Tag: 0-100

Name: 4-Aminobutan-1-olIn 2020 ,《A general method for site-selective Csp3-S bond formation via cooperative catalysisã€?was published in Chemical Science. The article was written by Qin, Yuman; Han, Yujie; Tang, Yongzhen; Wei, Junfa; Yang, Mingyu. The article contains the following contents:

A copper-catalyzed site-selective thiolation of Csp3-H bonds of aliphatic amines to get thioaryl amines e.g., I. The method featured a broad substrate scope and good functional group compatibility. Primary, secondary and tertiary C-H bonds could be converted into C-S bonds with a high efficiency. The late-stage modification of biol. active compounds by this method was also demonstrated. Furthermore, the one-pot preparation of pyrrolidine or piperidine compounds via a domino process was achieved. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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Liu, Xiaofeng; Shao, Ying; Sun, Jiangtao published their research in Organic Letters in 2021. The article was titled 《Ruthenium-Catalyzed Chemoselective N-H Bond Insertion Reactions of 2-Pyridones/7-Azaindoles with Sulfoxonium Ylidesã€?Recommanded Product: 7748-36-9 The article contains the following contents:

A ruthenium-catalyzed highly chemoselective N-alkylation of 2-pyridones I [R1 = H, 3-Cl, 5-Me, 4-(benzyloxy), etc.] has been developed, affording N-alkylated 2-pyridone derivatives II (R2 = Ph, n-Bu, thiophen-2-yl, etc.) in good yields and excellent N-selectivity. The key to achieve this unprecedented N-H rather than O-H insertion reaction is the use of CpRu(PPh3)2Cl as the catalyst and sulfoxonium ylides R2C(O)CH=S(O)(CH3)2 as the alkylation reagents. Moreover, this protocol is also amenable to 7-azaindoles III (R3 = H, 2-Et-3-Me, 4-Cl, etc.) by slightly varying the reaction conditions. Furthermore, sulfonium ylides are also suitable alkylation reagents, providing the N-alkylated 2-pyridones II in good selectivity. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Rhodium-catalyzed regioselective C(sp2)-H bond activation reactions of N-(hetero)aryl-7-azaindoles and cross-coupling with α-carbonyl sulfoxonium ylidesã€?was written by Tian, Yan; Kong, Xian-Qiang; Niu, Jie; Huang, Yi-Bo; Wu, Zhao-Hua; Xu, Bo. SDS of cas: 7748-36-9 And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

A protocol for rhodium-catalyzed C(sp2)-H bond activation reactions of N-(hetero)aryl-7-azaindoles and cross-coupling with α-carbonyl sulfoxonium ylides were described. In the C-H activation reaction, the 7-azaindole moiety acted as a directing group which results in high regioselectivity. The protocol features excellent chem. yields and good functional group tolerance. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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《Ambipolar organic field-effect transistors based on N-Unsubstituted thienoisoindigo derivativesã€?was published in Dyes and Pigments in 2020. These research results belong to Yoo, Dongho; Hasegawa, Tsukasa; Kohara, Akihiro; Sugiyama, Haruki; Ashizawa, Minoru; Kawamoto, Tadashi; Masunaga, Hiroyasu; Hikima, Takaaki; Ohta, Noboru; Uekusa, Hidehiro; Matsumoto, Hidetoshi; Mori, Takehiko. Name: Oxetan-3-ol The article mentions the following:

To investigate a hybrid of isoindigo and thienoisoindigo (TIIG), a new series of unsym. TIIG analogs, in which one of the outer thiophene rings of TIIG is replaced by benzene (CS) or pyridine (NS) are prepared In addition, the π-skeleton extension effects are studied by examining α-substituted TIIG derivatives with thienyl (Dth-TIIG), furyl (Dfu-TIIG), and 1-phenyl-5-pyrazolyl groups (Bis(1-ph-5-py)-TIIG). These materials exhibit ambipolar transistor properties as expected from the energy levels. Dth-TIIG and Dfu-TIIG show hole mobilities exceeding 0.05 cm2 V-1 s-1, and electron mobilities about 0.04 cm2 V-1 s-1, which are close to those of the di-Ph derivative These mols. are arranged nearly perpendicularly to the substrates in the thin films, and Dth-TIIG has a brickwork-like structure, whereas Dfu-TIIG has uniform columns. CS and Bis(1-ph-5-py)-TIIG have uniform stacking structures, but NS has a dimerized stacking structure due to the slightly bent mol. plane that results from largely unbalanced electron d. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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The author of 《A photo-selective chain-end modification of polyacrylate-iodide and its application in patterned polymer brush synthesisã€?were Chen, Chen; Wang, Chen-Gang; Guan, Wenxun; Goto, Atsushi. And the article was published in Polymer Chemistry in 2019. Name: 4-Aminobutan-1-ol The author mentioned the following in the article:

A photo-selective chain-end modification of polyacrylate-iodide (polymer-I) was developed. In the presence of a functional primary amine (NH2-R-X with an X functionality) and formic acid, by simply switching the UV light on and off, polymer-I was selectively converted to hydrogen-terminated polymer-H and chain-end functionalized polymer-NH-R-X (polymer-X), resp. The scopes of the amenable functional X groups and polyacrylates are wide, and hence this method may serve as a general and versatile method for selective chain-end modification. As a useful application, this method was successfully used to fabricate chain-end patterned binary polymer brushes on surfaces. This method is free from metal, amenable to various functionalities, and useful for designing a range of chain-end functionalized polymers and surface-functionalized materials. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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In 2022,Barth, Maximilian; Rudolph, Stefan; Kampschulze, Jan; Meyer zu Vilsendorf, Imke; Hanekamp, Walburga; Mulac, Dennis; Langer, Klaus; Lehr, Matthias published an article in ChemMedChem. The title of the article was 《Hexafluoroisopropyl Carbamates as Selective MAGL and Dual MAGL/FAAH Inhibitors: Biochemical and Physicochemical Propertiesã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

A series of hexafluoroisopropyl carbamates with indolylalkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). The synthesized derivatives with Bu to heptyl spacers between the heteroaryl and the carbamate moiety were inhibitors of both enzymes. For investigated compounds in which the alkyl chain was partially incorporated into a piperidine ring, different results were obtained. Compounds with a methylene spacer between the piperidine ring and the heteroaromatic system were found to be selective MAGL inhibitors, while an extension of the alkyl spacer to two to four atoms resulted in dual inhibition of FAAH/MAGL. The only small change in enzyme inhibitory activity with variation of the heteroaromatic system indicates that the reactive hexafluoroisopropyl carbamate group is mainly responsible for the strength of the inhibitory effect of the compounds Selected derivatives were also tested for hydrolytic stability in aqueous solution, liver homogenate and blood plasma as well as for aqueous solubility and for permeability in a Caco-2 cell model. Some compounds showed a slightly higher MAGL inhibitory effect than the known selective MAGL inhibitor ABX-1431 and also partly surpassed this substance with regard to certain physicochem. and biochem. properties such as water solubility and cell permeability. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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In 2022,Sun, Lincong; Zhao, Yuyao; Liu, Bingxian; Chang, Junbiao; Li, Xingwei published an article in Chemical Science. The title of the article was 《RhodiumIII-catalyzed remote difunctionalization of arenes assisted by a relay directing groupã€?Product Details of 7748-36-9 The author mentioned the following in the article:

Rhodium-catalyzed diverse tandem twofold C-H bond activation reactions of para-olefin-tethered arenes were realized, with unsaturated reagents such as internal alkynes, dioxazolones, and isocyanates being the coupling partner as well as a relay directing group which triggers cyclization of the para-olefin group under oxidative or redox-neutral conditions. The reaction proceeded via initial ortho-C-H activation assisted by a built-in directing group in the arene, and the ortho-incorporation of the unsaturated coupling partner simultaneously generated a relay directing group that allows sequential C-H activation at the meta-position and subsequent cyclization of the para-olefins. The overall reaction represents C-C or N-C difunctionalization of the arene with the generation of diverse 2,3-dihydrobenzofuran platforms, e.g., I. The catalytic system proceeded with good efficiency, simple reaction conditions, and broad substrate scope. The diverse transformations of the products demonstrated the synthetic utility of this tandem reaction. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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Yadav, Bhavna; Baire, Beeraiah published an article in 2022. The article was titled 《Ag(I)-Promoted, Diastereoselective Cyclo-isomerization of N-Alkynyl-7-azaindole-2-carbinols. Selective Synthesis of syn-1,2-Diarylpyrrolo[1,2-a]indol-3-ones and (Z)-8-Benzylideneoxazolo[3′,4”:1,5]pyrrolo[2,3-b]pyridinesã€? and you may find the article in Organic Letters.Safety of Oxetan-3-ol The information in the text is summarized as follows:

The design and development of an Ag(I)-promoted, highly diastereoselective cycloisomerization strategy for the synthesis of syn-1,2-diarylpyrrolo[1,2-a]indol-3-ones from N-alkynyl-indole-2-carbinols was reported. The H218O control experiment and identification of 18O-labeled product suggested the involvement of an external water. The 7-azaindole substrates showed a distinct reactivity to give the (Z)-8-benzylideneoxazolo[3′,4′:1,5]pyrrolo[2,3-b]pyridines. Key features of this strategy were its 100% atom economy, access to important heterocycles, diverse substrate scope, yields up to 95%, operationally simple procedure, and distinct reactivity of indole vs 7-azaindoles.Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol

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Nowosielski, Bartosz; Jamrogiewicz, Marzena; Luczak, Justyna; Warminska, Dorota published an article in 2022. The article was titled 《Novel Binary Mixtures of Alkanolamine Based Deep Eutectic Solvents with Water-Thermodynamic Calculation and Correlation of Crucial Physicochemical Propertiesã€? and you may find the article in Molecules.Reference of 3-Aminopropan-1-ol The information in the text is summarized as follows:

This paper demonstrates the assessment of physicochem. and thermodn. properties of aqueous solutions of novel deep eutectic solvent (DES) built of tetrabutylammonium chloride and 3-amino-1-propanol or tetrabutylammonium bromide and 3-amino-1-propanol or 2-(methylamino)ethanol or 2-(butylamino)ethanol. Densities, speeds of sound, refractive indexes, and viscosities for both pure and aqueous mixtures of DES were investigated over the entire range of compositions at atm. pressure and T = (293.15 – 313.15) K. It was concluded that the exptl. data were successfully fitted using the Jouyban-Acree model with respect to the concentration Obtained results showed that this math. equation is an accurate correlation for the prediction of aqueous DES properties. Key physicochem. properties of the mixtures-such as excess molar volumes, excess isentropic compressibilities, deviations in viscosity, and deviations in refractive indexes-were calculated and correlated by the Redlich-Kister equation with temperature-dependent parameters. The non-ideal behavior of the studied systems were also evaluated by using the Prigogine-Flory-Patterson theory and the results were interpreted in terms of interactions between the mixture components. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Reference of 3-Aminopropan-1-ol

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《Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET-Based Assay of Synapsin III Bindingã€?was written by Casiraghi, Andrea; Longhena, Francesca; Straniero, Valentina; Faustini, Gaia; Newman, Amy H.; Bellucci, Arianna; Valoti, Ermanno. Category: alcohols-buliding-blocks And the article was included in ChemMedChem in 2020. The article conveys some information:

The authors previously described synapsin III (Syn III) as a synaptic phosphoprotein that controls dopamine release in cooperation with α-synuclein (aSyn). Moreover, in Parkinson’s disease (PD), Syn III also participates in aSyn aggregation and toxicity. The authors’ recent observations point to threo-methylphenidate (MPH), a monoamine re-uptake inhibitor that efficiently counteracts the freezing-gait characteristic of advanced PD, as a ligand for Syn III. The authors have designed and synthesized two different fluorescently labeled MPH derivatives, one with Rhodamine Red (RHOD) and one with 5-carboxytetramethylrhodamine (TAMRA), to be used for assessing MPH binding to Syn III by FRET. TAMRA-MPH exhibited the ideal characteristics to be used as a FRET acceptor, as it was able to enter into the SK-N-SH cells and could interact specifically with human green fluorescent protein (GFP)-tagged Syn III but not with GFP alone. Moreover, the uptake of TAMRA-MPH and co-localization with Syn III was also observed in primary mesencephalic neurons. These findings support that MPH is a Syn III ligand and that TAMRA-conjugated drug mols. might be valuable tools to study drug-ligand interactions by FRET or to detect Syn III in cytol. and histol. samples. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Category: alcohols-buliding-blocks

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