Tag: 100-200

Liu, Jiaming; Liu, Rongjuan; Yang, Zhijie; Wei, Jingjing published an article in 2022, the title of the article was Folding of two-dimensional nanoparticle superlattices enabled by emulsion-confined supramolecular co-assembly.Synthetic Route of 143-10-2 And the article contains the following content:

Folding of two-dimensional nanoparticle superlattices is achieved through templated assembly on as-formed supramol. nanosheets, which undergo a folding process within the emulsion droplets during the evaporation of the inner phase liquid Building the folded nanoparticle superlattices opens a new gateway to reshape the properties of inorganic solids. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Synthetic Route of 143-10-2

The Article related to two dimensional nanoparticle superlattice emulsion folding process, Placeholder for records without volume info and other aspects.Synthetic Route of 143-10-2

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On August 21, 2020, Forneris, Clarissa C.; Nguy, Andy K. L.; Seyedsayamdost, Mohammad R. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. And the article contained the following:

Vancomycin is one of the most important clin. antibiotics in the fight against infectious disease. Its biol. activity relies on three aromatic cross-links, which create a cup-shaped topol. and allow tight binding to nascent peptidoglycan chains. The cytochrome P 450 enzymes OxyB, OxyA, and OxyC have been shown to introduce these synthetically challenging aromatic linkages. The ability to utilize the P 450 enzymes in a chemo-enzymic scheme to generate vancomycin derivatives is appealing but requires a thorough understanding of their reactivities and mechanisms. Herein, we systematically explore the scope of OxyB biocatalysis and report installation of diverse diaryl ether and biaryl cross-links with varying macrocycle sizes and compositions, when the enzyme is presented with modified vancomycin precursor peptides. The structures of the resulting products were determined using one-dimensional/two-dimensional NMR spectroscopy, high-resolution mass spectrometry (HR-MS), tandem HR-MS, and isotopic labeling, as well as UV-visible light absorption and fluorescence emission spectroscopies. An exploration of the biol. activities of these alternative OxyB products surprisingly revealed antifungal properties. Taking advantage of the promiscuity of OxyB, we chemo-enzymically generated a vancomycin aglycon variant containing an expanded macrocycle. Mechanistic implications for OxyB and future directions for creating vancomycin analog libraries are discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to oxyb monooxygenase vancomycin aglycon variant, biosynthesis, chemo-enzymatic synthesis, macrocycles, vancomycin, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

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On May 20, 2021, Liu, Kun; Chen, Kennedy S.; Sen, Dipankar; Yu, Hua-Zhong published an article.Computed Properties of 143-10-2 The title of the article was Ultrasensitive detection of total copper with an electrochemical biosensor built on the in cis coupling of hexynyl CLICK-17 DNAzyme with azido self-assembled monolayers. And the article contained the following:

New methods to detect Cu sensitively and specifically are of practical importance because of its presence in both ecol. and biol. systems. Herein, the authors report a newly selected DNAzyme, CLICK-17, which catalyzes the azide-alkyne cycloaddition reaction strictly dependent on the presence of Cu, as a superior transducer for electrochem. Cu quantitation. CLICK-17 offers the following notable advantages: it does not require the presence of an unstable reducing agent (detects both Cu(II) and Cu(I) in samples); it offers rapid detection owing to the fast in cis coupling kinetics; and, it generates no background because its catalytic activity strictly relies on the presence of Cu (signal-on). For performing electrochem. sensing, the DNAzyme efficiently couples to a binary 11-azido-1-undecanethiolate/octanethiolate monolayer on Au (N3C11S-/C8S-Au), which is then accurately quantitated by the cyclic voltammetric response of electrostatically bound [Ru(NH3)6]3+. As the neg. charges on the phosphate backbone of surface-bound 79nt-DNA strands (CLICK-17) are inclusively compensated by the multiply charged redox cations (e.g., [Ru(NH3)6]3+) at low ionic strength, the electrochem. signal is naturally amplified (∼ 30 folds). Thus constructed biosensor detects Cu(II) with a LOD of 3.5 nM and Cu(I) with a LOD of 0.8 nM, which is also free of background signals and highly specific against other metal ions. More importantly, the authors showed the successful application of this DNAzyme-based electrochem. sensor to determine Cu concentrations in natural ores from the mining industry, with performance comparable to the Au standard flame at. absorption spectrophotometry. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Computed Properties of 143-10-2

The Article related to detection copper electrochem biosensor coupling hexynyl click17 dnazyme, azido self assembled monolayer sensor, Placeholder for records without volume info and other aspects.Computed Properties of 143-10-2

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Zhao, Shuang; Fu, Haoshuang; Zhou, Tianhui; Cai, Minghao; Huang, Yan; Gan, Qinyi; Zhang, Chenxi; Qian, Cong; Wang, Jiexiao; Zhang, Zhenglan; Wang, Xiaolin; Xiang, Xiaogang; Xie, Qing published an article in 2022, the title of the article was Alteration of bile acids and omega-6 PUFAs are correlated with the progression and prognosis of drug-induced liver injury.Electric Literature of 473-81-4 And the article contains the following content:

Drug-induced liver injury (DILI) is one of the leading causes of liver failure with some of the patients progressed to chronic DILI. The mechanisms underlying the severity and chronicity of DILI are poorly elucidated and the biomarkers are limited. Metabolites and gut microbiota played a crucial role in the development of various liver diseases. Herein, a systematic anal. of serum metabolites and gut microbiota was performed in DILI patients, aiming to identify metabolites correlated with the progression and clin. prognosis of DILI. Various serum metabolites were quantitated using a metabolite array technol. in this prospective study. Gut microbiome compositions and the expression profiles of liver genes were determined in patients with DILI and healthy controls. Metabolomic anal. revealed that bile acids (BAs) and polyunsaturated fatty acids (PUFAs) were closely related to DILI severity and chronicity resp. The ratios of serum primary/secondary BAs and omega-6/omega-3 PUFAs were elevated in DILI patients. A model established by adrenic acid (AdA) and aspartic acid (Asp) exerts good performance for predicting the chronicity of DLIL. Hepatic transcriptome revealed enhanced expression of PUFA peroxidation and suppressed expression of BA synthesis related genes in DILI patients. In addition, Lactic acid bacteria and BA converting bacteria were increased in gut of DILI patients. Besides, elevated serum malondialdehyde (MDA) and fibroblast growth factor 19 (FGF19) was observed in DILI patients. BAs and PUFAs could be potent markers for the severity and chronicity of DILI resp. The panel of AdA and Asp could be ideal predictive model for the risk of chronicity at the acute stage of DILI. Gut microbiota might act as a neg. feedback mechanism to maintain the homeostasis of BAs and PUFAs via FGF19 signalling and PUFA saturation, resp. Our study revealed novel biomarkers for severe and chronic DILI and provided new therapeutic targets for DILI. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Electric Literature of 473-81-4

The Article related to bile acid pufa drug induced liver injury progression prognosis, bas, dili, pufas, chronicity, gut microbiota, Placeholder for records without volume info and other aspects.Electric Literature of 473-81-4

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On July 31, 2022, de Falco, Bruna; Grauso, Laura; Fiore, Alberto; Bonanomi, Giuliano; Lanzotti, Virginia published an article.Reference of 2,3-Dihydroxypropanoic acid The title of the article was Metabolomics and chemometrics of seven aromatic plants: Carob, eucalyptus, laurel, mint, myrtle, rosemary and strawberry tree. And the article contained the following:

Arbutus unedo L. (strawberry tree), Ceratonia siliqua L. (carob), Eucalyptus camaldulensis Dehnh. (eucalyptus), Laurus nobilis L. (laurel), Mentha aquatica L. (water mint), Myrtus communis L. (common myrtle), and Rosmarinus officinalis L. (rosemary) are aromatic plants from the Mediterranean region whose parts and preparations are used for their nutritional properties and health benefits. To evaluate and compare the metabolites profile, total phenol content (TPC), and antioxidant activity of plant leaves for their future use. Gas chromatog.-mass spectrometry (GC-MS) was used for metabolomics. Data comparison was performed by chemometrics. Polar and apolar extracts were analyzed using untargeted GC-MS metabolomics followed by chemometrics (principal component anal., heatmap correlation and dendrogram) to identify, quantify and compare the major organic compounds in the plants. Addnl., NMR (NMR) spectroscopy was used for the laurel polar extract to identify D-gluco-L-glycero-3-octulose whose presence was unclear from the GC-MS data. TPC and antioxidant assays were performed using classical methods (Folin-Ciocalteu, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH)) and correlated to the phytochem. profiles. Forty-three metabolites were identified including amino acids, organic acids, carbohydrates, phenols, polyols, fatty acids, and alkanes. Eight metabolites (D-fructose, D-glucose, D-mannose, gallic acid, quinic acid, myo-inositol, palmitic and stearic acids) were in common between all species. D-Gluco-L-glycero-3-octulose (37.29 ± 1.19%), D-pinitol (31.33 ± 5.12%), and arbutin (1.30 ± 0.44%,) were characteristic compounds of laurel, carob, and strawberry tree, resp. Carob showed the highest values of TPC and antioxidant activity. GC-MS metabolomics and chemometrics analyses are fast and useful methods to determine and compare the metabolomics profiling of aromatic plants of food and industrial interest. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to arbutus ceratonia eucalyptus laurus mentha chemometrics metabolomics, gc-ms, nmr, pca, dendrogram, heatmap, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Bu, Ting; Zhang, Ming; Lee, Sun-Hee; Cheong, Yu Eun; Park, Yukyung; Kim, Kyoung Heon; Kim, Dongwon; Kim, Sooah published an article in 2022, the title of the article was GC-TOF/MS-Based Metabolomics for Comparison of Volar and Non-Volar Skin Types.Reference of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Skin has heterogenous identities on different body sites despite similar cellular compositions There are two types of skin, volar (palmoplantar) and non-volar (dorsal), which are characterized by epidermal thickness, pigmentation, and presence of hair follicles. However, the mechanisms underlying the development of these different skin types remain unclear. To investigate these, we profiled the cellular metabolites of volar and non-volar skin in mice using gas chromatog.-time-of-flight/mass spectrometry (GC-TOF/MS), and further assessed the metabolic differences between them. In total, 96 metabolites from both volar and non-volar skin of mice were identified using the BinBase database system. Metabolomics anal. revealed important differences associated with amino acid metabolism (phenylalanine, tyrosine, and tryptophan biosynthesis; aspartate and glutamate metabolism), sugar metabolism (pentose phosphate pathway), and nucleotide metabolism (pyrimidine metabolism) in volar skin. Fifty metabolites were identified as potential biomarkers differentiating the physiol. characteristics of these skin types. Of these, nine were highly increased whereas 41 were significantly decreased in volar skin compared with those in non-volar skin. Overall, these results provide valuable information for understanding the metabolic differences between volar and non-volar skin. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Reference of 2,3-Dihydroxypropanoic acid

The Article related to volar nonvolar skin metabolomics gctof ms, gc-tof/ms, metabolomic analysis, non-volar skin, volar skin, Placeholder for records without volume info and other aspects.Reference of 2,3-Dihydroxypropanoic acid

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Zhang, Zhanjiang; Shen, Guang; Yang, Yihua; Li, Cui; Chen, Xiaoying; Yang, Xiaonan; Guo, Xiaoyun; Miao, Jianhua; Li, Li; Lei, Ming published an article in 2022, the title of the article was Metabolic and Transcriptomic Analyses Reveal the Effects of Ethephon on Taraxacum kok-saghyz Rodin.Category: alcohols-buliding-blocks And the article contains the following content:

The roots of Taraxacum kok-saghyz Rodin (TKS) are well-known and valued for their rubber-producing ability. Therefore, research on the anal. and detection of metabolites from the roots of TKS have been reported in previous studies. However, all of these studies have the shortcoming of focusing on only the rubber of TKS, without profiling the other metabolites in a systematic and comprehensive way. Here, the primary and secondary metabolites from the leaves of TKS were investigated using UPLC-ESI-MS/MS, and a total of 229 metabolites were characterized. Carboxylic acid derivatives, fatty acyls, phenols, and organooxygen compounds were found to be the major metabolites of TKS. The transcriptome data indicated that ribosomal, glycolysis/gluconeogenesis, phenylpropanoid biosynthesis, and linoleic acid metabolism genes were significantly differentially expressed. This study is the first to report the differences in the metabolic and transcriptome profiles of TKS leaves under exogenous ethephon spray, which improves our understanding of the main metabolites and their mol. mechanisms in TKS leaves. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to taraxacum ethephon transcriptomic analyses, taraxacum kok-saghyz rodin, metabolomics, transcriptomics, Placeholder for records without volume info and other aspects.Category: alcohols-buliding-blocks

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Seguido, Miguel Angel; Tarradas, Rosa Maria; Gonzalez-Ramila, Susana; Garcia-Cordero, Joaquin; Sarria, Beatriz; Bravo-Clemente, Laura; Mateos, Raquel published an article in 2022, the title of the article was Influence of 8-week daily consumption of a new product combining green coffee hydroxycinnamates and beta-glucans on polyphenol bioavailability in subjects with overweight and obesity.Recommanded Product: 621-37-4 And the article contains the following content:

Nutraceuticals based on plant extracts rich in polyphenols, as well as dietary fibers, are new means to fight overweight/obesity and associated diseases. However, to understand the potential effects of polyphenols on health it is critical to study their bioavailability and metabolic fate. Consumption of a green coffee phenolic extract (GCPE) in combination with oat beta-glucan (BG) could affect the pharmacokinetic profile of the main polyphenols present in coffee (hydroxycinnamates). Moreover, the regular intake of the combination could also induce changes. Nine overweight men and women consumed a novel nutraceutical product containing 300 mg of green coffee hydroxycinnamic acids and 2.5 g of BG twice a day for 8 wk. A pharmacokinetic study was carried out in blood and urine samples taken before (baseline) and at week 8 after the nutraceutical intervention, collecting samples at different times in a 0-24 h interval. Faecal samples were also obtained at 0 and 24 h after the intake of the nutraceutical at baseline and week 8. Phenolic metabolites were analyzed by LC-MS-QToF. Results showed that polyphenols were differentially absorbed and extensively metabolized throughout the gastrointestinal tract. An apparent reduction in the excretion of small intestinal metabolites was accompanied by a tendency to increase colonic metabolites after sustained intake (p = 0.052). In conclusion, continued consumption of the GCPE/BG nutraceutical appears to enhance the absorption of hydroxycinnamates by increasing the colonic bioavailability of their derived metabolites compared to baseline, although the regular intake of the nutraceutical did not modify the metabolite profile in any of the biol. samples. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Recommanded Product: 621-37-4

The Article related to human green coffee hydroxycinnamate betaglucan polyphenol bioavailability overweight obesity, Placeholder for records without volume info and other aspects.Recommanded Product: 621-37-4

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On April 13, 2021, Pandey, Renu; Collins, Meghan; Lu, Xiyuan; Sweeney, Shannon R.; Chiou, Jennifer; Lodi, Alessia; Tiziani, Stefano published an article.Electric Literature of 32462-30-9 The title of the article was Novel Strategy for Untargeted Chiral Metabolomics using Liquid Chromatography-High Resolution Tandem Mass Spectrometry. And the article contained the following:

Stereospecific recognition of metabolites plays a significant role in the detection of potential disease biomarkers thereby providing new insights in diagnosis and prognosis. D-Hdroxy/amino acids are recognized as potential biomarkers in several metabolic disorders. Despite continuous advances in metabolomics technologies, the simultaneous measurement of different classes of enantiomeric metabolites in a single anal. run remains challenging. Here, we develop a novel strategy for untargeted chiral metabolomics of hydroxy/amine groups (-OH/-NH2) containing metabolites, including all hydroxy acids (HAs) and amino acids (AAs), by chiral derivatization coupled with liquid chromatog.-high resolution tandem mass spectrometry (LC-HR-MS/MS). Diacetyl-tartaric anhydride (DATAN) was used for the simultaneous derivatization of-OH/-NH2 containing metabolites as well as the resulting diastereomers, and all the derivatized metabolites were resolved in a single anal. run. Data independent MS/MS acquisition (DIA) was applied to pos. identify DATAN-labeled metabolites based on reagent specific diagnostic fragment ions. We discriminated chiral from achiral metabolites based on the reversal of elution order of D and L isomers derivatized with the enantiomeric pair (±) of DATAN in an untargeted manner. Using the developed strategy, a library of 301 standards that consisted of 214 chiral and 87 achiral metabolites were separated and detected in a single anal. run. This approach was then applied to investigate the enantioselective metabolic profile of the bone marrow (BM) and peripheral blood (PB) plasma samples from patients with acute myeloid leukemia (AML) at diagnosis and following completion of the induction phase of chemotherapeutic treatment. The sensitivity and selectivity of the developed method enabled the detection of trace levels of the D-enantiomer of HAs and AAs in primary plasma patient samples. Several of these metabolites were significantly altered in response to chemotherapy. The developed LC-HR-MS method entails a valuable step forward in chiral metabolomics. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to untargeted chiral metabolomics liquid chromatog high resolution mass spectrometry, tandem, Placeholder for records without volume info and other aspects.Electric Literature of 32462-30-9

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On December 24, 2020, Ang, Chee Wei; Tan, Lendl; Sykes, Melissa L.; AbuGharbiyeh, Neda; Debnath, Anjan; Reid, Janet C.; West, Nicholas P.; Avery, Vicky M.; Cooper, Matthew A.; Blaskovich, Mark A. T. published an article.Formula: C7H6F3NO The title of the article was Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility. And the article contained the following:

Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described a nitroimidazopyrazinone bicyclic subclass with promising antitubercular and antiparasitic activity, prompting addnl. efforts to generate analogs with improved solubility and enhanced potency. The key pendant aryl substituent was modified by (i) introducing polar functionality to the methylene linker, (ii) replacing the terminal Ph group with less lipophilic heterocycles, or (iii) generating extended biaryl side chains. Improved antitubercular and antitrypanosomal activity was observed with the biaryl side chains, with most analogs achieved 2- to 175-fold higher activity than the monoaryl parent compounds, with encouraging improvements in solubility when pyridyl groups were incorporated. This study has contributed to understanding the existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a panel of disease-causing organisms to support future lead optimization. The experimental process involved the reaction of (6-(Trifluoromethyl)pyridin-3-yl)methanol(cas: 386704-04-7).Formula: C7H6F3NO

The Article related to structure antitubercular antiparasitic nitroimidazo pyrazinone derivative preparation, Placeholder for records without volume info and other aspects.Formula: C7H6F3NO

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