Tag: 100-200

Photo-responsive polymeric micelles and prodrugs: synthesis and characterization was written by Wang, Shiu-Wei;Lin, Yin-Ku;Fang, Jia-You;Lee, Ren-Shen. And the article was included in RSC Advances in 2018.Recommanded Product: 60463-12-9 This article mentions the following:

Bio-recognizable and photocleavable amphiphilic glycopolymers and prodrugs containing photodegradable linkers (i.e. 5-hydroxy-2-nitrobenzyl alc.) as junction points between bio-recognizable hydrophilic glucose (or maltose) and hydrophobic poly(α-azo-ε-caprolactone)-grafted alkyne or drug chains were synthesized by combining ring-opening polymerization, nucleophilic substitution, and “click” post-functionalization with alkynyl-pyrene and 2-nitrobenzyl-functionalized indomethacin (IMC). The block-grafted glycocopolymers could self-assemble into spherical photoresponsive micelles with hydrodynamic sizes of <200 nm. Fluorescence emission measurements indicated the release of Nile red, a hydrophobic dye, encapsulated by the Glyco-ONB-P(αN₃CL-g-alkyne)_n micelles, in response to irradiation caused by micelle disruption. Light-triggered bursts were observed for IMC-loaded or -conjugated micelles during the first 5 h. Following light irradiation, the drug release rate of IMC-conjugated micelles was faster than that of IMC-loaded micelles. Selective lectin binding experiments confirmed that glycosylated Glyco-ONB-P(αN₃CL-g-alkyne)_n could be used in bio-recognition applications. The nano-prodrug with and without UV irradiation was associated with negligible levels of toxicity at concentrations of less than 30μg mL^-1. The confocal microscopy and flow cytometry results indicated that the uptake of doxorubicin (DOX)-loaded micelles with UV irradiation by HeLa cells was faster than without UV irradiation The DOX-loaded Gluco-ONB-P(αN₃CL-g-PONBIMC)₁₀ micelles effectively inhibited HeLa cells’ proliferation with a half-maximal inhibitory concentration of 8.8μg mL^-1. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of Lafutidine was written by Tao, Feng;Lu, Chunxu. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2004.Synthetic Route of C6H6BrNO This article mentions the following:

Lafutidine, a histamine H₂-receptor antagonist, was synthesized by bromination, oxidation, reduction, oxidation, etherification of 2-amino-4-methylpyridine to give 2-[4-(tetrapyran-2-yloxyl)-(2Z)-buten-oxy]-4-(1,3-dioxolan-2-yl)pyridine, which was subjected to hydrolysis, chlorination, Gabriel reaction, hydrazinolysis in one pot followed by amidation, hydrolysis and then condensation with piperidine. The overall yield of lafutidine was 6.8%. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Synthetic Route of C6H6BrNO).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C6H6BrNO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxo-Rhenium-Catalyzed Radical Addition of Benzylic Alcohols to Olefins was written by Bandari, Chandrasekhar;Nicholas, Kenneth M.. And the article was included in Journal of Organic Chemistry in 2020.Computed Properties of C7H6Cl2O This article mentions the following:

Although carbon radicals generated from a variety of alc. derivatives have proven valuable in coupling and addition reactions, the direct use of alcs. as synthetically useful radical sources is less known. In this report, benzylic alcs. are shown to be effective radical precursors for addition reactions to alkenes when treated with triphenylphosphine or piperidine with the catalyst ReIO₂(PPh₃)₂ (I). In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-Macrocycle Framework (MMF): Supramolecular Nano-Channel Surfaces with Shape Sorting Capability was written by Tashiro, Shohei;Kubota, Ryou;Shionoya, Mitsuhiko. And the article was included in Journal of the American Chemical Society in 2012.COA of Formula: C8H9ClO This article mentions the following:

Hollow nanostructures for the functional assembly of chem. groups with inner surface geometry and regulable stoichiometry enable steric design of interior reaction centers. Herein the authors report a metal-macrocycle framework (MMF) that forms single-crystalline nanochannels with five distinct enantiomeric pairs of guest binding pockets. During crystal-soaking experiments, the MMF crystals can encapsulate aromatic mols. with high site selectivity. First, constitutional isomers of dibromobenzene are captured and sorted into different binding pockets. Second, each of the optical isomers of (1R/1S)-1-(3-chlorophenyl)ethanol is included diastereoselectively into one of an enantiomeric pair of binding pockets. An advantage of this strategy is that the interior walls can be “repainted” via replacement of the trapped mols. with alternatives. Such guest uptake behaviors would allow highly regioselective or stereoselective reactions within the nanochannel. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cyclization Reaction of 4-Acyl-1-sulfonyl-1,2,3-triazoles Possessing Phenyl Rings through Generation of Electron-deficient Carbenoids was written by Zhao, Qiang;Miura, Tomoya;Murakami, Masahiro. And the article was included in Chemistry Letters in 2019.SDS of cas: 2968-93-6 This article mentions the following:

A rhodium-catalyzed cyclization reaction of 4-acyl-1-sulfonyl-1,2,3-triazoles was reported for the synthesis of 2-indanone derivatives such as I [R = H, 5-Me, 6-OMe, etc. ; R¹ = Ms, Ts; R² = H, Ph, (CH₂)₂Ph]. Generated acceptor/acceptor carbenoids underwent cyclization by reacting either with a Ph ring through electrophilic aromatic substitution or with a benzylic C-H bond through insertion depending on the length of the carbon chain. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Natural cellulose fibers from Quinoa wastes reinforced carbon nanotube/ZnO bio-nanocomposite as a novel recyclable catalyst for oxidation reaction was written by Naeimi, Atena;Khoshkam, Sibgol;Eslaminejad, Touba. And the article was included in Polymer Bulletin (Heidelberg, Germany) in 2022.Electric Literature of C7H7ClO This article mentions the following:

Cellulose fibers from Quinoa wastes were successfully incorporated with multi-walled carbon nanotubes/ZnO (MWCNTs/ZnO). Manganese complex was supported on natural cellulose and reacted with MWCNT/Zn bio-nanocomposite to have MWCNT/ZnO/Mn complex@oxidized cellulose. This novel bio-nanocomposite was characterized by SEM, TEM, FT-IR, TGA, and EDS. The catalytic activity of this composite was considered on the oxidation of alcs. High conversion and selectivities of desired aldehyde and ketone products were obtained applying H2O2 and under solvent-free conditions. This heterogeneous catalyst was easily recycled and reused eight times without any significant catalytic activities and stabilities. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Electric Literature of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Essential oils nano-emulsion confers resistance against Penicillium digitatum in primeNewhallprime navel orange by promoting phenylpropanoid metabolism was written by Yang, Ruopeng;Miao, Jinyu;Chen, Xiu;Chen, Chuying;Simal-Gandara, Jesus;Chen, Jinyin;Wan, Chunpeng. And the article was included in Industrial Crops and Products in 2022.Recommanded Product: 5-Isopropyl-2-methylphenol This article mentions the following:

Inducing natural resistance against pathogen infection in postharvest citrus by exogenous elicitor is a promising alternative to reduce postharvest losses. Here, the potential induced resistance mechanism of blended cinnamaldehyde, carvacrol and eugenol nano-emulsion against P. digitatum in primeNewhallprime navel orange (Citrus sinensis (L.) Osbeck) was evaluated through combined transcriptomic and metabolomics anal. Application of nano-emulsion maintained fruit firmness after P. digitatum inoculation, nano-emulsion reduced H₂O₂ and MDA accumulation of citrus fruit, increased PAL, C4H, 4CL and CAD activity, and higher contents of flavonoids, lignin and total phenolic compounds Furthermore, higher activities of SOD, CAT, POD and APX in nano-emulsion treated fruit possibly benefited reducing ROS accumulation and lipid peroxidation The activities of the defense enzymes CHI, GLU were higher in the nano-emulsion treated fruits. RNA-seq identified 653 differentially expressed genes (DEGs) between the control and the nano-emulsion-treated fruit at 48 hpi, including 444 up-regulated and 209 downregulated genes. Genes encoding shikimate O-hydroxycinnamoyltransferase (HCT), caffeoyl-CoA O-methyltransferase (CCoAOMT), caffeic acid 3-O-methyltransferase / acetylserotonin O-methyltransferase (COMT), cinnamyl-alc. dehydrogenase (CAD) and peroxidase (POD) were differentially expressed by nano-emulsion treatment. In addition, 175 differential accumulated metabolites between the control and the nano-emulsion-treated fruit at 48 hpi also were identified, the different accumulated metabolites from phenylpropanoid biosynthesis pathway related with disease resistance including -phenylalanine, caffeic acid, caffeoyl quinic acid, coniferyl alc., coniferaldehyde. The integrated transcriptomic and metabolomic profiling indicated that the differentially expressed genes (DEGs) and the differentially accumulated metabolites (DAMs) were mainly involved in phenylpropanoid biosynthesis pathway. Besides, the nano-emulsion significantly induced accumulation of primary metabolites including amino acids, soluble sugars, organic acids, lipids, sugar and alcs. All these results indicated that blended essential oil nano-emulsion as an antifungal delivery system to induce resistance against P. digitatum infection of ‘Newhall ‘ navel orange by promoting phenylpropanoid metabolism In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Recommanded Product: 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electro organic synthesis as green and sustainable approach for synthesis of chloro substituted benzyl alcohols was written by Saharan, Ritu. And the article was included in Journal of the Indian Chemical Society in 2022.Related Products of 1777-82-8 This article mentions the following:

A green and sustainable approach for synthesis of chloro substituted benzyl alcs. has been established. In present research paper cyclic voltammetry study followed by constant current electrolysis and characterization of synthesized 2-chlorobenzyl alc., 3-chlorobenzyl alc., 4-chlorobenzyl alc. and 2,4-dichlorobenzyl alc. has been reported. Cyclic voltammetry measurements have been employed to setup optimum conditions for electrolysis and to find out electrochem. nature of various Chloro substituted benzaldehydes. Then these results have been judiciary used to carry out electrochem. reduction of various chloro substituted benzaldehydes using constant current electrolysis. Influence of scan rate and pH on reduction peaks has also been investigated referring irreversible electron transfer phenomenon in basic medium. The kinetic parameters for reduction reactions have been estimated showing the process under the influence of diffusion control. This has a scientific achievement in terms of the obtained products and their derivatives which are industrially and pharmaceutically significant chems. owing to their huge applications in petrochem. industries and medical sectors. Throat lozenges containing dichlorobenzyl alc. (DCBA) are used for treatment of respiratory tract infections. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Related Products of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization and identification of pork flavor compounds and their precursors in Chinese indigenous pig breeds by volatile profiling and multivariate analysis was written by Wu, Weida;Zhan, Junliang;Tang, Xiaoyan;Li, Ting;Duan, Shengnan. And the article was included in Food Chemistry in 2022.Reference of 3391-86-4 This article mentions the following:

Chinese indigenous pigs are favored for their rich flavor, which is generated through complex reactions involving lipid-oxidation-related flavor precursors. In this research, we characterized the aroma compounds and fatty acids of representative Chinese pig breeds by gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and GC-ion mobility spectrometry (GC-IMS) with multivariate anal. A total of 79 volatile compounds were identified, among which 15 compounds were selected as odorants in pork. According to multivariate statistical anal., some odorants, including hexanal, 1-octen-3-ol, 2,3-octanedione, (E, E)-2,4-decadienal and dodecanal could be discriminative compounds explaining breed-originated differences in flavor profiles. As confirmed by partial least squares regression (PLS-R), some fatty acids, including C18:1n9c, C22:6n3 and C18:3n3, were major precursors for the formation of rich flavor in indigenous pig breeds. These results revealed that fatty acids and volatile compounds were breed-dependent, and the differences in flavor were related to the variance in the fatty acid content. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Reference of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric Hydrogenation of Ketones and Enones with Chiral Lewis Base Derived Frustrated Lewis Pairs was written by Gao, Bochao;Feng, Xiangqing;Meng, Wei;Du, Haifeng. And the article was included in Angewandte Chemie, International Edition in 2020.SDS of cas: 120121-01-9 This article mentions the following:

The concept of frustrated Lewis pairs (FLPs) has been widely applied in various research areas, and metal-free hydrogenation undoubtedly belongs to the most significant and successful ones. In the past decade, great efforts have been devoted to the synthesis of chiral boron Lewis acids. In a sharp contrast, chiral Lewis base derived FLPs have rarely been disclosed for the asym. hydrogenation. In this work, a novel type of chiral FLP was developed by simple combination of chiral oxazoline Lewis bases with achiral boron Lewis acids, thus providing a promising new direction for the development of chiral FLPs in the future. These chiral FLPs proved to be highly effective for the asym. hydrogenation of ketones, enones, and chromones, giving the corresponding products in high yields with up to 95% ee. Mechanistic studies suggest that the hydrogen transfer to simple ketones likely proceeds in a concerted manner. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9SDS of cas: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts