Tag: 100-200

《Thermogravimetric analysis of aromatic boronic acids for potential flame retardant applications》 was published in Thermochimica Acta in 2020. These research results belong to Cromwell, Benjamin; Levenson, Adelaide; Levine, Mindy. HPLC of Formula: 89466-08-0 The article mentions the following:

The need for non-halogenated flame retardants continues to increase as more information about the toxicity of halogenated flame retardants and their pyrolytic byproducts becomes available. One class of non-halogenated flame retardants, organic boronic acids, has been reported in a number of papers as having flame retardant effects for cellulosic fibers as well as synthetic polymers. To improve this performance, an understanding of how the structure of the boronic acid affects its flame-retardant properties as well as its thermal stability is necessary. Reported herein are experiments aimed at achieving precisely this understanding, by investigating the thermal stability and degradation pathways of a broad variety of boronic acids, and using the resulting data to develop rules about the relationship between boronic acid structure (number of boronic acid moieties; presence/absence of functional groups, etc.) and the compound’s thermal stability. These experiments highlight a number of boronic acids with exceptional thermal stability, with pyrene-1-boronic acid (compound 18) in particular showing stability up to 600°C. In the experiment, the researchers used many compounds, for example, 2-Hydroxyphenylboronic acid(cas: 89466-08-0HPLC of Formula: 89466-08-0)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. HPLC of Formula: 89466-08-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Dehydroxylative Trifluoromethylthiolation, Trifluoromethylation, and Difluoromethylation of Alcohols》 was published in Chinese Journal of Chemistry in 2020. These research results belong to Zhang, Wei; Lin, Jin-Hong; Wu, Wenfeng; Cao, Yu-Cai; Xiao, Ji-Chang. Application In Synthesis of 3-Pyridinemethanol The article mentions the following:

Described here is the dehydroxylative trifluoromethylthiolation, trifluoromethylation and difluoromethylation of alcs. promoted by a R3P/ICH2CH2I (R3P = Ph3P or Ph2PCH=CH2) system. All of these dehydroxylative reactions were achieved under mild conditions via the activation of the hydroxyl group by the R3P/ICH2CH2I system. A wide substrate scope and good functional group tolerance were observed After reading the article, we found that the author used 3-Pyridinemethanol(cas: 100-55-0Application In Synthesis of 3-Pyridinemethanol)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Application In Synthesis of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cobalt-Catalyzed Acceptorless Dehydrogenation of Alcohols to Carboxylate Salts and Hydrogen》 was published in Organic Letters in 2020. These research results belong to Pradhan, Deepak Ranjan; Pattanaik, Sandip; Kishore, Jugal; Gunanathan, Chidambaram. Recommanded Product: 2,6-Pyridinedimethanol The article mentions the following:

The facile oxidation of alcs. to carboxylate salts and H2 is achieved using a simple and readily accessible cobalt pincer catalyst (NNNHtBuCoBr2). The reaction follows an acceptorless dehydrogenation pathway and displays good functional group tolerance. The amine-amide metal-ligand cooperation in cobalt catalyst is suggested to facilitate this transformation. The mechanistic studies indicate that in-situ-formed aldehydes react with a base through a Cannizzaro-type pathway, resulting in potassium hemiacetolate, which further underwent catalytic dehydrogenation to provide the carboxylate salts and H2. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Recommanded Product: 2,6-Pyridinedimethanol)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Recommanded Product: 2,6-Pyridinedimethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Aerobic Oxidation of Alcohols Catalyzed by in Situ Generated Gold Nanoparticles inside the Channels of Periodic Mesoporous Organosilica with Ionic Liquid Framework》 was published in ACS Combinatorial Science in 2020. These research results belong to Karimi, Babak; Bigdeli, Akram; Safari, Ali Asghar; Khorasani, Mojtaba; Vali, Hojatollah; Khodadadi Karimvand, Somaiyeh. Safety of 3-Pyridinemethanol The article mentions the following:

In situ generated gold nanoparticles inside the nanospaces of periodic mesoporous organosilica with an imidazolium framework (Au@PMO-IL) were found to be highly active, selective, and reusable catalysts for the aerobic oxidation of activated and nonactivated alcs. under mild reaction conditions. The catalyst was characterized by nitrogen adsorption-desorption measurement, thermogravimetric anal. (TGA), transmission electron microscopy (TEM), elemental anal. (EA), diffuse reflectance IR Fourier transform spectroscopy (DRIFT), XPS, and inductively coupled plasma at. emission spectroscopy (ICP-AES). The catalyst exhibited excellent catalytic activity in the presence of either Cs2CO3 (35°) or K2CO3 (60°) as reaction bases in toluene as a reaction solvent. Under both reaction conditions, various types of alcs. (up to 35 examples) including activated benzylic, primary and secondary aliphatic, heterocyclic, and challenging cyclic aliphatic alcs. converted to the expected carbonyl compounds in good to excellent yields and selectivity. The catalyst was also recovered and reused for at least seven reaction cycles. Data from three independent leaching tests indicated that amounts of leached gold particles were negligible (<0.2 ppm). It is believed that the combination of bridged imidazolium groups and confined nanospaces of PMO-IL might be a major reason explaining the remarkable stabilization and homogeneous distribution of in situ generated gold nanoparticles, thus resulting in the highly active and recyclable catalyst system.3-Pyridinemethanol(cas: 100-55-0Safety of 3-Pyridinemethanol) was used in this study.

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Safety of 3-Pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《A smart pH-sensitive delivery system for enhanced anticancer efficacy via paclitaxel endosomal escape》 were Yang, Yihua; Wang, Zhe; Peng, Ying; Ding, Jinsong; Zhou, Wenhu. And the article was published in Frontiers in Pharmacology in 2019. Quality Control of 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

Micelles are highly attractive nano-drug delivery systems for targeted cancer therapy. While they have been demonstrated to significantly alleviate the side-effects of their cargo drugs, the therapy outcomes are usually suboptimal partially due to ineffective drug release and endosome entrapment. Stimulus-responsive nanoparticles have allowed controlled drug release in a smart fashion, and we want to use this concept to design novel micelles. Herein, we reported pH-sensitive paclitaxel (PTX)-loaded poly (ethylene glycol)-phenylhydrazone-dilaurate (PEG-BHyd-dC12) micelles (PEG-BHyddC12/ PTX). The micelles were spherical, with an average particle size of ∼135 nm and a uniform size distribution. The pH-responsive properties of the micelles were certified by both colloidal stability and drug release profile, where the particle size was strikingly increased accompanied by faster drug release as pH decreased from 7.4 to 5.5. As a result, the micelles exhibited much stronger cytotoxicity than the pH-insensitive counterpart micelles against various types of cancer cells due to the hydrolysis of the building block polymers and subsequent rapid PTX release. Overall, these results demonstrate that the PEG-BHyd-dC12 micelle is a promising drug delivery system for cancer therapy. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT)》 were Bang, EunJin; Lee, Eun Kyeong; Noh, Sang-Gyun; Jung, Hee Jin; Moon, Kyoung Mi; Park, Mi Hwa; Park, Yeo Jin; Hyun, Min Kyung; Lee, A. Kyoung; Kim, Su Jeong; Yang, Jungho; Park, Yujin; Chun, Pusoon; Moon, Hyung Ryong; Chung, Hae Young. And the article was published in Experimental Dermatology in 2019. Related Products of 26153-38-8 The author mentioned the following in the article:

Tyrosinase is a key enzyme that catalyzes the initial rate-limiting steps of melanin synthesis. Due to its critical role in melanogenesis, various attempts were made to find potent tyrosinase inhibitors although many were not safe and effective in vivo. We evaluated tyrosinase inhibitory activity of six compounds Among them, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT) had the greatest inhibitory effect and potency as the IC50 value of 5-HMT was lower than that of kojic acid, widely-known tyrosinase inhibitor. Based on in silico docking simulation, 5-HMT had a greater binding affinity than kojic acid with a different binding conformation in the tyrosinase catalytic site. Furthermore, its skin depigmentation effect was confirmed in vivo as 5-HMT topical treatment significantly reduced UVB-induced melanogenesis in HRM2 hairless mice. In conclusion, our study demonstrated that 5-HMT has a greater binding affinity and inhibitory effect on tyrosinase and may be a potential candidate for a therapeutic agent for preventing melanogenesis. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Electrocatalytic water oxidation studies of a tetranuclear Cu(II) complex with cubane-like core Cu4(μ3-O)4》 were Gao, Wei-Song; Wang, Jin-Miao; Shi, Ning-Ning; Chen, Chang-Neng; Fan, Yu-Hua; Wang, Mei. And the article was published in New Journal of Chemistry in 2019. Related Products of 1195-59-1 The author mentioned the following in the article:

To mimic the strategy used by natural photosynthesis in Photosystem II, which adopts the cubic Mn4CaO5 cluster as a natural O-evolving complex, a bio-inspired cubane-like tetranuclear cluster [Cu4(pdmH)4(OAc)2](NO3)2·3H2O (1) was synthesized successfully with pyridine-2, 6-dimethanol as the ideal ligand, and studied by x-ray crystallog., PXRD, in situ UV-visible-NIR spectroelectrochem. anal., and magneto- and electrochem. By x-ray anal., the distorted cubane-like core Cu4(μ3-O)4 is composed of 4 CuII and 4 μ3-O which arrange at the vertexes of a slightly distorted cube. Electrochem. studies indicate that complex 1 presents potential properties as an effective mol. catalyst for electrocatalytic H2O oxidation under aqueous alk. conditions at a potential of ∼1.20 V vs. Normal H electrode with a relatively low overpotential of ∼400-665 mV vs. Normal H electrode, which may result from the unique covalent metal-oxo bonding. Magnetic susceptibility measurements reveal that complex 1 displays overall antiferromagnetic exchanges between the Cu(II) ions within the clusters. Temperature dependence of in-phase (χM′) a.c. susceptibility signals display frequency-dependence, whereas the out-of-phase (χM′′) signals show no significant frequency-dependence for complex 1, which indicates that the complex may not be a SMM. The experimental part of the paper was very detailed, including the reaction process of 2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1)

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Related Products of 1195-59-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2006,Isoda, Takeshi; Ushirogochi, Hideki; Satoh, Koichi; Takasaki, Tsuyoshi; Yamamura, Itsuki; Sato, Chisato; Mihira, Ado; Abe, Takao; Tamai, Satoshi; Yamamoto, Shigeki; Kumagai, Toshio; Nagao, Yoshimitsu published 《Syntheses and pharmacokinetic studies of prodrug esters for the development of oral carbapenem, L-084》.Journal of Antibiotics published the findings.Application of 18621-18-6 The information in the text is summarized as follows:

We discovered an orally active carbapenem, L-084, through pharmacokinetic studies on various prodrug esters of (1R,5S,6S)-6-[(R)-1-hydroxyethyl]-1-methyl-2-[1-(1,3-thiazolin-2-yl)azetidin-3-yl]thio-1-carbapen-2-em-3-carboxylic acid (LJC11,036). L-084 showed a strong antimicrobial activity against Gram-pos. and Gram-neg. bacteria and exhibited the highest intestinal absorption among synthesized prodrugs of LJC11,036. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6Application of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Application of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 1999,Hayashi, Kazuhiko; Sato, Chisato; Hiki, Shinsuke; Kumagai, Toshio; Tamai, Satoshi; Abe, Takao; Nagao, Yoshimitsu published 《Novel efficient synthesis of 1-azabicyclo[1.1.0]butane and its application to the synthesis of 1-(1,3-thiazolin-2-yl)azetidine-3-thiol useful for the pendant moiety of an oral 1β-methylcarbapenem antibiotic L-084》.Tetrahedron Letters published the findings.Product Details of 18621-18-6 The information in the text is summarized as follows:

1-Azabicyclo[1.1.0]butane was successfully synthesized by treatment of 2,3-dibromopropylamine hydrobromide with organolithium compounds and was readily converted to 1-(1,3-thiazolin-2-yl)azetidine-3-thiol hydrochloride and versatile 3-hydroxyazetidine hydrochloride and 3-bromoazetidine hydrobromide. In the part of experimental materials, we found many familiar compounds, such as Azetidin-3-ol hydrochloride(cas: 18621-18-6Product Details of 18621-18-6)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Product Details of 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wan, Ruiying; Xu, Shicheng; Wang, Jin; Yang, Yunfei; Zhang, Dengji; He, Ronghuan published an article on January 5 ,2021. The article was titled 《Construction of ion conducting channels by embedding hydrophilic oligomers in piperidine functionalized poly(2,6-dimethyl-1,4-phenylene oxide) membranes》, and you may find the article in European Polymer Journal.COA of Formula: C8H19NO2 The information in the text is summarized as follows:

A suitable microphase separation morphol. has been demonstrated to be an efficient strategy to achieve high ionic conductivity with reasonable durability to anion exchange membranes (AEMs). Herein, hydrophilic oligomers of polyethylene glycols (PEGs) with different mol. weights were blended, sep., with poly(2,6-dimethyl-1,4-phenylene oxide) modified by 4,4-diethoxybutan-1-amine and 1-methylpiperidine (20PDM). The presence of hydrophilic PEGs facilitates the formation of the interconnected nano-channels in the AEMs for ion conduction according to the anal. results by both transmission electron microscopy (TEM) and small angle X-ray scattering (SAXS). The membrane containing 2 wt% PEGs with a mol. weight of 2 kDa reaches a hydroxide conductivity of 97.2 mS cm-1 at 80°C, which is 25 mS cm-1 higher than that the pristine 20PDM membrane possessing the same ion exchange capacity. A peak power d. of 328 mW cm-2 is attained at 60°C by the proposed membrane based single fuel cell fueling with humidified H2 and O2 with 0.1 MPa of back pressure. The chem. structure, water uptake and swelling as well as resistance to hot alkali solutions of the prepared membranes were investigated. In the experiment, the researchers used many compounds, for example, 4,4-Diethoxybutan-1-amine(cas: 6346-09-4COA of Formula: C8H19NO2)

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.COA of Formula: C8H19NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts