Tag: 100-200

Palladium-Catalyzed Oxidative Nonclassical Heck Reaction of Arylhydrazines with Allylic Alcohols via C-N Bond Cleavage: Access to β-Arylated Carbonyl Compounds was written by Wang, Xiaoshuo;Wang, Xiaojing;Pan, Hongwu;Ming, Xiayi;Zhang, Zhenming;Wang, Tao. And the article was included in Journal of Organic Chemistry in 2022.Computed Properties of C8H16O This article mentions the following:

An efficient palladium-catalyzed oxidative nonclassical Heck reaction of arylhydrazines with allylic alcs. via C-N bond cleavage to form β-arylated carbonyl compounds I [R = Me, Et, Cy, etc.; R¹ = Ph, pentyl] was successfully developed. This method provided a series of β-arylated carbonyl compounds I with broad functional group tolerance under base-free, simple, and mild open air reaction conditions. In the reaction, arylhydrazines with the smaller mol. weight of the leaving group were employed as the “green”; arylation reagent, which released N₂ and water as the byproducts under air. Mechanistic studies suggested that an aryl radical process and Pd-H complex migration reinsertion were involved. Moreover, the synthesis of the antiarrhythmic drug propafenone was completed with this transformation as the key step. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Computed Properties of C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of N-heteroarenemethyl esters via C-C bond cleavage of acyl cyanides under transition metal-free conditions was written by Lai, Miao;Su, Fangyao;Hu, Jingyi;Wang, Mengzhuo;Zhao, Mingqin;Zhang, Ganlin. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2021.SDS of cas: 1122-71-0 This article mentions the following:

A practical method to synthesize N-heteroaryl esters from N-heteroaryl methanols with acyl cyanides via C-C bond cleavage without using any transition metal is demonstrated here. The use of Na₂CO₃/15-crown-5 couple enables access to a series of N-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0SDS of cas: 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Laser-induced sound pinging for the rapid determination of total sugar or sweetener content in commercial beverages was written by Bhawawet, Nakara;Larm, Nathaniel E.;Adhikari, Laxmi;Polo-Parada, Luis;Gutierrez-Juarez, Gerardo;Baker, Gary A.. And the article was included in Talanta in 2022.Category: alcohols-buliding-blocks This article mentions the following:

We recently reported on fixed-path length laser-induced sound pinging (FPL-LISP) as a rapid photoacoustic technique employing an inexpensive benchtop tattoo-removal laser for reliably determining the speed of sound in low-volume fluids. In this contribution, we demonstrate the capacity of FPL-LISP to analyze representative com. beverages for their natural or artificial sweetener contents. As a benchmark, the speed of sound was determined for solutions of sugars (glucose, fructose, sucrose), mock high fructose corn syrup (HFCS-55), and 12 household sweeteners (culinary sugars, syrups, honey, molasses) across the concentration range of 1-20% w/v in water, simulating the typical sweetener range found in com. soft drinks. The setup was then employed to estimate sweetener contents of 26 popular com. beverages using the HFCS-55 standard curve as a training data set. Our results are remarkably consistent with the label values for these representative com. beverages, in spite of the fact that some beverages clearly employ a sweetener other than HFCS-55 or a proprietary blend, suggesting the excellent potential of the FPL-LISP setup as a quick screening tool well-suited to quality control and real-time assessment in the beverage and fermentation industrial sectors. The proposed approach represents a significant improvement over many existing methods on the basis of measurement time (down to 1 s, which can be considered real time for many applications), lenient sample requirements (tens of microliters to 1 mL), robust and user-friendly anal., practical considerations (e.g., economical, minimal service and maintenance concerns), and prospects for advancing both online monitoring and fully portable versions of this instrumentation. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Redox-driven deracemization of secondary alcohols by sequential ether/O₂-mediated oxidation and Ru-catalyzed asymmetric reduction was written by Yang, Bing;Cui, Peng;Chen, Yongsheng;Liu, Qixing;Zhou, Haifeng. And the article was included in Tetrahedron Letters in 2020.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

The deracemization of secondary alcs. had been achieved using a redox-driven one-pot two-step process. The racemic alcs. were oxidized by bis(methoxypropyl) ether and oxygen to gave the ketone intermediates, followed by an asym. transfer hydrogenation with a chiral ruthenium catalyst. This compatible oxidation/reduction process gave the enantiomerically enriched alcs. such as RCH(OH)R¹ [R = Ph, 2-FC₆H₄, 3-thienyl, etc.; R¹ = Me, pentyl, CO₂Me, Ph] with up to 95% ee values. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Safety of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anchored [RuCl₂(p-cymene)]₂ in hybrid zirconium phosphate-phosphonate coated and pillared with double-stranded hydrophobic linear polystyrene as heterogeneous catalyst suitable for aqueous asymmetric transfer hydrogenation was written by Wang, Rui;Wan, Jingwei;Ma, Xuebing;Xu, Xiao;Liu, Liu. And the article was included in Dalton Transactions in 2013.Electric Literature of C8H9ClO This article mentions the following:

A novel type of phosphonate-containing polystyrene copolymers 1a-e bearing an N’-alkylated TsDPEN chiral ligand and double-stranded polystyrene chains were prepared for the first time using simple radical copolymerization of 1-phosphonate styrene with (R,R)-N’-4′-vinylbenzyl-N-4-vinylbenzenesulfonyl-1,2-diphenylethylene-1,2-diamine. Through the coprecipitation of their supported Ru polystyrene copolymers 2a-e and NaH₂PO₄ with ZrOCl₂, pillared hybrid zirconium phosphate-phosphonate-anchored Ru catalysts 3a-e and 4d₁-d₅ were obtained as heterogeneous catalysts suitable for aqueous asym. transfer hydrogenation. In the aqueous asym. transfer hydrogenation of aromatic ketones, the anchored Ru catalysts showed good catalytic activities, chemoselectivities (∼100%), and enantioselectivities (73.6% ee to 95.6% ee). The Ru catalysts retained their catalytic properties even at the fifth recycle time (92.2% conv., 92.1% ee). However, corresponding supported Ru catalyst 3d’ resulted in disappointing reusability because of the loss of ruthenium in every recycle process. The conversions of aromatic ketones were closely related to the o-, m- or p-positions of the substituents on the aromatic ring caused by shape-selective matching. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Electric Literature of C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An O-Benzyl Phosphonamidate Prodrug of Tenofovir for the Treatment of Hepatitis B Virus Infection was written by Zhang, Qianqian;Peng, Youmei;Hou, Jiao;Chen, Yanhong;Liu, Bingjie;Zhang, Pinghu;Yu, Wenquan;Chang, Junbiao. And the article was included in Journal of Medicinal Chemistry in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A series of new O-(substituted benzyl) phosphoramidate prodrugs of tenofovir for the treatment of hepatitis B virus (HBV) infections have been designed and synthesized. An investigation of structure-activity relationships revealed that the compound bearing an o-methylbenzyl group (1a) has the most potent in vitro anti-HBV activity. This prodrug (1a) was well-tolerated in KM mice via intragastric administration at a dosage of up to 1.5 g/kg. In DHBV-infected ducks, prodrug 1a displayed a good inhibitory effect on the viral DNA replication in both the serum and the liver in a time- and dose-dependent manner and did not cause any necrosis, hemorrhage, or inflammatory response in the animal livers. Further investigation demonstrated that prodrug 1a achieved a higher exposure of the bioactive metabolite (tenofovir diphosphate, TFV-DP) in the liver, the target organ for the treatment of HBV infection, than tenofovir alafenamide fumarate (TAF) did at an equimolar dose. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Category: alcohols-buliding-blocks).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Spreadable plant-based cheese analogue with dry-fractioned pea protein and inulin-olive oil emulsion-filled gel was written by Mefleh, Marina;Pasqualone, Antonella;Caponio, Francesco;De Angelis, Davide;Natrella, Giuseppe;Summo, Carmine;Faccia, Michele. And the article was included in Journal of the Science of Food and Agriculture in 2022.SDS of cas: 3391-86-4 This article mentions the following:

BACKGROUND : Consumer demand for plant-based cheese analogs (PCA) is growing because of the easy and versatile ways in which they can be used. However, the products available on the market are nutritionally poor. They are low in protein, high in saturated fat and sodium, and often characterized by a long list of ingredients. RESULTS : A clean label spreadable plant-based cheese analog was developed using dry-fractionated pea protein and an emulsion-filled gel composed of extra virgin olive oil and inulin, added in different concentrations as fat replacer (10%, 13% and 15% of the formulation). First, nutritional and textural analyses were performed, and the results were compared with two com. products. The products were high in protein (134 g kg-1) and low in fat (52.2 g kg-1). The formulated PCAs had similar spreadability index to the dairy cheese but lower hardness (15.1 vs. 19.0 N) and a higher elasticity (0.60 vs. 0.35) consequent to their lower fat content (52.2 vs. 250 g kg-1). Then, dry oregano and rosemary (5 g kg-1) were added to the PCA, and sensory evaluation and anal. of volatile compounds were conducted. The addition of spices masked the legume flavor and significantly enriched the final product with aromatic compounds CONCLUSION : The use of dry-fractioned pea protein and of the emulsion-filled gel allowed us to develop a clean label and nutritionally valuable spreadable plant-based cheese analog. Overall, the ingredients and product concepts developed could be used to upgrade the formulation of plant-based cheese on a larger scale. 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4SDS of cas: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification of aroma-active compounds responsible for the floral and sweet odors of Congou black teas using gas chromatography-mass spectrometry/olfactometry, odor activity value, and chemometrics was written by Xue, Jinjin;Guo, Guiyi;Liu, Panpan;Chen, Lin;Wang, Weiwei;Zhang, Jianyong;Yin, Junfeng;Ni, Dejiang;Engelhardt, Ulrich H.;Jiang, Heyuan. And the article was included in Journal of the Science of Food and Agriculture in 2022.Electric Literature of C8H16O This article mentions the following:

Floral and sweet odors are two typical characteristic aromas of Congou black tea, but their aroma-active compounds are still unclear. Characterizing the key aroma-active compounds can provide a theor. foundation for the practical aroma quality evaluation of Congou black tea and directional processing technol. of high-quality black tea with floral or sweet odors. Gas chromatog.-olfactometry (GC-O) combined with odor activity value (OAV) is often used to screen key aroma-active substances, but the interaction between aroma components and their impact on the overall sensory quality is ignored. Therefore, in this study, OAV combined with variable importance in projection (VIP) and Spearman correlation anal. (SCA) were used to characterize the aroma-active components of Congou black teas with floral and sweet odors. Eighty-five volatiles were identified in these samples using gas chromatog.-mass spectrometry (GC-MS). Twenty-three compounds were identified as potential markers for the floral and sweet odors of Congou black teas from orthogonal partial least squares discriminant anal. (OPLS-DA). Eighteen compounds were selected as candidate aroma compounds based on GC-O anal. and OAV calculations In addition, 26 compounds were screened as crucial aroma compounds based on SCA. Finally, 19 compounds were evaluated as key aroma compounds by the comprehensive evaluation of VIP, OAV, and SCA. Terpenoids are the main active compounds that contribute to the floral odor of Congou black tea, whereas aldehydes are the key compounds for the sweet odor. The proposed method can effectively screen the aroma-active compounds and can be used for comprehensive quality control of products. 2022 Society of Chem. Industry. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Electric Literature of C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Electric Literature of C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Backbone-anchoring, solid-phase synthesis strategy to access a library of peptidouridine-containing small molecules was written by Arbour, Christine A.;Imperiali, Barbara. And the article was included in Organic Letters in 2022.Recommanded Product: (5-Methylpyridin-3-yl)methanol This article mentions the following:

Nucleoside diphosphate sugar (NDP-sugar) substrates provide the inspiration for nucleoside analog inhibitor scaffolds. By employing solid-phase synthesis, we provide a method to access a library of peptidouridine inhibitors with both minimal compound handling and purification steps. Specifically, this strategy is exemplified by generating uridine diphosphate sugar (UDP-sugar) mimics, which allow for compound elaboration by altering the dipeptide composition, the N-terminal linkage, and a pendant aryl group. To exemplify the versatility, 41 unique nucleoside analogs are presented. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1Recommanded Product: (5-Methylpyridin-3-yl)methanol).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: (5-Methylpyridin-3-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Multiscale Charge Injection and Transport Properties in Self-Assembled Monolayers of Biphenyl Thiols with Varying Torsion Angles was written by Masillamani, Appan Merari;Crivillers, Nuria;Orgiu, Emanuele;Rotzler, Juergen;Bossert, David;Thippeswamy, Ramakrishnappa;Zharnikov, Michael;Mayor, Marcel;Samori, Paolo. And the article was included in Chemistry – A European Journal in 2012.Related Products of 29364-29-2 This article mentions the following:

This article describes the mol. structure-function relation for biphenylthiol derivatives with varying torsional degree of freedom in their mol. backbone when self-assembled on gold electrodes. These biphenylthiol mols. chemisorbed on Au exhibit different tilt angles with respect to the surface normal and different packing densities. The charge transport through the biphenylthiol self-assembled monolayers (SAMs) showed a characteristic decay trend with the effective monolayer thickness. Based on parallel pathways model the tunneling decay factor β is 0.27 Å^-1. The hole mobility of poly(3-hexylthiophene)-based thin-film transistors incorporating a biphenylthiol SAM coating the Au source and drain electrodes revealed a dependence on the injection barrier with the HOMO level of the semiconductor. The possible role of the resistivity of the SAMs on transistor electrodes on the threshold voltage shift is discussed. The control over the chem. structure, electronic properties, and packing order of the SAMs provides a versatile platform to regulate the charge injection in organic electronic devices. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Related Products of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts