Tag: 100-200

Sources of fine organic aerosol. 4. Particulate abrasion products from leaf surfaces of urban plants was written by Rogge, Wolfgang F.;Hildemann, Lynn M.;Mazurek, Monica A.;Cass, Glen R.;Simoneit, Bernd R. T.. And the article was included in Environmental Science and Technology in 1993.Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Green and dead leaves from 62 plant species characteristic of the Los Angeles area were harvested and composited according to the actual leaf mass distribution for that area. To simulate leaf surface abrasion by the wind, the leaf composites were agitated in clean Teflon bags while a purified air stream flowed through. Fine particles (≤2 μm) shed from the leaf surfaces were extracted and analyzed using gas chromatog./mass spectrometry. Organic constituents including n-alkanes, n-alkanoic and n-alkenoic acids, n-alkanols, n-alkanals, terpenoid compounds, and trace amounts of PAH were identified and quantified. N-Alkanes showed similar concentrations in both dead and green leaf surface matter; mono-, sesqui-, and triterpenoids were depleted in dead leaf material while n-alkanoic acids were enriched in dead leaf abrasion products. It is shown that the higher mol. weight n-alkanes (C₂₇-C₃₃), with their pronounced odd/even C number predominance, provide a suitable marker compound assemblage for tracing vegetative detritus in the urban atm. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents was written by Miller, John F.;Turner, Elizabeth M.;Gudmundsson, Kristjan S.;Jenkinson, Stephen;Spaltenstein, Andrew;Thomson, Michael;Wheelan, Pat. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Application of 142253-56-3 This article mentions the following:

The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochem. optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar anti-HIV activity. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Application of 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 142253-56-3

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Alcohol – Wikipedia,
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SO₂F₂ mediated dehydrative cross-coupling of alcohols with electron-deficient olefins in DMSO using a Pd-catalyst: one-pot transformation of alcohols into 1,3-dienes was written by Lekkala, Revathi;Lekkala, Ravindar;Moku, Balakrishna;Qin, Hua-Li. And the article was included in Organic Chemistry Frontiers in 2019.COA of Formula: C9H9F3O This article mentions the following:

A Pd-catalyzed, SO₂F₂ mediated dehydrative cross-coupling reaction of alcs. with acrylates for the construction of 1,3-dienes I [Ar = Ph, 2-MeC₆H₄, 1-naphthyl, 2-thienyl, etc.; R = CO₂Me, CO₂Et, C(O)Et, etc.; stereo = E/E] was developed. The reaction proceeded efficiently under mild conditions and tolerated a wide range of functional groups. This new reaction provided a strategically distinct approach to highly valuable 1,3-diene derivatives from readily available and abundant alcs. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6COA of Formula: C9H9F3O).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.COA of Formula: C9H9F3O

Referemce:
Alcohol – Wikipedia,
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A Protic Mn(I) Complex Based on a Naphthyridine-N-oxide Scaffold: Protonation/Deprotonation Studies and Catalytic Applications for Alkylation of Ketones was written by Patra, Kamaless;Laskar, Roshayed Ali;Nath, Anubhav;Bera, Jitendra K.. And the article was included in Organometallics in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A Mn(I) complex (1) bearing a proton responsive hydroxy unit on 1,8-naphthyridine-N-oxide scaffold (L¹H) was synthesized. The mol. structure of 1 revealed the lactim form of the ligand. The corresponding deprotonated lactam complexes [18-C-6-K·2] and 3 were prepared and structurally characterized. The acid-base equilibrium between the lactim and lactam forms was studied by ¹H NMR and UV-visible spectra. The catalytic efficiency of 1 was evaluated by performing α-alkylation reaction of ketones with primary alcs. The scope of the α-alkylation reaction is broad in terms of both ketones and alcs. The efficacy of the protic catalyst is demonstrated in the alkylation of the bioactive steroids progesterone and pregnenolone. A controlled catalyst [Mn(L²)(CO)₃Br] (4), which is structurally similar to 1 but devoid of the proton responsive hydroxy unit, shows significantly reduced catalytic efficiency validating the crucial role of the hydroxy functionality in 1. Kinetic study, control reactions, and D labeling experiments were conducted to gain mechanistic insights. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

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Alcohol – Wikipedia,
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Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen was written by Ouyang, Yao;Xu, Xiu-Hua;Qing, Feng-Ling. And the article was included in Angewandte Chemie, International Edition in 2022.SDS of cas: 2216-51-5 This article mentions the following:

A conceptually new and operationally simple protocol for the direct C-H trifluoromethoxylation of (hetero)aromatics by the combination of the readily available trifluoromethylating reagent and oxygen under electrochem. reaction conditions was discussed. This reaction proceeded through the initial generation of CF₃ radical followed by conversion to CF₃O radical, addition to (hetero)aromatics and rearomatization. The utility of this electrochem. trifluoromethoxylation was illustrated by the direct incorporation of CF₃O group into a variety of (hetero)aromatics as well as bio-relevant mols. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 2216-51-5

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Alcohol – Wikipedia,
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A bagasse-supported magnetic manganese dioxide nanoparticle: applications in the selective aerobic oxidation of alcohols and one-pot tandem oxidative synthesis of quinazolinones was written by Rashidi Vahid, Adina;Hajishaabanha, Fatemeh;Shaabani, Shabnam;Farhid, Hassan;Shaabani, Ahmad. And the article was included in Journal of the Iranian Chemical Society in 2022.Computed Properties of C7H6Cl2O This article mentions the following:

Magnetic manganese dioxide nanoparticles (MnO₂-Fe₃O₄) were coated on sugarcane bagasse as a sugar industrial waste and bio-support (MnO₂-Fe₃O₄@bagasse) via an in situ reduction strategy, in which potassium permanganate was used as the precursor of MnO₂ and sugarcane bagasse as a bio-support and reducing agent of KMnO4. The synthesized bio-based catalyst was characterized by X-ray diffraction, thermogravimetric anal., inductively coupled plasma optical emission spectroscopy, SEM, energy dispersive spectroscopy, Brunauer-Emmett-Teller surface area anal., and vibrating sample magnetometer anal. The catalyst was successfully utilized in the selective aerobic oxidation of primary and secondary benzylic alcs. R¹CH(OH)R² (R¹ = Ph, 4-nitrophenyl, 2,4-dichlorophenyl, 3-phenylpropyl, etc.; R² = H, Me, Ph, 2-oxo-2-phenylethyl) to their corresponding carbonyl compounds R¹C(O)R² and one-pot tandem oxidative synthesis of 2-(substituted)quinazoline-4(3H)-ones I (R³ = Ph, 3-methoxyphenyl, 4-nitrophenyl, 2,4-dichlorophenyl, etc.) from the o-aminobenzamide and aromatic alcs. R³CH₂OH in the absence of oxidizing reagent or initiator. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C7H6Cl2O

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Alcohol – Wikipedia,
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Na⁺-Glucose Cotransporter (SGLT) Inhibitors as Antidiabetic Agents. 4. Synthesis and Pharmacological Properties of 4′-Dehydroxyphlorizin Derivatives Substituted on the B Ring was written by Tsujihara, Kenji;Hongu, Mitsuya;Saito, Kunio;Kawanishi, Hiroyuki;Kuriyama, Kayoko;Matsumoto, Mamoru;Oku, Akira;Ueta, Kiichiro;Tsuda, Minoru;Saito, Akira. And the article was included in Journal of Medicinal Chemistry in 1999.Synthetic Route of C9H10O3 This article mentions the following:

In the authors’ studies of Na⁺-glucose cotransporter (SGLT) inhibitors as antidiabetic agents, a series of novel 4′-dehydroxyphlorizin derivatives substituted on the B ring was prepared and their effects on urinary glucose excretion were evaluated in rats. Introduction of only a small alkyl group at the 4′-position increased the activity, and 3-(benzo[b]furan-5-yl)-2′,6′-dihydroxy-4′-methylpropiophenone 2′-O-β-D-glucopyranoside I (R = H) showed the most potent effect. To overcome hydrolysis by β-glucosidase in the digestive tract, the OH groups on the glucose moiety of I (R = H) were modified. Three prodrugs were more potent than the parent compound by oral administration, and finally 3-(benzo[b]furan-5-yl)-2′,6′-dihydroxy-4′-methylpropiophenone 2′-O-(6-O-methoxycarbonyl-β-D-glucopyranoside) I (R = CO₂Me) was selected as a new promising candidate. This compound was metabolized mainly by liver esterase to the active form, I (R = H) which was about 10 times more potent in inhibiting SGLT. In oral glucose tolerance test in db/db mice, I (R = CO₂Me) dose-dependently suppressed the elevation of glucose levels. Single administration reduced hyperglycemia concurrently with increase of glucose excretion into urine in diabetic KK-A^y mice. Furthermore, I (R = CO₂Me) suppressed the elevation of blood glucose levels but did not lower it below the normal level even in fasted conditions in KK-A^y mice. Addnl., long-term treatment dose-dependently reduced hyperglycemia and HbA1c in KK-A^y mice. These pharmacol. data strongly suggest that I (R = CO₂Me) has a therapeutic potential in the treatment of NIDDM. In the experiment, the researchers used many compounds, for example, 2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0Synthetic Route of C9H10O3).

2′,6′-Dihydroxy-4′-methylacetophenone (cas: 1634-34-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Synthetic Route of C9H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and antiproliferative properties of N_3/8-disubstituted 3,8-diazabicyclo[3.2.1]octane analogues of 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl-piperazine was written by Filosa, Rosanna;Peduto, Antonella;De Caprariis, Paolo;Saturnino, Carmela;Festa, Michela;Petrella, Antonello;Pau, Amedeo;Pinna, Gerard Aime;La Colla, Paolo;Busonera, Bernardetta;Loddo, Roberta. And the article was included in European Journal of Medicinal Chemistry in 2007.Electric Literature of C6H6BrNO This article mentions the following:

A series of novel N_3/8-disubstituted-3,8-diazabicyclo[3.2.1]octanes in order to improve the in vitro activity of the prototype 3,8-bis[2-(3,4,5-trimethoxyphenyl)pyridyl-4-yl]methylpiperazine were synthesized and evaluated by assays of growth inhibition against several tumor cell lines. Several compounds demonstrated not only growth-inhibitory activities against leukemia cancer cells, but also fairly good activities against the growth of certain solid tumors. Among them, I is the most potent one with IC₅₀ values in the low micromolar range. Moreover, I has been selected for in vitro testing on MCF-7 cell to evaluate the mode of action of this lead compound In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Electric Literature of C6H6BrNO).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C6H6BrNO

Referemce:
Alcohol – Wikipedia,
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Facile Synthesis of Hybrid Core-Shell Nanospheres for the Asymmetric Transfer Hydrogenation of Aromatic Ketones was written by Wei, Juan;Zhang, Xiaomin;Zhang, Xiaoming;Zhao, Yaopeng;Li, Ruixiang;Yang, Qihua. And the article was included in ChemCatChem in 2014.Recommanded Product: 120121-01-9 This article mentions the following:

The polymer-inorganic hybrid core-shell nanospheres with N-(para-toluenesulfonyl)-1,2-diphenylethylenediamine in the core and the poly(Me acrylate) (PMA) polymer in the shell were prepared by using a sol-gel process. The surface properties of solid catalysts were modified by controlling PMA and the cetyltrimethylammonium bromide surfactant in the shell. The water contact angle results suggest that the presence of PMA and cn the shell increases the surface hydrophobicity. In the Rh-catalyzed transfer hydrogenation of aromatic ketones in aqueous HCOONa, the solid catalyst with higher surface hydrophobicity demonstrates higher activity, which suggests that suitable surface properties increase the reaction rate by increasing the diffusion rates of hydrophobic substrates. Furthermore, this heterogeneous catalyst can be reused conveniently without loss of ee values. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Solubilization of terpin hydrate and anethole was written by Regdon-Kiss, E.;Mester, L.. And the article was included in Pharmazie in 1966.Formula: C10H22O3 This article mentions the following:

Earlier studies (CA 60, 9104c) were continued in an effort to demonstrate surface tension changes during, and to explain the mechanism of, solubilization of insoluble substances. Maximum solubilization of 0.3% terpin hydrate (I) occurred with 5% Tweens; the solution was stable for ≥2 months when Tween 20 was used. Thus, a large excess, ten times or more, of solubilizing agent must be used. I itself possesses a small degree of surface activity, a 1% concentration reducing the surface-tension of aqueous Tween solutions to a small extent. I incorporated in the micellae plays a role at the surface of the solution, but the filmlike wedged-in association of the combined Tweens-H₂O-I is also involved. Anethole (II) and anise oil aqueous suspensions behave like I as regards the surface tension of Tweens. Both reduce the surface tension of Tween 20 solution to approx. the same extent. The greatest reduction was with 0.01% Tween 20. Just as with I, here also it was shown that surface tension changes resulted from filmlike association of Tweens-H₂O-II (or anise oil). In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Formula: C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts