Tag: 100-200

Catalytic β C-H amination via an imidate radical relay was written by Stateman, Leah M.;Wappes, Ethan A.;Nakafuku, Kohki M.;Edwards, Kara M.;Nagib, David A.. And the article was included in Chemical Science in 2019.SDS of cas: 94022-96-5 This article mentions the following:

The first catalytic strategy to harness imidate radicals for C-H functionalization has been developed. This iodine-catalyzed approach enables β C-H amination of alcs. e.g., 4-trichloroacetamidyl cholesterol by an imidate-mediated radical relay. In contrast to the first-generation, (super)stoichiometric protocol, this catalytic method enables faster and more efficient reactivity. Furthermore, lower oxidant concentration affords broader functional group tolerance, including alkenes (6-methyl-5-hepten-2-one, 3,7-dimethyl-2,6-octadienol), alkynes (isonicotinonitrile), alcs.(1-octanol), carbonyls (Me 2-(([(4-nitrobenzene)sulfonyl]oxy)amino)-3-phenylpropanoate) and heteroarenes (quinoline, benzofuran, benzo[b]thiophene, etc.). Mechanistic experiments interrogating the electronic nature of the key 1,5 H-atom transfer event are included, as well as probes for chemo-, regio-, and stereo-selectivity. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5SDS of cas: 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Basic carbapenem analogs: synthesis and in vitro activity of 1β-methyl-2-(pyridylmethylthio)-carbapenems was written by Balkovec, James M.;Szymonifka, Michael J.;Heck, James V.;Ratcliffe, Ronald W.. And the article was included in Journal of Antibiotics in 1991.Recommanded Product: 79651-64-2 This article mentions the following:

The title compounds I (R = pyridyl, aminopyridyl) were prepared and demonstrated more potent activity than thienamycin especially against Gram-neg. organisms. The structure-activity relationship of I is also reported. In the experiment, the researchers used many compounds, for example, (6-Aminopyridin-2-yl)methanol (cas: 79651-64-2Recommanded Product: 79651-64-2).

(6-Aminopyridin-2-yl)methanol (cas: 79651-64-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 79651-64-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel duodenal-release formulation of caraway oil and L-menthol is a safe, effective and well tolerated therapy for functional dyspepsia was written by Lacy, Brian E.;Chey, William D.;Epstein, Michael S.;Shah, Syed M.;Corsino, Patrick;Zeitzoff, Linda R.;Cash, Brooks D.. And the article was included in BMC Gastroenterology in 2022.Application of 2216-51-5 This article mentions the following:

A randomized, placebo-controlled clin. trial (FDREST) of a novel formulation of caraway oil and L-menthol (COLM-SST) demonstrated symptom relief in patients with functional dyspepsia (FD). Two follow-up studies were conducted to evaluate patient satisfaction, self-regulated dosing, and long-term safety data: FDACT, Functional Dyspepsia Adherence and Compliance Trial, and FDSU36, Functional Dyspepsia Safety Update at 36 mo. A patient reported outcomes (PRO) questionnaire was designed and distributed online to assess real-world satisfaction and dosing frequency of open-label COLM-SST in patients with FD. A sep. study analyzing voluntary safety surveillance data evaluated the frequency and severity of reported adverse events (AEs). A total of 600 FD patients were enrolled in the PRO study. Ninety five percent of respondents reported a major or moderate improvement in their FD symptoms and 91.7% indicated a major or moderate improvement in quality of life (QOL) using COLM-SST. Between 1 and 4 capsules were consumed daily by 91.2% of respondents, with 56.2% taking them before meals. Symptom relief was rapid, with 86.4% of respondents indicating relief within 2 h of taking COLM-SST. Few adverse events (AEs) were reported (0.0187%) by patients using COLM-SST. No serious AEs were identified. Conclusion: COLM-SST is safe, well tolerated, and provides rapid relief of FD symptoms. These findings, demonstrated in the FDREST trial, were further supported by a large prospective PRO study evaluating self-regulated dosing frequency, symptom improvement, and QOL. COLM-SST was well-tolerated based on review of AE data at 36 mo. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application of 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Application of 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The ethanol-extracted polysaccharide from Cynanchum paniculatum: Optimization, structure, antioxidant and antitumor effects was written by Ji, Hai-yu;Dai, Ke-yao;Liu, Chao;Yu, Juan;Liu, An-jun;Chen, Ye-fu. And the article was included in Industrial Crops and Products in 2022.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Cynanchum paniculatum has been applied for various diseases treatments, however, the polysaccharide components especially extracted using ethanol were rarely researched. In this study, ethanol solution with volume fraction of 75% was used for C. paniculatum polysaccharide preparation, and the extraction process optimization, structural characteristics, and bioactivities anal. were investigated. These results showed that extraction yield reached to 4.79 ± 0.24% under extraction temperature of 60°C, extraction time of 4.5 h, liquid/solid ratio of 30 mL/g. Chem. constitutions and monosaccharide compositions, mol. weight determination results showed that the polysaccharide was mainly composed of glucose and xylose with a molar ratio of 1.00:0.63 (carbohydrate content of 94.91%, mol. weight of 5.1 kDa). Periodate oxidation, smith degradation, methylation, fourier transform IR spectra and NMR anal. demonstrated that the glycosidic bonds configurations were mainly comprised of (1→2)-α–Glcp (39.86%), (1→2,4)-α–Glcp (10.32%) and (1→4)-β–Xylp (29.58%). The bioactivities determination experiments results suggested that the polysaccharide exhibited strong antioxidant activities and antitumor effects both in vitro and in vivo. These data indicated that the ethanol-extracted polysaccharide from C. paniculatum holds great application prospect as a novel bioactive adjuvant in the future due to the feasibility of industrial production In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of Photocleavable Poly(styrene-block-ethylene oxide) and Its Self-Assembly into Nanoporous Thin Films was written by Kang, Minhyuck;Moon, Bongjin. And the article was included in Macromolecules (Washington, DC, United States) in 2009.Recommanded Product: 60463-12-9 This article mentions the following:

A selectively photocleavable PS-b-PEO block copolymer (ONB-(PS-b-PEO)) was synthesized by ATRP with a good control of mol. weight and polydispersity. The key in the design of this unique block copolymer was to incorporate a photocleavable linking unit, ONB, in the middle of the block copolymer. The facile photocleavage of ONB-(PS-b-PEO) was carried out by simple irradiation with long-wavelength UV light (350 nm) for several hours with low-power UV lamps (8 × 8 W, 5.3 mW/cm²) in both solution and thin films. Fabrication of nanoporous PS films was easily achieved using this block copolymer. We are aiming to exploit the utility of this polymer by taking advantage of the functionality inside the nanopores because COOH groups should be generated by ONB group cleavage. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Recommanded Product: 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ketals of L-rhamnoheptonolactones: potential mimics of L-rhamnose was written by Wheatley, Joseph R.;Beacham, Annable R.;Lilley, Paul M. de Q.;Watkin, David J.;Fleet, George W. J.. And the article was included in Tetrahedron: Asymmetry in 1994.Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

Isopropylidene and cyclohexylidene ketals of γ- and δ-heptonolactones derived from Kiliani ascensions of protected L-rhamnose. The x-ray crystal structure of 7-deoxy-3,4-O-isopropylidene-L-glycero-L-galacto-heptono-1,5-lactone provides an example of a δ-lactone in a boat conformation with a substituent in a flagpole position. The size of ring in the lactones is completely consistent with Hudson’s classical lactone rotation rule of 1910. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production of α-terpineol from α-pinene was written by Benkli, Kadriye;Isikdag, Ilhan;Baser, K. Husnu Can. And the article was included in Acta Pharmaceutica Turcica in 1995.Product Details of 2451-01-6 This article mentions the following:

α-Terpineol (I) is a monoterpenic alc. used as a fragrance material in the perfumery industry and for the production of some volatile compounds Several techniques have been described in the literature for its synthesis. These techniques recommend the conversion of olefinic terpenes to their hydrochlorides or esters with acids, followed by hydrolysis into the desired alc. This paper describes a method which involves hydration of α-pinene (II) to terpinhydrate which is then dehydrated to give I. Cation exchange resin was also used in an oxygen-free medium to obtain I in higher (73%) yield from II. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Product Details of 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mesoporous Mn-Se/Al₂O₃: A recyclable and reusable catalyst for selective oxidation of alcohols was written by Zeng, Yan;Chen, Tian;Zhang, Xu;Chen, Ying;Zhou, Hongwei;Yu, Lei. And the article was included in Applied Organometallic Chemistry in 2022.Application of 873-76-7 This article mentions the following:

Mesoporous Mn-Se/Al₂O₃ were easily fabricated by calcining the selenium sources with the manganese and aluminum hydroxides. It was an efficient catalyst for alc. oxidation using H₂O₂ as the clean oxidant, afforded carbonyls 58%-83% yields. The reaction of primary alcs. were produced aldehydes specifically, while no carboxylic acids were generated. The easily accessible features and low cost of Mn-Se/Al₂O₃ was endowed the material great potential in the industrial-scale applications. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Application of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nucleophilic addition of arylmethylzinc reagents (ArCH₂ZnCl) to formaldehyde: An easy access to 2-(hetero)arylethyl alcohols was written by Bhatt, V. P.;Samant, S. D.;Pednekar, Suhas. And the article was included in Synthetic Communications in 2017.Computed Properties of C9H9F3O This article mentions the following:

The nucleophilic addition of benzyl zinc reagents derived from inexpensive and abundant benzyl chlorides to paraformaldehyde was reported. The reaction investigated herein is hitherto unknown and was found to be selective, operationally simple, atom- and step-economical and high yielding to deliver phenethyl alcs. utilized as key perfumery ingredients in 60-83% yields. After successful establishment of the reaction condition, the reaction was also scaled up successfully to deliver a large-scale preparation of the phenethyl alc. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Computed Properties of C9H9F3O).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Computed Properties of C9H9F3O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-catalyzed electrochemical reductive relay cross-coupling of alkyl halides with alkyl carboxylic acids was written by Jiao, Ke-Jin;Ma, Cong;Liu, Dong;Qiu, Hui;Cheng, Bin;Mei, Tian-Sheng. And the article was included in Organic Chemistry Frontiers in 2021.Recommanded Product: 2968-93-6 This article mentions the following:

A highly regioselective Ni-catalyzed electrochem. (undivided cell) reductive relay cross-coupling between alkyl carboxylic acids and alkyl bromides was developed. This strategy allowed the direct acylation of benzylic C(sp³)-H bonds in good yields from com. available alkyl carboxylic acids, thus provided an alternative strategy for the synthesis of dialkyl ketones. Various functional groups were tolerated under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts