Tag: 100-200

Regiospecific opening of oxetanes with trimethylsilyl cyanide-zinc iodide. A general approach to γ-amino alcohols was written by Gassman, Paul G.;Haberman, Leonard M.. And the article was included in Tetrahedron Letters in 1985.Product Details of 42514-50-1 This article mentions the following:

Me₃SiOCH₂CH₂CRR¹NC (I; R = H, Me; R¹ = H, Me, Ph, CH₂:CH) were formed regiospecifically in 73-94% yield by the ring opening of oxetanes II with Me₃SiCN-ZnI₂. Deprotection and hydrolysis of I gave HOCH₂CH₂CRR¹NH₂. In the experiment, the researchers used many compounds, for example, 3-Amino-3-methylbutan-1-ol (cas: 42514-50-1Product Details of 42514-50-1).

3-Amino-3-methylbutan-1-ol (cas: 42514-50-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 42514-50-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Regio- and stereoselective hydroxylation of some nitrogen heterocyclic compounds by microorganisms was written by Zefirov, N. S.;Terent’ev, P. B.;Modyanova, L. V.;Dovgilevich, E. V.. And the article was included in Indian Journal of Chemistry in 1993.Category: alcohols-buliding-blocks This article mentions the following:

Microbial hydroxylation of pyridine and alkylpyridines, as well as of some saturated monocyclic compounds, provides an efficient regio- and stereoselective route to biol. active and synthetically useful hydroxy derivatives Thus, the picolines I (R = 2-, 3-, 4-Me) are converted by fungi, such as Aspergillus and Penicillium, into the corresponding pyridinemethanols I (R = 2-, 3-, 4-CH₂OH) in up to 45% yields. Transformation of condensed polycyclic N-heterocycles, however proceeds in a different manner. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1Category: alcohols-buliding-blocks).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective O-demethylation of an aromatic methyl ether in the presence of an aromatic methylenedioxy group with trimethylsilyl iodide in quinoline was written by Minamikawa, Junichi;Brossi, Arnold. And the article was included in Tetrahedron Letters in 1978.HPLC of Formula: 69393-72-2 This article mentions the following:

Heating the methylenedioxy compounds I (R = H, R¹ = OMe; R = OMe, R¹ = H) with trimethylsilyl iodide (II) in quinoline (III) gave ∼72% of the corresponding demethylated products. The mechanism involves formation of a 1:1 complex of II and III, observed as unstable yellow crystals on mixing II and III in hexane. In the experiment, the researchers used many compounds, for example, Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2HPLC of Formula: 69393-72-2).

Benzo[d][1,3]dioxol-4-ol (cas: 69393-72-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 69393-72-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review was written by Khazdair, Mahammad R.;Ghorani, Vahideh;Boskabady, Mohammad H.. And the article was included in BioFactors in 2022.Safety of 5-Isopropyl-2-methylphenol This article mentions the following:

Carvacrol (CAR) showed various pharmacol. and therapeutic effects in different disorders. In the current article, the exptl. and clin. effects of CAR on respiratory, allergic, and immunol. disorders are described. Various databases, including PubMed, Science Direct, and Scopus, were searched regarding the effects of CAR on respiratory and allergic disorders until the end of Oct. 2021. CAR showed the relaxant effect, with various possible mechanisms suggesting the bronchodilatory effect in obstructive pulmonary diseases. The preventive effects of CAR on exptl. animal models of respiratory diseases were shown through mechanisms such as antioxidant, immunomodulatory, and anti-inflammatory. CAR also showed therapeutic potential on lung cancer, lung infections, and allergic and immunol. disorders. Clin. studies also revealed therapeutic effects of CAR on asthma, sulfur-mustard-induced lug disorders, and some other allergic and immunol. diseases. Pharmacol. and therapeutic effects of CAR indicate possible remedy effects of this agent in the treatment of respiratory, allergic, and immunol. diseases. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Safety of 5-Isopropyl-2-methylphenol).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Safety of 5-Isopropyl-2-methylphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Influence of Molecular Weight on the Performance of Polyelectrolyte Multilayer Nanofiltration Membranes was written by Regenspurg, Jurjen A.;Martins Costa, Ana F.;Achterhuis, Iske;de Vos, Wiebe M.. And the article was included in ACS Applied Polymer Materials in 2022.Computed Properties of C4H10O3 This article mentions the following:

Polyelectrolyte multilayers (PEMs) are highly promising selective layers for membrane applications, especially because of their versatility. By careful choice of the types of polyelectrolyte and the coating conditions, the PEM material properties can be controlled to achieve desired separations Less understood, however, is how the mol. weight (Mw) of the chosen polyelectrolytes (PEs) will impact layer build-up and thus separation properties. In this work, we investigate the influence of Mw on the performance of two types of PEM-based membranes. PEM membranes have been fabricated from low (15-20 kDa) and high (150-250 kDa) Mw poly(allylamine hydrochloride) (PAH), poly(sodium-4-styrenesulfonate)(PSS), and poly(acrylic acid) (PAA) to obtain PAH/PSS- and PAH/PAA-based nanofiltration membranes. For the linear growing PSS/PAH system, with low PE mobility, the Mw is found to influence the pore closure of the support membrane during coating but not its subsequent performance. In contrast, for the exponentially growing PAH/PAA system with a high PE mobility, much stronger effects of Mw are observed For low-Mw PAH/PAA PEM membranes, separation properties are found that would be expected of a neg. charged separation layer, while for high-Mw PAH/PAA PEMs a pos. separation layer is found. Moreover, mol. weight cutoff (MWCO) measurements show that the low-Mw PAH/PAA multilayers are much denser than their high-Mw counterparts. Here the higher mobility of the small PE chains is expected to lead to more optimal binding between the oppositely charged PEs, explaining the denser structure. Lastly, we find that PEM pH stability is lowest for low-Mw PAH/PAA multilayers which can again be attributed to their higher mobility. Clearly, the Mw can significantly influence the separation performance of PEM-based membranes, especially for more mobile PEM systems such as PAA/PAH. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Computed Properties of C4H10O3).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C4H10O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microwave-mediated asymmetric hydrogen transfer by SBA-15-supported ruthenium catalyst was written by Jin, Myung-Jong;Jun, In-Chul. And the article was included in Hwahak Konghak in 2008.Product Details of 120121-01-9 This article mentions the following:

Mesoporous SBA-15 silica-supported TsCHDA and TsDPEN ligands have been prepared by reaction of SBA-15 silica with (1R,2R)-N-(trimethoxysilylpropyl-N-sulfonyl)-1,2-cyclohaxanediamine or (1R,2R)-N-(trimethoxysilylpropyl-N-sulfonyl)-1,2-diphenylethylenediamine-1,2- diphenylethylenediamine, resp. The Ru complexes exhibited excellent catalytic activity and satisfactory enantioselectivity in the asym. hydrogen transfer of ketones under microwave conditions. The heterogeneous Ru catalyst was reusable as well as air-stable to allow easy use. Microwave-assisted efficient procedure has been developed for asym. hydrogen transfer. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Product Details of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Facile Synthesis of Thienoacenes via Transition-Metal-Free Ladderization was written by Feofanov, Mikhail;Akhmetov, Vladimir;Takayama, Ryo;Amsharov, Konstantin Yu. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of Sodium 2-methyl-2-propanethiolate This article mentions the following:

Herein, a facile transition-metal-free approach to sulfur-containing heteroacenes e.g., dibenzo[b,d]thiophene from fluorinated oligophenylenes e.g., 2,2′-difluoro-1,1′-biphenyl was reported. Unlike most existing methods, the presented approach is not restricted to simple dibenzothiophene derivatives and thus appears to be a useful tool for the synthesis of extended sulfur-containing heteroacenes. The incorporation of sulfur is unambiguously preprogrammed via the positions of fluorines in the precursors, allowing the selective synthesis of extended thienoacenes with up to 96% yield. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Quality Control of Sodium 2-methyl-2-propanethiolate).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Sodium 2-methyl-2-propanethiolate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chromatography of pyridine derivatives on a thin unfixed layer of aluminum oxide was written by Grandberg, I. I.;Faizova, G. K.;Kost, A. N.. And the article was included in Zhurnal Analiticheskoi Khimii in 1965.Name: 6-Methyl-2-pyridinemethanol This article mentions the following:

Thin-layer chromatog. in Al₂O₃ (CA 59, 1616d) is used for the identification and separation of a number of pyridine bases. The relation between the R_f values and the place and the nature of the derivative gives an indication of its identity. The disubstituted pyridines with a high R_f value are the most chromatog. active; tri- or tetrasubstitutes are less active and have a low R_f value. In 25:1 C₆H₆MeOH, the following mixtures can be separated: pyridine-pyridine N-oxide (R_f 0.64 and 0.14, resp.), 3-bromopyridine and 3-hydroxypyridine (0.76, 0.09) 2-chloropyridine and 2-aminopyridine (0.33, 0.38), α,α’-bipyridyl and γ,γ’-bipyridyl (0.72, 0.30). In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Name: 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Automated solid sample dissolution coupled with sugaring-out homogenous liquid-liquid extraction. Application for the analysis of throat lozenge samples was written by Shishov, Andrey;Nechaeva, Daria;Moskvin, Leonid;Andruch, Vasil;Bulatov, Andrey. And the article was included in Journal of Molecular Liquids in 2017.Product Details of 1777-82-8 This article mentions the following:

A novel automated procedure for anal. of solid samples based on the online dissolution of solid sample and sugaring-out reagent in water-acetonitrile mixture coupled with sugaring-out homogenous liquid-liquid extraction was developed. The procedure was performed in a mixing chamber of a stepwise injection anal. manifold. The performance of the suggested approach was demonstrated by the determination of 2,4-dichlorobenzyl alc., amylmetacresol, Yellow Orange S, Azo Rubine and Ponceau 4R in pharmaceutical samples. After phase separation, the upper acetonitrile phase containing 2,4-dichlorobenzyl alc., amylmetacresol and lower aqueous phase containing artificial dyes were sequentially analyzed. Under optimal exptl. conditions the linear ranges were found to be 0.1-10 mg L^– 1 for 2,4 dichlorobenzyl alc., 0.5-50 mg L^– 1 for amylmetacresol, and 1-100 mg L^– 1 for artificial dyes. The sample throughput was 10 h^– 1. The proposed method was successfully applied for the automated anal. of com. throat lozenges and the anal. results agreed fairly well with the results obtained by reference HPLC-UV method. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Product Details of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogenation and Reductive Amination of Aldehydes using Triphos Ruthenium Catalysts was written by Christie, Francesca;Zanotti-Gerosa, Antonio;Grainger, Damian. And the article was included in ChemCatChem in 2018.HPLC of Formula: 1777-82-8 This article mentions the following:

An air-stable and readily accessible ruthenium dihydride complex catalyzes aldehyde hydrogenation under neutral conditions. A high activity has been shown in a number of examples, and solvent-free conditions are also applicable, which favors industrial-scale applications. The catalyst has also been demonstrated to be active at low catalyst loadings for the reductive amination of aldehydes under mildly acidic conditions. A number of examples of chemoselectivity challenges are also presented in which the catalyst does not reduce carbon-halogen groups, alkene or ketone functionality. The advantage of using the pre-formed complex, Triphos-Ru(CO)H₂ (1), over in situ formed catalysts from Triphos and Ru(acac)₃ (acac=acetylacetonate) is also shown in terms of both chemoselectivity and activity, in particular this can be seen if low reaction temperatures are used. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts