Alcohols-buliding-blocks

Direct and indirect eluates from bulk fill resin-based-composites was written by Durner, Juergen;Schrickel, Klaus;Watts, David C.;Becker, Marc;Draenert, Miriam E.. And the article was included in Dental Materials in 2022.SDS of cas: 109-17-1 This article mentions the following:

To compare elutable substances directly released from bulk-fill (BF) resin-based composites (RBCs) with indirect elution from teeth restored with a BF composite. In addition to (co)monomers, the anal. focus was on other potentially toxic ingredients or impurities. Furthermore, the barrier function of the residual dentin/adhesive layer was studied.Six BF-RBC materials were studied. For each material subgroup, ten human third molar teeth with standard Class-I occlusal cavities were prepared and provided with a three-step adhesive system and the resp. composite restoration (tooth groups). Same sized control specimens of the restorative material were prepared (′direct BF-RBC′ groups). Each specimen was placed in an elution chamber such that the elution media (ethanol/water, 3:1) only contacted the tooth root or 3/4 height of each specimen. They were incubated at 37 °C for up to 7 d. Samples of eluate were taken after 1, 2, 4 and 7 d and were analyzed by high-temperature gas chromatog./mass spectrometry.(Co)monomers such as Bisphenol A ethoxylate dimethacrylate (bisEMA) or tetraethylene glycol dimethacrylate (TEEGDMA) were mostly found in the eluates of the ′direct BF-RBC′ groups in statistically significantly greater amounts than in the eluates of the ′tooth groups′. The residual dentin and/or adhesive layers acted as a diffusion barrier for most of the substances except for triethylene glycol dimethacrylate (TEGDMA) or diethylene glycol dimethacrylate (DEGDMA). For TEGDMA up to 3 orders of magnitude more were found in the ′tooth groups′ compared to the ′direct BF-RBC′ groups, evidently released by the adhesive system.Substances of Very High Concern (SVHC) including TINUVIN 328 and BPA were found mainly in the eluates of ′direct BF-RBC′ groups.For estimation of biocompatibility, a total system, specifically BF-RBC + adhesive, should always be investigated since individual considerations, such as only elution from a BF-RBC, do not correctly reflect the total clin. situation. The focus of elution tests should not only be on the co(monomers), but also on other ingredients or impurities that may be released. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1SDS of cas: 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 109-17-1

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Alcohol – Wikipedia,
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Potential of supercritical fluid myrtle extracts as an active ingredient and co-preservative for cosmetic and topical pharmaceutical applications was written by Pereira, Paula;Mauricio, Elisabete Muchagato;Duarte, Maria Paula;Lima, Katelene;Fernandes, Ana S.;Bernardo-Gil, Gabriela;Cebola, Maria-Joao. And the article was included in Sustainable Chemistry and Pharmacy in 2022.Related Products of 57-55-6 This article mentions the following:

This study investigated the applications of a myrtle extract obtained by supercritical fluid extraction (SFE), a technique considered environmentally friendly, as a possible antimicrobial ingredient in cosmetic and pharmaceutical formulations. The supercritical fluid extract was obtained at 230 bar and 45 °C, for 2 h, with a flow of CO₂ of 0.3 kg h^-1. A cosolvent (ethanol) was also used, with a flow 0.09 kg h^-1. The extracts thus obtained were tested against seven Gram-pos. bacteria and one yeast using the well diffusion and the broth dilution techniques. The results showed that the myrtle extract exhibits good antibacterial activity against all the bacteria strains studied and is superior to most of those obtained by conventional extraction methods. Antifungal activity was also present but at a lesser extent. Cell viability studies were carried out by exposing HaCat cells to a range of extract concentrations, from 0.1 μg/mL up to 60 μg/mL for 24 h, using the MTT assay. The Salmonella mutagenicity assay was applied to evaluate the mutagenicity and antimutagenicity of the extract The results obtained suggest that the myrtle extract obtained using a green solvent, supercritical CO₂, is safe and could reduce the genotoxic damage induced by reactive oxygen species (ROSs). In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 57-55-6

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Alcohol – Wikipedia,
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An outstanding catalyst for asymmetric transfer hydrogenation in aqueous solution and formic acid/triethylamine was written by Matharu, Daljit S.;Morris, David J.;Clarkson, Guy J.;Wills, Martin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2006.Formula: C8H9ClO This article mentions the following:

A Rh/tetramethylcyclopentadienyl complex containing a tethered functionality has been demonstrated to give excellent results in the asym. transfer hydrogenation of ketones in both aqueous and formic acid/triethylamine media. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C8H9ClO

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Alcohol – Wikipedia,
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Preparation and characterization of discrete mass polyether-based polyurethane oligomers was written by Tomlinson, Ian D.;May, Jody C.;Harris, Rachel A.;Buck, Kevin M.;Rosenthal, Sandra J.;McLean, John A.;Hercules, David M.. And the article was included in Polymer in 2022.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

Polyurethanes are specialized polymeric materials with a diverse range of applications including foams, insulators, sealants, adhesives and elastomers. Anal. of these materials utilizing mass spectrometry is hampered by the polydispersity and the range of isomeric products produced during the polymerization process. To aid with the mass spectral studies of these materials we have developed methodologies to synthesize discreet polyether-based polyurethane oligomers that may be studied by mass spectrometry and used as standards in the anal. of more complex polymer products. We have synthesized oligomers consisting of polyethylene glycol and poly(tetrahydrofuran) adducts of methylene di-Ph diisocyanate (MDI) and characterized these by NMR and mass spectrometry. These oligomers represent both sym. and asym. polyurethane derivatives In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)

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Alcohol – Wikipedia,
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Water-Triggered Metal-Free Synthesis of Pyranopyrazoles via One-Pot Oxidation/Michael Addition/Cyclization/Dehydration Sequence. was written by Dandia, Anshu;Bansal, Sarika;Sharma, Ruchi;Parewa, Vijay. And the article was included in ChemistrySelect in 2018.HPLC of Formula: 1777-82-8 This article mentions the following:

An ”all water” strategy for the catalyst free chemo-selective synthesis of pyranopyrazoles via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one with benzyl alcs. was developed. Water actuated the reaction via ‘electrophile-nucleophile dual activation’ of the reactants through the concerted hydrogen bonding network and impel the reactants for C-C bond formation. Reaction proceeded by metal and catalyst free oxidation-Michael addition-cyclization-dehydration sequence. This method gave pyrano[[2, 3-c:6,5-c’]dipyrazol]-2-ones selectivity over other possible products. Furthermore, this method was also applied on the reaction of the benzyl alcs. and dimedone to give arylmethylene[bis(5,5-dimethyl-3-hydroxy-2-cyclohexene-1-ones)] in good to excellent yields. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8HPLC of Formula: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 1777-82-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Substrate-Assisted, Transition-Metal-Free Diboration of Alkynamides with Mixed Diboron: Regio- and Stereoselective Access to trans-1,2-Vinyldiboronates was written by Verma, Astha;Snead, Russell F.;Dai, Yumin;Slebodnick, Carla;Yang, Yinuo;Yu, Haizhu;Yao, Fu;Santos, Webster L.. And the article was included in Angewandte Chemie, International Edition in 2017.Application In Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine This article mentions the following:

A substrate-assisted diboration of alkynamides using the unsym. pinacolato-1,8-diaminonaphthalenato diboron (pinBBdan) is described. The transition-metal-free reaction proceeds in a regio- and stereoselective fashion to exclusively afford trans-vinyldiboronates in good to excellent yields. Notably, Bdan and Bpin are installed on the α- and β-carbon atoms, resp. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Application In Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cryptococcus laurentii as a new biocatalyst for the asymmetric reduction of substituted acetophenones was written by Kurbanoglu, Esabi B.;Zilbeyaz, Kani;Kurbanoglu, Namudar I.. And the article was included in Tetrahedron: Asymmetry in 2011.Quality Control of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Immobilized cells of the yeast Cryptococcus laurentii attached to calcium alginate have been introduced as a biocatalyst in the asym. reduction of substituted acetophenones. Forty isolates of microorganisms belonging to this taxonomical yeast group were isolated from various samples. Immobilized cells of these isolates were screened as reducing agents for acetophenone 1a to its corresponding alc. 1b. The four best isolates were selected and identified as Rhodotorula glutinis, Saccharomyces cerevisiae, Hansenula capsulata and C. laurentii by the VITEK 2 compact system. The use of the first three microorganisms is well known and therefore it was decided to explore C. laurentii as a new biocatalyst in organic reactions. The aim was to determine whether C. laurentii could be used to catalyze the bio-reduction of ketones to obtain the (R)- or (S)-isomer of the alc. with high enantiomeric purity. The isolate C. laurentii EBK-19 was selected for further experiments and studied in detail. More than 70% of the ketones tested were obtained with almost complete conversion (100%), while all the ketones tested were converted to the corresponding (S)-isomer-alcs. in up to > 99% enantiomeric excess (ee) under very mild reaction conditions. Amongst the chiral alcs. obtained, the enantiopure 1b obtained from the complete conversion of 1a using C. laurentii EBK-19 was produced on a large scale (9.3 g) using an immobilized cell reaction system. In conclusion, we have presented C. laurentii as a promising biocatalyst for the production of optically active phenylethanols. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Quality Control of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural Diversities of Silver(I) Coordination Compounds with Flexible Dithioether Ligands Based upon Changing the Ligand Spacers was written by Li, Jian-Rong;Zhang, Ruo-Hua;Bu, Xian-He. And the article was included in Crystal Growth & Design in 2003.SDS of cas: 29364-29-2 This article mentions the following:

To study the influences of ligand spacers of flexible bis(thioether) bridging ligands on the framework formations of their complexes, six new Ag^I coordination compounds with structurally related bis(tert-butylthio)alkane ligands, Lⁿ = Me₃CS-(CH₂)_n-SCMe₃ where n = 1-6, [(AgL¹)ClO₄]_n (1), {[Ag(L²)_1.5]ClO₄}_n (2), [(AgL³)ClO₄]₂ (3), {[Ag(L⁴)_1.5]ClO₄}_n (4), [(AgL⁵)ClO₄]₂ (5), and {[Ag(L⁶)_1.5]ClO₄}_n (6), were synthesized and structurally characterized by elemental anal., IR, ¹H NMR spectra, and x-ray crystallog. In 1, the Ag^I centers are linked by bridging L¹ to form a 1-dimensional (1-D) zigzag chain, and 2 has an extended two-dimensional (2-D) (6,3) topol. array with hexagonal 30-membered macrometallacycles. Complexes 3 and 5 show similar discrete dinuclear structures. Complexes 4 and 6 consist of single-double bridging chains in which dinuclear macrometallacycles are further linked by single bridging L ligands. The differences among these structures indicate that the spacers of ligands have important effects on the framework formation of their Ag^I complexes, and this presents a feasible way for controlling the structures of such complexes by modifying the ligand spacers. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2SDS of cas: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 29364-29-2

Referemce:
Alcohol – Wikipedia,
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Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader was written by Divakaran, Anand;Scholtz, Cole R.;Zahid, Huda;Lin, Wenwei;Griffith, Elizabeth C.;Lee, Richard E.;Chen, Taosheng;Harki, Daniel A.;Pomerantz, William C. K.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Synthetic Route of C10H14O This article mentions the following:

Targeted protein degradation is a powerful induced-proximity tool to control cellular protein concentrations using small mols. However, the design of selective degraders remains empirical. Among bromodomain and extra-terminal (BET) family proteins, BRD4 is the primary therapeutic target over family members BRD2/3/T. Existing strategies for selective BRD4 degradation use pan-BET inhibitors optimized for BRD4:E3 ubiquitin ligase (E3) ternary complex formation, but these result in residual inhibition of undegraded BET-bromodomains by the pan-BET ligand, obscuring BRD4-degradation phenotypes. Using our selective inhibitor of the first BRD4 bromodomain, iBRD4-BD1 (I) (IC₅₀ = 12 nM, 23- to 6200-fold intra-BET selectivity), we developed dBRD4-BD1 to selectively degrade BRD4 (DC₅₀ = 280 nM). Notably, dBRD4-BD1 upregulates BRD2/3, a result not observed with degraders using pan-BET ligands. Designing BRD4 selectivity up front enables anal. of BRD4 biol. without wider BET-inhibition and simplifies designing BRD4-selective heterobifunctional mols., such as degraders with new E3 recruiting ligands or for addnl. probes beyond degraders. In the experiment, the researchers used many compounds, for example, 5-Isopropyl-2-methylphenol (cas: 499-75-2Synthetic Route of C10H14O).

5-Isopropyl-2-methylphenol (cas: 499-75-2) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C10H14O

Referemce:
Alcohol – Wikipedia,
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Metabolomics analysis of freeze-thaw tolerance enhancement mechanism of ε-poly-L-lysine on industrial yeast was written by Lu, Lu;Zhu, Ke-Xue;Yang, Zhen;Guo, Xiao-Na;Xing, Jun-Jie. And the article was included in Food Chemistry in 2022.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Antimicrobial polycationic peptide ε-poly-L-lysine (ε-PL) enhanced the freeze-thaw tolerance of industrial yeast; the enhancement mechanism of ε-PL on yeast was studied. The results showed that a ε-PL coating was observed in ε-PL-treated yeast. After 4 times of freeze-thaw, the cell viability, glycerol content, and CO2 production of 0.6 mg/mL ε-PL-treated yeast were higher than those of untreated yeast, specifically, the cell viability of ε-PL-treated yeast was 87.6%, and that of untreated yeast was 68.5%. Metabolomic results showed that the enhancement mechanism of ε-PL on yeast was related to the promotion of cell membrane-related fatty acid synthesis pathways before freeze-thaw treatment, and the promotion of biosynthesis and glycerophospholipid metabolism pathways after freeze-thaw. Furthermore, ε-PL induced inhibition of the tricarboxylic acid cycle, resulting in a longer stationary phase at the beginning of the freeze-thaw and ultimately providing a higher level of freeze-thaw stress tolerance than untreated yeast. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts