Tag: 100-200

The author of 《A Gas Phase Route to [18F]fluoroform with Limited Molar Activity Dilution》 were Yang, Bo Yeun; Telu, Sanjay; Haskali, Mohammad B.; Morse, Cheryl L.; Pike, Victor W.. And the article was published in Scientific Reports in 2019. Recommanded Product: 2-Hydroxyphenylboronic acid The author mentioned the following in the article:

Positron emission tomog. (PET) is an important imaging modality for biomedical research and drug development. PET requires biochem. selective radiotracers to realize full potential. Fluorine-18 (t1/2 = 109.8 min) is a major radionuclide for labeling such radiotracers but is only readily available in high activities from cyclotrons as [18F]fluoride ion. [18F]fluoroform has emerged for labeling tracers in trifluoromethyl groups. Prior methods of [18F]fluoroform synthesis used difluoro precursors in solution and led to high dilution with carrier and low molar activity (Am). We explored a new approach for the synthesis of [18F]fluoroform based on the radiosynthesis of [18F]fluoromethane from [18F]fluoride ion and then cobaltIII fluoride mediated gas phase fluorination. We estimate that carrier dilution in this process is limited to about 3-fold and find that moderate to high Am values can be achieved. We show that [18F]fluoroform so produced is highly versatile for rapidly and efficiently labeling various chemotypes that carry trifluoromethyl groups, thereby expanding prospects for developing new PET radiotracers. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Recommanded Product: 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Recommanded Product: 2-Hydroxyphenylboronic acid

Referemce:
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Alcohols – Chemistry LibreTexts

In 2018,Inorganic Chemistry included an article by Li, Changda; Tang, Haitong; Fang, Yu; Xiao, Zhifeng; Wang, Kunyu; Wu, Xiang; Niu, Helin; Zhu, Chengfeng; Zhou, Hong-cai. Recommanded Product: 126456-43-7. The article was titled 《Bottom-Up Assembly of a Highly Efficient Metal-Organic Framework for Cooperative Catalysis》. The information in the text is summarized as follows:

A bottom-up assembly of a monomeric Cu complex and a 2-dimensional (2-D) heterometallic metal-organic framework (MOF) from a carboxylate-functionalized tridentate Schiff base ligand and metal ions is demonstrated. The obtained 2-D MOF features a unique bimetallic Cu center which is different from its monometallic precursor and acts as an efficient heterogeneous catalyst for the Friedel-Crafts reaction and Henry reaction. The MOF catalyst shows a remarkably superior activity compared to its homogeneous counterparts in a wide range of substrates. It is presumably ascribed to the dual activation of the substrates by the active bimetallic Cu center confined in the MOF network, which is supported by the significant changes in catalytic activity at low catalyst/substrates ratios when using the 2-D MOF and its precursor as catalysts, resp. The MOF catalyst shows an excellent stability and recyclability. The work provides a stepwise strategy to design a heterogeneous cooperative catalyst, by taking advantage of the modulated structure of MOF and tunable functionality of the tridentate Schiff base, with high performance in a variety of organic synthesis. The experimental part of the paper was very detailed, including the reaction process of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Recommanded Product: 126456-43-7)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Recommanded Product: 126456-43-7

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In 2017,Han, Zhengxu S.; Wu, Hao; Xu, Yibo; Zhang, Yongda; Qu, Bo; Li, Zhibin; Caldwell, Donald R.; Fandrick, Keith R.; Zhang, Li; Roschangar, Frank; Song, Jinhua J.; Senanayake, Chris H. published 《General and stereoselective method for the synthesis of sterically congested and structurally diverse P-stereogenic secondary phosphine oxides》.Organic Letters published the findings.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The information in the text is summarized as follows:

Reaction of dichlorophosphines RPCl2 (R = aryl, hetaryl, ferrocenyl, aralkyl) with chiral N-sulfonyl-β-aminoalc. auxiliaries R*OH produced phosphinate esters RPH(O)(OR*), which were then alkylated with tBuLi yielding phosphorus-chiral secondary phosphine oxides RPH(O)(tBu) (3a-k) with >97% ee. A general and efficient method for the synthesis of bulky and structurally diverse P-stereogenic chiral secondary phosphine oxides (SPOs) by using readily available chiral amino alc. templates is described. These chiral SPOs could be used as chiral building blocks for the synthesis of difficult-to-access bulky P-stereogenic phosphine compounds or ligands for organic catalysis. In the experiment, the researchers used many compounds, for example, (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
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In 2016,Siebeneicher, Holger; Cleve, Arwed; Rehwinkel, Hartmut; Neuhaus, Roland; Heisler, Iring; Mueller, Thomas; Bauser, Marcus; Buchmann, Bernd published 《Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876》.ChemMedChem published the findings.Safety of Azetidin-3-ol hydrochloride The information in the text is summarized as follows:

Despite the long-known fact that the facilitative glucose transporter GLUT1 is one of the key players safeguarding the increase in glucose consumption of many tumor entities even under conditions of normal oxygen supply (known as the Warburg effect), only few endeavors have been undertaken to find a GLUT1-selective small-mol. inhibitor. Because other transporters of the GLUT1 family are involved in crucial processes, these transporters should not be addressed by such an inhibitor. A high-throughput screen against a library of ∼3 million compounds was performed to find a small mol. with this challenging potency and selectivity profile. The N-(1H-pyrazol-4-yl)quinoline-4-carboxamides were identified as an excellent starting point for further compound optimization. After extensive structure-activity relationship explorations, single-digit nanomolar inhibitors with a selectivity factor of >100 against GLUT2, GLUT3, and GLUT4 were obtained. The most promising compound, BAY-876 [N4-[1-(4-cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide], showed good metabolic stability in vitro and high oral bioavailability in vivo. In the experiment, the researchers used Azetidin-3-ol hydrochloride(cas: 18621-18-6Safety of Azetidin-3-ol hydrochloride)

Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.Safety of Azetidin-3-ol hydrochloride Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Flotation of antimony oxide》 were Thrun, Eberhard. And the article was published in Chemiker-Zeitung in 1959. HPLC of Formula: 2525-05-5 The author mentioned the following in the article:

The flotation of Sb2O3 ore is discussed theoretically on the basis of chem., phys.-chem., and unit-process parameters. Without resorting to the trial and error approach, it was possible to establish the optimal conditions under which certain dihydroxybutylbenzenes are most effective for the flotation of Sb2O3. The small affinity of the collector at the ore interface was overcome by the simultaneous use of a nonspecific cation-active compound As flotation agents 10 mg. 1,2-dihydroxy-4-butylbenzene/l. and its isomers were used. For the larger-scale flotation experiments, a synthetic mixture was prepared consisting of Sb metal (pretreated Sb2O3) 3.0, SiO2 60.0, CaCO3 17.2, Al2O3 10.3, Fe2O3 5.0%. Other experiments were carried out with the lower Sb contents of 0.8 and 0.24%. After reading the article, we found that the author used 4-Butylbenzene-1,2-diol(cas: 2525-05-5HPLC of Formula: 2525-05-5)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.HPLC of Formula: 2525-05-5 Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Natural Product Research included an article by Feng, Jie; Zhao, Danyang; Xu, Qiannan; Liu, Xiangzhong; Zhou, Mi; Ye, Xiansheng; Lin, Ting; Wang, Guanghui; Sun, Cuiling; Ding, Rong; Tian, Wenjing; Chen, Haifeng. HPLC of Formula: 54-17-1. The article was titled 《A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities》. The information in the text is summarized as follows:

A undescribed phenolic glycoside, trochinenol A, was isolated from the flowers of Trollius chinensis Bunge and the structure was identified by spectroscopic methods. Its anti-inflammatory and antibacterial effects were investigated by broth microdilution and NF-κB reporter gene assays. Consequently, compound exhibited an appreciable effect against Staphylococcus aureus with the MIC value of 6.25μg/mL. Besides, it showed moderate effect against TNFα-induced activation of NF-κB pathway. The experimental process involved the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1HPLC of Formula: 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.HPLC of Formula: 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Twist to Boost: Circumventing Quantum Yield and Dissymmetry Factor Trade-Off in Circularly Polarized Luminescence》 was written by Lee, Sumin; Lee, Yongmoon; Kim, Kyungmin; Heo, Seunga; Jeong, Dong Yeun; Kim, Sangsub; Cho, Jaeheung; Kim, Changsoon; You, Youngmin. Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-olThis research focused ontwist boost circumventing quantum yield dissymmetry factor trade off. The article conveys some information:

Circularly polarized luminescence (CPL) enables promising applications in asym. photonics. However, the performances of CPL mols. do not yet meet the requirements of these applications. The shortcoming originates from the trade-off in CPL between the photoluminescence quantum yield (PLQY) and the photoluminescence dissymmetry factor (gPL). In this study, we developed a mol. strategy to circumvent this trade-off. Our approach takes advantage of the strong propensity of [Pt(N^C^N)Cl], where the N^C^N ligand is 1-(2-oxazoline)-3-(2-pyridyl)phenylate, to form face-to-face stacks. We introduced chiral substituents, including (S)-Me, (R)- and (S)-iso-Pr, and (S)-indanyl groups, into the ligand framework. This asym. control induces torsional displacements that give homohelical stacks of the Pt(II) complexes. X-ray single-crystal structure analyses for the (S)-iso-Pr Pt(II) complex reveal the formation of a homohelical dimer with a Pt···Pt distance of 3.48 Å, which is less than the sum of the van der Waals radii of Pt. This helical stack elicits the metal-metal-to-ligand charge-transfer (MMLCT) transition that exhibits strong chiroptical activity due to the elec. transition moment making an acute angle to the magnetic transition moment. The PLQY and gPL values of the MMLCT phosphorescence emission of the (S)-iso-Pr Pt(II) complex are 0.49 and 8.4 x 10-4, which are improved by factors of ca. 6 and 4, resp., relative to the values of the unimol. emission (PLQY, 0.078; gPL, 2.4 x 10-4). Our photophys. measurements for the systematically controlled Pt(II) complexes reveal that the CPL amplifications depend on the chiral substituent. Our investigations also indicate that excimers are not responsible for the enhanced chiroptical activity. To demonstrate the effectiveness of our approach, organic electroluminescence devices were fabricated. The MMLCT emission devices were found to exhibit simultaneous enhancements in the external quantum efficiency (EQE, 9.7%) and the electroluminescence dissymmetry factor (gEL, 1.2 x 10-4) over the unimol. emission devices (EQE, 5.8%; gEL, 0.3 x 10-4). These results demonstrate the usefulness of using the chiroptically active MMLCT emission for achieving an amplified CPL. After reading the article, we found that the author used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Influence of temperature variations on the intensities of absorption bands in the infrared spectra of aliphatic compounds》 was published in Spectrochimica Acta in 1957. These research results belong to Dijkstra, G.. Electric Literature of C10H14O2 The article mentions the following:

Marked changes occur in band intensities throughout the spectra of aliphatic long-chain mols. when liquid samples of these are heated to temperatures up to 200°. In all cases the band intensities are reduced with increasing temperatures, the changes being reversible. These reductions vary considerably from one band to another. The fatty acid dimers form an exception, which, however, can be readily explained. In these substances the C:O stretching band at 1715 cm.-1 gradually disappears on heating, and is replaced by the C:O stretching band of the monomers at 1765 cm.-1 In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5Electric Literature of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Electric Literature of C10H14O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Cu-Catalyzed Dehydrogenative C-O Cyclization for the Synthesis of Furan-Fused Thienoacenes》 was written by Mitsudo, Koichi; Kobashi, Yoshiaki; Nakata, Kaito; Kurimoto, Yuji; Sato, Eisuke; Mandai, Hiroki; Suga, Seiji. Category: alcohols-buliding-blocksThis research focused onthiophenyl phenol copper catalyst dehydrogenative cyclization coupling; furan fused thienoacene preparation. The article conveys some information:

The first Cu-catalyzed dehydrogenative C-O cyclization for the synthesis of furan-fused thienoacenes is described. A variety of heteroacenes including a thieno[3,2-b]furan or a thieno[2,3-b]furan skeleton were synthesized by intramol. C-H/O-H coupling. The use of a mixed solvent of N-methyl-2-pyrrolidone, ethylene glycol monomethyl ether, and toluene was essential for suppressing side reactions and efficiently promoting the reaction. Double C-O cyclization was also conducted to afford highly π-expanded furan-fused thienoacenes. In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxyphenylboronic acid(cas: 89466-08-0Category: alcohols-buliding-blocks)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA), a synthetic molecule applied in RNA affinity chromatography, is able to form reversible covalent ester bonds with 1,2- or 1,3-cis-doils on the ribose ringCategory: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《A new megastigmane glucoside and other constituents fromDesmodium gangeticum》 was published in Journal of Chemistry in 2020. These research results belong to Dang, Hau Viet; Do, Giang Hoang; Ngo, Phuong Thi; Nguyen, Tien Dat; Le, Ha Minh. Application of 54-17-1 The article mentions the following:

A new megastigmane glycoside, gangeticoside (1), and three known compounds leonuriside A (2), Me benzoate 2-O-β-D-glucopyranoside (3), and tortoside A (4) were isolated from the aerial part of Desmodium gangeticum. Their structures were determined by 1D and 2D NMR spectra. The isolated compounds were evaluated for their inhibitory effect on NO production in LPS-stimulated RAW264.7 cells. Among them, compounds 1, 2, and 3 exhibited strong effect with the IC50 values of 22.3, 15.6, 7.3 μM, resp. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Application of 54-17-1)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Application of 54-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts