Tag: 100-200

Synthetic Route of C6H12O6On October 31, 2019 ,《Initial pyrolysis mechanism of cellulose revealed by in-situ DRIFT analysis and theoretical calculation》 appeared in Combustion and Flame. The author of the article were Dai, Gongxin; Wang, Kaige; Wang, Guanyu; Wang, Shurong. The article conveys some information:

Cellulose is one of the major components of biomass. The study on its pyrolysis process will be beneficial to the in-depth understanding of biomass pyrolysis mechanism. In this work, in-situ diffuse reflectance IR Fourier transform spectroscopy (in-situ DRIFT) combined with two-dimensional perturbation correlation IR spectroscopy (2D-PCIS) was first used to characterize the evolution process of the functional groups in cellulose during pyrolysis. The results showed that the degradation of carbon skeleton was prior to the dehydration of free hydroxyls after the destruction of hydrogen bond networks during pyrolysis. The thermal stability of C-O in cellulose followed by the order of glycosidic bond Synthetic Route of C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.Synthetic Route of C6H12O6

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《Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres》 was written by Mattio, Luce Micaela; Pinna, Cecilia; Catinella, Giorgia; Musso, Loana; Pedersen, Kasandra Juliet; Krogfelt, Karen Angeliki; Dallavalle, Sabrina; Pinto, Andrea. HPLC of Formula: 26153-38-8This research focused onviniferin analog preparation antibacterial; antimicrobials; benzofuran nucleus; stilbenoids; viniferin derivatives. The article conveys some information:

The construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed to prepare a focused collection of dehydro-δ-viniferin analogs. was reported. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analog 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4μg/mL). In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.HPLC of Formula: 26153-38-8

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《Syntheses of diselenide-containing dynamic polymers and their application in polymer alloys》 was written by Liu, Jia; Ma, Xiaoning; Tong, Yanping; Lang, Meidong. Recommanded Product: 627-18-9This research focused ontrimethylenecarbonate polycarbonate diselenidediol initiated blend mech property; caprolactone polyester diselenidediol initiated blend mech property. The article conveys some information:

The diselenide-containing polycarbonate ((PTMCSe)2) and diselenide-containing poly(ε-caprolactone) ((PCLSe)2) were synthesized by the ring opening polymerization using a new compound of di-(1-hydroxypropyl) diselenide ((HOC3H6Se)2) as initiator. The dynamic properties of these diselenide-containing polymers were revealed by diselenide exchange reactions, which could be realized under visible irradiation at room temperature As the result of the diselenide exchange between (PTMCSe)2 and (PCLSe)2, a di-block polymer (PCLSeSePTMC) was formed in (PTMCSe)2/(PCLSe)2 alloy. Taking advantage of the diselenide exchange, the compatibility and miscibility of (PTMCSe)2/(PCLSe)2 alloy was significantly improved by the exchange product (PCLSeSePTMC) which acted as polymeric compatibilizer. This novel concept may be applied in other polymer alloys containing dynamic covalent polymers. In the part of experimental materials, we found many familiar compounds, such as 3-Bromopropan-1-ol(cas: 627-18-9Recommanded Product: 627-18-9)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Recommanded Product: 627-18-9

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Electric Literature of C3H7BrOIn 2019 ,《Diblock copolymers consisting of a redox polymer block based on a stable radical linked to an electrically conducting polymer block as cathode materials for organic radical batteries》 appeared in Polymer Chemistry. The author of the article were Hergue, Noemie; Ernould, Bruno; Minoia, Andrea; De Winter, Julien; Gerbaux, Pascal; Lazzaroni, Roberto; Gohy, Jean-Francois; Dubois, Philippe; Coulembier, Olivier. The article conveys some information:

End-functionalized poly(3-hexylthiophene) (P3HT) and poly(2,2,6,6-tetramethylpiperidinyloxy-4-yl methacrylate) (PTMA) were synthesized using controlled polymerization techniques and linked together to lead to a diblock copolymer structure via click cycloaddition These diblock copolymers were further blended with carbon nanotubes (CNTs) to be used as cathodes in organic radical batteries. The performances of these batteries were studied during charge/discharge cycling at constant and variable current densities (C rate). In order to shed light on the importance of the diblock copolymer architecture, the results were compared to the capacities measured on electrodes made of blends of P3HT and PTMA homopolymers. Theor. simulations were finally used to corroborate the good electrochem. properties of the synthesized diblock copolymers. The results came from multiple reactions, including the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Electric Literature of C3H7BrO)

3-Bromopropan-1-ol(cas: 627-18-9) is used in the synthesis of fluorescent halide-sensitive quinolinium dyes, chiral, quaternary prolines through cyclization of quaternary amino acids and molten salt-polymers. It is utilized for the study of micellar media and in microemulsions based on cationic or a nonionic surfactant by reacting with phenols.Electric Literature of C3H7BrO

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Related Products of 1195-59-1In 2021 ,《Structural and Thermodynamics Studies on Polyaminophosphonate Ligands for Uranyl Decorporation》 appeared in Inorganic Chemistry. The author of the article were Ye, Gaoyang; Roques, Jerome; Solari, Pier-Lorenzo; Den Auwer, Christophe; Jeanson, Aurelie; Brandel, Jeremy; Charbonniere, Loic J.; Wu, Wangsuo; Simoni, Eric. The article conveys some information:

The development of actinide decorporation agents with high complexation affinity, high tissue specificity, and low biol. toxicity is of vital importance for the sustained and healthy development of nuclear energy. After accidental actinide intake, sequestration by chelation therapy to reduce acute damage is considered as the most effective method. Bis- and tetra-phosphonated pyridine ligands were designed, synthesized, and characterized for uranyl (UO22+) decorporation. Owing to the absorption of the ligand and the luminescence of the uranyl ion, UV-visible spectroscopy and time-resolved laser-induced fluorescence spectroscopy (TRLFS) were used to probe in situ complexation and structure variation of the complexes formed by the ligands with uranyl. D. functional theory (DFT) calculations and x-ray absorption fine structure (XAFS) spectroscopy on uranyl-ligand complexes revealed the coordination geometry around the uranyl center at pH 3 and 7.4. High affinity constants (log K ~17) toward the uranyl ion were determined by displacement titration A preliminary in vitro chelation study proves that bis-phosphonated pyridine ligands can remove uranium from calmodulin (CaM) at a low dose and in the short term, which supports further uranyl decorporation applications of these ligands.2,6-Pyridinedimethanol(cas: 1195-59-1Related Products of 1195-59-1) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Related Products of 1195-59-1

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Synthetic Route of C7H9NO2In 2019 ,《Functionally Versatile and Highly Stable Chelator for 111In and 177Lu: Proof-of-Principle Prostate-Specific Membrane Antigen Targeting》 appeared in Bioconjugate Chemistry. The author of the article were Li, Lily; Jaraquemada-Pelaez, Maria de Guadalupe; Kuo, Hsiou-Ting; Merkens, Helen; Choudhary, Neha; Gitschtaler, Katrin; Jermilova, Una; Colpo, Nadine; Uribe-Munoz, Carlos; Radchenko, Valery; Schaffer, Paul; Lin, Kuo-Shyan; Benard, Francois; Orvig, Chris. The article conveys some information:

Here, we present the synthesis and characterization of a new potentially nonadentate chelator, H4pypa and its bifunctional analog tBu4pypa-C7-NHS conjugated to PSMA (prostate-specific membrane antigen) – targeting peptidomimetic (Glu-urea-Lys). H4pypa is very functionally versatile and biol. stable. Compared to the conventional chelators (e.g. DOTA, DTPA), H4pypa has outstanding affinities for both 111In (EC, t1/2 ∼2.8 d) and 177Lu (β-,γ t1/2∼6.64 d). Its radiolabeled complexes were achieved at >98% radiochem. yield, RT within 10 min, at ligand concentration as low as 10-6 M, with excellent stability in human serum over at least 5-7 days (<1% transchelation). The thermodn. stabilities of the [M(pypa)]- complexes (M3+ = In3+, Lu3+, La3+) were dependent on the ionic radii, where the smaller In3+ has the highest pM value (30.5), followed by Lu3+ (22.6) and La3+ (19.9). All pM values are remarkably higher than those with DOTA, DTPA, H4octapa, H4octox and H4neunpa. Moreover, the facile and versatile bifunctionalization enabled by the p-OH group in the central pyridyl bridge of the pypa scaffold (compound 14) allows incorporation of a variety of linkers for bioconjugation through easy nucleophilic substitution. In this work, an alkyl linker was selected to couple H4pypa to a PSMA-targeting pharmacophore, proving that the bioconjugation sacrifices neither the tumor-targeting nor the chelation properties. The biodistribution profiles of 111In- and 177Lu-labeled tracers are different, but promising, with the 177Lu analog particularly outstanding. In addition to this study using 2,6-Pyridinedimethanol, there are many other studies that have used 2,6-Pyridinedimethanol(cas: 1195-59-1Synthetic Route of C7H9NO2) was used in this study.

2,6-Pyridinedimethanol(cas: 1195-59-1) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Synthetic Route of C7H9NO2

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In 2022,Lee, Ju Young; Varshnaya, Rohit Kumar; Yoo, Eun Jeong published an article in Organic Letters. The title of the article was 《Synthesis of Chiral Diazocine Derivatives via a Copper-Catalyzed Dearomative [5+3] Cycloaddition》.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol The author mentioned the following in the article:

Copper-catalyzed [5+3] cycloaddition of N-aromatic zwitterions and enol diazoacetates produced enantio-enriched diazocine derivatives A sterically encumbered BOX ligand and NaBArF additive played significant roles in driving the overall catalytic process via the unfavorable dearomatization to construct the desired eight-membered heterocyclic compounds The induced stereoselectivity was preserved after further modifications of the skeleton, which demonstrates the potential applications of the developed asym. catalysis. In the experimental materials used by the author, we found (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol)

(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol

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Schwartz, Zachary T.; Theisen, Peter D.; Bjornstal, Olaf T.; Rodebaugh, Mary; Jemal, Mauricio A.; Lee, Dallas; Shelton, Spencer D.; Zhao, Zhenze; Du, Liqin; Kerwin, Sean M. published an article in 2022. The article was titled 《Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues》, and you may find the article in Molecules.Formula: C7H6O3 The information in the text is summarized as follows:

Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism Embarking upon a program to systematically examine potentially more metabolically stable replacements for the catechol rings in rooperol, we report here a general, scalable synthesis of rooperol and analogs that builds on our previous synthetic approach incorporating a key Pd-catalyzed decarboxylative coupling strategy. Using this approach, we have prepared and evaluated the cancer cell cytotoxicity of rooperol and a series of analogs. While none of the analogs examined here were superior to rooperol in preventing the growth of cancer cells, analogs containing phenol or methylenedioxyphenyl replacements for one or both catechol rings were nearly as effective as rooperol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Formula: C7H6O3

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Li, Shuai; Li, Xin-yang; Zhang, Ting-jian; Zhu, Ju; Liu, Kai-li; Wang, De-pu; Meng, Fan-hao published their research in Bioorganic Chemistry in 2021. The article was titled 《Novel 4,5-dihydrospiro[benzo[c]azepine-1,1′-cyclohexan]-3(2H)-one derivatives as PARP-1 inhibitors: Design, synthesis and biological evaluation》.Reference of 2-Hydroxyphenylboronic acid The article contains the following contents:

To further explore the research of novel PARP-1 inhibitors, design and synthesis of a series of novel 4,5-dihydrospiro[benzo[c]azepine-1,1′-cyclohexan]-3(2H)-one derivatives I (R = H, 2-Cl, 3-F, etc.) PARP-1 inhibitors based on the author’s previous research is reported. Most compounds displayed certain antitumor activities against four tumor cell lines (A549, HepG2, HCT-116, and MCF-7). Specifically, the candidate compound I (R = 2-F) possessed strong anti-proliferative potency toward A549 cells with the IC50 value of 2.01μM and showed low toxicity to lung cancer cell line. And the in vitro enzyme inhibitory activity of compound I (R = 2-F) was better than rucaparib. Mol. docking studies provided a rational binding model of the above compound in complex with rucaparib. The following cell cycle and apoptosis assays revealed that this compound could arrest cell cycle in the S phase and induce cell apoptosis and western blot anal. further showed that it could effectively inhibit the PAR’s biosynthesis and was more effective than rucaparib. Overall, based on the biol. activity evaluation, compound I (R = 2-F) could be a potential lead compound for further developing novel amide PARP-1 inhibitors. In the experiment, the researchers used 2-Hydroxyphenylboronic acid(cas: 89466-08-0Reference of 2-Hydroxyphenylboronic acid)

2-Hydroxyphenylboronic acid(cas: 89466-08-0) belongs to acyl phenylboronic acid. Phenylboronic acid (PBA) has been used to extract β-blockers (a class of aminoalcohol-containing drugs) from aqueous solution, rat, and human plasma. Reference of 2-Hydroxyphenylboronic acid

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Coufourier, Sebastien; Ndiaye, Daouda; Gaillard, Quentin Gaignard; Bettoni, Leo; Joly, Nicolas; Mbaye, Mbaye Diagne; Poater, Albert; Gaillard, Sylvain; Renaud, Jean-Luc published their research in Tetrahedron in 2021. The article was titled 《Iron-catalyzed chemoselective hydride transfer reactions》.SDS of cas: 100-55-0 The article contains the following contents:

A diaminocyclopentadienone iron tricarbonyl complex has been applied in chemoselective hydrogen transfer reductions This bifunctional iron complex demonstrated a broad applicability in mild conditions in various reactions, such as reduction of aldehydes over ketones, reductive alkylation of various functionalized amines with functionalized aldehydes and reduction of α,β-unsaturated ketones into the corresponding saturated ketones. A broad range of functionalized substrates has been isolated in excellent yields with this practical procedure. The experimental process involved the reaction of 3-Pyridinemethanol(cas: 100-55-0SDS of cas: 100-55-0)

3-Pyridinemethanol(cas: 100-55-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.SDS of cas: 100-55-0

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