Tag: 100-200

On December 31, 2021, Malheiros, Jessica Moraes; Correia, Banny Silva Barbosa; Ceribeli, Caroline; Cardoso, Daniel Rodrigues; Colnago, Luiz Alberto; Junior, Stanislau Bogusz; Reecy, James Mark; Mourao, Gerson Barreto; Coutinho, Luiz Lehmann; Palhares, Julio Cesar Pascale; Berndt, Alexandre; de Almeida Regitano, Luciana Correia published an article.Safety of 3-Hydroxyphenylacetic acid The title of the article was Comparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus). And the article contained the following:

We conducted a study to identify the fecal metabolite profile and its proximity to the ruminal metabolism of Nelore steers based on an untargeted metabolomic approach. Twenty-six Nelore were feedlot with same diet during 105 d. Feces and rumen fluid were collected before and at slaughter, resp. The metabolomics anal. indicated 49 common polar metabolites in the rumen and feces. Acetate, propionate, and butyrate were the most abundant polar metabolites in both bio-samples. The rumen presented significantly higher concentrations of the polar compounds when compared to feces (P < 0.05); even though, fecal metabolites presented an accentuated representability of the ruminal fluid metabolites. All fatty acids present in the ruminal fluid were also observed in the feces, except for C20:2n6 and C20:4n6. The identified metabolites offer information on the main metabolic pathways (higher impact factor and P < 0.05), as synthesis and degradation of ketone bodies; the alanine, aspartate and glutamate metabolisms, the glycine, serine; and threonine metabolism and the pyruvate metabolism The findings reported herein on the close relationship between the ruminal fluid and feces metabolic profiles may offer new metabolic information, in addition to facilitating the sampling for metabolism investigation in animal production and health routines. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Safety of 3-Hydroxyphenylacetic acid

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Fraga, Layanne Nascimento; Coutinho, Camille Perella; Rozenbaum, Adriana Campos; Tobaruela, Eric de Castro; Lajolo, Franco Maria; Hassimotto, Neuza Mariko Aymoto published an article in 2021, the title of the article was Blood pressure and body fat % reduction is mainly related to flavanone phase II conjugates and minor extension by phenolic acid after long-term intake of orange juice.HPLC of Formula: 621-37-4 And the article contains the following content:

Hesperidin and narirutin are the major flavanones present in orange juice, and they are associated with a reduction in risk of cardiometabolic disease. However, there is heterogeneity in their biol. responses, which is partly due to the large interindividual variation in these flavonoids bioavailability. We investigated the relation between interindividual variability in the excretion of phase II conjugates and gut-derived phenolic acids, and cardiometabolic biomarkers response. Seventy-four subjects, both men and women, were included in a single-arm study. Over the 60 days, volunteers consumed 500 mL of orange juice daily. All measurements and blood collections were performed before and after the intervention period. Moreover, 24 h urine collection was performed after first consumption. Individuals were stratified according to the excretion of phase II conjugates and, for the first time, according to phenolic acids in high, medium, and low excretors. Furthermore, for the first time, the ratio between phenolic acids and flavanones-phase II conjugates has shown groups with different metabolization patterns. Groups with a low or intermediate ratio, corresponding to a higher amount of phase II conjugates excreted, showed a significant reduction in body fat % and blood pressure. This finding suggests that these improvements could be associated in a major way to flavanones-phase II conjugates, as well as to phenolic acids and stratification of volunteers according to metabolite excretions could be a good strategy to better understand the effects of orange juice on metabolism and health. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).HPLC of Formula: 621-37-4

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On September 16, 2022, Moore, Keith P.; Schwaid, Adam G.; Tudor, Matthew; Park, Sangho; Beshore, Douglas C.; Converso, Antonella; Shipe, William D.; Anand, Rajan; Lan, Ping; Moningka, Remond; Rothman, Deborah M.; Sun, Wanying; Chi, An; Cornella-Taracido, Ivan; Adam, Gregory C.; Bahnck-Teets, Carolyn; Carroll, Steven S.; Fay, John F.; Goh, Shih Lin; Lusen, Jeffrey; Quan, Shuo; Rodriguez, Silveria; Xu, Min; Andrews, Christine L.; Song, Cheng; Filzen, Tracey; Li, Jing; Hollenstein, Kaspar; Klein, Daniel J.; Lammens, Alfred; Lim, U-Ming; Fang, Zhiyu; McHale, Carolyn; Li, Yuan; Lu, Meiqing; Diamond, Tracy L.; Howell, Bonnie J.; Zuck, Paul; Balibar, Carl J. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. And the article contained the following:

Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that can lead to eradication of persistent viral reservoirs in people living with HIV-1 (PLWH) remains an outstanding challenge to achieving cure. Utilizing a phenotypic screen, we identified a novel chem. class capable of killing HIV-1 infected peripheral blood mononuclear cells. Tool compounds ICeD-1 and ICeD-2 (“inducer of cell death-1 and 2”), optimized for potency and selectivity from screening hits, were used to deconvolute the mechanism of action using a combination of chemoproteomic, biochem., pharmacol., and genetic approaches. We determined that these compounds function by modulating dipeptidyl peptidase 9 (DPP9) and activating the caspase recruitment domain family member 8 (CARD8) inflammasome. Efficacy of ICeD-1 and ICeD-2 was dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells. This in vitro synergy lowers the efficacious cell kill concentration of efavirenz to a clin. relevant dose at concentrations of ICeD-1 or ICeD-2 that do not result in complete DPP9 inhibition. These results suggest engagement of the pyroptotic pathway as a potential approach to eliminate HIV-1 infected cells. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

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On December 8, 2020, Markovic, Aleksandra; Buschbeck, Leon; Brand, Izabella; Dosche, Carsten; Christoffers, Jens; Wittstock, Gunther published an article.Formula: C10H22S The title of the article was Electrochemical Activation of Self-Assembled Monolayers for the Binding of Effectors. And the article contained the following:

A self-assembled monolayer (SAM) on Au was prepared from a diaminoterephthalate (DAT) derivative as functional mol. and 1-decanthiol as a backfiller. The DAT derivative is N-protected by a tert-butyloxycarbonyl (Boc) group and is anchored to the Au surface via a liponic acid as a stable anchor group. The terminal DAT moiety exhibits interesting effector properties such as fluorescence and electrochem. activity. Irreversible oxidation of the monolayer at 0.4 V (Hg|Hg2SO4) in 0.1M HClO4 triggers deprotection of the DAT group and subsequent chem. reactions, during which 10% of the DAT groups of the original SAM are transformed to a new surface-bound, quasi-reversible redox couple with a formal potential of 0.0 V (Hg|Hg2SO4) and a standard rate constant of 8 s-1 in 0.1M HClO4. Immersion of the mixed SAM in 0.1M HClO4 at open circuit potential or oxidation in 0.1M H2SO4 did not produce this surface-bound redox couple. The monolayers were thoroughly characterized by XPS and polarization modulation IR reflection absorption spectroscopy (PM IRRAS) after the different preparation steps indicating only minor changes in the overall composition of the monolayer, in particular, the preservation of the heteroatoms. The new redox couple is likely a diimine, in agreement with its ability to bind nucleophiles such as anilines by conjugate addition that could be followed by multicycle voltammetry and XPS. The DAT effector group is especially interesting because it can also report the binding reaction by changed electrochem. and fluorescence signals. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Formula: C10H22S

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Perumal, GanesanMruga; Prabhu, K.; Rao, Mrk; Janaki, C. S.; Kalaivannan, J.; Kavimani, M. published an article in 2021, the title of the article was The GC MS analysis of ethyl acetate extract of one herbal plant, ′Canthiumparviflorum′.Safety of Pentane-1,5-diol And the article contains the following content:

The present study deals with the GC MS anal. of one medicinal plant, ′Canthiumparviflorum′. Ethno-pharmacol. this plant is used to treat diarrhea, fever, worm infestation, respiratory disorders, obesity and also as a diuretic. This plant was collected from nearby hills of Chengalpattu, Tamilnadu. The Et acetate extract of the aerial parts of the plant was subjected to GC MS study following standard protocols. It was observed that some very important mols. such as Butanedioic acid, di-Me ester, Butanedioic acid, hydroxy-, di-Me ester, Benzoic acid, 1-Methyl-1-ethoxycyclobutane, Cyclopentanecarboxylic acid, 4-nitrophenyl ester, 1, 5-Pentanediol, O, O′-divaleryl-, 3-Pyridinecarboxylic acid, 6-amino-, .beta.-D-Glucopyranose, 1, 6-anhydro-, Me .beta.-d-galactopyranoside, Hexadecanoic acid, Me ester, n-Hexadecanoic acid etc. were found in the GC MS profile of this plant which have far reaching medicinal roles, thereby supporting the medicinal value of this plant. The experimental process involved the reaction of Pentane-1,5-diol(cas: 111-29-5).Safety of Pentane-1,5-diol

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Pereira-Caro, Gema; Gaillet, Sylvie; Ordonez, Jose Luis; Mena, Pedro; Bresciani, Letizia; Bindon, Keren A.; Del Rio, Daniele; Rouanet, Jean-Max; Moreno-Rojas, Jose Manuel; Crozier, Alan published an article in 2020, the title of the article was Bioavailability of red wine and grape seed proanthocyanidins in rats.Application of 621-37-4 And the article contains the following content:

This study explored plasma levels and urinary and fecal excretion of metabolites and microbial-derived catabolites over a 24 h period following the ingestion of red wine (RWP) or grape seed (GSP) proanthocyanidin-rich extracts by rats. In total, 35 structurally-related (epi)catechin metabolites (SREMs) and 5-carbon side chain ring fission metabolites (5C-RFMs) (phenyl-γ-valerolactones and phenylvaleric acids), and 50 phenolic acid and aromatic catabolites were detected after intakes of both extracts The consumption of the RWP extract, but not the GSP extract, led to the appearance of a ∼200 nmol L-1 peak plasma concentration of SREMs formed from flavan-3-ol monomers. In contrast, ingestion of the GSPs, but not the RWPs, resulted in a substantial increase in microbiota-derived 5-carbon side chain ring fission metabolites (5C-RFMs) in plasma. 5C-RFMs, along with low mol. weight phenolic catabolites were detected in urine after ingestion of both extracts The GSP and RWP extracts had resp. mean degrees of polymerization 5.9 and 6.5 subunits, and the RWP extract had an upper polymer size of 21 subunits compared to 44 subunits for the GSP extract The differences in plasma metabolite profiles might, therefore, be a consequence of this polydispersity impacting on the microbiota-mediated rates of cleavage of the proanthocyanidin subunits and their subsequent metabolism and absorption. Urinary excretion of phenolic catabolites indicated that 11% of RWPs and 7% for GSPs were subjected to microbial degradation In all probability these figures, rather than representing the percentage of proanthocyanidins that are completely degraded, indicate partial cleavage of monomer subunits producing a much higher percentage of shortened proanthocyanidin chains. Obtaining more detailed information on the in vivo fate of proanthocyanidins is challenging because of the difficulties in analyzing unabsorbed parent proanthocyanidins and their partially degraded flavan-3-ol subunit chains in feces. Further progress awaits the development of improved purification and anal. techniques for proanthocyanidins and their use in feeding studies, and in vitro fecal and bacterial incubations, with radio and/or stable isotope-labeled substrates. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application of 621-37-4

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On June 15, 2022, Armbruster, Michael R.; Grady, Scott F.; Arnatt, Christopher K.; Edwards, James L. published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Isobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS. And the article contained the following:

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

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On June 15, 2022, Armbruster, Michael R.; Grady, Scott F.; Arnatt, Christopher K.; Edwards, James L. published an article.Product Details of 473-81-4 The title of the article was Isobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS. And the article contained the following:

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Product Details of 473-81-4

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da Camara, Bryce; Dietz, Philip C.; Chalek, Kevin R.; Mueller, Leonard J.; Hooley, Richard J. published an article in 2020, the title of the article was Selective, cofactor-mediated catalytic oxidation of alkanethiols in a self-assembled cage host.Electric Literature of 143-10-2 And the article contains the following content:

A spacious Fe(II)-iminopyridine self-assembled cage complex can catalyze the oxidative dimerization of alkanethiols, with air as stoichiometric oxidant. The reaction is aided by selective mol. recognition of the reactants, and the active catalyst is derived from the Fe(II) centers that provide the structural vertices of the host. The host is even capable of size-selective oxidation and can discriminate between alkanethiols of identical reactivity, based solely on size. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Electric Literature of 143-10-2

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On July 31, 2020, Bonegardt, Dmitry; Klyamer, Darya; Koksoy, Baybars; Durmus, Mahmut; Basova, Tamara published an article.Application In Synthesis of 1-Decanethiol The title of the article was Hybrid materials of carbon nanotubes with fluoroalkyl- and alkyl-substituted zinc phthalocyanines. And the article contained the following:

In this work, hybrid materials of single-walled carbon nanotubes (SWCNT) noncovalently functionalized with fluoroalkyl- (SWCNT/ZnPc-CF) and alkyl- (SWCNT/ZnPc-CH) substituted zinc(II) phthalocyanines were prepared The effect of fluorination of the substituents in phthalocyanine macrocycle on the functionalization degree of carbon nanotubes and sensor response to ammonia was investigated. It was shown that the type of substituents in the phthalocyanine macrocycle showed noticeable effect both on the degree of functionalization of carbon nanotubes and on the sensing performance of the investigated hybrids. The amount of phthalocyanine mols. adsorbed on SWCNT walls was shown to be 1.5 times higher in the SWCNT/ZnPc-CH hybrid. The SWCNT/ZnPc-CF layer exhibited 2 times less chemiresistive sensor response to ammonia than SWCNT/ZnPc-CH, while its sensor response was more stable at 70% relative humidity. The experimental process involved the reaction of 1-Decanethiol(cas: 143-10-2).Application In Synthesis of 1-Decanethiol

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