Alcohols-buliding-blocks

Lewis base-catalyzed Mukaiyama-aldol reaction of trimethylsilyl enolates with aldehydes was written by Zhang, Xingxian;Shi, Junchen;Hu, Shenghui. And the article was included in Journal of Chemical Research in 2010.Related Products of 1122-71-0 This article mentions the following:

An efficient Mukaiyama-type aldol reaction of three silyl enolates, such as 1-[(trimethylsilyl)oxy]-1-methoxy-2-methyl-2-propene [i.e., [(1-methoxy-2-methyl-1-propen-1-yl)oxy]trimethylsilane], 1-phenyl-1-[(trimethylsilyl)oxy]ethene [i.e., [1-[(trimethylsilyl)oxy]ethenyl]silane] and 1,2-bis[(trimethylsilyl)oxy]cyclobutene with aryl aldehydes and 伪,尾-unsaturated aldehydes catalyzed by 5 mol% Lewis base catalyst (4-nitrophenoxy)magnesium iodide [i.e., 4-O₂NPhOMgI] in CH₂Cl₂ solvent is described. The reaction proceeds under mild reaction conditions and the synthesis of the target compounds was achieved in good yield. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Related Products of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formation of secondary organic aerosol tracers from anthropogenic and biogenic volatile organic compounds under varied NO_x and oxidant conditions was written by Sato, Kei;Ikemori, Fumikazu;Ramasamy, Sathiyamurthi;Iijima, Akihiro;Kumagai, Kimiyo;Fushimi, Akihiro;Fujitani, Yuji;Chatani, Satoru;Tanabe, Kiyoshi;Takami, Akinori;Tago, Hiroshi;Saito, Yoshinori;Saito, Shinji;Hoshi, Junya;Morino, Yu. And the article was included in Atmospheric Environment: X in 2022.Computed Properties of C7H7NO4 This article mentions the following:

For source apportionment by tracer method of secondary organic aerosol (SOA), the ratios of aerosol tracer to total SOA mass (fSOA) were determined during the oxidation of toluene, naphthalene, 伪-pinene, and isoprene by a series of laboratory experiments Seven anthropogenic SOA tracers maintaining an aromatic ring structure, including 4-nitrophthalic acid and 3,5-dinitrosalicylic, were newly investigated as a chamber study together with 21 traditional aerosol tracers of anthropogenic and biogenic SOA. Experiments of the OH-initiated oxidation of anthropogenic VOCs were conducted as a function of the initial VOC/NOx ratio. No significant dependence on the VOC/NOx ratio was observed for the fSOA of 2,3-dihydroxy-4-oxopentanoic acid from toluene and phthalic acid from naphthalene, whereas the fSOA of nitroarom. compounds such as 5-nitrosalicylic acid, 3,5-dinitrosalicylic acid, and 4-nitrophthalic acid increased with decreasing VOC/NOx ratio. Among seven newly evaluated anthropogenic SOA tracers, we concluded that 3,5-dinitronsalicylic can be used as a toluene SOA tracer, whereas 4-nitrophthalic acid can be used as a naphthalene SOA tracer. Results of kinetic calculations suggest that naphthalene is a major source of 5-nitrosalicylic acid under urban and rural conditions of previous observation studies. The ozonolysis and NO₃-initiated oxidation of biogenic VOCs were investigated in addition to OH-initiated oxidation of biogenic VOCs. As for biogenic SOA tracers such as pinic acid and 2-methyltetrols, the fSOA value measured for the NO₃-intiated reaction was lower than that of the OH-initiated oxidation and the fSOA value measured for the ozonolysis was not necessarily close to that of the OH-initiated oxidation These results suggest that daytime and nighttime biogenic SOA formation events are interpreted by using different sets of the fSOA values. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Computed Properties of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper(II) complexes supported by 8-hydroxyquinoline-imine ligands: Synthesis, characterization and catalysis in aerobic alcohols oxidation was written by Gao, Tianye;Meng, Lizhen;Zeng, Guang;Hao, Zhiqiang;Han, Zhangang;Feng, Qi;Lin, Jin. And the article was included in Polyhedron in 2022.Computed Properties of C7H7ClO This article mentions the following:

Treatment of Cu(OAc)₂路4H₂O with 8-hydroxylquinoline-imine ligands [2-(ArN = H_c)-8-OH]C₉H₅N (Ar = 2,6-ⁱPr₂C₆H₃, L1H; Ar = 4-ClC₆H₄, L2H; Ar = 4-BrC₆H₄, L3H and Ar = 4-OMeC₆H₄, L4H) in refluxing EtOH gave the dual-ligand coordinated copper complexes [L₂Cu] (1a–1d) in good yields, resp. All the four Cu complexes were characterized by IR, EPR, elemental anal. and HR-MS. Furthermore, the mol. structures of 1a and 1d were further confirmed by x-ray crystallog. anal. These complexes displayed high catalytic activity and good selectivity for aerobic oxidation of primary and secondary alcs. in the presence of TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxyl) as the co-catalyst. The yields of desired aldehydes are decent (up to 84%) and the corresponding yields of ketones are at 78-91%. In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7Computed Properties of C7H7ClO).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Computed Properties of C7H7ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iron-Decorated, Guanidine Functionalized Metal-Organic Framework as a Non-heme Iron-Based Enzyme Mimic System for Catalytic Oxidation of Organic Substrates was written by Shaabani, Ahmad;Mohammadian, Reza;Farhid, Hassan;Karimi Alavijeh, Masoumeh;Amini, Mostafa M.. And the article was included in Catalysis Letters in 2019.COA of Formula: C7H6Cl2O This article mentions the following:

A novel porous functionalized metal-organic framework (MOF) as a non-heme iron-based enzyme mimic system was achieved via two-step post-synthetic modification of the MIL-101(Cr)-NH₂, and characterized by FT-IR, PXRD, TGA, SEM, EDS, CHN, BET surface area, and ICP-OES analyses. This new modified MOF (MIL-101(Cr)-guanidine-Fe) has been demonstrated to be a highly efficient, active, and reusable catalyst for oxidation of various organic substrates, including alcs., alkenes and alkyl arenes at room temperature using H₂O₂ as an oxidant. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8COA of Formula: C7H6Cl2O).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C7H6Cl2O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and Evaluation of 3,4-Dihydropyrimidin-2(1H)-ones as Sodium Iodide Symporter Inhibitors was written by Lacotte, Pierre;Puente, Celine;Ambroise, Yves. And the article was included in ChemMedChem in 2013.Product Details of 1122-71-0 This article mentions the following:

The sodium iodide symporter (NIS) is responsible for the accumulation of iodide in the thyroid gland. This transport process is involved in numerous thyroid dysfunction and is the basis for human contamination in the case of exposure to radioactive iodine species. 4-Aryl-3,4-dihydro-2(1H)-pyrimidinone derivatives were recently discovered by high-throughput screening as the first NIS inhibitors. Described herein are the synthesis and evaluation of 115 derivatives with structural modifications at five key positions on the pyrimidone core. This study provides extensive structure-activity relationships for this new class of inhibitors that will serve as a basis for further development of compounds with in vivo efficacy and adequate pharmacokinetic properties. In addition, the SAR investigation provided a more potent compound, which exhibits an IC₅₀ value of 3.2 n in a thyroid cell line (FRTL5, animal model, rat model). The title compounds thus formed included analogs and derivatives of 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenyl-5-pyrimidinecarboxylic acid (4-methoxyphenyl)methyl ester (I), such as thiophene derivatives, pyridine derivatives, imidazole derivatives, naphthalene derivatives, etc. The synthesis of the target compounds was achieved using Meldrum’s acid, amines aldehydes and alcs. as simple starting materials. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Product Details of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Product Details of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Arylated Amines via C-N Coupling of Chiral Amines with Aryl Bromides Promoted by Light was written by Song, Geyang;Yang, Liu;Li, Jing-Sheng;Tang, Wei-Jun;Zhang, Wei;Cao, Rui;Wang, Chao;Xiao, Jianliang;Xue, Dong. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

A method based on mol. Ni catalysis driven by light, which enabled stereoretentive C-N coupling of optically active amines, amino alcs. and amino acid esters with aryl bromides, with no need for any external photosensitizer was reported. The method was effective for a wide variety of coupling partners, including those bearing functional groups sensitive to bases and nucleophiles, thus providing a viable alternative to accessing synthetically important chiral N-aryl amines, amino alcs. and amino acids esters. Its viability was demonstrated by 92 examples with up to 99% ee. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Investigation of volatile flavor compounds and characterization of aroma-active compounds of water-boiled salted duck using GC-MS-O, GC-IMS, and E-nose was written by Li, Cong;Al-Dalali, Sam;Wang, Zhouping;Xu, Baocai;Zhou, Hui. And the article was included in Food Chemistry in 2022.Electric Literature of C8H16O This article mentions the following:

To clarify the characteristic aroma substances of water-boiled salted duck (WSD), headspace-gas chromatog.-mass spectrometry-olfactometry (HS-GC-MS-O), gas chromatog.-ion mobility spectrometry (GC-IMS) combined with an electronic nose (E-nose) were used to analyze the volatile flavor profile of three types of WSD (containing four samples). Thirty-one and fifty volatile flavor components were identified by GC-MS and GC-IMS, including aldehydes, alcs., esters, ketones, hydrocarbons, and others. The characteristic aroma compounds of WSD, including pentanal, hexanal, heptanal, octanal, nonanal, (E)-2-octenal, benzaldehyde, (E)-2-nonenal, decanal, 1-octen-3-ol, 1-octanol, 1-pentanol, Et acetate, D-limonene, and 2-pentylfuran, were confirmed by GC-O, odor activity values (OAVs), and aroma-recombination and omission experiments The aroma description of these aroma-active compounds can be divided into 6 categories, namely, “fruity”, “mushroom”, “fat”, “sweet”, “faint scent” and “potato, scorch” aromas. The difference between samples was mainly caused by the differential volatile compounds, followed by the identification method. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Electric Literature of C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Influence of amino acid moiety accessibility on the chiral recognition of cyclodextrin-amino acid mixed selectors in enantioselective gas chromatography was written by Stephany, Olivier;Tisse, Severine;Coadou, Gael;Bouillon, Jean-Philippe;Peulon-Agasse, Valerie;Cardinael, Pascal. And the article was included in Journal of Chromatography A in 2012.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Original mixed selectors were synthesized by coupling a single L-valine diamide moiety on permethylated 尾-cyclodextrin. The structures of the new selectors were designed to limit the interactions between the L-valine derivative and cyclodextrin by removing the amino acid moiety from the cyclodextrin cavity by an amide linkage on mono-6-amino permethylated 尾-CD or the insertion of a carboxymethyl group. The accessibility of the amino acid group moiety was thus facilitated. The new mixed selectors exhibited better enantioselectivity than Chirasil-L-Val for half (selector based on mono-6-amino permethylated 尾-CD) or more (selector with the carboxymethyl group) of the 41 amino acid derivatives Mol. modeling confirmed that these results could be attributed to an increase in the distance between the chiral center of the amino acid and the cyclodextrin cavity allowing better access of the amino acid moiety. These new mixed chiral selectors demonstrated a novel enantioselective capability with the successful separation of >90 racemic mixtures among the 105 chiral compounds tested. These mixed selectors exhibited enhanced enantioselectivity in comparison to binary selectors previously described with respect to both enantiomer resolution and the number of separated chiral compounds Also, an improvement of the enantioseparation factors compared to the corresponding parent phases for the amino acid derivatives was observed in many cases. These mixed selectors should therefore be considered some of the most versatile selectors for chiral gas chromatog. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxidation of sodium mercaptide with sulfonated cobalt phthalocyanine as catalyst was written by Liu, Ruiting;Xia, Daohong;Xiang, Yuzhi. And the article was included in Preprints – American Chemical Society, Division of Petroleum Chemistry in 2003.COA of Formula: C4H9NaS This article mentions the following:

The oxidation of Na mercaptides by air in alk. solution with CoSPc as catalyst was studied. Effects of various factors, including temperature, structures of mercaptides and concentration of alk. solution, on the oxidation of Na mercaptides were analyzed, which can provide some guides for the design of parameters in LPG sweetening. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2COA of Formula: C4H9NaS).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C4H9NaS

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3,3′-Diphosphoryl-1,1′-bi-2-naphthol-Zn(II) Complexes as Conjugate Acid-Base Catalysts for Enantioselective Dialkylzinc Addition to Aldehydes was written by Hatano, Manabu;Miyamoto, Takashi;Ishihara, Kazuaki. And the article was included in Journal of Organic Chemistry in 2006.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

A highly enantioselective dialkylzinc (R²₂Zn) addition to a series of aromatic, aliphatic, and heteroaromatic aldehydes was developed based on conjugate Lewis acid-Lewis base catalysis. Bifunctional BINOL ligands bearing phosphine oxides [P(:O)R₂], phosphonates [P(:O)(OR)₂], or phosphoramides [P(:O)(NR₂)₂] at the 3,3′-positions were prepared by using a phospho-Fries rearrangement as a key step. The coordination of a NaphO-Zn(II)-R² center as a Lewis acid to a carbonyl group in a substrate and the activation of R²₂Zn(II) with a phosphoryl group (P:O) as a Lewis base in the 3,3′-diphosphoryl-BINOL-Zn(II) catalyst could promote carbon-carbon bond formation with high enantioselectivities (up to >99% ee). Mechanistic studies were performed by X-ray analyses of a free ligand and a tetranuclear Zn(II) cluster, a ³¹P NMR experiment on Zn(II) complexes, an absence of nonlinear effect between the ligand and Et-adduct of benzaldehyde, and stoichiometric reactions with some chiral or achiral Zn(II) complexes to propose a transition-state assembly including monomeric active intermediates. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts