Alcohols-buliding-blocks

Tandem Synthesis of Ultra-High Molecular Weight Drag Reducing Poly-α-Olefins for Low-Temperature Pipeline Transportation was written by Nifant’ev, Ilya E.;Tavtorkin, Alexander N.;Vinogradov, Alexey A.;Korchagina, Sofia A.;Chinova, Maria S.;Borisov, Roman S.;Artem’ev, Grigory A.;Ivchenko, Pavel V.. And the article was included in Polymers (Basel, Switzerland) in 2021.Product Details of 115-84-4 The following contents are mentioned in the article:

Ultra-high mol. weight poly-α-olefins are widely used as drag reducing agents (DRAs) for pipeline transportation of oil and refined petroleum products. The synthesis of polyolefin DRAs is based on low-temperature Ziegler-Natta (ZN) polymerization of higher α-olefins. 1-Hexene based DRAs, the most effective at room temperature, typically lose DR activity at low temperatures The use of 1-hexene copolymers with C8-C12 linear α-olefins appears to offer a solution to the problem of low-temperature drag reducing. The present work aims to develop two-stage synthesis of polyolefin DRAs that is based on selective oligomerization of ethylene in the presence of efficient chromium/aminodiphosphine catalysts (Cr-PNP), followed by polymerization of the olefin mixtures, formed at oligomerization stage, using efficient titanium-magnesium ZN catalyst. We have shown that oligomerization of ethylene in α-olefin reaction media proceeds faster than in saturated hydrocarbons, providing the formation of 1-hexene, 1-octene, and branched C10 and C12 olefins; the composition and the ratio of the reaction products depended on the nature of PNP ligand. Oligomerizates were used in ZN polymerization ‘as is’, without addnl. treatment. We assume that faster solubility and more efficient solvation of the polyolefins, prepared using ‘tandem’ ethylene-based process, represent an advantage of these type polymers over conventional poly(1-hexene) and linear α-olefin-based polymers when used as ‘winter’ DRAs. This study involved multiple reactions and reactants, such as 2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4Product Details of 115-84-4).

2-Butyl-2-ethylpropane-1,3-diol (cas: 115-84-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 115-84-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Associations of bisphenol exposure with the risk of gestational diabetes mellitus: a nested case-control study in Guangxi, China was written by Tang, Peng;Liang, Jun;Liao, Qian;Huang, Huishen;Guo, Xiaojing;Lin, Mengrui;Liu, Bihu;Wei, Bincai;Zeng, Xiaoyun;Liu, Shun;Huang, Dongping;Qiu, Xiaoqiang. And the article was included in Environmental Science and Pollution Research.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

A growing number of epidemiol. studies have estimated the associations between endocrine-disrupting chems. and gestational diabetes mellitus (GDM). However, reports on the association between bisphenol A (BPA) substitutes and GDM are limited. This investigation aimed to explore the associations of maternal serum BPA, bisphenol B (BPB), bisphenol F (BPF), bisphenol S (BPS), and tetrabromobisphenol A (TBBPA) with the risk of GDM. A nested case-control study was performed among 500 pregnant women. In conditional logistic regression models, the OR for BPS was significantly increased in the medium exposure groups (OR = 1.77; 95% CI: 1.01, 3.13) compared with the reference group, while BPA (OR: 0.38, 95%CI: 0.29, 0.50) and TBBPA (OR: 0.67, 95%CI: 0.54, 0.85) were neg. associated with the risk of GDM. In the Bayesian kernel machine regression (BKMR) anal., the joint effect of bisphenols was pos. associated with the risk of GDM. BPS showed pos. relationship, while BPA and TBBPA showed neg. relationship, resp. The quantile g-computation revealed a statistically significant and neg. joint effect of the five bisphenols on the risk of GDM (OR: 0.57; 95% CI: 0.46, 0.72) with BPA (70.2%), TBBPA (21.3%), and BPB (8.5%) had pos. contribution to the overall effect. These findings suggested that BPS had a pos. effect on the risk of GDM, while BPA and TBBPA had neg. effect on the risk of GDM. Moreover, exposure to the mixture of the five bisphenols was neg. associated with the risk of GDM. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Synthetic Route of C13H12O2).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C13H12O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The role of halogens in the catalyst transfer polycondensation for π-conjugated polymers was written by Ye, Shuyang;Foster, Scott M.;Pollit, Adam A.;Cheng, Susan;Seferos, Dwight S.. And the article was included in Chemical Science in 2019.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Catalyst transfer polycondensation is the only method to prepare π-conjugated polymers in a chain-growth manner, yet several aspects that underlie this polymerization are not fully understood. Here, we investigate the nickel-catalyzed polymerization mechanisms of a series of thiophene monomers bearing different halogen functionalities (Cl, Br, I). We have discovered the significant role that halogens and magnesium salts play in this polymerization More specifically, the catalyst resting state changes depending on the type of halogenated monomer. For chlorinated monomers a mixture of Ni(II)-dithienyl and dissociated Ni(phosphine) complexes are the resting states, which results in uncontrolled polymerization For brominated monomers, a Ni(II)-dithienyl complex is the resting state, which leads to controlled polymerization For iodinated monomers, a Ni(II)-thienyl iodide complex is the resting state, and notable inhibition by magnesium salt byproducts is observed The catalyst resting state changes to a Ni(II)-dithienyl complex when a turbo Grignard reagent (i-PrMgCl.LiCl) is used. These findings are used to guide the design of a new monomer, 2-bromo-3-(2-ethylhexyl)-5-iodotellurophene, which enables the first controlled polymerization of a tellurophene monomer containing a sterically encumbered 2-ethylhexyl side chain. These insights are crucial for deepening the mechanistic understanding of Kumada cross coupling reactions and the controlled synthesis of π-conjugated polymers. This study involved multiple reactions and reactants, such as 3,7-Dimethyloctan-1-ol (cas: 106-21-8Category: alcohols-buliding-blocks).

3,7-Dimethyloctan-1-ol (cas: 106-21-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metabolite profiling of Shuganzhi tablets in rats and pharmacokinetics study of four bioactive compounds with liquid chromatography combined with electrospray ionization tandem mass spectrometry was written by Tang, Jie;Shi, Mengge;Xu, Yan;Ju, Zhengcai;Guan, Huida;Lin, Jun;Li, Gan;Han, Han;Zhang, Tong. And the article was included in Journal of Chromatography B in 2021.Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

Shuganzhi Tablets (SGZT) is developed on the basis of a clin. empirical formula as a hospital preparation for the treatment of fatty liver. In this study, a rapid and highly sensitive LC-MS/MS method was established and validated for simultaneous determination of ginsenoside Re, ginsenoside Rg1, notoginsenoside R1, naringin, specnuezhenide, emodin, polydatin, hesperidin and saikosaponin A in rat plasma. Multiple reaction monitoring mode played an important role in simultaneous quant. anal. of multiple components. The analytes were separated by the action of an ACQUITY UPLC BEH C18 column (2.1 x 50 mm, 1.7μm) in five minutes. The validated LC-MS/MS method was successfully applied to the pharmacokinetic anal. of hesperidin, emodin, polydatin and naringin of SGZT in rat plasma after administration. A UHPLC system couple with a quadrupole combined with time of flight mass spectrometer was used for qual. analyzing of the composition of SGZT and its metabolites in serum, urine, bile and feces of rats. The results showed that a total of 65 components were detected in rat biol. samples, including 10 prototype components and 55 metabolites. It was speculated that the ingredients of SGZT experienced mainly the following reactions in rats: phase I reaction such as hydrolysis, oxidation, hydroxylation, carboxylation and dehydroxylation and phase II reaction such as glucuronidation and sulfation. These results provide useful information for the further study of its active ingredients. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlling expression and inhibiting function of the toxin reporter for simple detection of the promoters’ activities in Escherichia coli was written by Chen, Yinghua;Li, Jinfeng;Zhang, Shuncheng;Hu, Jiong;Chen, Xiaofeng;Lin, Tingting;Dang, Dongya;Fan, Jun. And the article was included in Enzyme and Microbial Technology in 2022.Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

The naturally occurring and mutated promoters inserted into expression plasmids or Escherichia coli chromosome are essential for recombinant protein production and metabolic engineering. Analyzing their activities and screening the promoter libraries require the simple and easy-to-use reporter. Here, we developed a novel and efficient approach to detect the promoter activity, based on E. coli cell growth inhibited by overexpression of bacteriophage ΦX174 gene E product (LyE), but recovered by pre-overexpression of Bacillus subtilis MraY (BsMraY). Under the conditional LyE construct expression in the absence or the presence of the BsMraY, activities of promoters including the reported P_T7/lac, P_tac, P_BAD, P_rha, P_hucR, P_prpB, P_cum, the wild type and engineered P_tet for leaky and induced expression, the P_thrC for auto-induction, and the P_ms for constitutive expression were assayed. In one-plasmid coexpression system, the PBAD promoter activity detected using the reporter gene was related to the insertion site. The constructed LyE toxic effects were correlated with toxin expression levels, as determined by the split green fluorescent protein reconstitution. Microscopic anal. showed that cells lysis occurred by the LyE induced with arabinose. Taken together, the toxin reporter construct is a convenient and cost-effective tool to examine the promoter activity in E. coli. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy was written by Yang, Zuo;Qiao, Chaoqiang;Jia, Qian;Chen, Zhuang;Wang, Xiaofei;liu, Xuelan;Zhang, Ruili;Pu, Kanyi;Wang, Zhongliang. And the article was included in Theranostics in 2022.Related Products of 923-61-5 The following contents are mentioned in the article:

Photodynamic therapy is a clin. approved anticancer treatment with a promising therapeutic prospect, however, usually suffers from the unfavorable intracellular environment including cellular hypoxia and excessive glutathione (GSH). Comprehensive and long-term modulation of tumor intracellular environment is crucial for optimizing therapeutic outcomes. A metabolic pre-intervention strategy that targets critical pathways of cellular metabolism, ensuring long-term modulation of the intracellular environment. A versatile lipid-coating photosensitive metal-organic framework nano-vehicle encapsulating aerobic respiration inhibitor metformin (Met) and GSH biosynthesis inhibitor buthionine sulfoximine (BSO) (termed PBMLR) was developed for comprehensive sustainable hypoxia alleviation and GSH downregulating. Since MPI could effectively circumvent the compensatory accessory pathway, PBMLR, therefore functioned as an efficient singlet oxygen (1O2) radical generator during the subsequent laser irradiation process and enhanced PDT anti-tumor efficiency. We emphasized the concordance of long-term hypoxia alleviation, persistent GSH depletion, and tumor enrichment of photosensitizers, which is very meaningful for a broad therapeutic time window and the successful enhancement of PDT. Our findings indicate that maintaining the sensitivity of tumor cells via MPI could enhance anti-tumor PDT, and may be applied to other dynamic therapies such as radiodynamic therapy and sonodynamic therapy. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Related Products of 923-61-5).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 923-61-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Co(II) complex of a vitamer of vitamin B₆ acts as a sensor for Hg²⁺ and pH in aqueous media was written by Sing, Nilam;Roy, Sanjay;Guin, Partha Sarathi;Mahali, Kalachand;Majee, Prakash;Mondal, Sudip Kumar;Mahata, Partha;Sengupta, Partha Sarathi;Mondal, Palash. And the article was included in New Journal of Chemistry in 2016.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A Co(II) complex of mol. formula C₂₄H_48.4N₆O_11.2CoCl, 1 CoL₂·7.2H₂O·Cl, was synthesized from the Schiff base [H₂pydmdp]Cl by a template reaction of pyridoxal (pyd), a vitamer of vitamin B₆, N-methyl-1,3-diaminopropane (mdp) and cobalt(II) acetate. It was characterized by elemental anal., ¹H NMR, IR and UV-visible spectroscopy, thermal anal., electrochem. and single crystal x-ray diffraction. The exptl. results suggested that in complex 1, the central Co(II) is bonded to two phenolato-oxygens, two imine nitrogens and two amine nitrogens in an octahedral geometry. In aqueous media complex 1 exhibits an intense fluorescence emission peak at 506 nm when it was excited at 425 nm. The fluorescence behavior of complex 1 in aqueous media was employed to determine whether it acts as a chemosensor for some selective toxic metal ions. The present complex behaves as a promising sensor for Hg²⁺ even at the sub-micromolar level. In addition in aqueous solution, complex 1 acts as a sensor for the pH of the medium. A detailed study on the mechanism of sensing behavior established that Hg²⁺ interacts with complex 1 via weak noncovalent interaction with the N-atom of the pyridine moiety of the mol. The pyridine nitrogen also plays a vital role in sensing the pH of the medium. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Overcoming glutamate auxotrophy in Escherichia coli itaconate overproducer by the Weimberg pathway was written by Lu, Ken W.;Wang, Chris T.;Chang, Hengray;Wang, Ryan S.;Shen, Claire R.. And the article was included in Metabolic Engineering Communications in 2021.Synthetic Route of C9H18O5S The following contents are mentioned in the article:

Biosynthesis of itaconic acid occurs through decarboxylation of the TCA cycle intermediate cis-aconitate. Engineering of efficient itaconate producers often requires elimination of the highly active isocitrate dehydrogenase to conserve cis-aconitate, leading to 2-ketoglutarate auxotrophy in the producing strains. Supplementation of glutamate or complex protein hydrolyzate then becomes necessary, often in large quantities, to support the high cell d. desired during itaconate fermentation and adds to the production cost. Here, we present an alternative approach to overcome the glutamate auxotrophy in itaconate producers by synthetically introducing the Weimberg pathway from Burkholderia xenovorans for 2-ketoglutarate biosynthesis. Because of its independence from natural carbohydrate assimilation pathways in Escherichia coli, the Weimberg pathway is able to provide 2-ketoglutarate using xylose without compromising the carbon flux toward itaconate. With xylose concentration carefully tuned to minimize excess 2-ketoglutarate flux in the stationary phase, the final strain accumulated 20 g/L of itaconate in minimal medium from 18 g/L of xylose and 45 g/L of glycerol. Necessity of the recombinant Weimberg pathway for growth also allowed us to maintain multi-copy plasmids carrying in operon the itaconate-producing genes without addition of antibiotics. Use of the Weimberg pathway for growth restoration is applicable to other production systems with disrupted 2-ketoglutarate synthesis. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Synthetic Route of C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Identification of unusual phospholipids from bovine heart mitochondria by HPLC-MS/MS was written by Kim, Junhwan;Hoppel, Charles L.. And the article was included in Journal of Lipid Research in 2020.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

Phospholipids, including ether phospholipids, are composed of numerous isomeric and isobaric species that have the same backbone and acyl chains. This structural resemblance results in similar fragmentation patterns by collision-induced dissociation of phospholipids regardless of class, yielding complicated MS/MS spectra when isobaric species are analyzed together. Furthermore, the presence of isobaric species can lead to misassignment of species when made solely based on their mol. weights In this study, we used normal-phase HPLC for ESI-MS/MS anal. of phospholipids from bovine heart mitochondria. Class separation by HPLC eliminates chances for misidentification of isobaric species from different classes of phospholipids. Chromatog. yields simple MS/MS spectra without interference from isobaric species, allowing clear identification of peaks corresponding to fragmented ions containing monoacylglycerol backbone derived from losing one acyl chain. Using these fragmented ions, we characterized individual and isomeric species in each class of mitochondrial phospholipids, including unusual species, such as PS, containing an ether linkage and species containing odd-numbered acyl chains in cardiolipin, PS, PI, and PG. We also characterized monolysocardiolipin and dilysocardiolipin, the least abundant but nevertheless important mitochondrial phospholipids. The results clearly show the power of HPLC-MS/MS for identification and characterization of phospholipids, including minor species. This study involved multiple reactions and reactants, such as (2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5Category: alcohols-buliding-blocks).

(2R)-3-(((2-Aminoethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (cas: 923-61-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Environmental level of bisphenol F induced reproductive toxicity toward zebrafish was written by Mu, Xiyan;Qi, Suzhen;Liu, Jia;Wang, Hui;Yuan, Lilai;Qian, Le;Li, Tiejun;Huang, Ying;Wang, Chengju;Guo, Yuanming;Li, Yingren. And the article was included in Science of the Total Environment in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Bisphenol F (BPF), as an important bisphenol A substitute, is being increasingly used for industrial production Here we performed large scale fecundity test for zebrafish that are continuous exposed to environmental levels of BPF (0.5, 5 and 50μg/L) from embryonic stage, and identified suppressed spawning capacity of females and reduced fertility rate of males in adulthood. Although pathol. change is only observed in female gonads, the transcriptional change in the hypothalamic-pituitary-gonad axis genes occurred in the gonads of both female and male fish at 150 days post-exposure. F1 generation embryos showed abnormal developmental outcomes including decreased heart rate, reduced body length, and inhibition of spontaneous movement after parental exposure to BPF. RNA-sequencing showed that the genes involved in skeletal/cardiac muscle development were significantly altered in F1 embryos spawned by BPF-treated zebrafish. The advanced pathway anal. showed that cancer and tumor formation were the most enriched pathways in the offspring of 0.5 and 5.0μg/L groups; organismal development and cardiovascular system development were mainly affected after parental exposure to 50μg/L of BPF; these changes were mediated by several involved regulators such as GATA4, MYF6, and MEF2C. These findings confirmed that long-term exposure to BPF at environment relevant concentration would result in reproductive toxicity among zebrafish indicating the urgent demand for the control of BPA substitutes. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts