Tag: 100-200

Synthesis and SAR of tolylamine 5-HT₆ antagonists was written by Singer, Jamie M.;Wilson, Michael W.;Johnson, Paul D.;Graham, Shelley R.;Cooke, Leonard W.;Roof, Robin L.;Boxer, Peter A.;Gold, Lisa H.;Meltzer, Leonard T.;Janssen, Ann;Roush, Nicole;Campbell, Jeffrey E.;Su, Ti-Zhi;Hurst, Susan I.;Stoner, Chad L.;Schwarz, Jacob B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2009.Recommanded Product: 120121-01-9 This article mentions the following:

The synthesis and SAR of tolylamines with 5-HT₆ receptor antagonist activity was presented. The amine, core aromatic, peripheral aromatic, and ether linker moieties of an HTS hit were modulated and the effect on potency at 5-HT₆ examined Tolylpiperidine ether I was found to possess desirable pharmacokinetic properties, and was also shown to enhance cognition in the rat novel object recognition paradigm. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volatile profiles of commercial vetch prepared via different processing methods was written by Riley, Samuel;Lale, Aneesh;Nguyen, Vy;Xi, Hangwei;Wilkinson, Kerry;Searle, Iain R.;Fisk, Ian. And the article was included in Food Chemistry in 2022.HPLC of Formula: 3391-86-4 This article mentions the following:

Vicia sativa (Common Vetch) is currently an underutilized leguminous crop species with high protein content and superior drought tolerance. This study aimed to understand the mechanisms behind vetch flavor development following processing to facilitate its uptake as a future source of dietary protein. A total of 95 volatile compounds were identified by solid-phase microextraction gas chromatog.-mass spectrometry (SPME GC-MS) for a range of vetches processed by dehulling, soaking, germination, microwaving, and fermentation 2-pentyl furan, benzyl alc., benzaldehyde, 1-octen-3-ol and 1-hexanol were found to be characteristic aroma compounds of V. sativa. Anal. of a V. sativa landrace demonstrated significant intraspecies variation in volatile abundance, three-fold that of com. varieties. Both natto and tempeh fermentation produced significant quantities of alcs., esters, and carboxylic acids with specifically natto generating significant pyrazines. Concentrations of 1-octen-3-ol significantly decreased after tempeh fermentation indicating its potential to reduce documented off flavor generating volatiles within V. sativa. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4HPLC of Formula: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.HPLC of Formula: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The preparation and property of photo- and thermo-responsive hydrogels with a blending system was written by Shuai, Shirong;Zhou, Siyao;Liu, Yu;Huo, Weirong;Zhu, Hongyu;Li, Yang;Rao, Zikun;Zhao, Cong;Hao, Jianyuan. And the article was included in Journal of Materials Science in 2020.Category: alcohols-buliding-blocks This article mentions the following:

Hydrogels are the attractive biomaterials for biomedical applications. The dual-stimuli-responsive system, which is sensitive to both temperature and UV irradiation, was achieved through the self-assembly of amphiphilic block copolymers in aqueous solution and the cleavage of ο-nitrobenzyl (NB) ester groups under UV irradiation The copolymer of poly(ε-caprolactone)-b-ο-nitrobenzyl-poly(ethylene glycol)-ο-nitrobenzyl-b-poly(ε-caprolactone) (PCL-NB-PEG-NB-PCL) was prepared by ring-opening polymerization (ROP) and nucleophilic substitution reaction of ε-caprolactone (ε-CL) using photo-sensitized polyethylene glycol as an initiator. After blending with poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) (PCL-PEG-PCL), the system exhibited the promising dual sensitivity with wide gel-phase window and controllable sensitive properties. The structures and dual-responsive behaviors were characterized by ¹H-NMR, GPC, DMA, UV-Vis, DLS and SEM. The results demonstrated the temperature and photo-sensitivity of the synthesized hydrogel and indicated that the blending of these two copolymers can easily adjust the phase transition temperature and broaden the gel-phase window through the content of NB groups in PCL-NB-PEG-NB-PCL and the hydrophilic/hydrophobic balance of system. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Category: alcohols-buliding-blocks).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analysis of the essential oil of magnolia and its effect on antioxidant enzyme activity, sCD40L and phosphorylate-activate Akt protein levels in gastric cancer mice was written by Li, Rui;Chen, Wei-chang;Wang, Wei-peng;Tian, Wen-yan;Zhang, Xue-guang. And the article was included in Medicinal Chemistry Research in 2010.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The chem. composition of essential oil from magnolia collected in Suzhou city, China, was studied using gas chromatog.-mass spectroscopy. Fifty-four volatile compounds were identified in the essential oil, with eucalyptol (21.55%), β-Pinene(11.07%), D-Limonene (8.93%), 1R-α-Pinene (7.86%), Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl-, (1R)-(6.46%), Cyclohexene, 4-methylene-1-(1-methylethyl)- (5.30%), 1,4-Cyclohexadiene, 1-methyl-4-(1-methylethyl)- (5.10%), camphene (4.72%), being the major chem. constituents. In an in vivo approach, the protective effect of the essential oil against oxidative stress in gastric cancer (GC) mice was also investigated in terms of superoxide dismutase, CAT, and glutathione peroxidase activities. Our results indicate that the essential oil has an effective capability to enhance serum antioxidant enzyme activities and sCD40L, and decrease phosphorylate-activate Akt protein levels in a dose-dependent manner in gastric cancer mice. Overall, essential oil from magnolia appears to be an effective antioxidant and is quite suitable for further biol. evaluation. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron-Catalyzed Alkyne-Based Multicomponent Synthesis of Pyrimidines under Air was written by Mondal, Rakesh;Chakraborty, Gargi;Guin, Amit Kumar;Sarkar, Susmita;Paul, Nanda D.. And the article was included in Journal of Organic Chemistry in 2021.SDS of cas: 1777-82-8 This article mentions the following:

An iron-catalyzed sustainable, economically affordable, and eco-friendly synthetic protocol for the construction of various trisubstituted pyrimidines I (R = Ph, cyclopropyl, 2-thienyl, etc.; R¹ = Ph, cyclopropyl, 2-thienyl, etc.; R² = H, NH₂, Me, Ph, etc.) is described. A wide range of trisubstituted pyrimidines were prepared using a well-defined, easy to prepare, bench-stable, and phosphine-free iron catalyst featuring a redox non-innocent tridentate arylazo pincer under comparatively mild aerobic conditions via dehydrogenative functionalization of alcs. RCH₂OH with alkynes R¹CCH and amidines R²C(=NH)NH₂. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8SDS of cas: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly dispersed palladium nanoparticles supported on an imidazolium-based ionic liquid polymer: an efficient catalyst for oxidation of alcohols was written by Karimi, Z.;Hassanpour, A.;Kangari, S.;Marjani, A.. And the article was included in Russian Chemical Bulletin in 2022.Synthetic Route of C7H7ClO This article mentions the following:

An efficient and stable nanocatalyst for selective oxidation of alcs. was developed. It contains palladium nanoparticles, which are well distributed throughout the network of a copolymer based on an ionic liquid The synthesized nanomaterials were characterized by various techniques such as nitrogen adsorption-desorption anal., thermal gravimetric anal., TEM, and FTIR spectroscopy. A high surface area and the appropriate pore size of the nanocatalyst make active metal sites accessible to reagents, whereas the presence of an ionic liquid in the network of the polymer structure creates a good environment for the leaching protection and stabilization of extremely dispersed palladium nanoparticles. The availability and abundance of active sites of highly dispersed palladium nanoparticles make the synthesized nanocatalyst very promising for oxidation of alcs. The nanocatalyst has a number of features such as a high surface area, an appropriate size of pores with high catalytic activity, high thermal stability of the nanostructures, and low amounts of the ionic liquid needed for its synthesis. Using this nanocatalyst, carbonyl compounds were prepared from the corresponding alcs. in high yields. Addnl., the prepared nanocatalyst can easily be recovered by centrifugation after completion of the reactions and was reused five times without a significant loss in its catalytic activity. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Synthetic Route of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nucleophilic Substitution of Aliphatic Fluorides via Pseudohalide Intermediates was written by Jaiswal, Amit K.;Prasad, Pragati K.;Young, Rowan D.. And the article was included in Chemistry – A European Journal in 2019.Safety of (2,4-Dichlorophenyl)methanol This article mentions the following:

A method for aliphatic fluoride functionalization with a variety of nucleophiles has been reported. Carbon-fluoride bond cleavage is thermodynamically driven by the use of silylated pseudohalides TMS-OMs or TMS-NTf₂, resulting in the formation of TMS-F and a trapped aliphatic pseudohalide intermediate. The rate of fluoride/pseudohalide exchange and the stability of this intermediate are such that little rearrangement is observed for terminal fluoride positions in linear aliphatic fluorides. The ability to convert organofluoride positions into pseudohalide groups allows facile nucleophilic attack by a wide range of nucleophiles. The late introduction of the nucleophiles also allows for a wide range of functional-group tolerance in the coupling partners. Selective alkyl fluoride mesylation is observed in the presence of other alkyl halides, allowing for orthogonal synthetic strategies. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Safety of (2,4-Dichlorophenyl)methanol).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of (2,4-Dichlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biocide leaching from CBA treated wood – A mechanistic interpretation was written by Lupsea, Maria;Mathies, Helena;Schoknecht, Ute;Tiruta-Barna, Ligia;Schiopu, Nicoleta. And the article was included in Science of the Total Environment in 2013.Category: alcohols-buliding-blocks This article mentions the following:

Treated wood is frequently used for construction. However, there is a need to ensure that biocides used for the treatment are not a threat for people or environment. The paper focused on Pinus sylvestris treated with copper-boron-azole (CBA), containing tebuconazole as organic biocide and monoethanolamine (Mea). This study investigates chem. mechanisms of fixation and mobilization involved in the leaching process of the used inorganic and organic biocides in CBA. A pH dependent leaching test was performed, followed by a set of complementary anal. methods in order to identify and quantify the species released from wood. The main findings of this study are:Organic compounds are released from untreated and treated wood; the quantity of released total organic carbon, carboxylic and phenolic functions increasing with the pH. Nitrogen containing compounds, i.e. mainly Mea and its reaction products with extractives, are released in important quantities from CBA treated wood, especially at low pH. The release of copper is the result of competitive reactions: fixation via complexation reactions and complexation with extractives in the liquid phase. The specific pH dependency of Cu leaching is explained by the competition of ligands for protonation and complexation. Tebuconazole is released to a lesser extent relative to its initial content. Its fixation on solid wood structure seems to be influenced by pH, suggesting interactions with OH groups on wood. Boron release appears to be pH independent and very high. This confirms its weak fixation on wood and also no or weak interaction with the extractives. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Category: alcohols-buliding-blocks).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly (E)-Selective Tri-Substituted Alkene Synthesis by Low-Valent Titanium-Mediated Homolytic Cleavage of Alcohol C-O Bond was written by Suga, Takuya;Takada, Ryusei;Shimazu, Shoma;Sakata, Mizuki;Ukaji, Yutaka. And the article was included in Journal of Organic Chemistry in 2022.Name: (4-Chlorophenyl)methanol This article mentions the following:

Ti-mediated homolytic C-O bond cleavage was useful for cascade radical-ionic reactions. Benzyl alcs. treated with TiCl₄(col) (col = 2,4,6-collidine) and Mn powder generated the corresponding benzyl radicals; in addition, their reaction with 2-carboxy-allyl acetates and the subsequent elimination of the acetoxy group yielded α,β-unsaturated carbonyl compounds I [R = Ph, 1-phenylethyl, undecyl, etc.; Ar = Ph, 4-MeOC₆H₄, 1-naphthyl, etc.] with exclusive (E)-stereoselectivity. The simplicity of the procedure and its wide substrate scope represented a solution to the drawbacks associated with the reactions. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Name: (4-Chlorophenyl)methanol).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (4-Chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kinetic analysis of the conversion of aqueous erythritol solution on Ir/ReO_x/TiO₂ in a batch slurry reactor was written by Virgilio, Emanuel M.;Sad, Maria E.;Padro, Cristina L.. And the article was included in Applied Catalysis, A: General in 2022.Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

The influence of temperature, H₂ pressure and erythritol concentration on the hydrogenolysis of erythritol was studied using Ir/ReO_x/TiO₂. Under the conditions used here, four reaction routes coexist: isomerization, dehydration, C-O and C-C hydrogenolysis. The initial rates as well as reaction orders and activation energy were estimated for each pathway. The variation of the hydrogen pressure produced slight changes in the isomerization, dehydration, and C-C hydrogenolysis routes, whereas C-O hydrogenolysis showed order 1 with respect to this reagent. The change in erythritol concentration affected more the dehydration, resulting in a reaction order for this reactant close to 1, while for the other routes the order was close to 0.5. Regarding the influence of the temperature, dehydration of erythritol showed the highest activation energy (212.1 kJ mol^-1) and the isomerization the lowest (20.0 kJ mol^-1). Furthermore, it was found that the ruptures of C-C bonds require higher energy than C-O bonds break. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts