Alcohols-buliding-blocks

Reinvestigating FeBr₃-Catalyzed Alcohol Oxidation with H₂O₂: Is High-valent Iron Species (HIS) or Reactive Brominating Species (RBS) Responsible for Alcohol Oxidation? was written by He, Chenxi;Ma, Foqing;Zhang, Wei;Tong, Rongbiao. And the article was included in Organic Letters in 2022.Related Products of 873-76-7 This article mentions the following:

The in-situ generated RBS from the related FeBr₂/H₂O₂ or CeBr₃/H₂O₂ systems, (2) This results of a series of controlled experiments, and (3) some related RBS-based precedents (NBS, NBA, or Br₂) showing similar high oxidation selectivity of secondary over primary alcs. These studies enable to discover that RBS from CeBr₃/H₂O₂ was much more efficient for the oxidation of secondary and benzylic alcs., which represents a new green protocol for selective oxidation of alcs. to carbonyls. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Related Products of 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, spectral characterization, SC-XRD, HSA, DFT and catalytic activity of a dioxidomolybdenum complex with aminosalicyl-hydrazone Schiff base ligand: An experimental and theoretical approach was written by Kargar, Hadi;Fallah-Mehrjardi, Mehdi;Behjatmanesh-Ardakani, Reza;Munawar, Khurram Shahzad;Ashfaq, Muhammad;Tahir, Muhammad Nawaz. And the article was included in Polyhedron in 2021.Computed Properties of C7H6Cl2O This article mentions the following:

A new dioxidomolybdenum(VI) complex has been successfully prepared by the reaction of an ONO donor Schiff base, derived by condensing 4-amino-2-hydroxybenzohydrazide and 3-methoxysalicylaldehyde, with MoO₂(acac)₂. The structures of synthesized products were explored spectroscopically through FT-IR, ¹H & ¹³C NMR and by elemental composition (CHN) through combustion anal. The structural investigations of the dioxidomolybdenum(VI) complex were accomplished by taking its diffraction data through X-ray crystallog. The tridentate Schiff base ligand is bonded to the central metal through its deprotonated enolic and phenolic oxygen atoms and by the nitrogen of the azomethine group. The interpretation of the data obtained through diffraction anal. validates the distorted octahedral geometry of the prepared metal complex. QTAIM, MEP and NCI calculations and Hirshfeld surface anal. were performed to investigate the nature and types of non-covalent linkages present among the sample mols. The theor. calculations, performed by DFT using the B3LYP/Def2-TZVP level of theory, direct that the intended outcomes are in compliance with the actual consequences. Furthermore, the catalytic potential of the molybdenum complex was explored for the selective oxidation of benzylic alcs. to the desirable aryl aldehydes at room temperature in the presence of 70% aqueous tert-Bu hydroperoxide (TBHP) under solvent-free conditions. The main advantage of the present catalytic work is the accomplishment of reaction in a short period of time, high percentage yield and easy work-out procedure. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Computed Properties of C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket was written by Frederick, Raphael;Charlier, Caroline;Robert, Severine;Wouters, Johan;Masereel, Bernard;Pochet, Lionel. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2006.Product Details of 224309-64-2 This article mentions the following:

The synthesis of novel coumarins bearing on the lateral side chain in the 3-position an amine or a guanidine group is described. In vitro evaluation highlighted I which possesses a meta aniline side chain as a very potent THR inhibitor. Surprisingly, the introduction of a guanidine moiety always led to a decrease in THR inhibiting properties. We, thus, used docking experiments to rationalize the SAR in the series. This study showed the crucial role of a conserved water mol. in the specificity pocket of THR during docking simulation in order to explain the inactivity of guanidine derivatives In the experiment, the researchers used many compounds, for example, tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2Product Details of 224309-64-2).

tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 224309-64-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS-stabilized Ru in ionic liquids was written by Wang, Jinbo;Feng, Jian;Qin, Ruixiang;Fu, Haiyan;Yuan, Maolin;Chen, Hua;Li, Xianjun. And the article was included in Tetrahedron: Asymmetry in 2007.Recommanded Product: 171032-87-4 This article mentions the following:

Ruthenium nanoparticles generated from ruthenium trichloride and TPPTS [3-(NaSO₃)C₆H₄]₃P and the nonracemic ligand I together act as a catalyst for the enantioselective hydrogenation of aralkyl ketones RCOR¹ (R = Ph, 2-BrC₆H₄, 2-ClC₆H₄, 2-FC₆H₄, 2-MeOC₆H₄, 4-F₃CC₆H₄, 4-MeOC₆H₄; R¹ = Me, Et) in mixtures of imidazolium ionic liquids and water to give nonracemic aralkyl alcs. RCH(OH)R¹ in 48-100% conversions and in 45-85% ee. The effect of temperature, of potassium hydroxide and water concentrations, and of ionic liquid on enantioselectivity and conversion are determined The aralkyl alcs. are easily separated from the catalyst by simple extraction with n-hexane. The catalyst solution in the ionic liquid can be reused six times with some loss in conversion but little loss in enantioselectivity. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Recommanded Product: 171032-87-4).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 171032-87-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly efficient asymmetric hydrogenation of alkyl aryl ketones catalyzed by iridium complexes with chiral planar ferrocenyl phosphino-thioether ligands was written by Le Roux, Erwan;Malacea, Raluca;Manoury, Eric;Poli, Rinaldo;Gonsalvi, Luca;Peruzzini, Maurizio. And the article was included in Advanced Synthesis & Catalysis in 2007.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Ir complexes of planar-chiral ferrocenyl phosphine-thioether ligands were tested in the hydrogenation of simple ketones. Optimization of the conditions led to a highly active catalytic system with turnover numbers up to 915 and turnover frequencies up to ∼250 h^-1. Also, very high enantioselectivities (up to > 99%) together with complete conversions were obtained for the asym. hydrogenation of various acetophenones at 10°. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A precision structured smart hydrogel for sensing applications was written by Menges, J.;Kleinschmidt, P.;Bart, H.-J.;Oesterschulze, E.. And the article was included in Journal of Applied Physics (Melville, NY, United States) in 2017.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The authors report on a macroinitiator based smart hydrogel film applied on a microcantilever for sensing applications. The studied hydrogel features a comparatively wide dynamic range for changes in the electrolyte’s ionic strength. Also, it offers a simple spin coating process for thin film deposition as well as the capability to obtain high aspect ratio microstructures by reactive ion etching. This makes the hydrogel compatible to microelectromech. system integration. As a proof of concept, the authors study the response of hydrogel functionalized cantilevers in aqueous sodium chloride solutions of varying ionic strength. In contrast to the majority of hydrogel materials reported in the literature, the authors’ hydrogel still responds in high ionic strength environments. This may be of future interest for sensing e.g., in sea water or physiol. environments like urine. (c) 2017 American Institute of Physics. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photocontrolled cationic degenerate chain transfer polymerizations via thioacetal initiators was written by Sifri, Renee J.;Kennedy, Audrey J.;Fors, Brett P.. And the article was included in Polymer Chemistry in 2020.Computed Properties of C4H9NaS This article mentions the following:

Recent developments in photocontrolled polymerizations have facilitated the development of previously inaccessible materials. While photocontrolled radical polymerizations have been extensively studied, related processes involving cationic polymerizations are underexplored and limited to RAFT processes. In this study, we disclose a visible light, temporally controlled cationic polymerization of vinyl ethers utilizing thioacetals and a photoredox catalyst. We demonstrate a broad scope of thioacetal initiators that achieve a well-controlled polymerization by recapping propagating chains via photocatalyst turnover in combination with a degenerate chain transfer process through sulfonium intermediates. Furthermore, we show that a photocatalyst with a more reducing ground state reduction potential allows for enhanced control and excellent temporal regulation of polymerization In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Computed Properties of C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlling Chemoselectivity of Catalytic Hydroboration with Light was written by Bergamaschi, Enrico;Lunic, Danijela;McLean, Liam A.;Hohenadel, Melissa;Chen, Yi-Kai;Teskey, Christopher J.. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 59960-32-6 This article mentions the following:

The ability to selectively react one functional group in the presence of another underpins efficient reaction sequences. Despite many designer catalytic systems being reported for hydroboration reactions, which allow introduction of a functional handle for cross-coupling or act as mild method for reducing polar functionality, these platforms rarely deal with more complex systems where multiple potentially reactive sites exist. Here authors demonstrate, for the first time, the ability to use light to distinguish between ketones and carboxylic acids in more complex mols. By taking advantage of different activation modes, a single catalytic system can be used for hydroboration, with the chemoselectivity dictated only by the presence or absence of visible light. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Product Details of 59960-32-6).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 59960-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Analytical methodology to evaluate potential migration in coatings and inks was written by Roqueta, C.;Fournier, F.;Hutchinson, I.;Dulongpont, H.;Cavalie, H.. And the article was included in Pitture e Vernici, European Coatings in 2009.Application of 4074-88-8 This article mentions the following:

Testing methods were evaluated to monitor leaching and migration of acrylate compounds from coatings and inks, into the environment, especially for food packaging applications. The techniques for quantification of the monomers include gas chromatog. with flame ionization detector, GC/FID; the monitoring of alcs. leading to acrylate monomers are ethylene glycol, diethylene glycol, triethylene glycol, and trimethylolpropane, for ethylene glycol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, and trimethylolpropane triacrylate. Model coatings from UV cured compositions were tested by solvent extraction and liquid chromatog./mass spectroscopy. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly was written by Ishida, Akiharu;Tajima, Yohei;Okabe, Yasuyuki;Matsushita, Takeshi;Sekiguchi, Tetsuya;Imaide, Satomi;Nomura, Yoshinori;Tanaka, Motoyuki;Nojima, Shoji;Yoshida, Atsushi;Iyoda, Yoko;Aoki, Shohei;Nishio, Takuya;Komagata, Tatsuya;Iwaki, Masanori;Shono, Tomoyuki;Naganawa, Atsushi;Imagawa, Akira. And the article was included in ACS Chemical Neuroscience in 2020.Recommanded Product: 142253-56-3 This article mentions the following:

Acromegaly is a disease caused by the oversecretion of growth hormone. It is currently treated by i.v. injection with cyclic peptide drugs that activate somatostatin receptor subtype 2 (SSTR2). Here, novel nonpeptidic, small-mol., and orally active SSTR2 agonists were identified from a hit compound (13). Pharmacophore studies enabled scaffold hopping to obtain a unique 3,4,5-trisubstituted pyridine motif. Further optimization conferred potent SSTR2 agonistic activity and metabolic stability. Several compounds were evaluated and these showed good oral pharmacokinetic profiles in rats, and one representative compound (25)(I) showed highly potent inhibition of growth hormone secretion induced by growth hormone-releasing hormone in rats. Based on these results, 25 was identified as a promising lead for further optimization. A structure-activity relationship (SAR) study and the metabolic stability data for this compound are also described. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Recommanded Product: 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts