Tag: 100-200

Synthesis and biological activity profile of novel triazole/quinoline hybrids was written by Jamshidi, Hoda;Naimi-Jamal, Mohammad Reza;Safavi, Maliheh;RayatSanati, Kimia;Azerang, Parisa;Tahghighi, Azar. And the article was included in Chemical Biology & Drug Design.HPLC of Formula: 1777-82-8 This article mentions the following:

A novel series of 1,2,3-triazole-based polyaromatic compounds containing chloroquinoline moiety I (Ar = 4-ClC₆H₄, 4-O₂NC₆H₄, 4-MeOC₆H₄, etc.) was synthesized through a well-established synthetic methodol., named click chem. The structure of the synthetic compounds was characterized by various spectroscopic methods. The final products of triazole/quinoline hybrids I and ((prop-2-yn-1-yloxy)methyl)benzene intermediates HCCCH₂OCH₂Ar were screened for their antibacterial (Staphylococcus aureus, Escherichia coli, Shigella flexneri, and Salmonella enterica), antifungal (Candida albicans, Saccharomyces cerevisiae, and Aspergillus fumigatus), and cytotoxic activities. The best antifungal compounds exhibited min. inhibitory concentration (MIC), in the range of 0.35-0.63 μM, against S. cerevisiae without any cytotoxic effect. These compounds can be selected as the potential candidates for treating invasive fungal infections caused by S. cerevisiae, after further investigation. Preliminary in silico ADME studies also predicted the favorable pharmacokinetic attributes of most compounds In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The aggregation pheromone of the German cockroach, Blattella germanica (L.)(Dictyoptera: Blattellidae): isolation and identification of the attractant components of the pheromone was written by Sakuma, Masayuki;Fukami, Hiroshi. And the article was included in Applied Entomology and Zoology in 1990.Related Products of 14123-48-9 This article mentions the following:

Attractant components of the aggregation pheromone of the German cockroach, B. germanica, were isolated from frass-contaminated filter paper. Successive purification steps were monitored by olfactometer assay, and each attractant component was eventually identified by gas chromatog. (GC)-mass spectrometry and the assay on each preparative GC fraction. The attractant comprised several volatile amines. Amine evaporation was restricted by salt formation with acid(s) in the excreta. All the identified NH₃ and 12 amines exerted both chemotaxis and anemotaxis on B. germanica nymphs. Typical excretory materials such as NH₃, methylamine, dimethylamine, and trimethylamine were the major components. The most active component was 1-dimethylamino-2-methyl-2-propanol (ED₅₀ = 10 pmol/L air), which was 50-1000-fold more active than the others. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Related Products of 14123-48-9).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 14123-48-9

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Self-assembled nanoporphyrins in the presence of gold bio-nanoparticles as heterogeneous nano-biocatalyst for green production of aldehydes and ketones was written by Taheri Bazmi, Mahmoud;Naeimi, Atena;Saeednia, Samira;Hatefi Ardakani, Mehdi. And the article was included in Applied Organometallic Chemistry in 2020.Recommanded Product: 1777-82-8 This article mentions the following:

A simple and facile self-assembly method for the successful fabrication of a biol. macromol., MnTPPCl (manganese(III) chloride 5,10,15,20-tetraphenylporphyrin), intercalated into gold nanoparticles using the cooperative effects of Sesbania sesban plant was reported. This biohybrid was characterized by using various techniques for further investigation. The catalytic activity of this biol. hybrid was considered in the production of aldehydes RCHO (R = Ph, furan-2-yl, 2-phenylethenyl, etc.) and ketones RC(O)R¹ (R = Ph; R¹ = Me, Et) from primary RCH₂OH and secondary alcs., RCH(OH)R¹ resp. Excellent conversions and selectivities were obtained applying Au@MnTPPCl colloidal nanocomposite and NaIO₄ as an oxygen donor in ethanol. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Recommanded Product: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of rupatadine fumarate was written by Li, Liulin;Chen, Li;Sheng, Rong. And the article was included in Zhongguo Xiandai Yingyong Yaoxue in 2014.Related Products of 102074-19-1 This article mentions the following:

OBJECTIVE To synthesis rupatadine fumarate and optimize the reaction conditions. METHODS Rupatadine fumarate was synthesized from 5-Me nicotinic via esterification, reduction, chlorination, alkylation and salification. RESULTS The rupatadine fumarate was synthesized with a total yield of 46.4% and its structure was confirmed by ¹H-NMR, MS and IR. CONCLUSION The synthetic route is suitable for production of rupatadine fumarate in industry. In the experiment, the researchers used many compounds, for example, (5-Methylpyridin-3-yl)methanol (cas: 102074-19-1Related Products of 102074-19-1).

(5-Methylpyridin-3-yl)methanol (cas: 102074-19-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 102074-19-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A fast, single column high-performance anion exchange chromatography with pulsed amperometric detection method for the determination of saccharides in atmospheric aerosol samples was written by Patil, Sachin;Rohrer, Jeffrey. And the article was included in Journal of Separation Science in 2022.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Saccharides, especially anhydro sugars present in atm. aerosols, can be used as tracers to track sources of atm. aerosols. High-performance anion-exchange chromatog. with pulsed amperometric detection is a commonly used technique for determining these saccharides, but the reported methods suffer from three drawbacks. First, to achieve separation of the complete set of atm. saccharides, run times are very long, typically longer than 60 min. Second, some methods require two columns to achieve the desired separation Finally, in an era when electrolytic eluent preparation allows for excellent precision and accuracy, these methods require manually prepared eluents, which can lead to separation inconsistency for closely eluting analytes. These drawbacks make existing methods difficult to automate. To address this issue, we developed a fast method that uses only a single column for separation and electrolytically generated eluent that resolves 12 key atm. aerosol saccharides in 20 min. The resolved saccharides include anhydro sugars (levoglucosan, galactosan, and mannosan), sugar alcs. (erythritol, xylitol, and mannitol), and mono-/disaccharides (arabinose, galactose, glucose, mannose, fructose, and sucrose). To our knowledge, this report is the first instance of achieving such a significant reduction in run time with good resolution for this set of saccharides. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, Synthesis, and Evaluation of Substituted Phenylpropanoic Acid Derivatives as Human Peroxisome Proliferator Activated Receptor Activators. Discovery of Potent and Human Peroxisome Proliferator Activated Receptor α Subtype-Selective Activators was written by Nomura, Masahiro;Tanase, Takahiro;Ide, Tomohiro;Tsunoda, Masaki;Suzuki, Masahiro;Uchiki, Hideharu;Murakami, Koji;Miyachi, Hiroyuki. And the article was included in Journal of Medicinal Chemistry in 2003.SDS of cas: 2968-93-6 This article mentions the following:

Substituted phenylpropanoic acid derivatives such as I are prepared as selective human peroxisome proliferator activated receptor α (PPARα) activators. Structure-activity relationships for the binding of a variety of substituted phenylpropanoic acid derivatives to human peroxisome proliferator activated receptors are determined The nature and the stereochem. of the substituent at the α-position of the head part containing the carboxyl group, the distance between the carboxyl group and the central benzene ring, the linking group between the central benzene ring and the distal benzene ring, and the substituent at the distal hydrophobic tail part of the mol. all play key roles in determining the potency and selectivity of PPAR subtype transactivation. Mol. mechanics calculations of the conformers of phenylpropanoic acid derivatives and of the enantiomers of an α-ethyl-substituted phenylpropanoic acid derivative are discussed. I is a particularly effective PPARα activator with significant selectivity for PPARα. In rats, I decreases serum cholesterol and lipids over five days of administration in a dose-dependent manner and with a significantly greater efficacy than a representative fibrate (bezafibrate) used for comparison. Phenylpropanoic acid II is found to be a dual activator of PPARα and of PPARδ. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6SDS of cas: 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An improved synthesis of the saponin, polyphyllin D was written by Li, B.;Yu, B.;Hui, Y.;Li, M.;Han, X.;Fung, K.-P.. And the article was included in Carbohydrate Research in 2001.HPLC of Formula: 10030-85-0 This article mentions the following:

Polyphyllin D, namely diosgenyl α-L-rhamnopyranosyl-(1,2)-[(α-L-arabinofuranosyl)-(1,4)]-β-D-glucopyranoside, was synthesized from diosgenyl-β-D-glucopyranoside in four steps and in 30% overall yield, taking advantage of regioselective pivaloylation and α-L-rhamnopyranosylation reactions. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0HPLC of Formula: 10030-85-0).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 10030-85-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thermal storage performance of eutectic sugar alcohols applied to buildings and enhancement of crystallization was written by Fan, Chenguang;Yuan, Guofeng;Wang, Yan;Zhang, Yu;Wang, Zhifeng. And the article was included in Solar Energy in 2022.Recommanded Product: 149-32-6 This article mentions the following:

Sugar alcs. are suitable for compact and high-d. building thermal energy storage systems because of the high enthalpy, low price, and non-toxicity. But most sugar alc. materials have severe supercooling characteristic, which limits their application as phase change materials (PCMs) in thermal energy storage systems. In this study, xylitol, sorbitol, erythritol, mannitol and dulcitol were selected as PCMs. Based on the five single sugar alcs., ten multicomponent eutectic sugar alcs. were obtained which melting temperatures is between 60°C and 90°C applied to buildings. The thermal parameters of sugar alcs. were tested by differential scanning calorimetry (DSC), the supercooled eutectic sugar alcs. were stimulated by means of mech. agitation to accelerate crystallization The crystallization after excitation was monitored by microscope, and the supercooled crystallization phenomenon of eutectic sugar alcs. was investigated by isothermal phase change tests. The results showed that only three eutectic sugar alcs. could crystallize by stirring, and the melting temperatures of three eutectic sugar alcs. are about 80°C. After multiple repetitive experiments, three eutectic sugar alcs. still have good crystallization characteristics. The results of the research provide a reference value in practical aspects for the design and selection of phase change materials in buildings. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Recommanded Product: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and biological studies of novel 2-aminoalkyl ethers as potential antiarrhythmic agents for the conversion of atrial fibrillation was written by Plouvier, Bertrand;Beatch, Gregory N.;Jung, Grace L.;Zolotoy, Alexander;Sheng, Tao;Clohs, Lilian;Barrett, Terrance D.;Fedida, David;Wang, Wei Q.;Zhu, Jeff J.;Liu, Yuzhong;Abraham, Shlomo;Lynn, Leah;Dong, Ying;Wall, Richard A.;Walker, Michael J. A.. And the article was included in Journal of Medicinal Chemistry in 2007.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol This article mentions the following:

A series of 2-aminoalkyl ethers R¹R²NCHR³CHR⁴O(CH₂)_nCHR⁵R⁶ (I) [n = 1 – 3; R¹ = R² = MeOCH₂CH₂; R¹R²N = 4-morpholinyl, 1-piperazinyl, 3-oxo-1-pyrrolidinyl, etc.; R³ = H, R⁴ = n-Bu; R³R⁴ = (CH₂)₃, (CH₂)₄; R⁵ = H, Ph; R⁶ = 1-naphthyl, 2-naphthyloxy, 4-BrC₆H₄, 3-benzothienyl, etc.] was prepared as potential antiarrhythmic agents. These compounds are mixed sodium and potassium ion channel blockers and exhibit antiarrhythmic activity in a rat model of ischemia-induced arrhythmias. Structure-activity studies led to the identification of three compounds I [n = 1; R¹R²N = 4-morpholinyl; R³R⁴ = (CH₂)₄; R⁵ = H; R⁶ = 1-naphthyl, 3,4-Cl₂C₆H₃] and I [n = 1; R¹R² = 3-oxo-1-pyrrolidinyl; R³R⁴ = (CH₂)₄; R⁵ = H; R⁶ = 1-naphthyl; (II)], which were selected based on their particular in vivo electrophysiol. properties, for studies in two canine atrial fibrillation (AF) models. These three compounds converted AF in both models, but only compound II was shown to be orally bioavailable. Resolution of the racemate II into its corresponding enantiomers and subsequent biol. testing of these enantiomers led to the selection of (1S,2S)-II as a potential atrial selective antiarrhythmic candidate for further development. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 2-(Trifluoromethyl)phenethyl alcohol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Light-Triggered Release of Biomolecules from Diamond Nanowire Electrodes was written by Wang, Qian;Coffinier, Yannick;Li, Musen;Boukherroub, Rabah;Szunerits, Sabine. And the article was included in Langmuir in 2016.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

The controlled release of biomols. from a substrate surface is a challenging task. Photocleavable linkers appear as attractive candidates for light-triggered delivery. We show here the possibility of creating photoactivable diamond nanowire interfaces, from which mols. can be photochem. released upon irradiation at 365 nm for several minutes. The approach is based on the covalent modification of boron-doped diamond nanowires (BDD NWs) with o-nitrobenzyl containing ligands, to which different biomols. can be attached via amide bond formation. The photodecomposition reaction and the subsequent release of small proteins such as lysozyme or enzymes such as horseradish peroxidase (HRP) are investigated using electrochem. impedance spectroscopy. Using a colorimetric assay, we demonstrate that, while complete cleavage of HRP was achieved upon irradiation for 10 min at 1 W cm^-2, this exposure time resulted in a partial loss of enzymic activity. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts