Tag: 100-200

Acid and light dual- stimuli-cleavable polymeric micelles was written by Fang, Jia-You;Lin, Yin-Ku;Wang, Shiu-Wei;Yu, Yung-Ching;Lee, Ren-Shen. And the article was included in Journal of Polymer Research in 2016.SDS of cas: 60463-12-9 This article mentions the following:

In this study, acid and light dual- stimuli-responsive amphiphilic AB-type methoxy poly(ethylene glycol)-acetal-ONB-poly(4-substituted-ε-caprolactone) (MPEG-a-ONB-PXCL) diblock copolymers were synthesized using ring-opening polymerization and nucleophilic substitution reactions. The prepared copolymer features an acid-cleavable acetal group and photocleavable o-nitrobenzyl linkage between the hydrophilic MPEG and hydrophobic PXCL blocks. The design enables the diblock copolymers to respond to both acid and UV light while ensuring the min. number of stimuli-reactive moieties in the copolymer structure. The disruption of the copolymeric micelles in aqueous solution was examined under the action of pH or UV light alone or under the combined stimulation pH and UV light. Under the combined stimulation of UV irradiation and pH, the micellar nanoparticles could dissociate; therefore, the loaded mols. could be released from the assemblies more efficiently than under either stimulus alone. The nanoparticles exhibited nonsignificant toxicity against human cervical cancer (HeLa) cells at concentrations ≤300 μg mL^-1. Doxorubicin (DOX)-loaded micelles facilitated the uptake of DOX by the HeLa cells at the initial stage. The dual stimuli-cleavable polymeric micelles show promising potential as new nanocarrier for precisely controlled release of encapsulated drug. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9SDS of cas: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective Difunctionalization of Unactivated Aliphatic Alkenes Enabled by a Metal-Metallaaromatic Catalytic System was written by Cui, Fei-Hu;Hua, Yuhui;Lin, Yu-Mei;Fei, Jiawei;Gao, Le-Han;Zhao, Xiaodan;Xia, Haiping. And the article was included in Journal of the American Chemical Society in 2022.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

The design of organometallic catalysts is crucial in the development of catalytic reactions. Herein, the authors describe a heterometallic [Os-Cu] complex with the characteristics of bimetallics, metallaaroms. and pincer complexes. This complex serves as a highly effective catalyst for selective amino- and oxyselenation of unactivated alkenes. More than 80 examples including challenging substrates of unsym. aliphatic alkenes and amine-based nucleophiles in such reactions are provided. These reactions produce 1,2-difunctionalized products with good yields and high levels of chemo-, regio- and stereoselectivity. The study revealed that (i) the usually inert Os center activates the N- or O-centered nucleophiles, (ii) the Cu-Os bonding and its cooperative effects play essential roles in control the selectivity by bringing the reaction components into close proximity, and (iii) the metallaarom. moiety helps to stabilize the intermediate. These findings provide a versatile platform for catalyst design based on metal-metallaarom. cooperative effects that were not attained previously with bimetallic complexes. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of Functionally Selective 7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazines as GABA_A Receptor Agonists at the α₃ Subunit was written by Russell, Michael G. N.;Carling, Robert W.;Atack, John R.;Bromidge, Frances A.;Cook, Susan M.;Hunt, Peter;Isted, Catherine;Lucas, Matt;McKernan, Ruth M.;Mitchinson, Andrew;Moore, Kevin W.;Narquizian, Robert;Macaulay, Alison J.;Thomas, David;Thompson, Sally-Anne;Wafford, Keith A.;Castro, Jose L.. And the article was included in Journal of Medicinal Chemistry in 2005.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

7,8,9,10-Tetrahydro-7,10-ethano-1,2,4-triazolo[3,4-a]phthalazine I (R¹ = Ph; R² = 2-pyridylmethyl) was previously identified as a potent partial agonist for the α₃ receptor subtype with 5-fold selectivity in binding affinity over α₁. This paper describes a detailed investigation of the substituents on this core structure at both the 3- and 6-positions. Despite evaluating a wide range of groups, the maximum selectivity that could be achieved in terms of affinity for the α₃ subtype over the α₁ subtype was 12-fold (for I [R¹ = Ph; R² = 4-(HOCH₂)C₆H₄CH₂]). Although most analogs showed no selectivity in terms of efficacy, some of them, e.g. I (R¹ = Ph; R² = 3,5-dimethyl-2-pyridylmethyl, pyrazol-1-ylmethyl), did show partial agonism at α₁ and antagonism at α₃. However, two analogs I (R¹ = Ph; R² = 1-methyl-1,2,4-triazol-3-ylmethyl, 2-propyl-1,2,4-triazol-3-ylmethyl), containing triazole substituents in the 6-position, showed significantly higher efficacy for the α₃ subtype over the α₁ subtype. This was the first indication that selectivity in efficacy in the required direction could be achieved in this series. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

AuPt NPs with enhanced electrochemical oxidization activity for ratiometric electrochemical aptasensor was written by Zhao, Yuan;Yao, Jie;Wu, Zhenglong;Liu, Han;Zheng, Wangwang. And the article was included in Biosensors & Bioelectronics in 2022.COA of Formula: C4H10O3 This article mentions the following:

Strong and stable electrochem. beacons are critical for the achievement of sensitive and reliable electroanal. applications. In this work, the electrochem. oxidation performance of AuPt NPs was studied and firstly found to be largely enhanced under light illumination. Plasmonic AuPt NPs collected light energy after local surface plasmon resonance (LSPR) excitation and generated much more holes to participate in the electrochem. oxidation process of Pt0 in AuPt NPs. AuPt NPs with the electrochem. oxidation peak at around -0.7 V were utilized as detection probes for the fabrication of ratiometric electrochem. aptasensor, by introducing Co-MOF/Fe3O4/Ag nanosheets (NSs) with the electrochem. oxidation peak at 0.1 V as reference beacons. The aptamers of epithelial cell adhesion mol. (EpCAM) modified AuPt NPs were assembled with Co-MOF/Fe3O4/Ag NSs, which generated strong detection and reference signals at -0.7 V and 0.1 V, resp. The high affinity between EpCAM and aptamers induced the separation of AuPt NPs from Co-MOF/Fe3O4/Ag NSs, resulting in the decrease of detection signal at -0.7 V and unchanged reference signal at 0.1 V. A ratiometric electrochem. aptasensor was achieved for the sensitive and reliable quantification of EpCAM in the range from 100 pg/mL to 100 ng/mL. The limit of detection (LOD) was calculated to be 13.8 pg/mL for EpCAM. Plasmon-driven electrochem. oxidation enhancement principle provides the possibility for the design and fabrication of more strong and anti-interference electroactive plasmonic metal-Pt composite nanostructures for the electroanal. applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6COA of Formula: C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Convenient and Stable Heterogeneous Nickel Catalyst for Hydrodehalogenation of Aryl Halides Using Molecular Hydrogen was written by Leonard, David K.;Ryabchuk, Pavel;Anwar, Muhammad;Dastgir, Sarim;Junge, Kathrin;Beller, Matthias. And the article was included in ChemSusChem in 2022.Category: alcohols-buliding-blocks This article mentions the following:

In this study, a nickel-based catalyst supported on titania (Ni-phen@TiO₂-800) was prepared and used as a safe alternative to pyrophoric Raney-nickel. The catalyst was prepared in a straightforward fashion by deposition of nickel(II)/1,10-phenanthroline on titania, followed by pyrolysis. The catalytic material, which was characterized by SEM, TEM, XRD and XPS, consisted of nickel nanoparticles covered with N-doped carbon layers. By using design of experiments (DoE), this nanostructured catalyst was found to be proficient for the facile and selective hydrodehalogenation of a diverse range of substrates bearing C-I, C-Br, or C-Cl bonds afforded aromatic hydrocarbons R-H [R = 1-naphthyl, 4-H₂NC₆H₄, 4-CO₂MeC₆H₄, etc.] (>30 examples). The practicality of this catalyst system was demonstrated by the dehalogenation of environmentally hazardous and polyhalogenated substrates atrazine, tetrabromobisphenol A, tetrachlorobenzene and a polybrominated di-Ph ether (PBDE). In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Halloysite-Based Nanomotors with Embedded Palladium Nanoparticles for Selective Benzyl Alcohol Oxidation was written by Wang, Jian;Zhang, Yan;Xu, Yang;Zhang, Peiping;Gao, Qian;Liang, Qing;Zhang, Wei;Li, Wenqing;Guo, Ruifeng;Jin, Bo;Miao, Shiding. And the article was included in ACS Applied Nano Materials in 2022.Product Details of 873-76-7 This article mentions the following:

Palladium (Pd) nanoparticles were impregnated in lumens of halloysite nanotubes by using ionic liquid (1-(2′-hydroxylethyl)-2,3-dimethylimidazolium chloride) as directing agents. On the basis of the asym. scroll-like structure of halloysite and the catalytic decomposition ability of Pd toward H₂O₂, the prepared catalyst (Pd-IL-HNTs) exhibited powerful self-propelled movement at an average speed of 276 ± 35μm/s in 30.0 wt % H₂O₂ solution The specific interaction between nanomotors and benzyl alc. was observed as a consequence of self-moving behavior and hydrophobic interaction introduced by ionic liquid With the synergistic coupling of the catalytic ability and powerful movement, Pd-IL-HNTs displayed outstanding catalytic benzyl alc. oxidation performance. Compared to other nonpropelling catalysts using lamellar clay (montmorillonite and kaolinite) as supports, such HNT-based nanomotors registered superior catalytic performance, and the TOF value of 118.1 h^-1 was obtained. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Product Details of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oregano essential oil showed limited effects on pigs carcass quality and haematology whereas a transcriptome analysis revealed significant modulations in the jejunum and the ileum was written by Hofmann, Haiko Hendrik;Heusler, Katharina;Roth, Katharina;Proll-Cornelissen, Maren Julia;Grosse-Brinkhaus, Christine;Schellander, Karl;Neuhoff, Christiane. And the article was included in Journal of Animal Physiology and Animal Nutrition in 2022.Computed Properties of C10H14O This article mentions the following:

Pig production depends on a health and performance balance. An approach to improve intestinal health is the oregano essential oil (OEO) supplementation within a conventional diet. Intestinal integrity regulating effects, for example gene expression, of some feed ingredients are important key factors for that balance. We hypothesized that OEO affects the expression of genes associated with pigs intestinal integrity. In four trials, a total of 86 pigs have been used. From weaning, the treated group (n = 42) was addnl. fed an oregano flavor additive [1500 mg/kg (7.5% pure OEO)] within the basal diet. The control group (n = 44) was kept under identical environmental conditions, except the OEO. At age of 6 mo, pigs were slaughtered with an average weight of 111.1 ± 10.9 kg. In addition to automatically generated Fat-o-Meter (AutoFOM) data, carcass quality factors have been measured manually. Valuable cuts of meat, such as ham and belly, were significantly reduced in the OEO group. Effects of OEO on pigs haematol. parameters were very limited. For transcriptome anal., the most interesting microarray expression results have been listed in a table (topTable). Selected genes were tech. validated by qPCR. As a result, few significant differences in animal development and meat quality have been found between the OEO treated and the control group. Depending on OEO supplementation, we found 93 differently regulated genes in the jejunal tissue (70 up, 23 down) and 60 in the ileal tissue (48 up, 12 down). Just three genes (GRIN3B [glutamate ionotropic receptor NMDA type subunit 3B], TJP1/ZO-1 [tight junction protein ZO-1] and one uncharacterized gene) were affected by OEO both in jejunum and ileum. qPCR validation revealed AKT serine/threonine kinase 3 (AKT3), Interferon (IFN) -ε, -ω, tight junction protein (TJP1)/ZO-1 (ZO-1) to be upregulated in the jejunum and C-C motif chemokine ligand 21 (CCL21) was upregulated in the ileum of pigs that were supplemented with OEO. OEO supplementation had limited effects on pigs performance traits. However, we were able to demonstrate that OEO alters the expression of genes associated with adaptive immune response in pigs small intestine. These findings help to explain OEOs beneficial impact on pigs intestinal integrity. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Computed Properties of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C10H14O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cobalt-catalysed CH-alkylation of indoles with alcohols by borrowing hydrogen methodology was written by Zhou, Bei;Ma, Zhuang;Alenad, Asma M.;Kreyenschulte, Carsten;Bartling, Stephan;Beller, Matthias;Jagadeesh, Rajenahally V.. And the article was included in Green Chemistry in 2022.Computed Properties of C7H9NO This article mentions the following:

A general heterogeneous cobalt-catalyzed CH-alkylation of indoles with alcs. was reported. Utilizing this straightforward borrowing hydrogen methodol., a series of substituted and functionalized indoles were easily coupled with benzylic, heterocyclic, and aliphatic alcs. including methanol to prepare >65 substituted indoles in good to excellent yields. The resulting products represented an interesting class of heterocyclic compounds widely used in organic synthesis and medicinal chem. Key for this synthesis was the use of specific cobalt-nanoparticles supported on N-doped carbon, which were conveniently prepared by the pyrolysis of a templated material generated in-situ by mixing cobalt-nitrate, zinc-nitrate, 2,6-diaminopyridine, and colloidal silica, and subsequent removal of silica. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Computed Properties of C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

One-pot transformation of alkynes into alcohols and amines with formic acid was written by Li, Jia;Wang, Chao;Xue, Dong;Wei, Yawen;Xiao, Jianliang. And the article was included in Green Chemistry in 2013.Recommanded Product: 120121-01-9 This article mentions the following:

Alkynes are converted into alcs. and amines through a formic acid-participated alkyne-to-ketone transformation and transfer hydrogenation process. The reaction proceeds well under aqueous conditions, furnishing chiral alcs. directly from alkynes. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rhodium-Catalyzed Atroposelective Click Cycloaddition of Azides and Alkynes was written by Zeng, Linwei;Li, Jiaming;Cui, Sunliang. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 111-46-6 This article mentions the following:

Herein, a rhodium-catalyzed enantioselective click cycloaddition of azides R¹N₃ (R¹ = benzyl, 2-naphthyl, pyridin-3-yl, etc.) and alkynes R³CCR² (R² = Ph, 2-naphthyl, cyclopropyl, etc.; R³ = 2-hydroxynaphthalen-1-yl, 6-bromo-2-hydroxynaphthalen-1-yl, 6-hydroxyquinolin-5-yl, etc.) for rapid and modular access to atropisomeric triazoles I in excellent yields and enantioselectivities was reported. The process is mild, efficient and scalable, and features broad substrate scope. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts