Tag: 100-200

Photoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition was written by Wang, Jia-Xin;Ge, Wei;Fu, Ming-Chen;Fu, Yao. And the article was included in Organic Letters in 2022.Computed Properties of C10H20O This article mentions the following:

Herein, a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes ArC(CF₃):CH₂ (Ar = 4-BrC₆H₄, naphthalen-2-yl, 6-methoxypyridin-3-yl, etc.) enabled by intermol. alkoxycarbonyl radical addition is disclosed. A wide variety of alc. oxalate derivatives ROC(O)CO₂H (R = Me, t-Bu, cyclopentyl, L-menthyl, N-Boc-piperidin-4-yl, etc.) was amenable, affording various β-gem-difluoroalkene esters ArC(:CF₂)CH₂COOR with excellent functional group tolerance. Notably, the potential synthetic value of this method is highlighted by successful late-stage modification for bioactive mols. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Computed Properties of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents was written by Haviv, Fortuna;DeNet, Robert W.;Michaels, Raymond J.;Ratajczyk, James D.;Carter, George W.;Young, Patrick R.. And the article was included in Journal of Medicinal Chemistry in 1983.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:

The title compounds I (R = H, Br, Cl, F, Me, NH₂, OMe, etc., R¹ = H, Cl, OH, Me, OMe, Ph, etc.) and related compounds as the HCl salts, prepared mostly by the reaction of 2-picolyl chloride [4377-33-7] or 2-(hydroxymethyl)pyridine  [586-98-1] with the appropriate mercaptol either in 48% HBr under reflux or in the presence of NaOEt in EtOH at room temperature, were investigated as inflammation inhibitors in rat. I (R = H, Br, Cl, F, or NO₂ and R¹ = H) were effective inhibitors of immune complex induced inflammation as represented by the rat reverse passive Arthus reaction. 2-[[(4-bromophenyl)thio]methyl]pyridine (I; R = Br, R¹ = H) [83782-10-9] also inhibited both exudate formation and cellular accumulation in the more conventional carrageenin pleural test, whereas indomethacin inhibited only exudate volume in this model. Structure-activity relations are discussed. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric transfer hydrogenation of C=O and C=N bonds by tethered Rh^III catalysts was written by Matharu, Daljit S.;Martins, Jose E. D.;Wills, Martin. And the article was included in Chemistry – An Asian Journal in 2008.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Rh^III catalysts containing a tetramethylcyclopentadienyl group linked by a ‘tether’ to a tosylated diamine ligand have previously been reported by our group for the asym. transfer hydrogenation (ATH) of ketones. The extension of these catalysts to the asym. reduction of imines, as well as to more highly functionalized substrates is reported. In some cases, the catalysts give better ee values than other methods for these transformations at lower catalyst loadings. The introduction of a methoxy group into the tethering aryl ring does not negate the performance of the catalyst, thus opening up a route to supported derivatives In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stretchable polymeric film with enhanced electrical and mechanical properties was written by Sau, Sanjib;Kundu, Sarathi. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Quality Control of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Stretchable conducting polymeric films are fabricated by blending poly(vinyl alc.) (PVA) and poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) in presence of polar organic solvents, e.g., DMSO (DMSO) and diethylene glycol (DEG) at different concentrations and their structures and superior properties are explored. X-ray diffraction anal. indicates the emergence of some crystalline domains, which are mostly formed by the PEDOT segments of PEDOT:PSS. Raman spectroscopy reveals the transformation from benzoid to quinoid structure of PEDOT in the presence of DMSO or DEG, which effectively enhances the elec. performance. Nonlinear current – voltage characteristics show that the maximum current is obtained for 7 and 3 wt% DMSO and DEG doped PVA/PEDOT:PSS films resp. and the corresponding current enhancement is around 12 and 38 times in comparison with the untreated film. The charge transport mechanism is illustrated with the Poole – Frenkel effect. FTIR study implies the hydrogen bond formation among PVA, PSS and polar organic solvents that makes the film stretchable. Stress – strain behavior exhibits nearly 2.0-3.0 and 2.5-4.5 times stretchability enhancement for 5 and 7 wt% DMSO and DEG doped films resp. Thus, flexible conducting polymeric films are prepared and their superior elec. and mech. properties for the specific solvent conditions are explored. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Quality Control of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Whole-cell bacterial biosensor for volatile detection from Pectobacterium-infected potatoes enables early identification of potato tuber soft rot disease was written by Veltman, Boris;Harpaz, Dorin;Melamed, Sarit;Tietel, Zipora;Tsror, Leah;Eltzov, Evgeni. And the article was included in Talanta in 2022.Computed Properties of C8H16O This article mentions the following:

Half of the harvested food is lost due to rots caused by microorganisms. Plants emit various volatile organic compounds (VOCs) into their surrounding environment, and the VOC profiles of healthy crops are altered upon infection. In this study, a whole-cell bacterial biosensor was used for the early identification of potato tuber soft rot disease caused by the pectinolytic bacteria Pectobacterium in potato tubers. The detection is based on monitoring the luminescent responses of the bacteria panel to changes in the VOC profile following inoculation. First, gas chromatog.-mass spectrometry (GC-MS) was used to specify the differences between the VOC patterns of the inoculated and non-inoculated potato tubers during early infection. Five VOCs were identified, 1-octanol, phenylethyl alc., 2-Et hexanol, nonanal, and 1-octen-3-ol. Then, the infection was detected by the bioreporter bacterial panel, firstly measured in a 96-well plate in solution, and then also tested in potato plugs and validated in whole tubers. Examination of the bacterial panel responses showed an extensive cytotoxic effect over the testing period, as seen by the elevated induction factor (IF) values in the bacterial strain TV1061 after exposure to both potato plugs and whole tubers. Moreover, quorum sensing influences were also observed by the elevated IF values in the bacterial strain K802NR. The developed whole-cell biosensor system based on bacterial detection will allow more efficient crop management during postharvest, storage, and transport of crops, to reduce food losses. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Computed Properties of C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Research on hydration and dehydration reactions in the preparation of terpin hydrate from turpentine was written by Wen, Furong. And the article was included in Linchan Huaxue Yu Gongye in 1994.COA of Formula: C10H22O3 This article mentions the following:

Perfumery terpineol with high alc. content was synthesized through terpin hydrate from turpentine. Main factor affecting the yield in the process of hydration and dehydration reactions were studied according to the theory of carbon frame arrangement by Wagner-Mecrwein. The most favorable reaction conditions were determined and confirmed. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6COA of Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Infused aqueous curry tea extracts ameliorate N^ω-Nitro-L-Arginine Methyl Ester-induced liver dysfunction in male albino Wistar rats was written by Ani, Franklin Ime;Nabofa, Enivwenaye Egide Williams;Omobowale, Temidayo Olutayo;Ajuzie, Nnenna Choice;Ajemigbitse, Jubilee;Oyagbemi, Ademola Adetokunbo;Attah, Alfred Francis;Adeoye, Bolade Kikelomo;Azubuike-Osu, Sharon Oluchukwu;Adedapo, Adeolu Alex;Alada, Abdul Rasak Akinola. And the article was included in Journal of Food Biochemistry in 2022.Product Details of 149-32-6 This article mentions the following:

Murraya koenigii (L.) Spreng.(Rutaceae) has been reported to pos. affect liver function. However, the effect of M. koenigii leaves on Nω-Nitro-L-Arginine Me Ester (L-NAME) induced liver dysfunction is unknown. The aim of the present study was therefore to investigate the effect of M.koenigii leaves as tea on L-NAME induced liver dysfunction. Two variants of curry tea were formulated; one was formulated entirely from leaves of M. koenigii, the other was formulated with thaumatin-rich aril obtained from seeds of Thaumatococcus danielii (Benn.) Benth. (Marantaceae). Group I animals served as control and were untreated. Groups II and V animals were administered curry tea (CT). Group III and VI animals received curry-thaumatin tea (CTT). Concurrently, L-NAME (40 mg/kg) was administered to groups IV-VI resp. for 21 days. Blood and liver samples were collected at the end of the study for biochem., histol., and immunohistochem. anal. L-NAME induced liver dysfunction evidenced by liver histol., increased activities of ALT, AST, hyperlipidemia, hepatic oxidative stress and increased hepatic NF-kB expression. Administration of CT and CTT ameliorated the L-NAME induced liver dysfunction evidenced by liver histol., increased NO hepatic bioavailability, reduced activity of ALT and AST, increased hepatic antioxidant system and decreased hepatic NF-kB expression. Thaumatin taste/flavor enhancer did not significantly reduce or potentiate the hepatoprotective, antioxidant and anti-lipidemic property of aqueous curry tea extracts in rats. L-NAME impaired liver function in rats. CT and CTT interfered with the ability of L-NAME to inhibit NO synthesis which was associated with ameliorated hepatic dysfunction. The study reports that non-selective inhibition of nitric oxide by L-NAME in rats impairs liver function and formulated curry tea types interfered with the ability of L-NAME to inhibit NO synthesis which was associated with ameliorated hepatic dysfunction in rats. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Product Details of 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Solvent-Dependent Assembly of Terphenyl- and Quaterphenyldithiol on Gold and Gallium Arsenide was written by Krapchetov, Dmitry A.;Ma, Hong;Jen, Alex K. Y.;Fischer, Daniel A.;Loo, Yueh-Lin. And the article was included in Langmuir in 2005.SDS of cas: 29364-29-2 This article mentions the following:

The assembly of terphenyldithiol (TPDT) and quaterphenyldithiol (QPDT) on Au and Ga arsenide from EtOH, THF, and solutions consisting of both solvents was characterized by near-edge x-ray absorption fine structure spectroscopy. The surface coverage and the average orientation of both TPDT and QPDT on Au are solvent-independent. These mols. readily form monolayers on Au with an ensemble-average backbone tilt of 30 ± 3° from the substrate normal. In sharp contrast, the assembly of TPDT and QPDT on Ga arsenide is extremely solvent-sensitive. At high EtOH fractions, both mols. form monolayers with an ensemble-average orientation that is indistinguishable from those on Au substrates. At low EtOH fractions and in pure THF, however, these mols. are disordered on Ga arsenide and the surface coverage is poor. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2SDS of cas: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

KF/clinoptilolite NPs: An efficient and heterogeneous catalyst for chemoselective silylation of alcohols and phenols was written by Oladee, Razieh;Zareyee, Daryoush;Khalilzadeh, Mohammad A.. And the article was included in Phosphorus, Sulfur and Silicon and the Related Elements in 2021.HPLC of Formula: 1777-82-8 This article mentions the following:

Potassium fluoride incorporated on clinoptilolite nanoparticles (KF/CP NPs) by ion exchanging is found to be an effective and inexpensive heterogeneous nanocatalyst for chemoselective silylation of alcs. and phenols with 1,1,1,3,3,3-hexamethyldisilazane (HMDS) at room temperature Nano-powder of clinoptilolite (CP) was prepared using a planetary ball mill mech. method and characterized by dynamic light scattering (DLS), X-ray powder diffraction (XRD) and scanning electron microscope (SEM) analyses. Almost all of products were obtained in high yields as well as short reaction times and the catalyst was also reused eight times without loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dynamics-Driven Controlled Polymerization to Synthesize Fully Renewable Poly(ester-ether)s was written by Wang, Rui;Zhang, Houyu;Jiang, Min;Wang, Zhipeng;Zhou, Guangyuan. And the article was included in Macromolecules (Washington, DC, United States) in 2022.COA of Formula: C4H10O3 This article mentions the following:

Producing aromatic poly(ester-ether)s from completely renewable feedstocks is almost inaccessible via existing ring-opening polymerization or melt polycondensation methods. Herein, we report a practical strategy to synthesize fully bio-based poly(ester-ether)s in a one-pot/two-component manner via industrial melt polycondensation. The polymerization process was controlled by applying Sc(OTf)₃ as a catalyst and bio-based 2,5-furandicarboxylic acid and ethylene glycol as the substrate template to afford poly(ester-ether)s with a controlled oligoethylene glycol segment in the range from 10 to 92%. Studying the mechanism and model kinetics of Sc(OTf)₃-catalyzed etherification reactions provided complete insights into the formation process and impetus of poly(ester-ether)s, validating that a “butterfly effect” occurred in the reaction process. In contrast to flexible conventional polyethers, computational studies revealed that the unique rigidity of the etherification moiety leads to superior thermal and mech. properties of poly(ester-ether)s. This synthetic protocol demonstrates applicability and versatility, exemplified by using various bio-based diacids/diesters to synthesize a series of poly(ester-ether)s. We envisage that this work will improve the privileged position that renewable poly(ester-ether)s hold as functional materials and broaden their applicability in diverse fields. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6COA of Formula: C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.COA of Formula: C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts