Tag: 100-200

Efficiently catalytic transfer hydrogenation of aryl and heteroaryl halides by ultrafine palladium nanoparticles confined into UiO-66 was written by Tong, Liangliang;Song, Xinluo;Jiang, Yuxin;Zhao, Bangyao;Li, Yafeng. And the article was included in International Journal of Hydrogen Energy in 2022.COA of Formula: C7H7ClO This article mentions the following:

The hydrodehalogenation of aryl and heteroaryl halides (AHHs) is very crucial for academic and industrial applications. Herein, ultrafine palladium nanoparticles (Pd NPs) with the size distribution about 1.77 ± 0.35 nm, were in-situ synthesized and confined into the metal-organic framework of UiO-66 (named as Pd@UiO-66) by impregnation reduction method without tedious post-reducing step. Pd@UiO-66 shows excellent activity with a high conversion (>90%) efficiency in the catalytic transfer hydrogenation (CTH) of AHHs under mild water systems utilizing ammonium formate as hydrogen donor. Furthermore, Pd@UiO-66 maintains highly excellent stability (conversion >95%) after 5 times reused cycles without losing catalytic activity and leaching Pd nanoparticles. This study supplies a new method for hybrid catalysts by immobilizing ultrafine Pd nanoparticles into crystalline MOFs, displaying efficient transform performance for halogen compounds by catalytic hydrogenation. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7COA of Formula: C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Possibility for the long-term storage of tableted drugs in plastic tubes was written by Malakhova, Z. N.;Artem’ev, A. I.. And the article was included in Farmatsiya (Moscow, Russian Federation) in 1976.HPLC of Formula: 2451-01-6 This article mentions the following:

Of the packaging materials tested, polyethylene [9002-88-4] and glass were the most effective, polystyrene [9003-53-6] was intermediate in effectiveness, and paper and cellophane were the least effective in controlling the moisture content of pharmaceutical tablets stored for 12 months. The relative effectiveness of each type of packaging material in controlling moisture varied somewhat with the drug tested. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6HPLC of Formula: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.HPLC of Formula: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of terpin hydrate from turpentine with ultrasound was written by Wang, Lin-lin;Chen, Xiao-peng;Wei, Xiao-jie;Zhu, Yuan-jiao. And the article was included in Tianranqi Huagong in 2003.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate This article mentions the following:

The hydration reaction of turpentine catalyzed by sulfuric acid was studied. The non-homogeneous phase mass transfer has been enhanceed by ultrasound, and factors which influence the hydration reaction were optimized by the simplex search method. The optimum reaction conditions were as follows: reaction time = 17 h, H₂SO₄ concentration = 30% wt, turpentine/H₂SO₄ weight ratio = 1:1.72; under these conditions the yield of terpin hydrate was up to 94.82%. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel 1,4-dihydropyridine calcium antagonists. I. Synthesis and hypotensive activity of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives was written by Ashimori, Atsuyuki;Ono, Taizo;Uchida, Takeshi;Ohtaki, Yutaka;Fukaya, Chikara;Watanabe, Masahiro;Yokoyama, Kazumasa. And the article was included in Chemical & Pharmaceutical Bulletin in 1990.Recommanded Product: 2-Bromopyridine-4-methanol This article mentions the following:

A series of 4-(substituted pyridyl)-1,4-dihydropyridine derivatives I (R = H, halo, CF₃, etc.) were synthesized and their hypotensive effects examined Several compounds have a hypotensive activity parallel to that of nicardipine; the 4-(3-trifluoromethyl-2-pyridyl) and 4-(2-trifluoromethyl-3-pyridyl) derivatives, in particular, had approx. twice the duration of nicardipine, and the 4-(4-cyano-2-pyridyl) derivative had the most potent hypotensive activity of all the derivatives synthesized. In the experiment, the researchers used many compounds, for example, 2-Bromopyridine-4-methanol (cas: 118289-16-0Recommanded Product: 2-Bromopyridine-4-methanol).

2-Bromopyridine-4-methanol (cas: 118289-16-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 2-Bromopyridine-4-methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stereoselective synthesis of N,N’-diacyl-p-menthan-1,8-diamines was written by Koval’skaya, S. S.;Kozlov, N. G.;Tikhonova, T. S.. And the article was included in Khimiya Prirodnykh Soedinenii in 1989.SDS of cas: 2451-01-6 This article mentions the following:

Reaction of terpin hydrate with RCN (R = Me, ClCH₂, Me₂CH, Ph) under Ritter reaction conditions stereoselectively leads to the formation of isomeric cis– and trans–N,N‘-diacyl-p-menthane-1,8-diamines in a 1:4 ratio. Structures were confirmed by proton and ¹³C NMR spectroscopy. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6SDS of cas: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comparative evaluation of encapsulation using β-cyclodextrin versus freeze-drying for better retention and stabilizing of black Perigord truffle (Tuber melanosporum) aroma was written by Phong, Win Nee;Al-Salami, Hani;Gibberd, Mark R.;Dykes, Gary A.;Payne, Alan D.;Coorey, Ranil. And the article was included in Journal of Food Science in 2022.Quality Control of Oct-1-en-3-ol This article mentions the following:

This study aimed to develop a novel technique to retain and stabilize compounds contributing to truffle aroma by encapsulation using β-cyclodextrin. Two experiments were conducted. In the first experiment, the key volatile profile and microbial population of products resulting from three different encapsulation methods, namely direct mixing method (M1), direct mixing followed by ethanol addition method (M2), and paste method (M3), were compared with untreated truffles (pos. control) over a 90-day period. The M2-derived product was the least optimal for retaining key volatile compounds despite showing the lowest microbial population. There was no significant difference in the volatile profile of products derived from M1 and M3 on day 0. However, it was observed that the M3-derived product could retain its volatile profile better than the M1-derived product by day 90. M3 was compared with freeze-drying in the second experiment Freeze-dried truffles showed an overall higher relative percentage of volatiles than the M3-derived product on day 0. However, by day 90, some volatile changes occurred in the freeze-dried truffles but not in the M3-derived product. The findings indicate that while freeze-drying could adequately conserve truffle volatiles, the encapsulation of volatile compounds in β-cyclodextrin could improve the volatile stability of truffle products and allow for longer storage times. Microbes were found in all encapsulated truffle products and freeze-dried truffles on days 0 and 90, suggesting the need to explore the possibility of incorporating a decontamination step in the process prior to either encapsulation or freeze-drying. Practical Application : A technique to capture and stabilize compounds responsible for truffle aroma by encapsulation using β-cyclodextrin was developed and compared with freeze-drying in this study. The overall finding suggests that while freeze-drying of truffle could sufficiently preserve volatiles, encapsulating truffle volatiles with β-cyclodextrin may improve its stability, extending its shelf life, which can be applied in the development of a natural truffle ingredient that can be applied in food product development. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Quality Control of Oct-1-en-3-ol).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Quality Control of Oct-1-en-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Arylazo Sulfones as Nonionic Visible-Light Photoacid Generators was written by Di Terlizzi, Lorenzo;Martinelli, Angelo;Merli, Daniele;Protti, Stefano;Fagnoni, Maurizio. And the article was included in Journal of Organic Chemistry.Synthetic Route of C10H20O This article mentions the following:

The selective visible-light-driven generation of a weak acid (sulfinic acid, in nitrogen-purged solutions) or a strong acid (sulfonic acid, in oxygen-purged solutions) by using shelf-stable arylazo sulfones was developed. These sulfones were then used for the green, smooth, and efficient photochem. catalytic protection of several (substituted) alcs. (and phenols) as tetrahydropyranyl ethers or acetals. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Synthetic Route of C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization of indigenous coagulase-negative staphylococci isolated from Chinese spontaneously fermented meat products was written by Chen, Juan;Zhang, Jingbin;Yang, Ziyao;Niu, Ying;Cai, Zijian;Wang, Jie;Yin, Liguo;Lin, Yaqiu;Lu, Xiaonan. And the article was included in Microbiological Research in 2022.COA of Formula: C8H16O This article mentions the following:

Technol., safety-related and volatile properties were analyzed in coagulase-neg. staphylococci (CNS) isolates from Chinese spontaneously fermented meat products. A total of 107 CNS isolates were identified via 16 S rRNA sequencing, and the most recovered species were S. saprophyticus (53.3%), S. edaphicus (12.1%), and S. epidermidis (10.3%). Among them, 58 CNS isolates belonging to 9 species were selected with higher activities of catalase, nitrate reductase, proteolysis, and lipolysis, as well as higher tolerance to stressful environmental conditions. Then, 7 CNS isolates belonging to 4 species were further selected based upon excellent technol. characteristics, lack of hemolysis and antibiotic resistance, and a low production of biogenic amines. The volatile profiles of these 7 strains cultivated in pork broth was determined S. casei Number 1 produced significant amounts of phenethyl alc., geraniol, and 3-methyl-butanol. S. xylosus Number 120 produced the highest amount of Me ketones with the potential to provide dry-cured odor of fermented meats. The volatile profile was highly strain dependent. Several CNS identified in this study have the potential to be used as the starter cultures for fermented meat products. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4COA of Formula: C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Characterization of Novel Volatile Imido-Aminoalkoxide Tantalum Compounds was written by Park, Bo Keun;Kim, Hyo-Suk;Shin, Su Jung;Min, Jae Ki;Lee, Kang Mun;Do, Youngkyu;Kim, Chang Gyoun;Chung, Taek-Mo. And the article was included in Organometallics in 2012.Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol This article mentions the following:

A novel Ta(V) ^tBu-imido/aminoalkoxide complex, Ta(N^tBu)(dmamp)₂Cl (1), was synthesized by metathesis reaction between Ta(N^tBu)Cl₃(py)₂ and 2 equiv of Na(dmamp), and subsequent reaction of 1 with 1 equiv of MeLi gave a new tantalum complex, Ta(N^tBu)(dmamp)₂Me (2). Compounds 1 and 2 have been characterized by IR, ¹H and ¹³C NMR spectroscopy, and microanal. data. The mol. structure of 1, determined by x-ray single crystallog., revealed distorted octahedral geometry. The behavior of compound 1 in solution was studied by variable-temperature ¹H NMR spectra. Thermogravimetric anal. revealed superior thermal properties of 2 as compared to those of 1. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of 1-(Dimethylamino)-2-methylpropan-2-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfur-Rich Zinc Chemistry: New Tris(thioimidazolyl)hydroborate Ligands and Their Zinc Complex Chemistry Related to the Structure and Function of Alcohol Dehydrogenase was written by Tesmer, Markus;Shu, Mouhai;Vahrenkamp, Heinrich. And the article was included in Inorganic Chemistry in 2001.Formula: C7H9NO This article mentions the following:

The 1-substituted tris(2-thioimidazolyl)hydroborate ligands Tt^R were prepared as the K salts from KBH₄ and the corresponding 1-R-2-thioxoimidazole for R = t-Bu and C₆H₄-p-CHMe₂ (Cum). Their reactions with Zn salts yielded the tetrahedral complexes Tt^RZn-X with X = F, Cl, ONO₂ and (Tt^t-Bu)₂Zn. With Zn(ClO₄)₂ the labile perchlorate complexes Tt^RZn-OClO₃ were obtained. They served as starting materials for the incorporation of substrates which are relevant for the chem. of horse liver alc. dehydrogenase: EtOH led to [Tt^t-BuZn·EtOH] ClO₄·EtOH, p-nitrophenol (NitOH) yielded Tt^CumZn-ONit. Pyridine-2-carbaldehyde and salicylaldehyde were incorporated as N(pyridine) and O(phenolate) coligands with possible addnl. O(aldehyde) coordination. Substituted pyridylmethanols (R-PyCH₂OH) yielded trinuclear [(Tt^t-Bu)₂Zn₃(R-PyCH₂O)₂](ClO₄)₂ with bridging Tt and pyridylmethoxide ligands. Preliminary experiments on the functional modeling of alc. dehydrogenase showed that TtZn complexes promote both the dehydrogenation of iso-PrOH and the hydrogenation of pentafluorobenzaldehyde. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Formula: C7H9NO).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C7H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts