Tag: 100-200

On January 1, 2022, Hillyer, Katie E.; Raes, Eric; Karsh, Kristen; Holmes, Bronwyn; Bissett, Andrew; Beale, David J. published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Metabolomics as a tool for in situ study of chronic metal exposure in estuarine invertebrates. And the article contained the following:

Estuaries are subject to intense human use globally, with impacts from multiple stressors, such as metal contaminants. A key challenge is extending beyond traditional monitoring approaches to understand effects to biota and system function. To explore the metabolic effects of complex metal contaminants to sediment dwelling (benthic) fauna, we apply a multiple-lines-of-evidence approach, coupling environmental monitoring, benthic sampling, total metals anal. and targeted metabolomics. We characterize metabolic signatures of metal exposure in three benthic invertebrate taxa, which differed in distribution across sites and severity of metal exposure: sipunculid (very high), amphipod (high), maldanid polychaete (moderate). We observed sediment and tissue metal loads far exceeding sediment guidelines where toxicity-related adverse effects may be expected, for metals including, As, Cd, Pb, Zn and Hg. Change in site- and taxa-specific metabolite profiles was highly correlated with natural environmental drivers (sediment total organic carbon and water temperature). At the most metal influenced sites, metabolite variation was also correlated with sediment metal loads. Using supervised multivariate regression, taxa-specific metabolic signatures of increased exposure and possibility of toxic effects were characterised against multiple reference sites. Metabolic signatures varied according to each taxon and degree of metal exposure, but primarily indicated altered cysteine and methionine metabolism, metal-binding and elimination (lysosomal) activity, coupled to change in complex biosynthesis pathways, responses to oxidative stress, and cellular damage. This novel multiple-lines-of-evidence approach combining metabolomics with traditional environmental monitoring, enabled detection and characterization of chronic metal exposure effects in situ in multiple invertebrate taxa. With capacity for application to rapid and effective monitoring of non-model species in complex environments, these approaches are critical for improved assessment and management of systems that are increasingly subject to anthropogenic drivers of change. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to metal contaminant metabolomics estuarine invertebrate, bioavailability, bioindicator, contaminant, metabolomics, toxicity, zinc, Placeholder for records without volume info and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

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On January 31, 2022, Jaskiw, George E.; Xu, Dongyan; Obrenovich, Mark E.; Donskey, Curtis J. published an article.Synthetic Route of 621-37-4 The title of the article was Small phenolic and indolic gut-dependent molecules in the primate central nervous system: levels vs. bioactivity. And the article contained the following:

Rapidly growing body of data documents associations between disease of the brain and small mols. generated by gut-microbiota (GMB). While such metabolites can affect brain function through a variety of mechanisms, the most direct action would be on the central nervous system (CNS) itself. Identify indolic and phenolic GMB-dependent small mols. that reach bioactive concentrations in primate CNS. We conducted a PubMed search for metabolomic studies of the primate CNS [brain tissue or cerebrospinal fluid (CSF)] and then selected for phenolic or indolic metabolites that (i) had been quantified, (ii) were GMB-dependent. For each chem. we then conducted a search for studies of bioactivity conducted in vitro in human cells of any kind or in CNS cells from the mouse or rat. 36 metabolites of interests were identified in primate CNS through targeted metabolomics. Quantification was available for 31/36 and in vitro bioactivity for 23/36. The reported CNS range for 8 metabolites 2-(3-hydroxyphenyl)acetic acid, 2-(4-hydroxyphenyl)acetic acid, 3-(3-hydroxyphenyl)propanoic acid, (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid [caffeic acid], 3-hydroxybenzoic acid, 4-hydroxybenzoic acid, 2-acetamido-3-(1H-indol-3-yl)propanoic acid [N-acetyltryptophan], 1H-indol-3-yl hydrogen sulfate [indoxyl-3-sulfate] overlapped with a bioactive concentration However, the number and quality of relevant studies of CNS neurochem. as well as of bioactivity were highly limited. Structural isomers, multiple metabolites and potential confounders were inadequately considered. The potential direct bioactivity of GMB-derived indolic and phenolic mols. on primate CNS remains largely unknown. The field requires addnl. strategies to identify and prioritize screening of the most promising small mols. that enter the CNS. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to phenol indole central nervous system, bioactivity, brain, cerebrospinal fluid, gut microbiota, indolic, neuroactivity, phenolic, Placeholder for records without volume info and other aspects.Synthetic Route of 621-37-4

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On May 31, 2021, van den Berg, Fons F.; van Dalen, Demi; Hyoju, Sanjiv K.; van Santvoort, Hjalmar C.; Besselink, Marc G.; Wiersinga, Willem Joost; Zaborina, Olga; Boermeester, Marja A.; Alverdy, John published an article.Category: alcohols-buliding-blocks The title of the article was Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate. And the article contained the following:

The gut microbiota are the main source of infections in necrotising pancreatitis. We investigated the effect of disruption of the intestinal microbiota by a Western-type diet on mortality and bacterial dissemination in necrotising pancreatitis and its reversal by butyrate supplementation. C57BL/6 mice were fed either standard chow or a Western-type diet for 4 wk and were then subjected to taurocholate-induced necrotising pancreatitis. Blood and pancreas were collected for bacteriol. and immune anal. The cecum microbiota composition of mice was analyzed using 16S rRNA gene amplicon sequencing and cecal content metabolites were analyzed by targeted (ie, butyrate) and untargeted metabolomics. Prevention of necrotising pancreatitis in this model was compared between faecal microbiota transplantation (FMT) from healthy mice, antibiotic decontamination against Gram-neg. bacteria and oral or systemic butyrate administration. Addnl., the faecal microbiota of patients with pancreatitis and healthy subjects were analyzed. Mortality, systemic inflammation and bacterial dissemination were increased in mice fed Western diet and their gut microbiota were characterised by a loss of diversity, a bloom of Escherichia coli and an altered metabolic profile with butyrate depletion. While antibiotic decontamination decreased mortality, Gram-pos. dissemination was increased. Both oral and systemic butyrate supplementation decreased mortality, bacterial dissemination, and reversed the microbiota alterations. Paradoxically, mortality and bacterial dissemination were increased with FMT administration. Finally, patients with acute pancreatitis demonstrated an increase in Proteobacteria and a decrease of butyrate producers compared with healthy subjects. Butyrate depletion and its repletion appear to play a central role in disease progression towards necrotising pancreatitis. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Category: alcohols-buliding-blocks

The Article related to necrotising pancreatitis mortality microbiota butyrate, acute pancreatitis, antibiotics, bacterial infection, butyrate, diet, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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On September 30, 2022, Balic, Ivan; Olmedo, Patricio; Zepeda, Baltasar; Rojas, Barbara; Ejsmentewicz, Troy; Barros, Miriam; Aguayo, Daniel; Moreno, Adrian A.; Pedreschi, Romina; Meneses, Claudio; Campos-Vargas, Reinaldo published an article.Product Details of 473-81-4 The title of the article was Metabolomic and biochemical analysis of mesocarp tissues from table grape berries with contrasting firmness reveals cell wall modifications associated to harvest and cold storage. And the article contained the following:

Tissue texture influences the grape berry consumers acceptance. We studied the biol. differences between the inner and outer mesocarp tissues in hard and soft berries of table grapes cv NN107. Texture anal. revealed lower levels of firmness in the inner mesocarp as compared with the outer tissue. HPAEC-PAD anal. showed an increased abundance of cell wall monosaccharides in the inner mesocarp of harder berries at harvest. Immunohistochem. anal. displayed differences in homogalacturonan methylesterification and cell wall calcium between soft and hard berries. This last finding correlated with a differential abundance of calcium measured in the alc.-insoluble residues (AIR) of the inner tissue of the hard berries. Anal. of abundance of polar metabolites suggested changes in cell wall carbon supply precursors, providing new clues in the identification of the biochem. factors that define the texture of the mesocarp of grape berries. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

The Article related to table grape mesocarp cell wall metabolomic harvest cold storage, calcium, pectin, polar metabolites, texture, vitis vinifera, Placeholder for records without volume info and other aspects.Product Details of 473-81-4

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On August 1, 2022, Macia, Alba; Romero, Maria-Paz; Yuste, Silvia; Ludwig, Iziar; Pedret, Anna; Valls, Rosa Maria; Salamanca, Patricia; Sola, Rosa; Jose Motilva, Maria; Rubio, Laura published an article.HPLC of Formula: 621-37-4 The title of the article was Phenol metabolic fingerprint and selection of intake biomarkers after acute and sustained consumption of red-fleshed apple versus common apple in humans. The AppleCOR study. And the article contained the following:

The present study aimed to evaluate the metabolism and bioavailability of anthocyanins (ACN) and other phenolics from red-fleshed apple (RFA) and to define the intake biomarkers compared to common white-fleshed apple (WFA). Acute and sustained (6-wk) interventions were combined in a randomized, controlled and parallel study with 121 hypercholesterolemic subjects. Another arm consuming ACN-rich infusion from aronia fruit (ARO) provided matched content and profile of ACN. Plasma, urine and faeces samples were analyzed using UPLC-MS/MS. Results showed higher bioavailability of ACN after ARO compared to RFA, showing a clear apple matrix effect. The dihydrochalcone phloretin-2′-O-glucuronide was the most discriminant intake biomarker of both apples. The urinary peonidin-3-O-galactoside was a good biomarker after both ARO and RFA intakes, whereas peonidin-O-arabinoside was reported to be specific from ARO. The elucidation of the phenolic metabolism and the selection of intake biomarkers is a promising approach to relate phenolic compounds and human health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to malus phenol metabolic fingerprint biomarker, anthocyanins, intake biomarkers, metabolism, red-fleshed apple, uplc-ms/ms, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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On September 1, 2022, Oberschelp, Gustavo Pedro Javier; Morales, Luisina Lourdes; Montecchiarini, Marina Lucia; Harrand, Leonel; Podesta, Florencio Esteban; Margarit, Ezequiel published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Harder, better, faster, stronger: Frost tolerance of Eucalyptus benthamii under cold acclimation. And the article contained the following:

Eucalypts are the most planted hardwood trees worldwide because of their very rapid growth, exceptional wood quality and adaptability. However, most com. species and derived hybrids are sensitive to frost, which remains as the largest obstacle to their introduction in warm/temperate climates. As evergreen species, Eucalypts have developed the ability to tolerate frost events based on physiol. and mol. responses triggered by previous exposure to cold temperatures, globally named cold acclimation. To characterize the acclimation process in two species with different tolerance to frost, E. grandis (Eg) and E. benthamii (Eb), seedlings were exposed for different times to low temperatures Frost tolerance was estimated in leaves by an electrolyte leakage assay, and metabolome and morpho-physiol. changes studied and correlated to the observed acclimation responses. Eb showed higher basal frost tolerance and an earlier and stronger acclimation response to cold temperatures than in the frost sensitive Eg. Eb was able to modify several morpho-physiol. parameters, with a restriction in plant height, leaf area and leaf fresh weight during acclimation. Metabolome characterization allowed us to differentiate species and strengthen our understanding of their acclimation response dynamics. Interestingly, Eb displayed an early phase of sugar accumulation followed by a rise of different metabolites with possible roles as osmolytes and antioxidants, that correlated to frost tolerance and may explain Eb higher capacity to acclimate. This novel approach has helped us to point to the main metabolic processes underlying the cold tolerance acquisition process in two relevant Eucalyptus species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to eucalyptus benthamii frost tolerance cold acclimation, acclimation, cold, eucalyptus, freezing, metabolomics, tolerance, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Pourafshar, Shirin; Nicchitta, Mira; Tyson, Crystal C.; Svetkey, Laura P.; Corcoran, David L.; Bain, James R.; Muehlbauer, Michael J.; Ilkayeva, Olga; O’Connell, Thomas M.; Lin, Pao-Hwa; Scialla, Julia J. published an article in 2021, the title of the article was Urine and plasma metabolome of healthy adults consuming the DASH (dietary approaches to stop hypertension) diet: a randomized pilot feeding study.Reference of 3-Hydroxyphenylacetic acid And the article contains the following content:

We aimed to identify plasma and urine metabolites altered by the Dietary Approaches to Stop Hypertension (DASH) diet in a post-hoc anal. of a pilot feeding trial. Twenty adult participants with un-medicated hypertension consumed a Control diet for one week followed by 2 wk of random assignment to either Control or DASH diet. Non-missing fasting plasma (n = 56) and 24-h urine (n = 40) were used to profile metabolites using untargeted gas chromatog./mass spectrometry. Linear models were used to compare metabolite levels between the groups. In urine, 19 identifiable untargeted metabolites differed between groups at p < 0.05. These included a variety of phenolic acids and their microbial metabolites that were higher during the DASH diet, with many at false discovery rate (FDR) adjusted p < 0.2. In plasma, eight identifiable untargeted metabolites were different at p < 0.05, but only gamma-tocopherol was significantly lower on DASH at FDR adjusted p < 0.2. The results provide insights into the mechanisms of benefit of the DASH diet. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Reference of 3-Hydroxyphenylacetic acid

The Article related to feeding urine phenolic acid plasma metabolome hypertension, dash, blood pressure, metabolomics, nutrition, polyphenols, Placeholder for records without volume info and other aspects.Reference of 3-Hydroxyphenylacetic acid

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On September 12, 2022, Zhang, Ling; Morshedi, Mahbod; Kodikara, Mahesh S.; Humphrey, Mark G. published an article.Recommanded Product: 1-Decanethiol The title of the article was Giant Multi-Photon Absorption by Heptazine Organometalation. And the article contained the following:

Multi-photon absorption (MPA) is of increasing interest for applications in technol. important windows of the electromagnetic spectrum (near-IR III, NIR-III, 1550-1870 nm; and the new 2080-2340 nm region); few mols. exist that display strong MPA at these long wavelengths. the syntheses of the 1st 2,5,8-s-heptazine-cored organometallic complexes, together with organic analogs, are reported. The complexes exhibit outstanding 3PA cross sections in the NIR-III and exceptional 4PA cross sections in the new 2080-2340 nm window. Replacing organic donor groups by organometallic units results in an order of magnitude increase in 3PA, the switching on of 4PA, and a dramatic improvement in photo-stability. The results highlight the impressive outcomes possible with an organometalation approach to NLO materials design. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Recommanded Product: 1-Decanethiol

The Article related to giant multiphoton near ir absorption heptazine organometalation, metal complexes, multi-photon absorption, nitrogen heterocycles, nonlinear optics, organometallics, Placeholder for records without volume info and other aspects.Recommanded Product: 1-Decanethiol

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Li, Ji; Pan, Weiwei; Qian, Jianqin; Ni, Yan; Fu, Junfen; Ni, Shaoqing published an article in 2022, the title of the article was Metabolomic differential compounds reflecting the clinical efficacy of polyethylene glycol recombinant human growth hormone in the treatment of childhood growth hormone deficiency.Category: alcohols-buliding-blocks And the article contains the following content:

Understanding metabolite profiles may aid in providing a reference for individualized treatment using PEG-rhGH. Therefore, this study aimed to evaluate the clin. efficacy of PEG-rhGH in treating GHD patients by using a metabolomic approach. Fifty-seven pediatric participants treated with PEG-rhGH were enrolled (28 GHD patients with high clin. efficacy and 29 GHD patients with lower clin. efficacy). Serum samples from all patients were first collected at baseline for biochem. detection; then metabolite levels were measured using gas chromatog. time-of-flight mass spectrometry. The candidates included heptadecanoic acid, stearic acid, 2-hydroxybutyric acid, myristic acid, palmitoleic acid, D-galactose, dodecanoic acid, and oleic acid. The related metabolic pathways involved fatty acid metabolism and energy metabolism This study suggested that growth gains of PEG-rhGH treatment might be differentiated by altered serum levels of fatty acid. Collectively, the metabolomic study provides unique insights into the use of PEG-rhGH as a therapeutic strategy for individualized treatment. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to polyethylene glycol human growth hormone deficiency energy metabolism metabolomic, peg-rhgh, biomarkers, clinical efficacy, growth hormone deficiency, metabolomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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On February 28, 2022, Escobar-Martinez, Ivan; Arreaza-Gil, Veronica; Muguerza, Begona; Arola-Arnal, Anna; Bravo, Francisca Isabel; Torres-Fuentes, Cristina; Suarez, Manuel published an article.Synthetic Route of 621-37-4 The title of the article was Administration Time Significantly Affects Plasma Bioavailability of Grape Seed Proanthocyanidins Extract in Healthy and Obese Fischer 344 Rats. And the article contained the following:

Phenolic compounds are bioactive mols. that are associated with several health benefits. Metabolization and absorption are the main determinants of their bioavailability and bioactivity. Thus, the study of the factors that modulate these processes, such as sex or diet is essential. Recently, it has been shown that biol. rhythms may also play a key role. Hence, the aim of this study is to evaluate if the bioavailability of a grape proanthocyanidin extract (GSPE) is affected by the administration time in an animal model of metabolic syndrome (MetS). Methods and Results : Female and male Fischer 344 rats are fed either a standard or a cafeteria diet (CAF) for 9 wk, and an oral dose of GSPE (25 mg kg-1) is daily administered either at 8:00 am (zeitgeber time (ZT)-0) or at 8:00 pm (ZT-12) during the last 4 wk. Plasma phenolic compounds are then quantified by liquid chromatog./electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Phase-II and gut microbiota-derived phenolic metabolites are affected by ZT in all conditions or only in obese rats, resp. CAF feeding affected the bioavailability of phenolic acids and free flavan-3-ols. Differences due to sex are also observed These findings demonstrate that ZT, diet, and sex are key factors influencing phenolic compounds bioavailability. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Synthetic Route of 621-37-4

The Article related to administration plasma bioavailability grape seed proanthocyanidin extract obese, gspe, bioavailability, circadian rhythms, metabolic syndrome, phenolic compounds, Placeholder for records without volume info and other aspects.Synthetic Route of 621-37-4

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