Alcohols-buliding-blocks

De Almeida, Laiza A.; Marcondes, Thayna H.; Milagre, Cintia D. F.; Milagre, Humberto M. S. published the artcile< Lipase-oxovanadium heterogeneous catalysis system: a robust protocol for the dynamic kinetic resolution of sec-alcohols>, Computed Properties of 403-41-8, the main research area is lipase oxovanadium dynamic kinetic resolution secondary alc.

Herein, we present a robust and eco-friendly dynamic kinetic resolution (DKR) protocol for secondary alcs. using a combined heterogeneous catalytic CAL-B/VOSO4 system at 50°C in the relatively green solvent heptane. This catalytic system is active and chemo- and enantioselective for up to 5 cycles. A set of 13 aromatic and heteroaromatic secondary alcs. were evaluated to determine the substrate scope. The performance of the combined CAL-B/VOSO4 system was improved by employing a low-cost, homemade Teflon tube to compartmentalize the catalysts in one-pot conditions, making this system for up to 8 reaction cycles.

ChemCatChem published new progress about Enantioselective biochemical synthesis. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Computed Properties of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jie; Yang, Weiyao; Wu, Cai; Gong, Yahui; Zhang, Jian; Shen, Chun published the artcile< Upgrading n-butanol to branched alcohols over Ni/CaxMgyO>, Application In Synthesis of 104-76-7, the main research area is upgrading butanol branched alc nickel calcium magnesium oxygen.

Despite the intensive development of heterogeneous catalysts with transition metal for the Guerbet reaction, a detailed understanding of the metal species and reaction mechanism (rate-determining step and active sites) is still deficient. Herein, we have developed a series of Ni/CaxMgyO catalysts to upgrade n-butanol into branched 2-ethyl-1-hexanol and establish the structure-activity correlation. Given the formation of solid solution between NiO and MgO, the addition of Mg element contributes to the formation of highly dispersed Ni nanoparticles with a small mean size. After optimization in reaction conditions, the highest conversion and selectivity of 80.2 and 79.1%, resp., were achieved at 240°C. The pivotal role of Ni0 sites and base sites during the Guerbet reaction, as confirmed by the selective poison experiments could be attributed to their synergistic catalysis during the dehydrogenation of n-butanol, which is the rate-determining step of the whole process. Moreover, a possible reaction mechanism for this rate-determining step over Ni/CaxMgyO catalysts was proposed based on exptl. results. Overall, this work pushes forward the understanding of the reaction mechanism of the Guerbet reaction over transition-metal-decorated catalysts, which would be constructive for the rational design of heterogeneous catalysts. Efficient upgrading of n-butanol to 2-ethyl-1-hexanol was achieved over Ni/CaxMgyO catalysts, and understanding about the reaction mechanism was pushed forward.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols, branched Role: SPN (Synthetic Preparation), PREP (Preparation). 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, Application In Synthesis of 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Saito, Tatsuya; Takojima, Kaoru; Oyama, Takafumi; Hatanaka, Shintaro; Konno, Takashi; Yamamoto, Takuya; Tajima, Kenji; Isono, Takuya; Satoh, Toshifumi published the artcile< Trimethyl Glycine as an Environmentally Benign and Biocompatible Organocatalyst for Ring-Opening Polymerization of Cyclic Carbonate>, Application of C9H8O, the main research area is trimethyl glycine environmentally benign biocompatible organocatalyst.

Tri-Me glycine (TMG), a natural product found in plants as well as in humans, was demonstrated to be an efficient catalyst for the ring-opening polymerization (ROP) of cyclic carbonate, enabling the environmentally benign synthesis of aliphatic polycarbonate (APC). The ROP of trimethylene carbonate (TMC) using TMG proceeded under the bulk condition at 70 °C to give poly(trimethylene carbonate), possessing controlled mol. weight (∼4000) and low dispersity (∼1.22). The results of a matrix-assisted laser desorption/ionization time-of-flight mass spectral anal. and a chain extension experiment confirmed the controlled/living nature of the present ROP system, where side reactions, such as inter- and intramol. transesterifications, were minimized during the polymerization The screening of TMG analogs as a catalyst for ROP revealed that the combination of the carboxylate and quaternary ammonium moieties in TMG is an essential structural requirement. The Fourier transform IR analyses of TMC and alc. initiator in the presence/absence of TMG confirmed the biactivation property of the TMG. End-functionalized APCs were obtained using alc. initiators bearing clickable functionalities, such as azido and ethynyl groups. Furthermore, we demonstrated the synthesis of APC-diol and -triol, which can be used as prepolymers for APC-based polyurethane.

ACS Sustainable Chemistry & Engineering published new progress about Polycarbonates, aliphatic Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Application of C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikoorazm, Mohsen; Ghorbani, Farshid; Ghorbani-Choghamarani, Arash; Erfani, Zahra published the artcile< Mild and highly efficient method for the oxidation of sulfides and oxidative coupling of thiols catalyzed by Fe3O4@MCM-41@VO-SPATB as efficient and magnetically recoverable nanocatalyst>, Name: 2-(Phenylthio)ethanol, the main research area is sulfide oxidation thiol coupling immobilized ferric oxide silica catalyst.

The use of oxo vanadium complex with s-propyl-2-aminobenzothioate ligand immobilized onto functionalized magnetic nanoporous MCM-41(Fe3O4@MCM-41@VO-SPATB) as efficient and magnetically recoverable nanocatalyst for oxidation of sulfides into sulfoxides and oxidative coupling of thiols into disulfides using H2O2 as green oxidant is presented. This method provides much improved modification of oxidation reactions in terms of mild reaction conditions, short reaction time and good-to-excellent yields of products. Another important feature of this method is the ability to reuse the magnetite nanocatalyst for several times with no loss of its catalytic activity.

Journal of the Iranian Chemical Society published new progress about Green chemistry. 699-12-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H10OS, Name: 2-(Phenylthio)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Cui; He, Qian; Zeng, Linlin; Shen, Ling; Luo, Qiaomei; Zhang, Wentao; Zhou, Xia; Wan, Jun published the artcile< Digestion-Promoting Effects and Mechanisms of Dashanzha Pill Based on Raw and Charred Crataegi Fructus>, Synthetic Route of 87-73-0, the main research area is digestion promotor dashanzha pill crataegi fructus; Crataegi Fructus; Dashanzha Pill; dyspepsia, gut microbiota; endoplasmic reticulum stress.

Emerging evidence suggests that a high-fat diet (HFD) can influence endoplasmic reticulum (ER) stress and gut microbiota. Crataegi Fructus is a traditional Chinese herb widely used in formulas for dyspepsia, with Dashanzha Pill composed of raw Crataegi Fructus (DR) being a representative drug. Processing products of Crataegi Fructus, however, have a stronger pro-digestive effect, and we hypothesized that Dashanzha Pill composed of charred Crataegi Fructus (DC) is more effective. We found that the contents of glucose 1-phosphate and luteolin in DR and DC were substantially different via ultra-high performance liquid chromatog.-hybrid quadrupole-Orbitrap high-resolution mass spectrometry. DC outperformed DR in improving histopathol. changes, increasing gastrin and motilin, and decreasing vasoactive intestinal peptides in rats with HFD induced dyspepsia. Fecal microbiota anal. revealed that DC could restore the disturbed intestinal microbiota composition, including that of Bacteroides, Akkermansia, and Intestinimonas to normal levels. Furthermore, DC significantly reduced the mRNA and protein levels of glucose-regulated protein 78, protein kinase R-like ER kinase, and eukaryotic initiation factor 2α. Taken together, DC outperformed DR in relieving dyspepsia by regulating gut microbiota and alleviating ER stress.

Chemistry & Biodiversity published new progress about Akkermansia. 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Synthetic Route of 87-73-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Zhengqiang; Qiao, Hong; Zeng, Fanlong published the artcile< Design, Synthesis, and Application of NNN Pincer Ligands Possessing a Remote Hydroxyl Group for Ruthenium-Catalyzed Transfer Hydrogenation of Ketones>, COA of Formula: C8H9FO, the main research area is ketone transfer hydrogenation alc preparation ruthenium pincer catalyst; crystal structure ruthenium NNN pincer triphenylphosphine dichloro complex preparation.

A new family of pyridyl-based NNN pincer ligands bearing a remote pendent OH group were developed. Considerable acceleration effects on the activity of Ru-catalyzed transfer hydrogenation of ketones were imparted by the pendent OH group, and importantly, introducing a CH2OH group to the 4′-position of the pyrazolyl moiety is an appropriate choice. The results present a general strategy for exploring bifunctional ligands to construct effective catalysts.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, COA of Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chakraborty, Priyanka; Gangwar, Manoj Kumar; Emayavaramban, Balakumar; Manoury, Eric; Poli, Rinaldo; Sundararaju, Basker published the artcile< α-Alkylation of Ketones with Secondary Alcohols Catalyzed by Well-Defined Cp*CoIII-Complexes>, Safety of 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is alkyl aryl ketone preparation; ketone secondary alc alkylation cobalt catalyst; alkylation; cobalt; ketones; secondary alcohols; α-alkylation.

Herein a well-defined, high-valence cobalt(III)-catalyst was applied for successful α-alkylation of ketones RC(O)CH3 (R = pentamethylphenyl, Ph, naphthalen-2-yl, etc.) and 1,2,3,4-tetrahydronaphthalen-1-one with secondary alcs. R1OH (R1 = 1-phenylethyl, cyclopentyl, octan-2-yl, etc.). A wide-variety of secondary alcs., which include cyclic, acyclic, sym., and unsym. compounds, was employed as alkylating agents to produce β-alkyl aryl ketones RC(O)CH2R1 and 2-(1-phenylethyl)-3,4-dihydronaphthalen-1(2H)-one.

ChemSusChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Safety of 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Man Kadayat, Tara; Eun Kim, Dong; Bong Lee, Sang; Jung, Kyungjin; Eun Park, Sang; Hong, Ji-Ye; Kim, Jina; Shrestha, Aarajana; Kim, Dong-Su; An, Hongchan; Kim, Nayeon; Lee, Su-Jeong; Kwon, Sugyeong; Kim, Suhui; Yeon Hwang, Jun; Kim, Shinae; Hahn, Dongyup; Choi, Hyukjae; Nam, Sang-Jip; Hyun Jeon, Yong; Jin Hwang, Jung; Jin Cho, Sung; Chin, Jungwook published the artcile< Antioxidative and anti-inflammatory activity of psiguadial B and its halogenated analogues as potential neuroprotective agents>, Quality Control of 4396-13-8, the main research area is psiguadial B halo derivative preparation antiinflammatory antioxidant neuroprotective; Anti-inflammatory effect; Antioxidative effect; Neuroprotective agent; Psiguadial B; Reactive oxygen species; Short synthetic route.

Psiguadial B (I, R = H), and its fluoro-, chloro-, and bromo-derivatives I (R = F, Cl, Br, resp.) were synthesized using a sodium acetate-catalyzed single step coupling of three components: β-caryophyllene , diformylphloroglucinol, and benzaldehyde. These compounds efficiently and dose-dependently decreased H2O2-induced cell death, a quant. marker of cell death, in primary cultures of mouse cortical neurons. Psiguadial B also decreased neuronal death and accumulation of ROS induced by FeCl2 in cortical cultures. The in vitro effects of these compounds in lipopolysaccharide (LPS)-induced expression of nitric oxide (NO), and TNF-α and IL-6 by suppressing the NF-κB pathway in immune cells demonstrated their antioxidative and anti-inflammatory activity. The present findings warrant further research on the development of psiguadial B-based neuroprotective agents for the treatment of neurodegenerative diseases, acute brain injuries and immunol. disorders.

Bioorganic Chemistry published new progress about Anti-inflammatory agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Quality Control of 4396-13-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Bin; Wang, Sijia; Wang, Yakun; Ke, Songze; Jin, Weihua; Chen, Jianwei; Zhang, Huawei; Sun, Jiadong; Henning, Susanne M.; Wang, Jian; Wang, Hong published the artcile< Gut microbiota-mediated xanthine metabolism is associated with resistance to high-fat diet-induced obesity>, Name: D-Glucosaccharic acid, the main research area is gut microbiota xanthine metabolism high fat diet induced obesity; 16S rRNA sequencing; Gut microbiome; High-fat diet resistance; Host-microbial co-metabolism; Metabolomics; Obesity.

Resistance to high-fat diet-induced obesity (DIR) has been observed in mice fed a high-fat diet and may provide a potential approach for anti-obesity drug discovery. However, the metabolic status, gut microbiota composition, and its associations with DIR are still unclear. Here, ultraperformance liquid chromatog.-tandem mass spectrometry-based urinary metabolomic and 16S rRNA gene sequencing-based fecal microbiome analyses were conducted to investigate the relationship between metabolic profile, gut microbiota composition, and body weight of C57BL/6J mice on chow or a high-fat diet for 8 wk. PICRUSt anal. of 16S rRNA gene sequences predicted the functional metagenomes of gut bacteria. The results demonstrated that feeding a high-fat diet increased body weight and fasting blood glucose of high-fat diet-induced obesity (DIO) mice and altered the host-microbial co-metabolism and gut microbiota composition In DIR mice, high-fat diet did not increase body weight while fasting blood glucose was increased significantly compared to chow fed mice. In DIR mice, the urinary metabolic pattern was shifted to a distinct direction compared to DIO mice, which was mainly contributed by xanthine. Moreover, high-fat diet caused gut microbiota dysbiosis in both DIO and DIR mice, but in DIR mice, the abundance of Bifidobacteriaceae, Roseburia, and Escherichia was not affected compared to mice fed a chow diet, which played an important role in the pathway coverage of FormylTHF biosynthesis I. Meanwhile, xanthine and pathway coverage of FormylTHF biosynthesis I showed significant pos. correlations with mouse body weight These findings suggest that gut microbiota-mediated xanthine metabolism correlates with resistance to high-fat DIO.

Journal of Nutritional Biochemistry published new progress about 16S rRNA Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (gene sequencing). 87-73-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H10O8, Name: D-Glucosaccharic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chimento, Adele; De Amicis, Francesca; Sirianni, Rosa; Sinicropi, Maria Stefania; Puoci, Francesco; Casaburi, Ivan; Saturnino, Carmela; Pezzi, Vincenzo published the artcile< Progress to improve oral bioavailability and beneficial effects of resveratrol>, Application In Synthesis of 501-36-0, the main research area is review resveratrol oral bioavailability beneficial effect; resveratrol; resveratrol bioavailability; resveratrol delivery systems; resveratrol derivatives.

A review. Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro and in vivo studies have shown that in addition to antioxidant, anti-inflammatory, cardioprotective and neuroprotective actions, it exhibits antitumor properties. In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its poor bioavailability, various methodol. approaches and different synthetic derivatives have been developed. In this review, we will describe the strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV. These methodol. approaches include RSV nanoencapsulation in lipid nanocarriers or liposomes, nanoemulsions, micelles, insertion into polymeric particles, solid dispersions, and nanocrystals. Moreover, the biol. results obtained on several synthetic derivatives containing different substituents, such as methoxylic, hydroxylic groups, or halogens on the RSV aromatic rings, will be described. Results reported in the literature are encouraging but require addnl. in vivo studies, to support clin. applications.

International Journal of Molecular Sciences published new progress about Arachis hypogaea. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Application In Synthesis of 501-36-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts