Tag: 100-200

Transition-metal-free formal cross-coupling of aryl methyl sulfoxides and alcohols via nucleophilic activation of C-S bond was written by Li, Guolin;Nieves-Quinones, Yexenia;Zhang, Hui;Liang, Qingjin;Su, Shuaisong;Liu, Qingchao;Kozlowski, Marisa C.;Jia, Tiezheng. And the article was included in Nature Communications in 2020.Electric Literature of C10H22O The following contents are mentioned in the article:

A transition-metal-free cross-coupling strategy utilizing aryl(heteroaryl) Me sulfoxides R¹S(O)Me (R¹ = Ph, 4-NCC₆H₄, 2-naphthyl, 3-pyridyl, 2-benzimidazolyl, etc.) and alcs. R²OH (R² = Me, i-Pr, 2-cyclohexylethyl, 1-adamantylmethyl, etc.) to afford alkyl aryl(heteroaryl) ethers R¹OR² is reported. Two drug mols. were successfully prepared using this protocol as a key step and emphasized its potential utility in medicinal chem. A DFT computational study suggests that the reaction proceeds via initial addition of the alkoxide to the sulfoxide. This adduct facilitates further intramol. addition of the alkoxide to the aromatic ring wherein charge on the aromatic system is stabilized by the nearby potassium cation. Rate-determining fragmentation then delivers Me sulfenate and the aryl or heteroaryl ether. This study establishes the feasibility of nucleophilic addition to an appended sulfoxide as a means to form a bond to aryl(heteroaryl) systems and this modality is expected to find use with many other electrophiles and nucleophiles leading to new cross-coupling processes. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Electric Literature of C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Influencing the Product Distribution in Citral Hydrogenation Using Ionic Liquid Modified Cu Catalysts was written by Naicker, Letisha;Schorner, Markus;Kremitzl, Daniel;Friedrich, Holger B.;Haumann, Marco;Wasserscheid, Peter. And the article was included in ChemCatChem in 2022.COA of Formula: C10H22O The following contents are mentioned in the article:

This work shows the effect of selected ionic liquids on the catalytic performance of a Cu/Al₂O₃ catalyst towards citral hydrogenation. The Cu/Al₂O₃ was prepared using a combination of wet impregnation and strong electrostatic interaction technique. The catalyst was coated with three ionic liquids, namely: [C₄C₁Pyrr][OTf], [C₂C₁C₁Im][NTf₂], and [C₂C₁Im][NTf₂] resulting in Cu-based SCILL catalysts (solid catalyst with an ionic liquid layer). The fresh and used SCILL catalysts were characterized using FT-IR spectroscopy and thermal gravimetric anal. All Cu-SCILL catalysts were stable throughout the liquid-phase reactions with no leaching of ionic liquid being detectable by means of TGA. All ionic liquids investigated prevented the formation of undesired isopulegol compared to the 30% isopulegol selectivity obtained over the bare Cu/Al₂O₃ catalyst. The Cu-SCILL (coated with 15 weight% [C₂C₁Im][NTf₂]) increased the selectivity towards geraniol and nerol by 340%. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8COA of Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Leek or garlic a chemical evaluation of elephant garlic volatiles was written by Ascrizzi, Roberta;Flamini, Guido. And the article was included in Molecules in 2020.Related Products of 106-21-8 The following contents are mentioned in the article:

“Aglione della Valdichiana” is listed among the Traditional Agronomic and Edible Products of Italy, as it is a typical product of the Chiana Valley (Tuscany, Italy). It is also known as “elephant garlic”, due to the dimension of its cloves, and, other than in the Italian Mediterranean area, its presence is also reported in North Africa and Southwest Asia. The current botanical classification identifies it as a leek variety (Allium ampeloprasum L.), although its appearance, except for its larger dimensions, resembles that of garlic. In the present study, the spontaneous volatile emission of whole and cut cloves of “Aglione della Valdichiana” (elephant garlic), garlic, and leek has been profiled by headspace solid phase micro-extraction The results have been subjected to statistical analyses (anal. of variance, hierarchical cluster, and principal component anal.) to assess whether the chem. profile confirmed the botanical proximity of elephant garlic and leek, rather than garlic. The phytochem. volatiles evaluation indicated a higher proximity of elephant garlic to garlic, rather than leek, at least for the Chiana Valley specimen analyzed in this study. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Related Products of 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel Tdp1 inhibitors based on adamantane connected with monoterpene moieties via heterocyclic fragments was written by Munkuev, Aldar A.;Mozhaitsev, Evgenii S.;Chepanova, Arina A.;Suslov, Evgeniy V.;Korchagina, Dina V.;Zakharova, Olga D.;Ilina, Ekaterina S.;Dyrkheeva, Nadezhda S.;Zakharenko, Alexandra L.;Reynisson, Johannes;Volcho, Konstantin P.;Salakhutdinov, Nariman F.;Lavrik, Olga I.. And the article was included in Molecules in 2021.SDS of cas: 106-21-8 The following contents are mentioned in the article:

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability to counter the effects topoisomerase 1 (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized and tested against Tdp1. All the derivatives exhibited inhibition at low micromolar or nanomolar concentrations with the most potent inhibitors having IC₅₀ values in the 0.35-0.57 μM range. The cytotoxicity was determined in the HeLa, HCT-116 and SW837 cancer cell lines; moderate CC₅₀ (μM) values were seen from the mid-teens to no effect at 100 μM. Furthermore, citral derivative 20c, α-pinene-derived compounds 20f, 20g and 25c, and the citronellic acid derivative 25b were found to have a sensitizing effect in conjunction with topotecan in the HeLa cervical cancer and colon adenocarcinoma HCT-116 cell lines. The ligands are predicted to bind in the catalytic pocket of Tdp1 and have favorable physicochem. properties for further development as a potential adjunct therapy with Top1 poisons. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8SDS of cas: 106-21-8).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 106-21-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

GC-MS and surface characteristics of polyvinyl siloxane-an in vitro analysis was written by Mohamed, K. Kasim;Banu, R. Fathima;Kumar, V. Anand;Sundaram, Lakshmi;Thyagarajan, S. P.. And the article was included in Journal of Chromatographic Science in 2022.Formula: C10H22O The following contents are mentioned in the article:

To assess the surface characteristics, composition and release of components of Polyvinyl siloxane (PVS) impression material and explore the use of the material other than for impressions. Forty samples of 0.5-mm thickness and 8-mm diameter PVS disks, with ew perforations, were prepared and divided into four groups. Group 1 in methanol was analyzed by GC-MS immediately and on 1st, 7th and 14th day. Group 2 and 3 placed in 10 mL of human saliva and in artificial nasal fluid, resp., were analyzed by GC-MS at 24 h. Group 4 was subjected to surface characteristics anal. by placing five PVS disks each in 1 mL of human saliva and 1 mL of artificial nasal fluid, resp. On Day 1, Dodecanoic acid, Me ester, Cyclononasiloxane, octadecamethyl, Cyclodecasiloxane and eicosamethyl (four peaks) were observed in Group 1. At 24 h, Group 2 had addnl. compounds of 2-Decene,7-methyl-(Z)-, 2-Undecene,8-methyl-(Z)- and Lauryl acetate. Group 3 showed release of 32 compounds, but their retention time was less. Surface characteristics on Day 14 revealed no noticeable changes. The study revealed that there was a lack of any adverse component release from PVS for a period of 2 wk based on GC-MS anal. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Formula: C10H22O).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cure of secondary carbamate groups by melamine-formaldehyde resins was written by Higginbottom, H. P.;Bowers, G. R.;Ferrell, P. E.. And the article was included in Journal of Coatings Technology in 1999.Synthetic Route of C9H20O2 The following contents are mentioned in the article:

Crosslink densities of films prepared from oligomeric urethane polyols suggested that the methoxymethyl groups of melamine-formaldehyde resins (I) could react with urethane groups (i.e., secondary carbamate groups) as well as reacting with hydroxyl groups. Co-reactants that contain secondary carbamate groups and no hydroxyl groups have been prepared with several types of backbone structures. Cure of such co-reactants by I resins has been studied using a gradient oven with determination of impact resistance, solvent resistance, and hardness. Several formulations from these cure profile sets have been selected for crosslink d. determinations by dynamic mech. anal. Crosslink densities of cured films are consistent with complete conversion of secondary carbamate groups at temperatures only slightly higher than those used for cure of hydroxyl groups. The -OH groups on certain acrylic polyols were converted to secondary carbamate groups. The original acrylic and the converted acrylic were both cured with I resins. Acid resistance was much better for films prepared from the acrylic that contained secondary carbamate groups. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Synthetic Route of C9H20O2).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H20O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The Role of the 1,2,3-Triazolyl Heterocycle in the Helical Columnar Assembly and Electric Field Response was written by Nguyen, Manh Linh;Byun, Jaeduk;Cho, Byoung-Ki. And the article was included in Journal of Physical Chemistry B in 2021.Safety of 3,7-Dimethyloctan-1-ol The following contents are mentioned in the article:

Here, we have proven the role of the 1,2,3-triazolyl group in the helical assembly and elec. field (E-field) response upon comparing liquid crystal analogs I and II (1 and 2, resp.) based on 1,2,3-triazolyl and 1,3,4-oxadiazolyl linkers, resp. An ordered helical column was only observed in 1, driven by the hydrogen-bonding interactions between the adjacent triazolyl nitrogen and hydrogen atoms. X-ray diffraction and energy simulations indicate that the helical column is a 11₂ helix and the helical axis does not coincide with the center of the mol. long axis. The key for the formation of the helical column is the tilted conformation of 1 originating from the steric repulsion between the triazolyl C-H and C-H of the aromatic core. Anal. of the dynamics in the simple hexagonal columnar phase revealed that the in-plane rotational motion of the triazolyl linker (1) is allowed, while the oxadiazolyl linker of 2 has limited conformational flexibility. A uniform alignment under an E-field only occurs in 1, demonstrating the requirement for conformational flexibility in the polar linker. This alignment enhances the elec. conductance of 1 by approx. two-fold. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Safety of 3,7-Dimethyloctan-1-ol).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of 3,7-Dimethyloctan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Role of graphene oxide and functionalized graphene oxide in protective hybrid coatings was written by Alrashed, Maher M.;Soucek, Mark D.;Jana, Sadhan C.. And the article was included in Progress in Organic Coatings in 2019.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

This work evaluates the performance of hybrid coatings of polyurethane/polysiloxane filled with graphene oxide as replacement of chromate conversion coatings for protection of 2024-T3 aluminum alloys. The polysiloxanes in the hybrid coating form strong covalent bonds with the metal surfaces and inhibit corrosion, polyurethanes provide mech. and optical properties, and graphene oxide and isocyanate-treated graphene oxide particles reduce oxygen and moisture diffusion through the coatings. The corrosion performance evaluated using electrochem. impedance spectroscopy and filiform corrosion test indicates the following trends. The hybrid coatings filled with isocyanate-treated graphene oxide particles show lower resistance to corrosion compared to hybrid coatings without graphene oxide, although oxygen diffusion and water vapor transmission are reduced by resp. 50% and 10% in the presence of only 0.67 weight% graphene oxide. It is revealed that graphene oxide and isocyanate-treated graphene oxide particles promote polysiloxane condensation on particle surfaces, thereby effectively reducing a part of polysiloxanes that form continuous corrosion-protective layers on the aluminum alloy surface. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Category: alcohols-buliding-blocks).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and properties of hyperbranched polyesters with diol as a core monomer was written by Wang, Yong;Zhu, Yan-an;Kong, Xia;Qu, Jin-qing. And the article was included in Gaoxiao Huaxue Gongcheng Xuebao in 2013.Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol The following contents are mentioned in the article:

The third generation hyperbranched polyesters (HBPs) were synthesized by the pseudo-one step method with 2, 2-bis(hydroxyl-methyl) propionic acid as AB₂ monomer, p-toluene sulfonic acid as catalyst, in which 2-butyl-2-ethyl-1, 3-propanediol (BEPD, HBP-1), 1, 4-butanediol (BDO, HBP-2), and neopentyl glycol (NPG, HBP-3) were used as the core monomers, resp. The structures and mol. weights of HBPs were characterized with FT-IR, NMR and GPC as well as their intrinsic viscosities were also given. The film properties of HBPs cured by the toluene diisocyanate adduct were tested. The thermal stability of cured HBPs films were also examined by thermogravimetric anal. (TGA). It was found that HBPs are successfully synthesized and HBP-1 displays the highest branching degree up to 0.55. The GPC measured mol. weights of HBPs approach to the theor. values, and HBP-1 exhibits the lowest polydispersity index up to 1.68. HBPs are soluble in strong polar solvents and insoluble in non-polar solvents and HBP-1 displays better solubility and lower intrinsic viscosity up to 4.24 mL·g^-1. The cured HBPs films exhibit good thermal stability, adhesion, flexibility, and high hardness. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of 2-Butyl-2-ethylpropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polyalcohols – important raw materials for the resin and paint industry was written by Soerensen, Kent. And the article was included in Faerg och Lack Scandinavia in 1992.Product Details of 115-84-4 The following contents are mentioned in the article:

A review with 12 references The most common polyalcs., their application in the resin and paint industry, their contribution to the properties of the resins and paints, especially alkyd resins, polyesters, and acrylic monomers, and their structure-property relationship are presented. Together with actual market prices, these data will allow the paint chemist to find the optimum formulation for performance and cost more rapidly, and avoid using unsuitable polyalcs., thereby decreasing the number of experiments and thus costs. The topics include: introduction; the significance of chem. structure (type of hydroxyl group, side groups, neo-structure, functionality); description of different polyalcs. [pentaerythritol (I), trimethylolpropane (II), glycerin, di-pentaerythritol, di-trimethylolpropane, alkoxylates of I and II, neopentylglycol, monoethyleneglycol, propyleneglycol, dimethylolpropionic acid, allyl ethers, and other polyalcs. (2-Et-2-Bu-1,3-propanediol, 1,6-hexanediol, 1,4-butanediol, 2,2,4-trimethyl-1,3-pentanediol, 1,4-cyclohexanediethanol, trimethylolethane, hydroxypivalyl hydroxypivalate, and cyclic II formal)]. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Product Details of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts