Alcohols-buliding-blocks

Enantioselective hydrogenation of aromatic ketones: structural effects was written by Hess, Reto;Mallat, Tamas;Baiker, Alfons. And the article was included in Journal of Catalysis in 2003.Safety of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Enantioselective hydrogenation of acetophenone derivatives demonstrates the potential of the Pt-cinchona system in the synthesis of chiral alcs. that possess no functional group in the α-position to the CH-OH group. Electron-withdrawing functional groups in the aromatic ring increased the reaction rate and enantiomeric excess (ee), and the position of the group (o-, m-, or p-) was also important. In the hydrogenation of 3,5-di(trifluoromethyl)acetophenone under ambient conditions, 60% ee was obtained, though the special role of reaction parameters has not been investigated yet. Addition of cinchonidine slowed down all hydrogenation reactions-an unprecedented behavior for chirally modified Pt. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Safety of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An Improved Synthesis of 4-O-Benzoyl-2,2-difluorooleandrose from L-Rhamnose. Factors Determining the Synthesis of 2,2-Difluoro-Carbohydrates from 2-Uloses was written by Barrena, M. Isabel;Matheu, M. Isabel;Castillon, Sergio. And the article was included in Journal of Organic Chemistry in 1998.COA of Formula: C6H14O6 This article mentions the following:

4-O-Benzoyl-2,2-difluorooleandrose I has been synthesized from L-rhamnose via DAST difluorination of ulose II followed by chemoselective etherification. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0COA of Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Structural hybridization of pyrrolidine-based T-type calcium channel inhibitors and exploration of their analgesic effects in a neuropathic pain model was written by Son, Woo Seung;Jeong, Kyu-Sung;Lim, Sang Min;Pae, Ae Nim. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2019.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

Highly effective and safe drugs for the treatment of neuropathic pain are urgently required and it was shown that blocking T-type calcium channels can be a promising strategy for drug development for neuropathic pain. We have developed pyrrolidine-based T-type calcium channel inhibitors by structural hybridization and subsequent assessment of in vitro activities against Ca_v3.1 and Ca_v3.2 channels. Profiling of in vitro ADME properties of compounds was also carried out. The representative compound 17h showed comparable in vivo efficacy to gabapentin in the SNL model, which indicates T-type calcium channel inhibitors can be developed as effective therapeutics for neuropathic pain. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Simple conversion of 3D electrospun nanofibrous cellulose acetate into a mechanically robust nanocomposite cellulose/calcium scaffold was written by Lee, Joshua;Moon, Joon Yeon;Lee, Jeong Chan;Hwang, Tae In;Park, Chan Hee;Kim, Cheol Sang. And the article was included in Carbohydrate Polymers in 2021.HPLC of Formula: 5743-47-5 This article mentions the following:

Cellulose and its derivatives are widely used as nanofibrous biomaterials, but obtaining 3D cellulose nanofibers is difficult and relevant research is scarce. In the present study, we propose a simple method for converting electrospun 3D cellulose acetate/lactic acid nanofibers via calcium hydroxide treatment into a 3D cellulose/calcium lactate nanocomposite matrix. The conversion resulted in producing a stronger nanofibrous matrix (1.382 MPa vs. 0.112 MPa) that is more hydrophilic and cell-friendly compared to the untreated cellulose acetate/lactic acid group. The successful conversion was verified via FTIR, XPS, TGA, DTG, and XRD. The ability of the scaffolds to provide a suitable environment for cell growth and infiltration was verified by CCK assay and confocal microscopy. The porous nature, mech. strength, and presence of calcium make the 3D cellulose/calcium lactate matrix a promising material for bone tissue engineering. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5HPLC of Formula: 5743-47-5).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 5743-47-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Implications of mistletoe parasitism for the host metabolome: A new plant identity in the forest canopy was written by Lazaro-Gonzalez, Alba;Gargallo-Garriga, Albert;Hodar, Jose Antonio;Sardans, Jordi;Oravec, Michal;Urban, Otmar;Penuelas, Josep;Zamora, Regino. And the article was included in Plant, Cell & Environment in 2021.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

Mistletoe-host systems exemplify an intimate and chronic relationship where mistletoes represent protracted stress for hosts, causing long-lasting impact. Although host changes in morphol. and reproductive traits due to parasitism are well known, shifts in their physiol. system, altering metabolite concentrations, are less known due to the difficulty of quantification. Here, we use ecometabolomic techniques in the plant-plant interaction, comparing the complete metabolome of the leaves from mistletoe (Viscum album) and needles from their host (Pinus nigra), both parasitized and unparasitized, to elucidate host responses to plant parasitism. Our results show that mistletoe acquires metabolites basically from the primary metabolism of its host and synthesizes its own defense compounds In response to mistletoe parasitism, pines modify a quarter of their metabolome over the year, making the pine canopy metabolome more homogeneous by reducing the seasonal shifts in top-down stratification. Overall, host pines increase antioxidant metabolites, suggesting oxidative stress, and also increase part of the metabolites required by mistletoe, which act as a permanent sink of host resources. In conclusion, by exerting biotic stress and thereby causing permanent systemic change, mistletoe parasitism generates a new host-plant metabolic identity available in forest canopy, which could have notable ecol. consequences in the forest ecosystem. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ruthenium Catalyzed N-Alkylation of Cyclic Amines with Primary Alcohols was written by Savela, Risto;Vogt, Dieter;Leino, Reko. And the article was included in European Journal of Organic Chemistry in 2020.SDS of cas: 1777-82-8 This article mentions the following:

A robust alc. amination protocol using common saturated amines and primary alcs. as starting materials is described. The reactions are catalyzed by combination of dichloro(p-cymene)ruthenium(II) dimer precatalyst with triphenylphosphine ligand, with the excess alc. substrate or toluene functioning as the solvent. The catalyst and ligand residues can be precipitated from the reaction media by addition of hexane or cold di-Et ether, followed by precipitation and isolation of the product as a hydrochloride salt. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8SDS of cas: 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Microwave-Assisted In Situ Synthesis of Poly L-Lactic Acid with Nanoparticles of Calcium Phosphate was written by Pandey, Anurag;Aswath, Pranesh. And the article was included in International Journal of Polymeric Materials in 2010.Category: alcohols-buliding-blocks This article mentions the following:

A microwave reactor was used to polymerize lactic acid and/or calcium lactate in the presence of phosphoric acid or ammonium hydrogen phosphate. The polar nature of lactic acid makes it a strong absorber of microwave radiation, and when present in a nonpolar solvent such as chloroform, it is possible to conduct the polymerization reaction in a microwave reactor. Using calcium lactate and ammonium hydrogen phosphate it is possible to create nanoparticles of calcium phosphate within the matrix of poly lactic acid in situ during the polymerization FTIR spectroscopy and gel permeation chromatog. were used to follow the polymerization process, and TEM was used to determine the size distribution of the calcium phosphate particles. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Category: alcohols-buliding-blocks).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

1-(Heteryloxy)silatranes was written by Iovel, I.;Golomba, L.;Popelis, J.;Grinberga, S.;Lukevics, E.. And the article was included in Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) in 2000.Safety of 6-Methyl-2-pyridinemethanol This article mentions the following:

Novel heterocyclic 1-derivatives I of silatranes were obtained [R = Et, PhCH₂, 2-tetrahydrofurfuryl, 3-pyridinyl, and (6-methyl-2-pyridyl)methyl -]. The optimal synthetic method for these compounds is transesterification of tetraethoxysilane by an equimolar mixture of triethanolamine and a heterocyclic (or aromatic) hydroxyl-containing compound E.g., heating 0.01 mol each PhCH₂OH, N(CH₂CH₂OH)₃ and Si(OEt)₄ in 14 mL xylene containing 0.2 g KOH at (120-130°) gave 1-benzyloxysilatrane I (R = PhCH₂) in 75% yield. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Safety of 6-Methyl-2-pyridinemethanol).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 6-Methyl-2-pyridinemethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Fully Biobased Aromatic Polyester Polyol for Polyisocyanurate Rigid Foams: Poly(diethylene furanoate) was written by Rhein, Michael;Demharter, Anton;Felker, Benjamin;Meier, Michael A. R.. And the article was included in ACS Applied Polymer Materials in 2022.Reference of 111-46-6 This article mentions the following:

Aromatic polyester polyols are often used in polyurethane rigid foam (PUR) and polyisocyanurate (PIR) synthesis, since they offer higher rigidity than polyether polyols. Herein, a route toward fully biobased aromatic polyester polyols was investigated using sugar-based 2,5-furandicarboxylic acid (FDCA) and diethylene glycol (DEG), enabling a direct one-step synthesis of a fully biobased aromatic polyester polyol, poly(diethylene furanoate) (PDEF), for applications in PIR rigid foam. Therefore, reaction conditions were optimized to obtain PDEF as a processable polyol with OH values and remaining unreacted DEG similar to a com., petroleum-based polyol. The processability was improved by either copolymerizing 10-20 mol % of a biobased aliphatic dicarboxylic acid, like succinic acid (SA) or adipic acid (AA), maintaining the fully biobased character of the polyol, or copolymerization with phthalic acid. The fully biobased polyester polyols were successfully prepared on a 100 g scale of dicarboxylic acids. Subsequent application in PIR rigid foam showed similar d., thermal conductivity, flame behavior, and compressive strength if compared to the rigid foam obtained from a com. polyol. Thus, fully biobased PDEF can substitute petroleum-based aromatic polyester polyols in PIR applications. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Reference of 111-46-6).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 111-46-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

White-rot fungus-mediated degradation of the analgesic ketoprofen and identification of intermediates by HPLC-DAD-MS and NMR was written by Marco-Urrea, Ernest;Perez-Trujillo, Miriam;Cruz-Morato, Carles;Caminal, Gloria;Vicent, Teresa. And the article was included in Chemosphere in 2010.Synthetic Route of C16H16O3 This article mentions the following:

Ketoprofen is a nonsteroidal anti-inflammatory drug that has been detected in the environment in the range of ng L^-1-μg L^-1 due to its low degradability in some wastewater treatment plants. In this study, the use of the white-rot fungus Trametes versicolor to effectively degrade ketoprofen in a defined liquid medium was assessed. The fungus eliminated ketoprofen to nondetectable levels in 24 h when it was added at 10 mg L^-1 whereas at low concentration of 40 μg L^-1 it was almost completely removed (95%) after 5 h. Low extracellular laccase activity was detected in the T. versicolor cultures but the addition of the laccase-mediator system did not lead to ketoprofen oxidation The cytochrome P 450 inhibitor 1-aminobenzotriazole reduced ketoprofen oxidation These data suggest that the first oxidation step is cytochrome P 450 mediated. During time-course degradation experiments, three intermediates were structurally elucidated and quantified by HPLC-DAD-MS and NMR: 2-[3-(4-hydroxybenzoyl)phenyl]-propanoic acid, 2-[(3-hydroxy(phenyl)methyl)phenyl]-propanoic acid, and 2-(3-benzoyl-4-hydroxyphenyl)-propanoic acid. The latter was reported for the first time in biol. systems. After 7 d of incubation, only small amounts of 2-[(3-hydroxy(phenyl)methyl)phenyl]-propanoic acid (0.08 mg) remained in the liquid medium in comparison with the initial ketoprofen dose (1.0 mg), suggesting possible mineralization of ketoprofen. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Synthetic Route of C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts