Tag: 100-200

Design and Synthesis of Fluorophore-Tagged Disparlure Enantiomers to Study Pheromone Enantiomer Discrimination in the Pheromone-Binding Proteins from the Gypsy Moth, Lymantria dispar was written by Pinnelli, Govardhana R.;Plettner, Erika. And the article was included in Journal of Chemical Ecology in 2022.Related Products of 111-46-6 This article mentions the following:

Fluorescent analogs of the gypsy moth sex pheromone (+)-disparlure and its enantiomer (-)-disparlure were designed, synthesized, and characterized. The fluorescently labeled analogs 6-FAM (+)-disparlure I and 6-FAM (-)-disparlure II were prepared by copper-catalyzed azide-alkyne cycloaddition of disparlure alkyne and 6-FAM azide. These fluorescent disparlure analogs I and II were used to measure disparlure binding to two pheromone-binding proteins from the gypsy moth, Lymantria dispar Pheromone-Binding Protein 1 (LdisPBP1) and LdisPBP2. The fluorescence binding assay showed that LdisPBP1 has a stronger affinity for 6-FAM (-)-disparlure II, whereas LdisPBP2 has a stronger affinity for 6-FAM (+)-disparlure I, consistent with findings from previous studies with disparlure enantiomers. The 6-FAM disparlure enantiomers appeared to be much stronger ligands for LdisPBPs, with binding constants (K_d) in the nanomolar range, compared to the fluorescent reporter 1-NPN (which had K_d values in the micromolar range). Fluorescence competitive binding assays were used to determine the displacement constant (K_i) for the disparlure enantiomers in competition with fluorescent disparlure analogs binding to LdisPBP1 and LdisPBP2. The K_i data show that disparlure enantiomers can effectively displace the fluorescent disparlure from the binding pocket of LdisPBPs and, therefore, occupy the same binding site. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Related Products of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Naked micelles: well-defined polymer nanoparticles from photo-cleavable block copolymer micelles was written by Quintieri, Giada;Groeschel, Andre H.. And the article was included in Polymer Chemistry in 2021.Reference of 60463-12-9 This article mentions the following:

Ultra-small nanoparticles (NPs) with accessible surface functionalities in the range of 3-50 nm are of great interest due to their defined size and surface properties, which could bridge the gap between natural and synthetic materials. Although NPs available in nature present more sophisticated functions as compared to synthetic materials, the physicochem. and colloidal behavior is primarily dominated by geometry and surface charge; synthetic counterparts could mimic aggregation and interaction behavior based on similar size, shape and surface structure. Inorganic ultra-small NPs exist in a large variety; however polymeric counterparts present major problems when trying to produce them in a controlled manner in the sub-50 nm range. Here, we present the synthesis and self-assembly of a photolabile diblock copolymers into spheres, worms and vesicles followed by photocleaving of the corona leaving the core unaltered, which is then surrounded by neg. charge. The polymer features a water-soluble polyethylene oxide (PEO) corona block and a hydrophobic polystyrene (PS) core block. The two blocks are covalently linked by an o-nitrobenzyl moiety (ONB), which upon exposure to UV light (λ = 365 nm) opens up, leaving a carboxylic acid functionality on the PS core for electrostatic stabilization. The neg. charged core then interacts with cationic species, e.g., cationic gold NPs (AuNPs), which will decorate the PS surface. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Reference of 60463-12-9).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 60463-12-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of cosmetic creams containing Black cumin (Nigella sativa)-Lemon balm (Melissa officinalis L.)-Aloe vera (Aloe barbadensis miller) essences by modeling with Box Behnken method in Design Expert was written by Turedi, Ece;Acarali, Nil. And the article was included in Industrial Crops and Products in 2022.Reference of 499-75-2 This article mentions the following:

In this investigation regarding medicinal and aromatic plants, an exptl. study was conducted on the effectiveness of black cumin, lemon balm and Aloe vera essences in cosmetic creams, which were selected for their beneficial biol. activities such as anti-inflammatory, moisturizing, etc. In line with this study stability test, which was important in the quality evaluation of cosmetic products, was carried out. Cream samples containing different concentrations of black cumin and lemon balm essences were kept at under 3 different temperature conditions as 0 °C, 25 °C and 40 °C and the necessary values were recorded. In this direction, the effects of the temperature on the phys. and chem. properties of the cosmetic creams were assessed. Homogenization and colors as phys. properties and pH value of the herbal cream samples were examined It was observed that the pH value, which was an important parameter for skin care products, was 6.5 under the optimum exptl. condition and it was an acceptable value for skin creams according to the literature. In the second part of the exptl. study, the effect of the essence obtained from the Aloe vera plant on the samples was tested with the optimum condition selected from 17 different exptl. sets by using the Design Expert optimization application. In addition, from the production of cosmetic products; it was necessary to pay attention to the environmental conditions stipulated in storage, transportation, and sales points. As a result of the tests, it was seen that the medicinal and aromatic plants used could be evaluated in the field of cosmetics and successful results could be obtained. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Reference of 499-75-2).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 499-75-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mechanistic and synthetic aspects of hydroboration with a simple atropisomeric ligand prepared from 1-(1′-isoquinolyl)-2-naphthol was written by Korostylev, Andrei;Gridnev, Ilya;Brown, John M.. And the article was included in Journal of Organometallic Chemistry in 2003.Reference of 171032-87-4 This article mentions the following:

A novel triaryl phosphite ligand was prepared directly from both enantiomers of BINOL and a single enantiomer of 1-(1′-isoquinolyl)-2-naphthol. In one of the two cases the cationic Rh complex proved to be reasonably effective in the asym. hydroboration of electron-poor styrenes. It was possible to identify binuclear reactive intermediates when the hydroboration pre-catalyst was examined in the presence of catecholborane at low temperatures In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Reference of 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric reduction of acetophenone analogues by Alternaria alternata using ram horn peptone was written by Kurbanoglu, Esabi B.;Zilbeyaz, Kani;Kurbanoglu, Namudar I.;Kilic, Hamdullah. And the article was included in Tetrahedron: Asymmetry in 2007.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Alternaria alternata EBK-4 fungus isolated from a plant sample was evaluated for the asym. reduction of acetophenone analogs. In a previous study, this isolate was used for the reduction of acetophenone to 1-phenylethanol in excellent enantiomeric excess. The substituted acetophenones were converted to the corresponding optically active alc. by A. alternata EBK-4 under optimized conditions in up to >99% enantiomeric excess (ee). This is the first report on the enantiomeric reduction of acetophenone analogs by A. alternata using ram horn peptone from waste material. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Host-guest complexation. 3. Organization of pyridyl binding sites was written by Newcomb, Martin;Timko, Joseph M.;Walba, David M.;Cram, Donald J.. And the article was included in Journal of the American Chemical Society in 1977.Recommanded Product: 6-Methyl-2-pyridinemethanol This article mentions the following:

Six new multiheteromacrocycles were prepared containing as part of the major ring system from one to four 2,6-pyridinedimethylyl units. The pKa of these compounds were comparable to those of open-chain models except for that of sym-dipyridyl-12-crown-4, e.g., I, whose conjugate acid was 4 kcal/mol more stable than the others. The 18-membered cycles, e.g., II, gave free energies of association for complexation with tert-BuNH3SCN in CDCl3 about 5 kcal/mol more neg. (complexes more stable) than either the 12- or the 24-membered ring systems. In CDCl3 for five 18-membered host compounds containing widely different binding units, tert-BuNH3SCN was better complexed than tert-BuNH3Cl by 2.9 ± 0.1 kcal/mol at 0°. Of the 13 possible 18-membered ring pyridocycles containing 6 binding sites that are either O or N, 3 were synthesized. The free energies of complexation of these cycles and 18-crown-6 with tert-BuNH3Cl were determined at 0° and estimated at 24°. The values for 3 of these cycles were dissected into 6 host-guest contact site parameters (4 different kinds) whose addition equaled the free energies of association of host and guest. The parameters taken in appropriate combinations dictated by host structure were then used to calculate the free energies of association of the 4th cycle. The measured and calculated values were in reasonable agreement. The 4 different kinds of free-energy contact site parameters were then used to predict the free energies of association of the remaining unsynthesized 10 cycles. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Recommanded Product: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Magnetic spent coffee ground as an efficient and green catalyst for aerobic oxidation of alcohols and tandem oxidative Groebke-Blackburn-Bienayme reaction was written by Farhid, Hassan;Shaabani, Ahmad. And the article was included in Journal of the Iranian Chemical Society in 2021.Recommanded Product: 1777-82-8 This article mentions the following:

Abstract: In this work, magnetic spent coffee ground as a green, inexpensive, and abundant material was synthesized and characterized by a variety of techniques, including X-ray diffraction pattern, thermal gravimetric anal., SEM, energy-dispersive spectroscopy, inductively coupled plasma optical emission spectrometry, and Fourier transform IR spectroscopy. The magnetic spent coffee ground was successfully utilized as a catalyst in aerobic oxidation of primary and secondary benzylic alcs. and tandem oxidative Groebke-Blackburn-Bienayme ́reaction. Graphic abstract: [graphic not available: see fulltext]. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comparative study on nucleophilic/electrophilic behaviour of divalent organosulfur compounds: a DFT study was written by Ahmed, Nizamuddin;Bhattacharjee, Saibal Kanti;Bhattacharyya, Pradip Kr.. And the article was included in Journal of the Indian Chemical Society in 2014.Related Products of 29364-29-2 This article mentions the following:

Electrophilic/nucleophilic behavior of twenty-five bivalent organosulfur compounds were studied using global and local DFT based reactivity descriptors at B3LYP/6-311++G(d,p) and MP2/6-311++G(d,p) levels of theory. Global reactivity descriptors are used to observe overall stability of the compounds and local parameters are used to quantify reactivity of the sulfur center. Further we have observed the effect of solvents, ethanol and water on the reactivity pattern. Gibbs free energy of solvation is used to measure stability of the compounds in solvent phases. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Related Products of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analytical applications of ion-exchange materials. V. Chromatographic separation of drugs on ferric phosphate papers was written by Thind, P. S.;Gandhi, J. S.. And the article was included in Journal of Liquid Chromatography in 1983.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

Chromatog. of 14 drugs is performed on papers impregnated with ferric phosphate. Nine solvent systems (phosphate buffers with different pHs, EtOH and EtOH-benzene) are used based on aqueous phosphate buffers and mixed organic solvents. The R_f values on plain and impregnated papers are compared. Binary separations are described. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electrode-assisted desorption electrospray ionization mass spectrometry was written by Ozdemir, Abdil;Chen, Chung-Hsuan. And the article was included in Journal of Mass Spectrometry in 2010.Computed Properties of C10H22O3 This article mentions the following:

A new ion source has been developed for rapid, noncontact anal. of materials at ambient conditions. The method provides desorption of analytes under ambient conditions directly from different surfaces with little or no sample preparation The new method, termed electrode-assisted desorption electrospray ionization (EADESI), is on the basis of the ionization of mols. on different surfaces by highly charged droplets produced on a sharp-edged high voltage tip, and ions produced are introduced into the mass spectrometer through a capillary. The EADESI technique can be applied to various samples including amino acids, peptides, proteins, drugs and human fluids such as urine and blood. EADESI is promising for routine analyses in different fields such as forensic, environmental and material sciences. EADESI interface can be fit to a conventional ion-trap mass spectrometer. It can be used for various types of samples with a broad mass range. EADESI can also provide real-time anal. which is very valuable for biomedical applications. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Computed Properties of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts