Tag: 100-200

On February 25, 2021, Li, Zhuo; Wang, Bing; Cui, Guo-Yi; Zhang, Bing-Bing; Wang, Ya-Fei; Yang, Lin; Ma, Hai-Xia; Jiao, Lin-Yu; Pang, Ling-Yan; Ma, Xiao-Xun published an article.Formula: C8H8O3 The title of the article was Construction of novel trimeric π-interaction subphthalocyanine-sensitized titanium dioxide for highly efficient photocatalytic degradation of organic pollutants. And the article contained the following:

In this study, highly active TiO2 sensitized by a novel axial substituted subphthalocyanine H12SubPcB-OPHCH2COOH (SubPc-3) was successfully prepared via a solvothermal method. Based on the crystallog. strategy, a new packing motif of SubPc-3 consisting of ligand-convex concave-concave head-head π-interaction was discovered for the first time, which affected its catalytic performance significantly. Furthermore, the DFT and TD-DFT methods were used to study the electronic feature and excited-state properties in SubPc-3 utilizing an optimized structure. By examining the degradation of methyl orange (MO) and bromophenol blue (BB) under visible light, the photocatalytic activities of the nanocomposites were investigated. The photocatalytic degradation rate of MO and BB degradation with TiO2/SubPc-3 are 97.8% and 99.5%, which are approx. 5.26 and 1.41 times compared to pure TiO2, resp. Besides, the reusability studies indicated that the photocatalytic activity of TiO2/SubPc-3 (25:1) could be maintained above 90.1% after five circulating photo-degradation This work revealed the correlation between π-interaction of sensitizer and photocatalytic performance, as well as further confirmed the great potential of TiO2/SubPc-3 photocatalytic materials in environmental remediation. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Formula: C8H8O3

The Article related to trimeric interaction subphthalocyanine sensitized titanium dioxide photocatalyst, Placeholder for records without volume info and other aspects.Formula: C8H8O3

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Buszewska-Forajta, Magdalena; Raczak-Gutknecht, Joanna; Struck-Lewicka, Wiktoria; Niziol, Magdalena; Artymowicz, Malgorzata; Markuszewski, Marcin; Kordalewska, Marta; Matuszewski, Marcin; Markuszewsk, Michal J. published an article in 2022, the title of the article was Untargeted metabolomics study of three matrices: seminal fluid, urine, and serum to search the potential indicators of prostate cancer.Recommanded Product: 2,3-Dihydroxypropanoic acid And the article contains the following content:

The simultaneous determination of metabolites from biol. fluids may provide more accurate information about the current body condition. So far, the metabolomics approach has been successfully applied to study the mechanism of several disorders and to search for novel biomarkers. Urine and plasma are widely accepted matrixes for the evaluation of several pathologies, while prostate cancer (CaP) development is still unknown. For this reason, an alternative matrix, the seminal fluid, was proposed to expand the knowledge about the CaP pathomechanism. The main aim of this study was to develop and optimize the sample preparation protocol to ensure the highest coverage of the metabolome of ejaculate samples. Parameters like the type and composition of the solvent mixture, time of extraction, and applied volume of the solvent were tested. The optimized method was applied for the untargeted metabolomics profiling of seminal fluid samples obtained from CaP patients. Moreover, urine and serum samples were also prepared for untargeted metabolomics anal. Analyses were carried out with the use of two complementary anal. techniques: GC-EI-QqQ/MS and LC-ESI-TOF/MS. Finally, the metabolic signature of seminal fluid (n = 7), urine (n = 7), and plasma (n = 7) samples was compared. Furthermore, the hypothesis of the increased level of metabolites in ejaculate samples related to the CaP development was evaluated. The results indicated that the developed and optimized sample preparation protocol for seminal fluid may be successfully applied for metabolomics study. Untargeted anal. of ejaculate enabled to determine the following classes of compounds: fatty acids, sphingolipids, phospholipids, sugars, and their derivatives, as well as amino acids. Finally, a comparison of the three tested matrixes was carried out. To our best knowledge, it is the first time when the metabolic profile of the three matrixes, namely, urine, plasma, and seminal fluid, was compared. Based on the results, it can be pointed out that ejaculate comprises the metabolic signature of both matrixes (polar compounds characteristic for urine, and nonpolar ones present in plasma samples). Compared to plasma, semen samples revealed to have a similar profile; however, determined levels of metabolites were lower in case of ejaculate. In case of urine samples, compared to semen metabolic profiles, the levels of detected metabolites were decreased in the latter ones. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Recommanded Product: 2,3-Dihydroxypropanoic acid

The Article related to seminal fluid urine serum prostate cancer metabolomic analysis, hplc, metabolites, metabolomics, plasma, prostate cancer, seminal fluid, urine, Placeholder for records without volume info and other aspects.Recommanded Product: 2,3-Dihydroxypropanoic acid

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On June 30, 2021, Wu, Yue; Yu, Jiaxiao; Liu, Xiyao; Wang, Wenling; Chen, Zhi; Qiao, Juan; Liu, Xiaohui; Jin, Huili; Li, Xin; Wen, Li; Tian, Jing; Saffery, Richard; Kilby, Mark D.; Qi, Hongbo; Tong, Chao; Baker, Philip N. published an article.Formula: C8H9NO3 The title of the article was Gestational diabetes mellitus-associated changes in the breast milk metabolome alters the neonatal growth trajectory. And the article contained the following:

Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy and leads to an altered metabolic profile of human breast milk (HBM). The association between HBM metabolites and neonatal growth in GDM pregnancies has not been thoroughly investigated.The primary aim was to quantify differences in the HBM metabolome between normal and GDM pregnancies. The secondary aim was to identify metabolites associated with neonatal growth during the first year postpartum.In the present study, mothers intending to exclusively breastfeed (BF) and their newborns (mother-infant pairs) were recruited at delivery (n = 129 normal pregnancies and n = 98 GDM pregnancies). HBM samples (colostrum, transition milk, and mature milk) from mothers with normal pregnancies (n = 50) and GDM pregnancies (n = 50) were subjected to metabolomic profiling via liquid chromatog. tandem mass spectrometry (LC-MS/MS). Receiver operating characteristic (ROC) anal. revealed the metabolomic fingerprints of GDM-associated mature HBM. Correlations between metabolites and neonatal body weight gain (BWG) were evaluated by Spearman correlation anal.In total, 620 metabolites were identified in each HBM sample; 253 compounds had the same variation patterns, whereas 38 compounds had significantly different pattern transitions between the GDM and normal groups. Moreover, 12, 49 and 28 metabolites exhibited significant differences in the 3 milk types between the 2 groups. Twenty-two metabolites were confirmed by ROC anal. as metabolomic fingerprints in the mature BM of GDM patients. Ten compounds were significantly neg. correlated with neonatal growth, and only 2 unsaturated lipids (eicosatrienoic acid (FA 20:3) and lysophosphatidylcholine (LysoPC) (22:6)) were pos. correlated with neonatal BWG.GDM is associated with alterations in the HBM metabolome. Only a small subset of compounds are associated with neonatal body weight (BW). The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to metabolome breast milk gestational diabetes mellitus neonate, gestational diabetes mellitus, human breast milk, metabolome, neonatal growth, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

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Farag, Mohamed A.; Kabbash, Eman M.; Mediani, Ahmed; Doll, Stefanie; Esatbeyoglu, Tuba; Afifi, Sherif M. published an article in 2022, the title of the article was Comparative Metabolite Fingerprinting of Four Different Cinnamon Species Analyzed via UPLC-MS and GC-MS and Chemometric Tools.Safety of 2,3-Dihydroxypropanoic acid And the article contains the following content:

The present study aimed to assess metabolites heterogeneity among four major Cinnamomum species, including true cinnamon (Cinnamomum verum) and less explored species (C. cassia, C. iners, and C. tamala). UPLC-MS led to the annotation of 74 secondary metabolites belonging to different classes, including phenolic acids, tannins, flavonoids, and lignans. A new proanthocyanidin was identified for the first time in C. tamala, along with several glycosylated flavonoid and dicarboxylic fatty acids reported for the first time in cinnamon. Multivariate data analyses revealed, for cinnamates, an abundance in C. verum vs. procyandins, dihydro-coumaroylglycosides, and coumarin in C. cassia. A total of 51 primary metabolites were detected using GC-MS anal. encompassing different classes, viz. sugars, fatty acids, and sugar alcs., with true cinnamon from Malaysia suggested as a good sugar source for diabetic patients. Glycerol in C. tamala, erythritol in C. iners, and glucose and fructose in C. verum from Malaysia were major metabolites contributing to the discrimination among species. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Safety of 2,3-Dihydroxypropanoic acid

The Article related to cinnamomum phenolic acid tannin flavonoid lignan glycerol erythritol, cinnamomum, chemometrics, erythritol, metabolomics, proanthocyanidin, Placeholder for records without volume info and other aspects.Safety of 2,3-Dihydroxypropanoic acid

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On November 30, 2022, Ijaz, Muawuz; Zhang, Dequan; Hou, Chengli; Mahmood, Mubarik; Hussain, Zubair; Zheng, Xiaochun; Li, Xin published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Changes in postmortem metabolites profile of atypical and typical DFD beef. And the article contained the following:

This study explored the changes in postmortem metabolites of atypical and typical DFD beef using UHPLC-Q-TOF/MS. The longissimus thoracis muscles were categorized into normal, atypical DFD and typical DFD groups. The L*, a*, b*, glycogen and lactic acid contents were lower (P < 0.05) in typical DFD than normal beef. A total of 240 compounds were significantly different among groups. Levels of glycerol-3-phosphate, D-ribose-5-phosphate, D-glucose-6-phosphate, D-fructose-6-phosphate, alpha-D-glucose-1-phosphate and dihydroxyacetone phosphate were higher in atypical DFD than those in the normal and typical DFD beef and the contents of 9 amino acids were elevated in typical DFD. KEGG anal. showed that metabolomic changes were primarily related with ATP-binding cassette transporters, metabolism of purine, central carbon, glycine, serine and threonine, biosynthesis of aminoacyl-tRNA, digestion and absorption of proteins, metabolism of amino sugar and nucleotide sugar, pyrimidine, bile secretion and galactose. In conclusion, development of atypical and typical DFD meat results in differences at level of postmortem metabolite concentrations of different metabolic pathways. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to beef atypical typical dark firm dry postmortem metabolite profile, beef, biochemical basis, dfd, non-targeted metabolomics, uhplc q-tof/ms, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Beale, David J.; Shah, Rohan; Karpe, Avinash V.; Hillyer, Katie E.; McAuley, Alexander J.; Au, Gough G.; Marsh, Glenn A.; Vasan, Seshadri S. published an article in 2021, the title of the article was Metabolic profiling from an asymptomatic ferret model of SARS-CoV-2 infection.HPLC of Formula: 621-37-4 And the article contains the following content:

Coronavirus disease (COVID-19) is a contagious respiratory disease that is causing significant global morbidity and mortality. Understanding the impact of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection on the host metabolism is still in its infancy but of great importance. Herein, we investigated the metabolic response during viral shedding and post-shedding in an asymptomatic SARS-CoV-2 ferret model (n = 6) challenged with two SARS-CoV-2 isolates. Virol. and metabolic analyses were performed on (minimally invasive) collected oral swabs, rectal swabs, and nasal washes. Fragments of SARS-CoV-2 RNA were only found in the nasal wash samples in four of the six ferrets, and in the samples collected 3 to 9 days post-infection (referred to as viral shedding). Central carbon metabolism metabolites were analyzed during viral shedding and post-shedding periods using a dynamic Multiple Reaction Monitoring (dMRM) database and method. Subsequent untargeted metabolomics and lipidomics of the same samples were performed using a Liquid Chromatog. Quadrupole Time-of-Flight Mass Spectrometry (LC-QToF-MS) methodol., building upon the identified differentiated central carbon metabolism metabolites. Multivariate anal. of the acquired data identified 29 significant metabolites and three lipids that were subjected to pathway enrichment and impact anal. The presence of viral shedding coincided with the challenge dose administered and significant changes in the citric acid cycle, purine metabolism, and pentose phosphate pathways, amongst others, in the host nasal wash samples. An elevated immune response in the host was also observed between the two isolates studied. These results support other metabolomic-based findings in clin. observational studies and indicate the utility of metabolomics applied to ferrets for further COVID-19 research that advances early diagnosis of asymptomatic and mild clin. COVID-19 infections, in addition to assessing the effectiveness of new or repurposed drug therapies. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

The Article related to covid 19 asymptomatic metabolomics viral shedding, covid-19, sars-cov-2, animal model, ferret, lipidomics, metabolomics, systems biology, Placeholder for records without volume info and other aspects.HPLC of Formula: 621-37-4

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On July 31, 2022, Lee, Hyun-Jong; Kim, Mi-Ja published an article.Synthetic Route of 473-81-4 The title of the article was Metabolites of oregano (Origanum vulgare) seed and their anti-obesity effects on 3T3-L1 adipocytes through down-regulated adipogenesis. And the article contained the following:

Metabolites of the 80% ethanol extract (OSE) and Et acetate fraction (OSEA) of oregano seed were analyzed by GC-MS, and anti-obesity effects of OSE and OSEA were evaluated in 3T3-L1 adipocyte. OSE possessed high content of glucose, fructofuranose, and sucrose while OSEA had high content of phenolic chems. OSEA contained higher levels of gallic acid, syringic acid, protocatechuic acid, and catechin than OSE. OSEA inhibited lipid droplet accumulation with concentration dependent manner in 3T3-L1 preadipocytes during differentiation. OSEA showed more inhibition ability than OSE by 13.7-fold at the level of 125 μg/mL. Addnl., relative mRNA and protein expression levels of pparγ, c/ebpα, fas, and srebp-1c which are related to adipogenesis were significantly lower in OSEA treatment group than in OSE treatment group (p < 0.05). Therefore, OSEA could be used as anti-obesity functional ingredient. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Synthetic Route of 473-81-4

The Article related to origanum vulgare seed metabolite adipocyte adipogenesis antiobesity effect, anti-obesity, antioxidant, metabolite, oregano seed, spice, Placeholder for records without volume info and other aspects.Synthetic Route of 473-81-4

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On March 15, 2022, Iio, Keita; Saitoh, Tsuyoshi; Ohshita, Ryuichiro; Hino, Tsubasa; Amezawa, Mao; Takayama, Yoshiaki; Nagumo, Yasuyuki; Yamamoto, Naoshi; Kutsumura, Noriki; Irukayama-Tomobe, Yoko; Ishikawa, Yukiko; Tanimura, Ryuji; Yanagisawa, Masashi; Nagase, Hiroshi published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was Discovery of orexin 2 receptor selective and dual orexin receptor agonists based on the tetralin structure: Switching of receptor selectivity by chirality on the tetralin ring. And the article contained the following:

A novel series of 1-amino-tetralin derivatives were designed and synthesized based on the putative binding mode of the naphthalene-type orexin receptor agonist 5 and their agonist activities against orexin receptors were evaluated. The introduction of N-methyl-(3-methoxyphenyl)acetamide unit onto the 1-amino-tetralin skeleton remarkably enhanced the potency of the agonist. The asym. synthesis of 6 revealed that (-)-6 having a (S)-1-amino-tetralin skeleton showed a OX2R selective agonist activity (EC50 = 2.69 nM for OX2R, OX1R/OX2R = 461) yet its enantiomer (R)-(+)-6 showed a potent OX1/2R dual agonist activity (EC50 = 13.5 nM for OX1R, 0.579 nM for OX2R, OX1R/OX2R = 23.3). These results suggested that upward orientation of the amide side chain against the tetralin scaffold (S-configuration) would be selective for OX2R activation, and the downward orientation (R-configuration) would be significant for dual agonist activity. To our best knowledge, there have been no reports thus far that the stereochem. of one carbon center on the agonist structure regulates the orexin receptor selectivity. Our results would provide important information for the development of OX1R selective agonists. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to orexin 2 receptor agonists chirality structure activity, agonist, diarylsulfonamide, ox1r, ox2r, orexin, orexin receptor, tetraline, Placeholder for records without volume info and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

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Qian, Heying; Li, Gang; Zhao, Guodong; Liu, Mingzhu; Xu, Anying published an article in 2020, the title of the article was Metabolic characterisation of the Midgut of Bombyx mori varieties after BmNPV infection using GC-MS-based metabolite profiling.Synthetic Route of 32462-30-9 And the article contains the following content:

Bombyx mori nucleopolyhedrovirus (BmNPV) is a silkworm disease that is especially harmful to cocoon production and seriously restricts sericultural development. Our laboratory successfully cultivated a new highly BmNPV-resistant silkworm variety, Huakang 2; however, its mechanism of BmNPV resistance remains unclear. To understand its resistance mechanism, we conducted a metabolomic and transcriptomic study of the midgut of silkworm varieties, Baiyu N and Baiyu after BmNPV infection. We identified 451 differential metabolites, which were mostly comprised of small mols., such as saccharides, acids, amines, alcs., and glycosides. We found that the primary differences in disease resistance between the silkworm varieties are metabolic-pathways, tryptophan metabolism, oxidative phosphorylation, ABC-transporters, beta-alanine metabolism, and phenylalanine metabolism Combined anal. with transcriptomic data suggested that tryptophan metabolism and oxidative phosphorylation are closely related to the silkworms BmNPV resistance. We hypothesize that the roles of the two metabolic pathways in the BmNPV resistance mechanism might be the following: Oxidative phosphorylation generates a large amount of ATP (ATP) in response to BmNPV infection to provide silkworms the energy required for establishing BmNPV resistance. Tryptophan metabolism then activates the aryl hydrocarbon receptor (AhR) through the exogenous virus BmNPV, which activates the silkworm′s immune system to defeat BmNPV infections. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to transcriptome metabolome oxidative phosphorylation nucleopolyhedrovirus bombyx, bmnpv, gc-ms, rna-seq, metabolic pathway, silkworm, Placeholder for records without volume info and other aspects.Synthetic Route of 32462-30-9

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On June 1, 2022, Yadav, Renu; Saini, Rashmi; Adhikary, Arindam; Kumar, Sanjeev published an article.Related Products of 473-81-4 The title of the article was Unravelling cross priming induced heat stress, combinatorial heat and drought stress response in contrasting chickpea varieties. And the article contained the following:

Drought and high temperature stress affect chickpea growth and productivity. Often these stresses occur simultaneously in the field and lead to a wide range of mol. and metabolic adaptations. Two chickpea varieties; GPF2 (heat sensitive) and PDG4 variety (heat tolerant) were exposed to 35 °C for 24 h individually and along with drought stress. Five heat responsive signalling genes and 11 structural genes were analyzed using qPCR along with untargeted metabolites anal. using GC MS. Expression of antioxidant genes (CaSOD and CaGPX, CaAPX and CaCAT), transcription factors (CaHSFB2, CaHSFB2A, CaHSFB2B, CaHSP17.5 and CaHSP22.7) and signalling genes (CaCAM, CaGAD, and CaMAPK) were upregulated in GPF2 as compared to PDG4 variety. Principal component anal. (PCA), partial least-square discriminant anal. (PLS-DA), and heat map anal. were applied to the metabolomics data to identify the differential response of metabolites in two chickpea varieties. GC-MS anal. identified 107 and 83 metabolites in PDG4 and GPF2 varieties resp. PDG4 variety accumulated more sugars, amino acids, sugar alcs., TCA cycle intermediates which provided heat resistance. Addnl., the differential metabolic pathways involved in heat tolerance were alanine, aspartate, and glutamate metabolism, pantothenate CoA biosynthesis, fructose and mannose metabolism and pentose phosphate pathway in PDG4 variety. There was less accumulation of metabolites in the primed plants of both varieties as compared to the non-primed plants indicating less damage due to heat stress. The present study gives an overview of the mol. changes occurring in response to heat stress in sensitive and tolerant chickpea. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Related Products of 473-81-4

The Article related to cicer drought leaf mannonic amino fatty acid, chickpea, gc-ms, gene expression, heat stress, metabolites, real time pcr, tolerance, Placeholder for records without volume info and other aspects.Related Products of 473-81-4

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