolution (MCR-ALS) source apportionment anal. identified primary emissions sources (traffic + biomass burning) that were responsible for the 50% and 20% of the organic aerosol contributions in Granada and Barcelona, resp. The contribution of biomass burning was higher in the holidays than in the working days in GRA while all primary combustion emissions decreased in holidays in BCN. The MCR-ALS identified that oxidative species and SOA formation processes contributed to 40% and 80% in Granada and Barcelona, resp. Aged SOA was dominant in Granada and Barcelona under stagnant atm. conditions and in presence of air pollution. On the other hand, fresh SOA contributions from α-pinene oxidation (cis-pinonic acid) were three times higher in Barcelona than Granada and could be related to new particle formation, essentially due to overall cleaner air conditions and elevated air temperatures The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).HPLC of Formula: 473-81-4

The Article related to polycyclic aromatic hydrocarbon primary secondary organic aerosol barcelona granada, organic aerosol, pah, pm, soa, source apportionment, urban air quality, Placeholder for records without volume info and other aspects.HPLC of Formula: 473-81-4

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