Alcohols-buliding-blocks

Deodorization of sunflower oil by high voltage electric field as a nonthermal method sunflower oil refining by electric field was written by Tavakoli, Atefeh;Sahari, Mohammad Ali;Barzegar, Mohsen;Ahmadi Gavlighi, Hassan;Marzocchi, Silvia;Marziali, Sara;Caboni, Maria. And the article was included in Journal of Food Science in 2022.HPLC of Formula: 3391-86-4 This article mentions the following:

In this study, the high voltage elec. field (HVEF) method was used for deodorization of sunflower oil to omit drawbacks of an established industrial method including long time, high energy, chems. and water consumption, loss of bioactive compounds, and formation of some contaminants due to exposure to heat. Response surface methodol. (RSM) was employed to find the optimal values of processing parameters. The effects of voltage (5-15 kV), clay (0-1%), electrolyte concentration (0-50 mM), the number of electrodes (1-5 pairs), and electrodes distance (1-3 cm) on the volatile compounds and tocopherols content were investigated by HS-SPME-GC/MS and HPLC, resp. The optimal processing conditions were determined to be a voltage of 5 kV, a distance of 1 cm between the electrodes and a number of five pairs of electrodes. The amount of bleaching clay and electrolyte concentration were zero under optimal conditions. The refining process by HVEF removed 32.33% of the volatile compounds from crude sunflower oil, while the industrial refining process reduced the volatile compounds by only 17.78%. Result indicated no change was observed in the tocopherols content of refined sunflower oil by HVEF method. Based on PCA results, HVEF-treated sample not only contained the lowest concentration of volatile compounds but also was the most similar to crude sample in terms of volatile compounds composition The oil refining process consists of four main stages, the last of which is deodorization. This step involves injecting steam at a temperature of about 240°C, under vacuum for about 50 min. High voltage elec. field (HVEF) was able to reduce the number of volatile compounds, while no change was made in the tocopherol content of sunflower oil samples. It also does not form contaminant such as 3-monochloropropane-1,2-diol fatty acid esters and glycidyl fatty acid esters. There is no need to apply the vacuum in HVEF refining, which reduces the production cost and makes the process flow straightforward as well as rapid. This research helps to propagate green refining procedures of vegetable oils in food plants. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4HPLC of Formula: 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-Catalyzed Protoboration of 1,3-Diynes as a Platform for Iterative Functionalization was written by Ghosh, Suman;Chakrabortty, Rajesh;Kumar, Shailendra;Das, Aniruddha;Ganesh, Venkataraman. And the article was included in ACS Catalysis in 2022.Electric Literature of C16H20B2N2O2 This article mentions the following:

This paper presents the protoboration of 1,3-diynes as a platform for the iterative functionalization of various groups on enynes and dienes. Synthetic approaches to targets with high complexity are directed toward using small, modular building blocks similar to a Lego construction using iterative chem. and automated synthesis. Organoboron compounds are currently in the spotlight for achieving these goals. Here, the authors report an operationally simple, regioselective protoboration of 1,3-diynes using a mixed diboron reagent and Cu(I)/phosphine catalyst to provide enynylboronates in good yields. Under similar conditions, diprotoboration of 1,3-diynes was also achieved to access bench-stable 1,4-diboryl-1,3-dienes in good yields and regioselectivities. The iterative coupling capabilities of the products were demonstrated along with other downstream transformations offering a range of value-added skeletons. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Electric Literature of C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Survey of New, Small-Molecule Isatin-Based Oxindole Hybrids as Multi-Targeted Drugs for the Treatment of Alzheimers Disease was written by Marques, Carolina S.;Lopez, Oscar;Leitzbach, Luisa;Fernandez-Bolanos, Jose G.;Stark, Holger;Burke, Anthony J.. And the article was included in Synthesis in 2022.Category: alcohols-buliding-blocks This article mentions the following:

In the last decade, our group has been very active at developing and assaying complex libraries of scaffolds with a focus on their potential to identify bioactive drug candidates for neurodegenerative diseases, particularly Alzheimers disease (AD). Attention has been focused on isatin-based oxindole scaffolds, for which promising results concerning butyrylcholinesterase (BuChE) inhibitory activity have previously been obtained. Considering some published reports and detailed anal. of the pharmacophores of com. available drugs for AD (powerful cholinesterase (ChE) inhibitors), we performed a strategic structural modification of the isatin core and generated a new family of isatin-based oxindole hybrids (27 new compounds) possessing crucial key functional units in their framework. The syntheses were accomplished using multiple approaches, including simple N-alkylation reactions, copper-catalyzed amination reactions, and click chem. The resulting library was evaluated on ChE and MAO enzymes, both of which are involved in the pathophysiol. of neurodegeneration. IC 50values of 1.6 and 2.6 μM (BuChE assays), were achieved for the best inhibitors. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Category: alcohols-buliding-blocks).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols was written by Rapacz, Anna;Waszkielewicz, Anna M.;Panczyk, Katarzyna;Pytka, Karolina;Koczurkiewicz, Paulina;Piska, Kamil;Pekala, Elzbieta;Budziszewska, Boguslawa;Starek-Swiechowicz, Beata;Marona, Henryk. And the article was included in MedChemComm in 2017.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indexes were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Addnl., in silico metabolism prediction for the compound has been performed. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of ultrasound pretreatment at different powers on flavor characteristics of enzymatic hydrolysates of cod (Gadus macrocephalus) head was written by Wang, Yuanyuan;Tang, Xuhua;Luan, Junjia;Zhu, Wenhui;Xu, Yongxia;Yi, Shumin;Li, Jianrong;Wang, Jinxiang;Li, Xuepeng. And the article was included in Food Research International in 2022.COA of Formula: C10H20O This article mentions the following:

To make better use of cod head (Gadus macrocephalus), a byproduct of fish processing, the effects of ultrasound pretreatment on the enzymic properties and volatile compounds of cod head enzymic hydrolyzates were investigated. The results demonstrated that ultrasound pretreatment at 150-600 W had a pos. effect cod head enzymic hydrolyzates. The soluble peptides content of the enzymic hydrolyzates reached the highest value of 5.31 ± 0.16 mg/mL at the ultrasound power level of 450 W, and the content of peptide mols. < 3-kDa was up to 93.96%. The type and relative content of volatile compounds, especially aldehydes, alcs., and ketones, also increased with the increase the ultrasound power. The electronic tongue results indicated that ultrasound pretreatment reduced bitterness and astringency. The electronic nose results indicated that the hydrogen- and alkane-containing odor components in the hydrolyzed liquid after ultrasound pretreatment differed significantly from conventional enzymic hydrolyzates. In conclusion, ultrasound pretreatment may be applicable as a suitable technol. to assist enzymic hydrolysis of the cod head, and as such, promote the utilization of fish byproducts. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5COA of Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Study of dehydration and water states in new and worn soft contact lens materials was written by Krysztofiak, Katarzyna;Szyczewski, Andrzej. And the article was included in Optica Applicata in 2014.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The purpose of this study was to examine the in vitro dehydration characteristics of new and worn conventional and silicone-hydrogel contact lenses. Four contact lens materials were investigated: three conventional hydrogels (etafilcon, nelfilcon, omafilcon) and one silicone-hydrogel (narafilcon). Gravimetric data were obtained with anal. balance with 1 min intervals. Quant. parameters of water content and dehydration rate were calculated allowing quant. description of dehydration process. Differential scanning calorimetry was used to monitor changes in water states in samples studied. As expected, dehydration behavior of each material is different in terms of mean dehydration rate values and phases of dehydration. Gravimetric data allowed us to distinguish three phases of dehydration. Interestingly, the effect of the osmolality of storing solutions on dehydration was found – lenses stored in hyperosmotic solutions needed more time to achieve equilibrium with the environment. Effect of wearing on dehydration patterns and water properties was confirmed. In worn samples, a decrease in water content was observed Addnl., there was a change in water structure after 6 h of wearing in all lenses studied. This behavior may be ascribed to tear film components deposition and changes in surface wettability that appear during wearing. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rheological Properties of Zirconium Oxide Suspensions in Acrylate Monomers For Use In 3D Printing was written by Sokolov, P. S.;Komissarenko, D. A.;Dosovitskii, G. A.;Shmeleva, I. A.;Slyusar, I. V.;Dosovitskii, A. E.. And the article was included in Glass and Ceramics in 2018.Quality Control of Diethyleneglycoldiacrylate This article mentions the following:

The rheol. properties of highly concentrated suspensions consisting of nanocrystalline powders of zirconium oxide with monoclinic, tetragonal, and cubic modification (stabilized at molar content of yttrium oxide 4 and 8%) and liquid UV-photocured monomers of different nature were studied. The dynamic viscosity of the suspensions with the highest filling to 32% by volume was equal to 3 Pa · sec at shear rate 10 s ^-1 and of the order of 1 Pa · sec at 100 s ^-1 and 20°C. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Quality Control of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smart hydrogels designed for use in microfabricated sensor arrays was written by Bates, Jeffrey S.;Cho, Seung Hei;Tathireddy, Prashant;Rieth, Loren W.;Magda, Jules J.. And the article was included in MRS Online Proceedings Library in 2013.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Hydrogels are considered smart materials because they respond to environmental stimuli. Sensors that monitor the body’s pH levels would be helpful for doctors to determine the severity of a patient’s condition, especially if they exhibit signs of shock. The motivation of this project is to create a biomedical device that can be worn sublingually or implanted into the body to help doctors with diagnosing a patient’s condition. The magnitude of the swelling/deswelling behavior can be measured by placing a sample of the hydrogel in a piezoresistive sensor. The degree of swelling/deswelling is directly proportional to the change in pH of the aqueous solution it is placed in. In this study, a variety of compositions of pH responsive hydrogels were designed and tested to determine the response time and magnitude for use in both macro and micro sensor arrays. This pressure sensor has been designed for use with thinner gels than have been used in the past. The results for swelling time and magnitude were compared to determine the effect of the thickness of the hydrogel samples on the swelling/deswelling kinetics of the material in order to find the appropriate composition, thickness and device that will yield the desired response rate and sensitivity. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Control of enantioselectivity in the enzymatic reduction of halogenated acetophenone analogs by substituent positions and sizes was written by Koesoema, Afifa Ayu;Standley, Daron M.;Ohshima, Shusuke;Tamura, Mayumi;Matsuda, Tomoko. And the article was included in Tetrahedron Letters in 2020.Related Products of 120121-01-9 This article mentions the following:

We utilized acetophenone reductase from Geotrichum candidum NBRC 4597 (GcAPRD), wild type and Trp288Ala mutant, to reduce halogenated acetophenone analogs to their corresponding (S)- and (R)-alcs. beneficial as pharmaceutical intermediates. Reduction by wild type resulted in excellent (S)-enantioselectivity for all of the substrates tested. Meanwhile, reduction by Trp288Ala resulted in high (R)-enantioselectivity for the reduction of 4′ substituted acetophenone and 2′-trifluoromethylacetophenone. In addition to that, we were able to control the enantioselectivity of Trp288Ala by the positions and sizes of the halogen substituents. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Related Products of 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antibacterial properties of laser-encapsulated titanium oxide nanotubes decorated with nanosilver and covered with chitosan/Eudragit polymers was written by Pawlowski, Lukasz;Wawrzyniak, Jakub;Banach-Kopec, Adrianna;Cieslik, Bartlomiej Michal;Jurak, Kacper;Karczewski, Jakub;Tylingo, Robert;Siuzdak, Katarzyna;Zielinski, Andrzej. And the article was included in Biomaterials Advances in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

To provide antibacterial properties, the titanium samples were subjected to electrochem. oxidation in the fluoride-containing diethylene glycol-based electrolyte to create a titanium oxide nanotubular surface. Afterward, the surface was covered by sputtering with silver 5 nm film, and the tops of the nanotubes were capped using laser treatment, resulting in an appearance of silver nanoparticles (AgNPs) of around 30 nm in diameter on such a modified surface. To ensure a controlled release of the bactericidal substance, the samples were addnl. coated with a pH-sensitive chitosan/Eudragit 100 coating, also exhibiting bactericidal properties. The modified titanium samples were characterized using SEM, EDS, AFM, Raman, and XPS techniques. The wettability, corrosion properties, adhesion of the coating to the substrate, the release of AgNPs into solutions simulating body fluids at different pH, and antibacterial properties were further investigated. The obtained composite coatings were hydrophilic, adjacent to the surface, and corrosion-resistant. An increase in the amount of silver released as ions or metallic particles into a simulated body fluid solution at acidic pH was observed for modified samples with the biopolymer coating after three days of exposure avoiding burst effect. The proposed modification was effective against both Gram-pos. and Gram-neg. bacteria. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts