Alcohols-buliding-blocks

Co-Assembly of Chiral Amines and a Four-Armed Cyano-Substituted Luminophore through Hydrogen Bonds for Potential Development of Smart Chiroptical Materials was written by Liu, Yiping;Hao, Aiyou;Xing, Pengyao. And the article was included in Chemistry – A European Journal in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Chirality transfer from chiral mols. to assemblies is of vital importance to the design of functional chiral materials. In this work, selective co-assembly behaviors between chiral mols. and an achiral luminophore, potentially driven by the intermol. salt-bridge type hydrogen bonds are reported. Cyano-substituted tetrakis(arylthio)benzene carboxylic acid (TA) served as the luminophore and hydrogen bond donors, which underwent co-assembly with different chiral amines. It was found that structures of chiral amines affect the chirality transfer and the properties of co-assemblies due to effects on hydrogen bonds and stacking pattern. Only in specific co-assemblies, the chiroptical properties occurred at both ground state and excited states based on the emerged Cotton effects and circularly polarized luminescence (CPL) signals, revealing that the chirality was successfully transferred from mol. level to supramol. level. In addition, accurate quant. examination of chiral amines was realized by CD spectra. This work demonstrates the characteristic chirality response and transfer through co-assembly, providing a potential method to develop smart chiroptical materials. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Erythritol confined in multiwalled carbon nanotubes reinforced silica aerogel as novel form-stable phase change materials was written by Li, Qi;Feng, Yang;Li, Yi-Ting;Ning, Yu-Hao;Hu, Ping;Lin, Chuan-Huang;Zhang, Yi-Hong;Zhou, Mei;Yu, Lin-Ping;Li, Chuan-Chang;Cao, Zhong;Zeng, Ju-Lan. And the article was included in Journal of Molecular Liquids in 2022.SDS of cas: 149-32-6 This article mentions the following:

In this work, pristine multiwalled carbon nanotubes (MCNTs) and mixed acids treated MCNTs (ACNTs) were applied as reinforcement fillers to prepare silica aerogels via ambient pressure drying followed by lyophilization. The prepared aerogels were then used as supporting materials to adsorb meso-erythritol (ME) to obtain novel form-stable PCMs by vacuum infiltration. Investigation of the prepared form-stable PCMs revealed that the ACNT/SiO₂ aerogels possessed higher porosity than MCNT/SiO₂ aerogels due to that the ACNTs exhibited stronger interactions with silica than the MCNTs, and could more effectively prevent the prepared ACNT/SiO₂ aerogels from collapsing and shrinking during drying. Consequently, the loading of ME in the form-stable PCMs supported by ACNT/SiO₂ aerogels (AFPCMs) was greatly higher than that in the form-stable PCMs supported by MCNT/SiO₂ aerogels (MFPCMs). When ACNT/SiO₂-6 aerogel, in which 60 mg ACNTs were used as reinforcement filler, was applied as supporting material, the obtained form-stable PCM (AFPCM-6) exhibited a very high melting latent heat of 297.3 J/g, an elevated crystallizing temperature of 56°C and an improved crystallizing latent heat of 231 J/g. Besides, the latent heat storage/release properties of AFPCM-6 maintained stable enough over 50 melting/crystallizing cycles. Meanwhile, the thermal conductivity of AFPCM-6 was 37.5% higher than that of pure ME. Hence, AFPCM-6 could be an excellent form-stable PCM and could find its applications in related fields. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6SDS of cas: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tf₂O- and Cu(OTf)₂-Assisted Acylamination Reaction of Unactivated Alcohols with Nitriles: A One-Pot P(IV) Activation, Stereoretention in Cycloalkanols and Deprotection Approach was written by Bhat, Mohammad Yaqoob;Ahmed, Sajjad;Ahmed, Qazi Naveed. And the article was included in Journal of Organic Chemistry in 2022.SDS of cas: 2216-51-5 This article mentions the following:

Described herein is a simple, novel, one-pot acylamination reaction of unactivated alcs. This reaction employs the combination of PCl₃ and triflic anhydride (Tf₂O) or copper triflate Cu(OTf)₂, which serves as a source of P(IV)-activated complex for nitriles to react under the Ritter-type mechanism. The synthetic utility of Tf₂O-promoted reactions was demonstrated by its effectiveness to generate different acylaminated products. By employing Cu(OTf)₂, this method represented a rare example of α-selective acylamination reaction. With chiral cycloalkanols, using the Cu(OTf)₂-promoted procedure, acylaminated products were formed with complete retention of configuration. The synthetic utility of the copper-assisted reaction in acetonitrile was readily demonstrated as a mild deprotection strategy. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5SDS of cas: 2216-51-5).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 2216-51-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Direct Conversion of Primary Alcohols to 1,2-Amino Alcohols: Enantioselective Iridium-Catalyzed Carbonyl Reductive Coupling of Phthalimido-Allene via Hydrogen Auto-Transfer was written by Spielmann, Kim;Xiang, Ming;Schwartz, Leyah A.;Krische, Michael J.. And the article was included in Journal of the American Chemical Society in 2019.HPLC of Formula: 142253-56-3 This article mentions the following:

The first catalytic enantioselective carbonyl (α-amino)allylations are described. Phthalimido-allene and primary alcs. engage in hydrogen auto-transfer-mediated carbonyl reductive coupling by way of (α-amino)allyliridium-aldehyde pairs to form vicinal amino alcs. with high levels of regio-, anti-diastereo-, and enantioselectivity. Reaction progress kinetic anal. and isotopic labeling studies corroborate a catalytic cycle involving turnover-limiting alc. dehydrogenation followed by rapid allene hydrometalation. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3HPLC of Formula: 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formulation of infant formula with different casein fractions and their effects on physical properties and digestion characteristics was written by Zhang, Junpeng;Du, Xinyu;Jiang, Shilong;Xie, Qinggang;Mu, Guangqing;Wu, Xiaomeng. And the article was included in Food & Function in 2022.SDS of cas: 137-08-6 This article mentions the following:

This study investigated whether casein (CN) fractions exhibit better phys. properties and digestibility than native casein micelles presently used in the production of infant formula. The structural performance of native casein micelles (micellar casein concentrates, MCC), β-CN, κ-CN and β + κ-CN were explored, and phys. properties and digestion characteristics (i.e., digestibility, particle size, zeta potential and microscopic morphol.) of the infant formula with MCC, β-CN, κ-CN or β + κ-CN were determined to elucidate the applicability of these casein types in infant formula. Results indicated that the β + κ-CN infant formula solution had the largest particle size with the most unstable potential. Moreover, both β-CN and κ-CN infant formula showed high solubility, while κ-CN displayed the lowest foaming capacity and high foaming stability. β-CN infant formula expressed an effective digestibility property, however, it possessed the largest particle size after gastrointestinal digestion. Therefore, β-CN fraction infant formula showed better digestibility than casein infant formula, and thus this work provides a theor. basis for the development of infant formula. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6SDS of cas: 137-08-6).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.SDS of cas: 137-08-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of (R)-1-(3-(4-Amino-3-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one (CHMFL-EGFR-202) as a Novel Irreversible EGFR Mutant Kinase Inhibitor with a Distinct Binding Mode was written by Wang, Aoli;Li, Xixiang;Wu, Hong;Zou, Fengming;Yan, Xiao-E.;Chen, Cheng;Hu, Chen;Yu, Kailin;Wang, Wenchao;Zhao, Peng;Wu, Jiaxin;Qi, Ziping;Wang, Wei;Wang, Beilei;Wang, Li;Ren, Tao;Zhang, Shanchun;Yun, Cai-Hong;Liu, Jing;Liu, Qingsong. And the article was included in Journal of Medicinal Chemistry in 2017.Computed Properties of C11H21NO3 This article mentions the following:

On the basis of Ibrutinib’s core pharmacophore, which was moderately active to EGFR T790M mutant, we discovered novel epidermal growth factor receptor (EGFR) inhibitor compound 19 (CHMFL-EGFR-202), which potently inhibited EGFR primary mutants (L858R, del19) and drug-resistant mutant L858R/T790M. Compound 19 displayed a good selectivity profile among 468 kinases/mutants tested in the KINOMEscan assay (S score (1) = 0.02). In particular, it did not exhibit apparent activities against INSR and IGF1R kinases. The X-ray crystal structure revealed that this class of inhibitors formed a covalent bond with Cys797 in a distinct “DFG-in-C-helix-out” inactive EGFR conformation. Compound 19 displayed strong antiproliferative effects against EGFR mutant-driven nonsmall cell lung cancer (NSCLC) cell lines such as H1975, PC9, HCC827, and H3255 but not the wild-type EGFR expressing cells. In the H1975 and PC9 cell-inoculated xenograft mouse models, compound 19 exhibited dose-dependent tumor growth suppression efficacy without obvious toxicity. Compound 19 might be a potential drug candidate for EGFR mutant-driven NSCLC. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2Computed Properties of C11H21NO3).

tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C11H21NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Exploiting self-assembly for ligand-scaffold optimization: substrate-tailored ligands for efficient catalytic asymmetric hydroboration was written by Moteki, Shin A.;Takacs, James M.. And the article was included in Angewandte Chemie, International Edition in 2008.Formula: C8H9FO This article mentions the following:

A self-assembled ligand library (SAL XY) affords a wide range of R/S ratios in Rh-catalyzed asym. hydroboration. Ligand-scaffold optimization reveals substrate-tailored ligands that afford high regio- and enantioselectivity for a variety of ortho-substituted styrene derivatives In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Formula: C8H9FO).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Formula: C8H9FO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hexafluoroisopropanol: A powerful solvent for the hydrogenation of functionalized aromatic compounds was written by Fache, Fabienne;Piva, Olivier. And the article was included in Synlett in 2004.SDS of cas: 94022-96-5 This article mentions the following:

Various substituted aromatic compounds have been reduced under H₂ using RuCl₃. The fluorous solvent hexafluoroisopropanol turned out to be particularly efficient in the case of compounds difficult to reduce in organic solvents. In the experiment, the researchers used many compounds, for example, 2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5SDS of cas: 94022-96-5).

2-(Trifluoromethyl)phenethyl alcohol (cas: 94022-96-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 94022-96-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Amino Alcohols and Derivatives with Therapeutic Properties. II was written by Fourneau, E.. And the article was included in Journal de Pharmacie et de Chimie in 1911.Product Details of 14123-48-9 This article mentions the following:

Dimethylaminodimethylethylcarbinol, Me₂NCH₂CMeEtOH, (1) by heating C₆H₆ solution of Me₂NH with ClCH₂MeCEtOH in a sealed tube, or (2) from Me₂NH and EtMeC – CH₂ in the same way, or (3) by the action of EtMgBr on Me₂NCH₂Ac; colorless liquid b. 149°, methiodide, prisms, m. 126°. The other bases described were prepared similarly. Diethylaminodimethylethylcarbinol. Dimethylaminotrimethylcarbinol, b₇₅₈ 130°. Methiodide, prisms, m. 130°. Dimethylaminodimethylpropylcarbinol, b₂₅ 78°. Methiodide, plates, m. 151°. Dimethylaminodimethylisoamylcarbinol, b₇₅₈ 199.5°. Hydrochloride, leaflets, m. 145°. Dimethylaminodimethylphenylcarbinol. Dimethylaminodimethylbenzylcarbinol, b₂₄₁ 144°. Dimethylaminodiethylmethylcarbinol, from EtMgBr and Me₂NCH₂CO₂Et, or EtMgBr and ClCH₂CO₂Et, followed by Me₂NH, b. 170°. Methiodide, prisms, m. 134°. Starting with excess of NH₃, by method (1) both primary and secondary bases are obtained. Aminodimethylethylcarbinol, H₂NCH₂CMeEtOH, syrup with nicotine odor, b. 170°, not precipitated by the usual alkaloid reagents. Hydrochloride, hygroscopi leaflets, m. 90°. Aminobisdimethylethylcarbinol, syrup with strong odor, b₂₆ 165-6°. Hydrochloride, brilliant, non-hygroscopic leaflets. Aminodimethylisoamylcarbinol, b₆₀ 125°. Aminobisdimethylisoamylcarbinol, crystalline, b₄₅ 206°. Hydrochloride, difficultly soluble in H₂O, affording a separation from the primary base, m. 183°. Aminodimethylphenylcarbinol, b₄₀ 174-5°. Aminobisdimethylphenylcarbinol, b₄₀ 258°. Hydrochloride, slightly soluble in H₂O, leaflets, m. 228-9°. Methylaminodimethylethylcarbinol, b. 160°. In the experiment, the researchers used many compounds, for example, 1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9Product Details of 14123-48-9).

1-(Dimethylamino)-2-methylpropan-2-ol (cas: 14123-48-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Product Details of 14123-48-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formulation and evaluation of nasal insert for nose-to-brain drug delivery of rivastigmine tartrate was written by Shaghlil, Lena;Alshishani, Anas;Sa’aleek, Asmaa Abu;Abdalkader, Hamdy;Al-ebini, Yousef. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Nose-to-Brain drug delivery can bypass blood-brain-barrier though the olfactory region using different devices and dosage forms. This work aimed to fabricate and characterize a novel dosage form, nasal inserts, containing rivastigmine tartrate. Four formulas were fabricated using gelatin/HPMC matrix in a different ratios and grades. The fabricated nasal inserts were characterized in terms of phys. appearance, surface pH, diameter and length, mech. properties, and mucoadhesive behavior. The content uniformity, release profile, Ex-vivo permeation of rivastigmine tartrate were also investigated. The release profiles for all nasal inserts were fitted to kinetics model. Phys. and chem. stability of the dosage form were evaluated. F2 appears to have the best sustained release profile, where F1 appears to have the best immediate release profile. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts