Alcohols-buliding-blocks

COA of Formula: C13H19Br2ClN2OOn September 30, 2022 ,《Facile approaches for determination of Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride using Eosin Y》 was published in Annales Pharmaceutiques Francaises. The article was written by El-Sayed, A.; Elmansi, H.; Shalan, S.; Eid, M.. The article contains the following contents:

New validated Spectroscopic methods were developed to assay Bromhexine Hydrochloride and its active metabolite Ambroxol Hydrochloride sep. in pure form and pharmaceutical formulations. The spectrophotometric assay (method I) shows complex formation between each of the drugs and Eosin Y at 540 nm at pH 3.6 and 3.4 mL of 4 x 10-4M Eosin for Bromhexine and Ambroxol. The Spectrofluorimetric assay (method II) depends on quenching eosin native fluorescence by the studied drugs, which measured at 540 nm after excitation at 302 nm. The spectrophotometric absorbance-concentration plot is rectilinear over the ranges (1.0-5.0) and (1.0-10.0) μg/mL for bromhexine and ambroxol with LOD of 0.31 and 0.14μg/mL and LOQ of 0.94 and 0.42μg/mL for the two drugs resp. The fluorometric-concentration plot is linear along the range (1.0-5.0) μg/mL and (1-10) μg/mL for the two drugs resp. with LOD of 0.13μg/mL and 0.22μg/mL and LOQ of 0.4μg/mL and 0.65μg/mL for the two drugs, resp. Developed assays have been validated in agreement with ICH recommendations and they were used in the anal. of com. drug formulations containing the two mucolytic drugs and the results were matching with those obtained by the comparison method.De nouvelles methodes spectroscopiques validees ont etedeveloppes pour doser le chlorhydrate de bromhexine et son metabolite actif, le chlorhydrate d’Ambroxol, sous forme pure et dans des formulations pharmaceutiques. Le dosage spectrophotometrique (methode I) montre la formation d’un complexe entre chacun des medicaments et l’eosine Y a540 nm a pH 3,6 et 3,4 mL d’eosine 4 x 10-4M pour la bromhexine et l’ambroxol. Le dosage spectrofluorimetrique (methode II) depend de l’extinction de la fluorescence native de l’eosine par les medicaments etudies, qui a ete mesuree a 540 nm apres excitation a 302 nm. Le trace spectrophotometrique. Le trace spectrophotometrique absorbance-concentration est lineaire sur les plages (1,0-5,0) et (1,0-10,0) μg/mL pour la bromhexine et l’ambroxol avec LOD de 0,31 et 0,14μg/mL et LOQ de 0,94 et 0,42μg/mL pour les deux medicaments respectivement. Le trace de la concentration fluorometrique est lineaire le long de la plage (1,0-5,0) μg/mL et (1-10) μg/mL pour les deux medicaments respectivement avec LOD de 0,13μg/mL et 0,22μg/mL et LOQ de 0,4μg/ mL et 0,65μg/mL pour les deux medicaments, respectivement. Les tests developpes ont ete valides en accord avec les recommandations de l’ICH et ils ont ete utilizes dans l’analyze des formulations de medicaments commerciaux contenant les deux medicaments mucolytiques et les resultats correspondaient a ceux obtenus par la methode de comparaison. In the experimental materials used by the author, we found trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4COA of Formula: C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.COA of Formula: C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 329735-68-4On October 31, 2008 ,《Conversion of propargylic alcohols to β-oxo esters catalyzed by novel ruthenium-phosphoramidite complexes》 appeared in Advanced Synthesis & Catalysis. The author of the article were Costin, Stephen; Rath, Nigam P.; Bauer, Eike B.. The article conveys some information:

A series of half-sandwich phosphoramidite complexes of ruthenium were synthesized and employed as catalysts in the atom-economical formation of β-oxo esters from carboxylic acids and propargylic alcs. Reaction of the phosphoramidites (R)-BINOL-PNR2 (R = Me, 1a; i-Pr, 1b; benzyl, 1c) and (rac)-6,6′-dibromo-BINOL-PNMe2 (1d) with the dimeric p-cymene-ruthenium dichloride complex, [RuCl2(p-cymene)]2, gave the complexes [RuCl2(p-cymene)(L)] (L = 1a, 7a; 1b, 7b; 1c, 7c; 1d, 7d) in 96-66% yield. Accordingly, reaction of (R)-BINOL(8H)-PNMe2 (2a) and (R)-BINOL(8H)-PN(benzyl)2 (2b) with [RuCl2(p-cymene)]2 afforded the complexes [RuCl2(p-cymene)(L)] (L = 2a, 8a; 2b, 8b) in 82% and 86% yield. In a similar reaction, treatment of (R)-BIPHEN-PNMe2 (9) with [RuCl2(p-cymene)]2 gave the complex [RuCl2(p-cymene)(9)] (11) in 60% yield. Finally, phosphoramidite 1b reacted with [RuCl2(C6Me6)]2 to give [RuCl2(C6Me6)(1b)] (12) in 78% yield. All novel complexes are catalytically active in the formation of β-oxo esters from propargylic alcs. and carboxylic acids. Standard conditions involve cyclohexane solvent, propargylic alc. (1.0 equivalent), carboxylic acid (1.0 equivalent), ruthenium catalyst (1.5 mol%), and 90° for 5-18 h. Isolated yields of the β-oxo esters range from 87 to 16% and show broad substrate generality. The reaction proceeds without racemization if a chiral propargylic alc. is employed. The method is practical as no additives are required and the exclusion of oxygen and moisture is not needed. Complex 7c turned out to be the most effective catalyst (5 h reaction time), showing that the ligand structure has a profound impact on the catalytic performance. The crystal structure of 7a was determined, confirming an octahedral coordination geometry about the ruthenium center. The results came from multiple reactions, including the reaction of (R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Application of 329735-68-4)

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Application of 329735-68-4

Referemce:
Alcohol – Wikipedia,
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Barlow, Thomas; Dipple, Anthony published an article on January 31 ,1998. The article was titled 《Aralkylation of Guanosine with p-Substituted Styrene Oxides》, and you may find the article in Chemical Research in Toxicology.Product Details of 157142-48-8 The information in the text is summarized as follows:

To probe mechanisms of nucleoside aralkylation, product distributions and product stereochemistries were determined in reactions of optically active p-methyl- and p-bromo-styrene oxide with guanosine. The proportion of 7-, N2- and O6-substituted guanosine products was 0.32:0.62:0.06 in neutral, aqueous reactions of the (R) p-methylstyrene oxide and 0.85:0.09:0.04 in reactions with the (R) p-bromostyrene oxide. The exocyclic positions opened The epoxide at the α-carbon. Epoxide ring-opening by the nitrogen at the 7-position showed little preference for the α- or β-carbons in reactions with p-methylstyrene oxide. However, the p-bromostyrene oxide favored reaction at the β-carbon almost 4-fold over reaction at the α-carbon. Almost total inversion of stereochem. was found to occur in reactions at the 7-position. In contrast, the ratio of inversion to retention of configuration in N- and O-substituted products was 2:1 and 1:1 for reactions with the p-methylstyrene oxide and 6:1 and 3:1 for reactions with p-bromostyrene oxide, resp. These experiments suggest that an SN2 mechanism is in effect with reactions at the 7-position, whereas substrates of an increasingly ionic nature are involved in reactions at the N2- and O6- positions, resp. The experimental part of the paper was very detailed, including the reaction process of 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Product Details of 157142-48-8)

2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Product Details of 157142-48-8

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Holmes, Sean T.; Vojvodin, Cameron S.; Schurko, Robert W. published their research in Journal of Physical Chemistry A on December 10 ,2020. The article was titled 《Dispersion-Corrected DFT Methods for Applications in Nuclear Magnetic Resonance Crystallography》.Electric Literature of C13H19Br2ClN2O The article contains the following contents:

Nuclear elec. field gradient (EFG) tensor parameters depend strongly on electronic structures, making their calculation from first principles an excellent metric for the prediction, refinement, and optimization of crystal structures. Here, we use plane-wave d. functional theory (DFT) calculations of EFG tensors in organic solids to optimize the Grimme (D2) and Tkatchenko-Scheffler (TS) at.-pairwise force field dispersion corrections. Refinements using these new force field correction methods result in better representations of true crystal structures, as gauged by calculations of 177 14N, 17O, and 35Cl EFG tensors from 95 materials. The most striking result is the degree by which calculations of 35Cl EFG tensors of chloride ions match with experiment, due to the ability of these new methods to properly locate the positions of hydrogen atoms participating in H···Cl- hydrogen bonds. These refined structures also feature at. coordinates that are more similar to those of neutron diffraction structures than those obtained from calculations that do not employ the optimized force fields. Addnl., we assess the quality of these new energy-minimization protocols for the prediction of 15N magnetic shielding tensors and unit cell volumes, which complement the larger anal. using EFG tensors, since these quantities have different phys. origins. It is hoped that these results will be useful in future NMR crystallog. studies and will be of great interest to a wide variety of researchers, in fields including NMR spectroscopy, computational chem., crystallog., pharmaceutical sciences, and crystal engineering. In the experiment, the researchers used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Electric Literature of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Electric Literature of C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2008,Chemistry – An Asian Journal included an article by Gabert, Andrea J.; Schrock, Richard R.; Muller, Peter. Computed Properties of C24H34O2. The article was titled 《Synthesis of bifunctional imido alkylidene bispyrrolide complexes of molybdenum and their conversion into bifunctional imido alkylidene diolate complexes that can be employed as ROMP initiators》. The information in the text is summarized as follows:

Addition of four equivalent of lithium 2,5-dimethylpyrrolide to a solution of [Mo(NAr)(ORF6)2(CHC5H4)]2Fe (ORF6 = OCMe(CF3)2) in dichloromethane led to [Mo(NAr)(Me2Pyr)2(CHC5H4)]2Fe (I) where Me2Pyr = 2,5-dimethylpyrrolide and lithium hexafluoro-tert-butoxide, which crystallizes out upon cooling the reaction mixture to -35°C. Attempts to prepare parent pyrrolide complexes analogous to I resulted in the formation of a mixture of two products. The one that could be isolated contains one equivalent of lithium pyrrolide per molybdenum, that is [Mo(NAr)(Pyr)3(CHC5H4)]2FeLi2 (II). The X-ray structure obtained shows it to be a dimer of dimers in which each lithium atom is bound to three pyrrolides. Addition of four equivalent of lithium 2,5-dimethylpyrrolide to [Mo(NAr)(ORF6)2]2(DME)2(CH-1,4-C6H4CH) in cold DME produced [Mo(NAr)(Me2Pyr)2]2(CH-1,4-C6H4CH) (III) in good yield, in which the bridging alkylidene is derived from 1,4-divinylbenzene. Three equivalent of (S)-H2[Biphen] are required for a clean reaction with II to form [Mo(NAr)(Biphen)(CHC5H4)]2Fe (IV) (H2[Biphen]=3,3′-di-tert-butyl-5,5′,6,6′-tetramethyl-1,1′-biphenyl-2,2′-diol), Li2[Biphen], and two equivalent of pyrrole. Reactions involving III with the chiral diols are the best behaved. Brown [Mo(NAr)(Benz2Bitet)]2(CH-1,4-C6H4CH) (V) can be isolated upon addition of (R)-H2[Benz2Bitet] H2[Benz2Bitet] = (3,3′-dibenzhydryl-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diol) to 4, while addition of (R)-H2[Mes2Bitet] (H2[Mes2Bitet] = 3,3′-dimesityl-5,5′,6,6′,7,7′,8,8′-octahydro-1,1′-binaphthyl-2,2′-diol) to 4 yields [Mo(NAr)(Mes2Bitet)]2(CH-1,4-C6H4CH) (VI). Compounds IV, V, and VI were employed as initiators for the polymerization of 2,3-dicarbomethoxynorbornadiene (DCMNBD) and 2,3-bis(trifluoromethyl)norbornadiene (NBDF6).(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4Computed Properties of C24H34O2) was used in this study.

(R)-3,3′-Di-tert-butyl-5,5′,6,6′-tetramethylbiphenyl-2,2′-diol(cas: 329735-68-4) belongs to phenols. Phenols are more acidic than typical alcohols. The acidity of the hydroxyl group in phenols is commonly intermediate between that of aliphatic alcohols and carboxylic acids (their pKa is usually between 10 and 12).Computed Properties of C24H34O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Helvetica Chimica Acta included an article by Kuzniewski, Christian N.; Glauser, Simon; Gaugaz, Fabienne Z.; Schiess, Raphael; Rodriguez-Salarichs, Javier; Vetterli, Stefan; Horlacher, Oliver P.; Gertsch, Juerg; Redondo-Horcajo, Mariano; Canales, Angeles; Jimenez-Barbero, Jesus; Diaz, Jose Fernando; Altmann, Karl-Heinz. Quality Control of (R)-Oxiran-2-ylmethanol. The article was titled 《Synthesis, Profiling, and Bioactive Conformation of trans-Cyclopropyl Epothilones》. The information in the text is summarized as follows:

A series of new 3-deoxy-C(12),C(13)-trans-cyclopropyl-epothilones have been prepared, bearing benzothiazole, quinoline, thiazol-5-ylvinyl, or isoxazol-3-ylvinyl side chains (I – IV, resp.). For analogs with fused aromatic side chains, macrocyclic ring-closure was based on ring-closing olefin metathesis (RCM) of a precursor incorporating the fully elaborated heavy atom framework of the target structure (including the side chain moiety), while side chain attachment for the thiazole and isoxazole-containing 16-desmethyl analogs was performed only after establishment of the macrolactone core. Two approaches were elaborated for a macrocyclic aldehyde as the common precursor for the latter analogs that involved ring-closure either by RCM or by macrolactonization. Benzothiazole- and quinoline-based analogs were found to be highly potent antiproliferative agents; the two analogs with a thiazol-5-ylvinyl or an isoxazol-3-ylvinyl side chain likewise showed good antiproliferative activity but were significantly less potent than the parent epothilone A. Surprisingly, the desaturation of the C(10)-C(11) bond in these analogs was associated with a virtually complete loss in antiproliferative activity, which likely reflects a requirement for a ca. 60 ° C(10)-C(11) torsion angle in the tubulin-bound conformation of 12,13-trans-epothilones. In the experiment, the researchers used many compounds, for example, (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Quality Control of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Quality Control of (R)-Oxiran-2-ylmethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2020,Polymers (Basel, Switzerland) included an article by Nasir, Nur’Izzah Md.; Abdulmalek, Emilia; Zainuddin, Norhazlin. Computed Properties of C6H12O6. The article was titled 《Preparation and optimization of water-soluble cationic sago starch with a high degree of substitution using response surface methodology》. The information in the text is summarized as follows:

Modification and characterizations of cationic sago starch with 3-chloro-2-hydroxypropyl trimethylammonium chloride (CHPTAC) prepared via etherification reaction was reported in this study. The optimization of cationic sago starch modification was performed by utilizing the combination of response surface methodol. and central composite design (RSM/CCD). The effect of each variable and the interaction between the three variables, the concentration of CHPTAC, concentration of the catalyst NaOH, and the reaction times on the degree of substitution (DS) of the product were investigated and modeled. Moderate conditions were employed and a water-soluble cationic sago starch with high DS value was obtained. Based on RSM, the highest DS = 1.195 was obtained at optimum conditions: 0.615 mol of CHPTAC concentration (CHPTAC/SS = 5), 30% w/v NaOH, and 5 h reaction time, at 60°C reaction temperature Furthermore, the cationic sago starch was characterized using Fourier transform IR spectroscopy, FTIR, X-ray diffraction, XRD, and field emission SEM, FESEM. In the part of experimental materials, we found many familiar compounds, such as rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1Computed Properties of C6H12O6)

rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is the monohydrate form of the alpha isoform of D-glucopyranose, a synthetic simple monosaccharide that is used as an energy source.Computed Properties of C6H12O6

Referemce:
Alcohol – Wikipedia,
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In 2021,Chemical & Pharmaceutical Bulletin included an article by Ijitsu, Shin; Hoashi, Yohei; Hori, Koji; Okimoto, Kazuto; Kai, Toshiya; Yoshida, Miyako; Uchida, Takahiro. Product Details of 23828-92-4. The article was titled 《Preparation of novel functional drug particles embedded in a gelling-swelling layer (PEGS) for taste masking and subsequent rapid drug release》. The information in the text is summarized as follows:

The purpose of this research was to develop novel functional drug particles embedded in a gelling-swelling layer (PEGS) which are capable of achieving both taste-masking of unpalatable drugs and rapid drug elution. The functional particles had a three-layer structure consisting of a core drug layer, a gelling-swelling layer and an outer water-penetration control layer containing a water-insoluble polymer. The concept of formulation design was as follows: when water reaches the gelling-swelling layer, pulverized fine gelling-swelling particles gellate and swell from water absorption to form a rigid layer, thereby preventing drug release. After a defined lag time, the increased volume of the gelling-swelling layer breaks down the outer water-penetration control layer, leading to rapid drug release. In order to adapt this system for use in orally disintegrating tablets, PEGS were prepared at a size of about 250μm using a fine particle-coating method. Ambroxol hydrochloride was used as a model drug for bitterness and the effects of different gelling-swelling agents and water-insoluble polymers on drug release characteristics from PEGS were examined In in vitro dissolution tests, it was shown that the drug dissolution rate from PEGS could be suppressed to about 5% after 2 min and increased to more than 85% after 30 min by adjusting the composition and thickness of the outer layer. The PEGS expanded about 1.5-fold and the outer layer was ruptured after 5 min in water. The experimental process involved the reaction of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Product Details of 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Product Details of 23828-92-4 Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sanceau, Jean-Yves; Maltais, Rene; Poirier, Donald; Marette, Andre published an article on January 18 ,2019. The article was titled 《Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C3H6O2 The information in the text is summarized as follows:

The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10S,17S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and C-17 were derived from readily available (S)-1,2,4-butanetriol and (R)-glycidol, resp. The two stereodefined E-double bonds were generated by a Takai olefination, and the skipped diene side chain was introduced with a stereocontrolled Wittig olefination. Importantly, the sensitive conjugated E,Z,E-triene intermediate was generated by a Boland reduction of the central triple bond of a E,E-dienyne. Overall, this synthetic strategy should allow the preparation of a larger quantity of PDX, which is inaccessible via previously reported biosynthetic approaches.(R)-Oxiran-2-ylmethanol(cas: 57044-25-4Electric Literature of C3H6O2) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Electric Literature of C3H6O2

Referemce:
Alcohol – Wikipedia,
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The author of 《Synthesis and evaluation of water-soluble 2-aryl-1-sulfonylpyrrolidine derivatives as bacterial biofilm formation inhibitors》 were Smolobochkin, Andrey V.; Muravyeva, Ekaterina A.; Vagapova, Liliya I.; Knyazeva, Irina R.; Voronina, Julia K.; Burilov, Alexander R.; Pudovik, Michail A.; Gildebrant, Anastasiya V.; Sazykin, Ivan S.; Sazykina, Marina A.; Gazizov, Almir S.. And the article was published in Chemistry & Biodiversity in 2019. Safety of 4,4-Diethoxybutan-1-amine The author mentioned the following in the article:

The approach to the novel 1-[(2-aminoethyl)sulfonyl]-2-arylpyrrolidines via unique intramol. cyclization/aza-Michael reactions of N-(4,4-diethoxybutyl)ethenesulfonamide have been developed, which benefits from high yields of target compounds, mild reaction conditions, usage of inexpensive and low-toxic reagents, and allows for wide variability in both amine and aryl moieties. Biotesting with whole-cell luminescent bacterial biosensors responding to DNA damage showed that all tested compounds are not genotoxic. Tested compounds differently affect the formation of biofilms by Vibrio aquamarinus DSM 26054. Some of the tested compounds were found to suppress the bacterial biofilms growth and thus are promising candidates for further studies.4,4-Diethoxybutan-1-amine(cas: 6346-09-4Safety of 4,4-Diethoxybutan-1-amine) was used in this study.

4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 4,4-Diethoxybutan-1-amine

Referemce:
Alcohol – Wikipedia,
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