Tag: 100-200

The nuclear magnetic resonance spectra of pyridine derivatives was written by Bruegel, W.. And the article was included in Zeitschrift fuer Elektrochemie und Angewandte Physikalische Chemie in 1962.Computed Properties of C7H9NO This article mentions the following:

The spectra of 154 pyridine derivatives were examined at 40 or 60 Mc. Liquids were run pure; solids were dissolved in Me₂SO, which caused a small upfield shift in chem. shifts, but had little or no effect on the coupling constants Spectra were analyzed for chem. shifts and coupling constants The compounds studied contained 1, 2, or 3 substituents. With the exception of strong electron donors in the 3 position, substituents had little effect on coupling constants The effect of such groups as NH₂ or COR in the 3 position was attributed to resonance of such groups with the ring. The ranges observed for the various coupling constants are as follows: J₂₃, 4.8-5.5; J₂₄, 0-2.5; J₂₅, 0-1.4; J₂₆, 0-0.6; J₃₄, 7.2-9.1; J₃₅, 0.5-1.8; J₃₆, 0.4-2.3; J₄₅, 6.8-8.8; J₄₆, 1.0-2.5; J₅₆, 4.0-5.5. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Computed Properties of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C7H9NO

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Synthesis and properties of poly(ethylene-co-diethylene glycol 2,5-furandicarboxylate) copolymers was written by Meng, Hongxu;Li, Zhisong;Wu, Linbo;Li, Bo-Geng;Hu, Yumiao;Wang, Kecheng. And the article was included in Journal of Applied Polymer Science in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Poly(ethylene 2,5-furandicarboxylate) (PEF) is a biobased polyester with high gas barrier properties, tensile modulus, and strength. In PEF chain, in addition to ethylene furandicarboxylate repeat unit, there is also a small amount of diethylene glycol furandicarboxylate (DF) unit which is formed by etherification side reactions. However, the effect of DF unit in a wide composition range on polymer properties is still unclear. In this study, random poly(ethylene-co-diethylene glycol 2,5-furandicarboxylate) (PEDF) copolymers were synthesized via melt copolycondensation of 2,5-furandicarboxylic acid, ethylene glycol and diethylene glycol. The copolymers were characterized and evaluated by intrinsic viscosity, ¹H NMR, thermal transition, thermogravimetric anal., tensile, impact, and O₂ penetration tests. The copolymers are amorphous in the full composition range. The presence of less than 58 mol% DF unit in PEDFs neither improves the tensile ductility nor deteriorates the oxygen barrier performance, but reduces the glass transition temperature clearly. In comparison with poly(ethylene terephthalate), the PEDF copolymers containing <58 mol% DF unit have higher tensile modulus, strength, and O₂ barrier properties. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Category: alcohols-buliding-blocks).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

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Site-Selective Acylation of Phenols Mediated by a Thioacid Surrogate through Sodium Thiosulfate Catalysis was written by Liao, Wei-Jr;Lin, Sih-Yu;Kuo, Yu-Shan;Liang, Chien-Fu. And the article was included in Organic Letters in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:

Sodium thiosulfate was used as the sulfur source that reacts with anhydrides to generate acyl-Bunte salts, after which a reaction with phenols was induced. This protocol can be applied for the site-selective acylation of the phenolic hydroxyl group in the presence of other alc. groups. The advantages of this acylation method are operational simplicity, high efficiency, and the use of odorless reagents with low toxicity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (4-Chlorophenyl)methanol

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The production of acetate derived hydroxyanthraquinones, -dianthrones, -naphthalenes and -benzenes in tissue cultures from Rumex alpinus was written by Van den Berg, A. J. J.;Labadie, R. P.. And the article was included in Planta Medica in 1981.Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone This article mentions the following:

Tissue cultures set up from roots of R. alpinus were grown on Murashige and Skoog’s medium with kinetin and either 2,4-D or NAA as growth factors. The 2,4-D cultures produced a broader spectrum of hydroxyanthracene, hydroxynaphthalene, and hydroxybenzene derivatives than the NAA cultures. In the 2,4-D cultures the anthraquinones chrysophanol, physcion, and emodin, the dianthrones of chrysophanol and physcion and their heterodianthrone, and the monoglucoside of chrysophanol were identified. Also the naphthalene-1,8-diols nepodin, nepodin monoglucoside, and methoxynepodin were identified. The occurrence of 2-acetyl-orcinol and its monoglucoside was also established. In the NAA cultures accumulation of only chrysophanol, physcion, and 2-acetyl-orcinol could be proved. The yields of these secondary metabolites produced in the NAA cultures were much lower than those produced by the 2,4-D cultures. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of 2′,6′-Dihydroxy-4′-methylacetophenone

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Enhancing the thermostability of engineered laccases in aqueous betaine-based natural deep eutectic solvents was written by Varriale, Simona;Delorme, Astrid E.;Andanson, Jean-Michel;Devemy, Julien;Malfreyt, Patrice;Verney, Vincent;Pezzella, Cinzia. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

In recent years, natural deep eutectic solvents (NADESs) have gained increasing attention as promising nontoxic solvents for biotechnol. applications, due to their compatibility with enzymes and ability to enhance their activity. Betaine-based NADESs at a concentration of 25 wt % in a buffered aqueous solution were used as media to inhibit thermal inactivation of POXA1b laccase and its five variants when incubated at 70 and 90°C. All the tested laccases showed higher residual activity when incubated in NADES solutions, with a further enhancement achieved also for the most thermostable variant. Furthermore, the residual activity of laccases in the presence of NADESs showed a clear advantage over the use of NADESs’ individual components. Mol. docking simulations were performed to understand the role of NADESs in the stabilization of laccases toward thermal inactivation, evaluating the interaction between each enzyme and NADESs’ individual components. A correlation within the binding energies between laccases and NADES components and the stabilization of the enzymes was demonstrated. These findings establish the possibility of preincubating enzymes in NADESs as a facile and cost-effective solution to inhibit thermal inactivation of enzymes when exposed to high temperatures This computer-aided approach can assist the tailoring of NADES composition for every enzyme of interest. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol

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Alcohol – Wikipedia,
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Synthesis of Anemoclemosides A and B, Two Saponins Isolated from Anemoclema glaucifolium was written by Bouillon, Marc E.;Bertocco, Katia;Bischoff, Laura;Buri, Michelle;Davies, Lucy R.;Wilkinson, Elizabeth J.;Lahmann, Martina. And the article was included in European Journal of Organic Chemistry in 2020.Synthetic Route of C6H14O6 This article mentions the following:

Steroidal and triterpenoid saponins are attractive for their wide-ranging pharmacol. properties. The triterpenoid saponins Anemoclemoside A and B are root constituents of the Chinese folk medicinal plant Anemoclema glaucifolium (Ranunculaceae). Both compounds feature an unusual cyclic acetal linkage to the carbohydrate L-arabinose in its open chain form rather than the typical glycosidic bond present in normal saponins. The straightforward and scalable syntheses of both saponins starting from L-arabinose as well as L-lyxose and L-rhamnose are described. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Synthetic Route of C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C6H14O6

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Investigation of the relationship between microbiota dynamics and volatile changes in chilled beef steaks held under high-oxygen packaging enriched in carbon dioxide was written by Yang, Jun;Yang, Xiaoyin;Lin, Hai;Liang, Rongrong;Niu, Lebao;Zhu, Lixian;Luo, Xin;Hopkins, David L.;Zhang, Yimin. And the article was included in Meat Science in 2022.Related Products of 3391-86-4 This article mentions the following:

Carbon dioxide (CO2) plays an important bacteriostatic role in high-oxygen modified atm. packaging (HiOx-MAP). This study aimed to explore the influence of CO2 on the volatile organic compounds (VOCs) profile in HiOx-MAP beef steaks and assess the changes in VOCs associated with microbiota dynamics during 20-days of chilled storage. Compared to control MAP (CMAP: 50% O2/50% N2), CO2-enriched MAP (TMAP: 50% O2/40% CO2/10% N2) rendered steaks with desirable appearance and odor freshness during storage through inhibiting bacterial growth and reducing the accumulation of acetoin, 2-ethyl-1-hexanol, 1,3-butanediol, diacetyl and 2-heptanone (P < 0.05). 1-Octen-3-ol and 2-ethyl-1-hexanol were main VOCs in TMAP steaks and were pos. related to Brochothrix thermosphacta levels. Acetoin and 2-ethyl-1-hexanol could be used as potential spoilage indicators in CMAP steaks, which were pos. related to B. thermosphacta and Pseudomonas levels. Overall, the desirable odor freshness of TMAP steaks was mainly attributed to the CO2-inhibitory effect on the off-odor VOCs production correlated with B. thermosphacta, Pseudomonas and Serratia growth. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Related Products of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 3391-86-4

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Alcohol – Wikipedia,
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Identification of key aroma-active compounds in beef tallow varieties using flash GC electronic nose and GC x GC-TOF/MS was written by Wang, Jing;Chen, Le;Liu, Ying;Olajide, Tosin Michael;Jiang, Yuanrong;Cao, Wenming. And the article was included in European Food Research and Technology in 2022.Application of 3391-86-4 This article mentions the following:

To uncover the integral flavor characteristics and individual odor active compounds in tallow derived from different beef fats: inguinal (IF), omental (OF), and perirenal fats (PF), we used flash GC electronic nose (flash GC E-nose) to analyze and characterize the samples. GC x GC-TOF/MS identified and quantified 195 volatile compounds with significant differences amongst the three kinds of fats. There were 45 important odorants (ROAV > 0.1) containing 23 key odorants (ROAV > 1), of which 43, 34, 35 important odorants were found in IF, OF, and PF, resp. Our results showed that the key odorants overall probably contribute to a fatty and sweat acid smell in IF, a meaty and slightly sweet taste in OF, and sweetness and slightly meaty taste in PF. Elucidating the distribution of key odorants in beef tallow from different parts of animals could provide a scientific basis for formulating and selecting raw materials of high-quality beef tallow flavor products. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Application of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 3391-86-4

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Alcohol – Wikipedia,
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A novel o-nitrobenzyl-based photocleavable antitumor prodrug with the capability of releasing 5-fluorourail was written by Mo, Shuli;Wen, Ying;Xue, Fengfeng;Lan, Haichuang;Mao, Yueyuan;Lv, Guanglei;Yi, Tao. And the article was included in Science Bulletin in 2016.Name: 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized. The photolysis properties of the prodrug were investigated by means of ¹H NMR, HPLC, UV, and MTT methods. The results showed that the toxicity of the anticancer drug was effectively shielded before release. However, the prodrug effectively regained the antitumor capability against cancer cells by release of 5-fluorouracil when it was exposed to UV irradiation In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Name: 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 3-(Hydroxymethyl)-4-nitrophenol

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Discovery of a novel and potent series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases was written by Claridge, Stephen;Raeppel, Franck;Granger, Marie-Claude;Bernstein, Naomy;Saavedra, Oscar;Zhan, Lijie;Llewellyn, David;Wahhab, Amal;Deziel, Robert;Rahil, Jubrail;Beaulieu, Normand;Nguyen, Hannah;Dupont, Isabelle;Barsalou, Annie;Beaulieu, Carole;Chute, Ian;Gravel, Serge;Robert, Marie-France;Lefebvre, Sylvain;Dubay, Marja;Pascal, Roussen;Gillespie, Jeff;Jin, Zhiyun;Wang, James;Besterman, Jeffrey M.;MacLeod, A. Robert;Vaisburg, Arkadii. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Application In Synthesis of Thieno[3,2-b]pyridin-7-ol This article mentions the following:

A series of thieno[3,2-b]pyridine-based inhibitors of c-Met and VEGFR2 tyrosine kinases is described. The compounds demonstrated potency with IC₅₀ values in the low nanomolar range in vitro while the lead compound also showed in vivo activity against various human tumor xenograft models in mice. Further exploration of this class of compounds is underway. In the experiment, the researchers used many compounds, for example, Thieno[3,2-b]pyridin-7-ol (cas: 107818-20-2Application In Synthesis of Thieno[3,2-b]pyridin-7-ol).

Thieno[3,2-b]pyridin-7-ol (cas: 107818-20-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of Thieno[3,2-b]pyridin-7-ol

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