Tag: 100-200

Optimization of the production of local cheese from cow milk processed with the seed of Moringa oleifera was written by Adesina, Adedeji R.;Ogunmoyela, Olugbenga A. B.;Arisa, Ngozi U.;Ololade, Zacchaeus S.. And the article was included in Journal of Food Processing and Preservation in 2022.Category: alcohols-buliding-blocks This article mentions the following:

This study was carried out to optimize the production process and assess the quality parameters and shelf life of cheese product obtained from cow′s milk using Moringa oleifera seeds extract as a coagulant. Optimum processing conditions were determined using response surface methodol. (RSM). The optimum conditions established showed 1.5% concentration of M. oleifera seed extract and 55°C coagulation temperature Cheese made was subjected to physicochem., sensory, and microbiol. analyses and compared with cheese produced using Calotropis procera extract as a coagulant (CPC1). Shelf life studies were carried out by subjecting them to storage at ambient and refrigeration temperatures for 10 days. Results showed that cheese produced using M. oleifera seed extract as a coagulant (MOC) had the highest protein and fat contents of 28.14% and 17.68%, resp. The sensory attributes were improved and it had the longest shelf life of 8 days at ambient temperature (28 ± 2°C). This study showed that optimization of the cheese production resulted in cheese with better proximate characteristics, sensory attributes, and longer shelf stability. Novelty impact statement : This research showed that Moringa oleifera seeds extract has better coagulating and antioxidant properties when compared with the conventional extract (Calotropis procera) used in the production of local cheese. The cheese produced with the former had a better yield, proximate characteristics, sensory attributes, and longer shelf stability. Basically, the preservative ability of this natural extract is very commendable as it does not have any side effects unlike other synthetic preservatives used in dairy products and is also readily available. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

1,2-Silylpyridylation Reaction of Aryl Alkenes with Silylboronate was written by Gao, Liuzhou;Liu, Xueting;Li, Guoao;Chen, Shengda;Cao, Jia;Wang, Guoqiang;Li, Shuhua. And the article was included in Organic Letters in 2022.Synthetic Route of C10H20O This article mentions the following:

A metal-free silyl-pyridylation of alkenes using silyl boronates and B₂pin₂ through a pyridine-mediated B-interelement activation was demonstrated, which provides a practical strategy for a variety of C₄-silylalkylated pyridines. DFT calculations and control experiments show that the reaction proceeds through a silyl radical addition/radical-radical coupling sequence. This protocol features a broad substrate scope and excellent functional group compatibility, and thus it showcases great potential in the late-stage modification of bioactive mols. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pharmacokinetic parameters explain the therapeutic activity of antimicrobial agents in a silkworm infection model was written by Paudel, Atmika;Panthee, Suresh;Urai, Makoto;Hamamoto, Hiroshi;Ohwada, Tomohiko;Sekimizu, Kazuhisa. And the article was included in Scientific Reports in 2018.Application of 1777-82-8 This article mentions the following:

Poor pharmacokinetic parameters are a major reason for the lack of therapeutic activity of some drug candidates. Determining the pharmacokinetic parameters of drug candidates at an early stage of development requires an inexpensive animal model with few associated ethical issues. In this study, we used the silkworm infection model to perform structure-activity relationship studies of an antimicrobial agent, GPI0039, a novel nitrofuran dichloro-benzyl ester, and successfully identified compound 5, a nitrothiophene dichloro-benzyl ester, as a potent antimicrobial agent with superior therapeutic activity in the silkworm infection model. Further, we compared the pharmacokinetic parameters of compound 5 with a nitrothiophene benzyl ester lacking chlorine, compound 7, that exerted similar antimicrobial activity but had less therapeutic activity in silkworms, and examined the metabolism of these antimicrobial agents in human liver fractions in vitro. Compound 5 had appropriate pharmacokinetic parameters, such as an adequate half-life, slow clearance, large area under the curve, low volume of distribution, and long mean residence time, compared with compound 7, and was slowly metabolized by human liver fractions. These findings suggest that the therapeutic effectiveness of an antimicrobial agent in the silkworms reflects appropriate pharmacokinetic properties. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Application of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of porous polymers by means of Michael addition reaction of multifunctional acetoacetate and poly(ethylene glycol) diacrylate was written by Naga, Naofumi;Satoh, Mitsusuke;Magara, Tomoyuki;Ahmed, Kumkum;Nakano, Tamaki. And the article was included in European Polymer Journal in 2022.Application of 149-32-6 This article mentions the following:

Michael-addition reaction between multifunctional-acetoacetate, meso-erythritol tetra-acetoacetate (ETAA) or d-sorbitol hexa-acetoacetate (SHAA), and poly(ethylene glycol) diacrylate (PEGDA) has been investigated to obtain the corresponding network polymer. The reactions in mixtures of ethanol (EtOH) and DMSO (DMSO) using 1,8-diazabicyclo[5.4.0]undecane-7-ene (DBU) as a catalyst successfully yielded porous polymers. Polymerization conditions, such as EtOH/DMSO volume ratio, DBU/PEGDA feed ratio, and monomer concentration, strongly affected the morphol. of the network polymer products, i.e., gel, porous polymer, or precipitate The surface morphol. of the porous polymers showed connected spheres with diameters ranged from 2μm to 50μm. The monomer concentration and molar mass of PEGDA affected the diameter of the spheres in the porous polymers. All the porous polymers were soft and flexible, and were not breakable by compression. Various solvents were absorbed into the porous polymer due to their high affinity with polyethylene glycol units in the network structure. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Application of 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Improvement of environmental stress cracking performance, load-carrying capacity, and UV light barrier property of polyethylene terephthalate packaging material was written by Inaner, Nihat Burhan;Demirel, Bilal;Yaras, Ali;Akkurt, Fatih;Daver, Fugen. And the article was included in Polymers for Advanced Technologies in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

This study deals with the improvement of light barrier properties and stress cracking strength of polyethylene terephthalate (PET) packaging materials by incorporating calcium metaborate (CaB₂O₄). CaB₂O₄ powders were synthesized by the sol-gel method. After the extrusion process produced PET/ CaB₂O₄ granules, the preform and bottle production was carried out by injection molding and blow molding. Compared to pure PET, UV transmittance is reduced (∼88%), and it is more effective at lower wavelengths (<800 nm). Similarly, the presence of CaB₂O₄ improved the environmental stress cracking performance of PET packaging materials. While the burst strength increased in the range of 0.05%-0.2% CaB₂O₄ concentration, it decreased at higher concentrations The load-carrying capacity is approx. 109% higher than pure PET. Acetic acid (COOH) degradation increased with the incorporation of CaB₂O₄ particles, while isophthalic acid and diethylene glycol degradations did not change. The exptl. data indicate that the photocatalytic degradation of the PET bottle is prevented significantly, and its mech. performance is also improved with the incorporation of CaB₂O₄. Thanks to this novel product, the quality of food and beverages in PET packaging materials can be protected from the harmful effects of light, and the deformation of PET packaging materials can be prevented for various reasons. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols was written by Drouet, Fleur;Noisier, Anais F. M.;Harris, Craig S.;Furkert, Daniel P.;Brimble, Margaret A.. And the article was included in European Journal of Organic Chemistry in 2014.HPLC of Formula: 220227-37-2 This article mentions the following:

Due to their numerous applications, fluorinated amino acids have recently attracted significant attention. The preparation of fluorine-containing phenylalanines and aliphatic fluorinated amino acids using Mitsunobu-Tsunoda alkylation of a chiral nucleophilic glycine equivalent with readily available alc. substrates is described. The reaction proceeds in high yields and with excellent diastereoselectivity. This method provides an efficient synthetic route to fluorinated amino acids for which asym. approaches are scarce. In the experiment, the researchers used many compounds, for example, (3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2HPLC of Formula: 220227-37-2).

(3,4,5-Trifluorophenyl)methanol (cas: 220227-37-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 220227-37-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Accelerated Decomposition of Potassium Permanganate in Ferrocenium Ion as Ferrocenium-Doped Manganese(IV) Oxide for Selective Oxidation of Alcohols was written by Chumkaeo, Peerapong;Poonsawat, Thinnaphat;Yunita, Isti;Temnuch, Natcha;Meechai, Titiya;Kumpan, Nuttapong;Khamthip, Achjana;Chuaitammakit, Laksamee Chaicharoenwimolkul;Chairam, Sanoe;Somsook, Ekasith. And the article was included in Synlett in 2022.HPLC of Formula: 873-76-7 This article mentions the following:

Ferrocenium-doped manganese(IV) oxide (Fc⁺/MnO₂) was synthesized through accelerated decomposition of KMnO₄ in the presence of ferrocenium ion (Fc⁺) generated by concentrated sulfuric acid. The corresponding catalysts enabled highly efficient oxidation of alcs. with aldehyde or ketone. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7HPLC of Formula: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selenium-Electrocatalytic Cyclization of 2-Vinylanilides towards Indoles of Peptide Labeling was written by Zeng, Shaogao;Fang, Songlin;Cai, Haiping;Wang, Dong;Liu, Weiliang;Hu, Xinwei;Sun, Pinghua;Ruan, Zhixiong. And the article was included in Chemistry – An Asian Journal in 2022.Computed Properties of C10H20O This article mentions the following:

A novel selenium-electrocatalytic intramol. cyclization of 2-vinylanilides for synthesis of functionalized indoles and azaindoles was developed. In contrast to the previous synthetic methods, this sustainable protocol enabled unparalleled broad substrates scope for viable indoles with highly functional and sensitive groups by employing recyclable selenium catalyst, under mild, metal- and external-oxidant-free conditions. The approach was used to the late-stage modification of complex bioactive mol. system, thereby setting the stage for versatile syntheses of decorated indoles with peptide labeling. A plausible catalytic pathway were proposed. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Computed Properties of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Computed Properties of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eucalyptus brevifolia F. Muell and Eucalyptus stricklandii Maiden leaves extracts: HPLC-DAD, GC-MS analysis and in vitro biological activities, combined with the principal component analysis was written by Hassine, Dorsaf Ben;Rahmani, Rami;Souchard, Jean Pierre;Abderrabba, Manef;Bouajila, Jalloul. And the article was included in South African Journal of Botany in 2022.Product Details of 149-32-6 This article mentions the following:

Natural products always have been relevant for the advancement of new pharmacol. products intended to prevent oxidative stress and many diseases since ancient times. Herein, the chem. composition was investigated via chromatog. anal. of varying polarity solvents (petroleum ether, Et acetate, methanol and distilled water) from Tunisian Eucalyptus brevifolia F.M and Eucalyptus stricklandii M. leaves. In vitro provision of biol. activities through their antioxidant power (ABTS.⁺), ability to inhibit 15-lipoxygenase (15-LOX), acetylcholinesterase (AChE), xanthine oxidase (XOD), as well as, cytotoxic potency were undertaken. Chem. profiling showed that the methanolic extracts of both species were the richest in total phenolic compounds GC-MS anal. of the two Eucalyptus species revealed that spathulenol, globulol, epiglobulol, and trans-Z-alpha-bisabolene-epoxide were the main volatile compounds detected in the different extracts In addition, the derivatization procedure allowed the identification of ethylene glycol, and D-fructofuranose as very abundant mols. The HPLC-DAD has enabled the identification of eight new mols. among them icariin (1.1 mg/g dr), and 5-hydroxy-3prime-methoxyflavone (7.5 mg/g dr) in the E. stricklandii MeOH and EtOAc extracts Aqueous E. brevifolia extract possessed the highest anti-AChE with an IC₅₀ (10 mug/mL). Whereas, the MeOH E. stricklandii extract possessed the highest anti 15-LOX with an IC₅₀ (9.7 mug/mL), as well as, the most important percentage of XOD inhibition 51.1%. All extracts revealed an antiproliferative potency against human cancer cell lines HCT-116, MCF-7 and OVCAR, with an inhibition percentage up to 96%. Taken together, both Eucalyptus species have a broad range of potential applications in several fields, such pharmaceutical, medical and food industries as nutraceutical supplements. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Product Details of 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1 was written by Akselsen, Oyvind W.;Odlo, Kristin;Cheng, Jing-Jy;Maccari, Giorgio;Botta, Maurizio;Hansen, Trond Vidar. And the article was included in Bioorganic & Medicinal Chemistry in 2012.Quality Control of Benzo[d][1,3]dioxol-4-ol This article mentions the following:

The synthesis, cytotoxicity, inhibition of tubulin polymerization data and anti-angiogenetic effects of seven 1,5-disubstituted 1,2,3-triazole analogs and two 1,4-disubstituted 1,2,3-triazole analogs of combretastatin A-1 are reported herein. The biol. studies revealed that the 1,5-disubstituted 1,2,3-triazoles 3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzene-1,2-diol, 3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazol-5-yl)benzene-1,2-diamine and 5-(2,3-difluoro-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-1,2,3-triazole were the three most active compounds regarding inhibition of both tubulin polymerization and angiogenesis. Mol. modeling studies revealed that combretastatins A-1 and A-4 and analogs 5-11 could be successfully docked into the colchicine binding site of α,β-tubulin. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2Quality Control of Benzo[d][1,3]dioxol-4-ol).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Benzo[d][1,3]dioxol-4-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts