Tag: 0-100

《Tuning the solubility parameters of carbon nanotubes by means of their adducts with Janus pyrrole compoundsã€?was published in Nanomaterials in 2020. These research results belong to Locatelli, Daniele; Barbera, Vincenzina; Brambilla, Luigi; Castiglioni, Chiara; Sironi, Annalisa; Galimberti, Maurizio. Formula: C3H9NO2 The article mentions the following:

The solubility parameters of multiwalled carbon nanotubes (CNTs) was tuned via their chem. modification with pyrrole compounds (PyCs), by means of a simple and sustainable methodol. PyCs were synthesized with high atom efficiency through the Paal-Knorr reaction of primary amines with 2,5-hexanedione, in the absence of solvents and catalysts. Methylamine, 1-dodecylamine, 2-amino-1,3-propanediol, and 3-(triethoxysilyl)propan-1-amine were selected. PyCs are characterized by two moieties, the pyrrole ring and the substituent of the nitrogen atom, and can be considered as Janus mols. The functionalization of CNTs occurred with a high yield by simply heating CNTs and PyC. The whole reaction pathway did not produce any waste and was characterized by a carbon efficiency up to almost 100%. Thanks to the variety of PyC chem. structures, the CNT solubility parameter was modified in a pretty broad range of values, in the expected direction. Stable CNT dispersions were prepared in different solvents. From the aqueous dispersion, coating layers were prepared with high elec. conductivity, larger with respect to a top com. product. The “”pyrrole methodol.”” reported here is based on one reaction and allows almost infinite variations of the CNT solubility parameter, thus promoting their compatibility with target matrixes and allowing the preparation of nanocomposite materials with improved properties. This work thus paves the way for a highly efficient exploitation of CNTs. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C3H9NO2

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Mudasani, Gopal; Paidikondala, Kalyani; Gundla, Rambabu; Joseph Maddirala, Shambabu; Das, Viswanath published their research in ChemistrySelect in 2021. The article was titled 《Synthesis and Biological Evaluation of 5′-Arylspiro[piperidine-4,3′-pyrrolo-[2,3-b]pyridin] Analogues》.Related Products of 7748-36-9 The article contains the following contents:

The synthesis of a novel series of spiro[piperidine-4,3′-pyrrolo[2,3-b]pyridin]-2′(1’H)-one analogs I [R = H, CONH2; Ar = pyrimidin-5-yl, 4-fluorophenyl, 1,3-benzodioxol-5-yl, etc.] and in-vitro antiproliferative activity of these compounds against four human cancer cell lines were reported. Synthesis of analogs I were done using a rational designing approach in a seven-step sequence and the characterization of compounds was performed using 1H-NMR, LC-MS, and 13C-NMR. Thirteen novel compounds I were synthesized in moderate to good yields. The anti-proliferation activity of the compounds I against human breast MCF-7 and MDA-MB-231, leukemic K-562 and lung A549 cancer cells were determined by a standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide assay. Two compounds among all the synthesized compounds I had moderate IC50 values in MCF-7 cells and thus were identified to have better antiproliferative activity against estrogen-receptor-pos. cancer cells. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Synthesis and photophysical studies of an indigo derivative: N-octyl-7,7′-diazaindigo》 was written by de Miguel, Gustavo; Garzon-Ruiz, Andres; Navarro, Amparo; Garcia-Frutos, Eva M.. Recommanded Product: Oxetan-3-ol And the article was included in RSC Advances in 2020. The article conveys some information:

In this paper, we explore the synthesis, characterization, and photophys. properties of a novel indigo derivative, N-octyl-7,7′-diazaindigo, being the first time that diazaindigos have been studied as photophys.-active chem. entities. Reduction of the neutral “”keto-form”” to the so-called “”leuco-form”” changes the global spectroscopic and photophys. behaviors. Both species have been investigated by different photophys. studies, such as anal. of absorption and emission spectra, fluorescence quantum yields (ϕF) and lifetimes. Finally, to appraise in depth the deactivation of the excited state of the keto form, femtosecond transient absorption (TA) experiments and D. Functional Theory (DFT) and Time Dependent (TD)-DFT calculations were performed. In an organic aprotic solvent (N,N-dimethylformamide), TA experiments showed a fast deactivation channel (τ1 = 2.9 ps), which was ascribed to solvent reorganization, and a longer decay component (τ2 = 86 ps) associated with an internal conversion (IC) process to the ground-state, in opposition to the excited state proton transfer (ESPT) mechanism that takes place in the indigo mols. but in protic solvents. A comparative study was also carried out on the parent mol., 7,7′-diazaindigo, corroborating the previous conclusions obtained for the alkyl derivative In agreement with exptl. observations, DFT and TD-DFT calculations revealed that the deactivation of the S1 state of the keto form takes place through an internal conversion process. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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《Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77》 was written by Fang, Hua; Zhang, Jianyu; Ao, Mingtao; He, Fengming; Chen, Weizhu; Qian, Yuqing; Zhang, Yuxiang; Xu, Yang; Fang, Meijuan. Related Products of 13325-10-5 And the article was included in Bioorganic Chemistry in 2020. The article conveys some information:

In this work, three series of ω-3 polyunsaturated fatty acid-alkanolamine derivatives (PUFA-AAs) were synthesized, characterized and their anti-inflammatory activity in vivo was evaluated. Three compounds exhibited marked anti-inflammatory activity in LPS-stimulated RAW 264.7 cells. The most promising compound cis-7,10,13,16,19-docosapentaenoic acid 2-hydroxyethyl amide (I) dose-dependently suppressed the cytokines with IC50 values in the low micromolar range. Further, I exhibited potential in vitro Nur77-binding affinity (Kd = 6.99 x 10-6 M) which is consistent with the result of docking studies. Next, the anti-inflammatory mechanism of I was found to be through NF-κB signal pathway in a Nur77-dependent manner. Moreover, we also observed I significantly inhibited LPS-induced expression of cytokines (IL-6, TNF-α, and IL-1β) through suppressing NF-κB activation and attenuated LPS-induced inflammation in mouse acute lung injury (ALI) model. In conclusion, the study strongly suggests that the PUFA-AA derivatives can be particularly as new Nur77 mediators for further treatment in inflammatory diseases. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

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《Eco-Friendly Sustainable Poly(benzoxazine-co-urethane) with Room-Temperature-Assisted Self-Healing Based on Supramolecular Interactions》 was published in ACS Omega in 2020. These research results belong to Sriharshitha, Salendra; Krishnadevi, Krishnamoorthy; Devaraju, Subramani; Srinivasadesikan, Venkatesan; Lee, Shyi-Long. Application of 156-87-6 The article mentions the following:

This work is an attempt to develop bio-based eco-friendly poly(benzoxazine-co-urethane) [poly(U-co-CDL-aee)] materials using cardanol-based benzoxazines (CDL) and hexamethylene diisocyanate (HMDI) to check their self-healing ability and thermal properties. CDL monomers were synthesized using cardanol, amino ethoxyethanol (aee) or 3-aminopropanol (3-ap), and paraformaldehyde through the Mannich reaction. Later, CDL-aee or CDL-3-ap monomers were copolymerized with a urethane precursor (HMDI), followed by ring-opening polymerization through thermal curing. The thermal properties of poly(U-co-CDL) were evaluated by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA). The self-healing behavior of the bio-based poly(U-co-CDL) was checked by applying a mild external pressure. The results revealed that the developed poly(U-co-CDL) showed repeatable self-healing ability due to supramol. hydrogen-bonding interactions. Further, the self-healing ability of poly(U-co-CDL) was studied using d. functional theory (DFT). From the above results, the developed material with superior self-healing ability can be used in the form of self-healing coatings and composites for various applications with extended shelf-life and reliability. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application of 156-87-6

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Borrel, Julien; Pisella, Guillaume; Waser, Jerome published an article on January 17 ,2020. The article was titled 《Copper-Catalyzed Oxyalkynylation of C-S Bonds in Thiiranes and Thietanes with Hypervalent Iodine Reagents》, and you may find the article in Organic Letters.Formula: C3H6O2 The information in the text is summarized as follows:

We report the oxyalkynylation of thiiranes and thietanes using ethynylbenziodoxolone reagents (EBXs) to readily access functionalized building blocks bearing an alkynyl, a benzoate, and an iodide group. The reaction proceeds with high atom efficiency most likely through an alkynyl-episulfonium intermediate. The transformation is copper-catalyzed and compatible with a large array of thiiranes and thietanes. In the experimental materials used by the author, we found (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Formula: C3H6O2)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Formula: C3H6O2

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Kashida, Hiromu; Nishikawa, Keiji; Shi, Wenjing; Miyagawa, Toshiki; Yamashita, Hayato; Abe, Masayuki; Asanuma, Hiroyuki published an article in 2021. The article was titled 《A helical amplification system composed of artificial nucleic acids》, and you may find the article in Chemical Science.Recommanded Product: 534-03-2 The information in the text is summarized as follows:

Herein we report an amplification system of helical excess triggered by nucleic acid hybridization for the first time. It is usually impossible to prepare achiral nanostructures composed of nucleic acids because of their intrinsic chirality. We used serinol nucleic acid (SNA) oligomers for the preparation of achiral nanowires because SNA oligomers with sym. sequences are achiral. Nanowire formation was confirmed by at. force microscopy and size exclusion chromatog. When a chiral nucleic acid with a sequence complementary to SNA was added to the nanostructure, helicity was induced and a strong CD signal was observed The SNA nanowire could amplify the helicity of chiral nucleic acids through nucleobase stacks. The SNA nanostructures have potential for use as platforms to detect chiral biomols. under aqueous conditions because SNA can be readily functionalized and is water-soluble After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Recommanded Product: 534-03-2

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《Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury》 was written by Wang, Xiao; Liang, Qiujun; Mao, Yiming; Zhang, Rujing; Deng, Qiurong; Chen, Yongbing; Zhu, Rongying; Duan, Shanzhou; Yin, Lichen. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Biomaterials Science in 2020. The article conveys some information:

SiRNA-mediated RNA interference (RNAi) against inflammation-related genes provides a promising modality for the treatment of myocardial ischemia reperfusion (IR) injury, and its success is critically dependent on the development of efficient yet safe siRNA delivery vehicles. Herein, we developed a bioreducible, branched poly(β-amino ester) with built-in redox-responsive domains (BPAE-SS) for the effective ICAM-1 siRNA delivery into injured rat cardiac microvascular endothelial cells (RCMECs). The branched BPAE-SS with a multivalent structure afforded potent siRNA binding affinity compared to its linear analog, while upon internalization into RCMECs it was instantaneously degraded by intracellular glutathione (GSH) into small segments to mediate “”on-demand”” siRNA release and diminish the toxicity of post-transfection materials. By synchronizingly overcoming these critical barriers, BPAE-SS mediated remarkable ICAM-1 knockdown in IR-injured rats at 400μg siRNA per kg via single i.v. injection, and subsequently suppressed myocardial inflammation, apoptosis, and fibrosis to recover the cardiac function. This study therefore provides a unique delivery system that can address the multiple critical challenges against non-viral siRNA delivery, and the potent therapeutic efficacy of BPAE-SS-mediated ICAM-1 silencing provides a promising strategy for the anti-inflammatory treatment of myocardial IR injury. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

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The author of 《Chemoselective Synthesis of α-Amino-α-cyanophosphonates by Reductive Gem-Cyanation-Phosphonylation of Secondary Amides》 were Chen, Ting-Ting; Wang, Ai-E.; Huang, Pei-Qiang. And the article was published in Organic Letters in 2019. Related Products of 13325-10-5 The author mentioned the following in the article:

A novel approach to α-amino-α-cyanophosphonates was developed. The method features a Tf2O-mediated reductive geminal cyanation/phosphonylation of secondary amides. Mild reaction conditions, high bond-forming efficiency, inexpensive readily available starting materials, and good to excellent yields with wide functional group compatibility constitute the main advantages of this method. The protocol can be run on a gram scale. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

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Computed Properties of C4H11NOIn 2022 ,《Synthesis of Tertiary Amines through Extrusive Alkylation of Carbamates》 was published in Organic Letters. The article was written by Zhang, Guoliang; Favela, David; Chow, Winston L.; Iyer, Rishab N.; Pell, Alexander J.; Olson, David E.. The article contains the following contents:

A step-economical approach was reported enabling the protection of secondary amines as carbamates prior to their conversion to tertiary amines via the formal extrusion of CO2. This method was applied to the synthesis of iboga alkaloids (±)-conodusine A and (±)-conodusine B. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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