Tag: 100-200

In 2021,IOSR Journal of Pharmacy included an article by Yadav, B. P.; Joshi, Ajit; Thakur, Meenakshi. Name: 3,3,3-Trifluoropropan-1-ol. The article was titled 《Synthesis of some novel pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs》. The information in the text is summarized as follows:

A new series of pyrimidine derivatives I (R1 = trifluoromethyl, Cl; R2 = Me, Et, i-Pr) have been synthesized by reacting substituted pyrimidine carboxylic acids II with 3-methoxyaniline, de-methylation using BBr3 to form hydroxy derivatives, which were then alkylated with resp. alkyl halides R2I to synthesize substituted pyrimidine derivatives I. The synthesized compounds I were screened for their in vitro growth inhibiting activity against different strains. After reading the article, we found that the author used 3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2Name: 3,3,3-Trifluoropropan-1-ol)

3,3,3-Trifluoropropan-1-ol(cas: 2240-88-2) is a important organic intermediate. It can be used in agrochemical, pharmaceutical and dyestuff field.Name: 3,3,3-Trifluoropropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Natural Product Research included an article by Zhu, Zhen-Yuan; Chen, Chun-Juan; Sun, Hui-Qing; Chen, Li-Jing. COA of Formula: C6H12O6. The article was titled 《Structural characterisation and ACE-inhibitory activities of polysaccharide from Gastrodia elata Blume》. The information in the text is summarized as follows:

The structural properties and Angiotensin-I converting enzyme (ACE) inhibition activities of a polysaccharide (PGE) extracted from Gastrodia elata Blume were investigated. PGE was extracted using hot water and purified by Sephadex G-200 followed by ultra-filtration. The structural characterization of PGE was analyzed by FT-IR, NMR spectroscopy, sp. rotation determination, periodate oxidation-smith degradation, methylation anal., GC-MS and Congo red test. The results revealed that PGE was composed by glucose, with an average mol. weight of 1.54 × 103 kDa. The structure of PGE was 1→3 and 1→4,6-branched-glucopyranose that had a linear backbone of (1 → 4)-linked-D-glucopyranose (Glcp). ACE-inhibitory activity results showed that PGE was efficient to inhibit ACE and the IC50 value was 0.66 mg/mL. In the experiment, the researchers used many compounds, for example, rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1COA of Formula: C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.COA of Formula: C6H12O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Unusual Reactivity and Metal Affinity of Water-Soluble Dipyrrins》 was written by El Khatib, Mirna; Cheprakov, Andrei V.; Vinogradov, Sergei A.. Recommanded Product: 26153-38-8This research focused onwater soluble dipyrrin preparation metal affinity. The article conveys some information:

The primary goal of the study was to evaluate dipyrrins functionalized with ester and amide groups in 2,2′-positions in sensing applications. While developing the synthesis, it was found that 3,3′,4,4′-tetraalkyldipyrrins 2,2′-diesters as well as 2,2′-diamides can undergo facile addition of water at the meso-bridge, transforming into colorless meso-hydroxydipyrromethanes. Spectroscopic and computational investigation revealed that this transformation proceeds via dipyrrin cations, which exist in equilibrium with the hydroxydipyrromethanes. While trace amounts of acid favor conversion of dipyrrins to hydroxydipyrromethanes, excess acid shifts the equilibrium toward the cations. Similarly, the presence of Zn2+ facilitates elimination of water from hydroxydipyrromethanes with chromogenic regeneration of the dipyrrin system. In organic solutions in the presence of Zn2+, dipyrrin-2,2′-diesters exist as mixtures of mono-(LZnX) and bis-(L2Zn) complexes. In L2Zn, the dipyrrin ligands are oriented in a nonorthogonal fashion, causing strong exciton coupling. In aqueous solutions, dipyrrins bind Zn2+ in a 1:1 stoichiometry, forming mono-dipyrrinates (LZnX). Unexpectedly, dipyrrins with more electron-rich 2,2′-carboxamide groups revealed ~20-fold lower affinity for Zn2+ than the corresponding 2,2′-diesters. D. Functional Theory (DFT) calculations with explicit inclusion of water reproduced the observed trends and allowed to trace the low affinity of the dipyrrin-diamides to the stabilization of the corresponding free bases via hydrogen bonding with water mols. Overall, the results reveal unusual trends in the reactivity of dipyrrins and provide clues for the design of dipyrrin-based sensors for biol. applications.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Structure-function studies of the aminothiol radioprotectants. Effect of carbon chain length in mercaptoethylamine homologs》 was published in Radiation Research in 1971. These research results belong to Swartz, Harold M.; Copeland, Edmund S.; Richardson, Earl C.. COA of Formula: C5H14ClNS The article mentions the following:

A study of the relation between chemical structure of aminothiols such as β-mercaptoethylamine-HCl (I) and its propyl, butyl, pentyl, and hexyl homologs, and the phys. chem. radiation protection in Escherichia coli which were irradiated in the presence of 0.1M protectant at either 1°C or 77°K and equilibrated with 100% O2 or N2 prior to irradiation showed that in contrast to mammalian systems no abrupt reduction in radioprotection occurred when the carbon chain separating amino acids and thiol groups was lengthened from 3 to 4 or more units. Free radical studies which were observed by ESR spectroscopy of treated bacteria preparations irradiated at 77°K and bacteriolog. studies indicated a gradual decrease in efficiency with no change in the mechanism of action either in O2 or N2. These results suggest a protective effect of aminothiols by specific interactions with cell components in addition to acting via a more general, non-specific radical scavenging and (or) repair mechanism. The experimental process involved the reaction of 5-Aminopentane-1-thiol hydrochloride(cas: 31110-78-8COA of Formula: C5H14ClNS)

5-Aminopentane-1-thiol hydrochloride(cas: 31110-78-8) belongs to thiols. Thiols show many reactions like those of the hydroxyl compounds, such as formation of thioesters and thioethers (sulfides).COA of Formula: C5H14ClNS Toward oxidation, however, they differ profoundly from alcohols: whereas oxidation of an alcohol usually leads to a product in which the oxidation state of a carbon atom has been changed, oxidation of a thiol affects the sulfur atom.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

New method for preparation of aluminum hydride solutions was written by Zakharov, V. V.; Bugaeva, G. P.; Naumenko, I. G.; Nechiporenko, G. N.; Petinov, V. I.. And the article was included in Zhurnal Prikladnoi Khimii (Sankt-Peterburg) on June 30,1999.SDS of cas: 60462-27-3 The following contents are mentioned in the article:

Stable solutions of AlH3 were obtained by precipitation of AlH3 (synthesized from Al and H2) from an ether or amine solvent onto a surface cooled by liquid N2, thawing, and separating the AlH3 solution from Al and other solid products. The AlH3 prepared in this way reduced 1,4-cubanedicarboxylic acid to 1,4-cubanedimethanol in 85% yield. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3SDS of cas: 60462-27-3).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60462-27-3

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Cubane Arrives on the Cucurbituril Scene was written by Jelinkova, Kristyna; Surmova, Heda; Matelova, Alena; Rouchal, Michal; Pruckova, Zdenka; Dastychova, Lenka; Necas, Marek; Vicha, Robert. And the article was included in Organic Letters on May 19,2017.Quality Control of Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

Cubane, an intriguing chem. curiosity first studied in the early 1960s, has become a valuable structural motif and has recently been involved in the structures of a great number of prospective compounds The first dicationic supramol. guest 5 is prepared and derived from a 1,4-disubstituted cubane moiety, and its binding behavior toward cucurbit[n]urils (CBn) and cyclodextrins (CD) is studied. The bisimidazolium salt 5 forms 1:1 inclusion complexes with CB7, CB8, and β-CD with the resp. association constants (6.7 ± 0.5) × 1011 M-1, (1.5 ± 0.2) × 109 M-1, and <102 M-1 in water. The solid-state structures of the 5@CB7 and 5@CB8 complexes are also reported. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Quality Control of Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Cubane derivatives 10. Synthesis and molecular structures of nitroxymethylcubanes was written by Romanova, L. B.; Barinova, L. S.; Zakharov, V. V.; Eremenko, L. T.; Aleksandrov, G. G.; Eremenko, I. L.. And the article was included in Russian Chemical Bulletin on May 31,2010.Recommanded Product: Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

The reactions of hydroxymethylcubanes with nitric acid result in the resp. nitroxymethylcubanes. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Recommanded Product: Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Polynorbornene-Based Double-Stranded Ladderphanes with Cubane, Cuneane, Tricyclooctadiene, and Cyclooctatetraene Linkers was written by Yeh, Nai-Hua; Chen, Chih-Wei; Lee, Shern-Long; Wu, Hung-Jen; Chen, Chun-hsien; Luh, Tien-Yau. And the article was included in Macromolecules (Washington, DC, United States) on March 27,2012.Recommanded Product: Cubane-1,4-diyldimethanol The following contents are mentioned in the article:

Double-stranded ladderphanes 2, 3, and 5 having cubane, cuneane, and cyclooctatetraene linkers are synthesized by ring-opening metathesis polymerization (ROMP) of the corresponding bisnorbornene monomers 10, 11, and 13, resp. Attempts to polymerize the corresponding tricyclooctadiene-linked bisnorbornene 12 are not successful, starting monomer being recovered. Polymer with this tricyclic diene linker 4 is obtained from the rhodium-catalyzed isomerization of 2. The scanning tunneling microscopic (STM) image of 2 shows an ordered pattern on the graphite surface by self-assembly. This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Recommanded Product: Cubane-1,4-diyldimethanol).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: Cubane-1,4-diyldimethanol

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Efficient preparation of apically substituted diamondoid derivatives was written by Kahl, Paul; Tkachenko, Boryslav A.; Novikovsky, Anatoliy A.; Becker, Jonathan; Dahl, Jeremy E. P.; Carlson, Robert M. K.; Fokin, Andrey A.; Schreiner, Peter R.. And the article was included in Synthesis in 2014.HPLC of Formula: 60462-27-3 The following contents are mentioned in the article:

The authors present an effective three-step chromatog.-free sequence for the preparation of apical monohydroxy derivatives of diamantane, triamantane and [121]tetramantane from the corresponding bis-apical diols utilizing tert-butyldimethylsilyl chloride as the silylation agent. The procedure was successfully applied to the protection of several other aliphatic and aromatic diols. Addnl., 9-amino-4-diamantanecarboxylic acid, which has significant potential in medicinal and material sciences, was prepared by a Ritter reaction of 4,9-dihydroxydiamantane in trifluoroacetic acid. The synthesis of the target compounds was achieved using octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3,7-diol (4,9-diamantanediol), decahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracene-2,7(1H,3H)-diol (9,15-triamantanediol) and tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysene-3,9-diol (6,13-tetramantanediol) as starting materials. The tilte compounds thus formed included octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalen-3(2H)-ol, dodecahydro-4,5,12-metheno-2,9,7-[1,2,3]propanetriylanthracen-2(1H)-ol, tetradecahydro-1,5,7,11-ethanediylidene-3,5:9,11-dimethanochrysen-3(4H)-ol. Other diols included bicyclo[2.2.2]octane-1,4-diol, Pentacyclo[4.2.0.02,5.03,8.04,7]octane-1,4-dimethanol (cubane derivative), 1,10-decanediol, 1,8-octanediol, 1,4-benzenediol, 2,6-naphthalenediol, [1,1′-binaphthalene]-2,2′-diol. 7-(Amino)octahydro-3,5,1,7-[1,2,3,4]butanetetraylnaphthalene-3(2H)-carboxylic acid [i.e., (amino)diamantanecarboxylic acid] was prepared This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3HPLC of Formula: 60462-27-3).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 60462-27-3

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3

Ring enlargement reactions of homocubyl-4- and cubyl-1,4-dicarbinols was written by Higuchi, Hiroyuki. And the article was included in Advances in Strained and Interesting Organic Molecules in 1999.Computed Properties of C10H12O2 The following contents are mentioned in the article:

A review. Carbinols of cubane and homocubane derivatives were prepared by Grignard reactions in good yields. These carbinols underwent smooth C-C bond cleavage under Wagner-Meerwein conditions to give mixtures of ring enlargement products along with unexpected products, in various ratios depending on the reaction conditions. 1,4-Bishomocubane, previously believed to be much less stable than 1,3-bishomocubane both exptl. and theor., was obtained as one of major products from the electronically modified homocubyl-and cubyldicarbinols. It is indicated that the ring enlargement reactions of the present carbinols proceeds along the reaction paths in a borderline area between kinetically and thermodynamically controlled pathways. A review with 34 references This study involved multiple reactions and reactants, such as Cubane-1,4-diyldimethanol (cas: 60462-27-3Computed Properties of C10H12O2).

Cubane-1,4-diyldimethanol (cas: 60462-27-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H12O2

60462-27-3;Cubane-1,4-diyldimethanol;The future of 60462-27-3;New trend of C10H12O2;function of 60462-27-3