Alcohols-buliding-blocks

Enantioselective Hydrogenation of Imidazo[1,2-a]pyridines was written by Schlepphorst, Christoph;Wiesenfeldt, Mario P.;Glorius, Frank. And the article was included in Chemistry – A European Journal in 2018.Quality Control of (6-Aminopyridin-2-yl)methanol This article mentions the following:

The enantioselective synthesis of tetrahydroimidazo[1,2-a]pyridines by direct hydrogenation was achieved using a ruthenium/N-heterocyclic carbene (NHC) catalyst. The reaction forgoes the need for protecting or activating groups, proceeds with complete regioselectivity, good to excellent yields, enantiomeric ratios of up to 98:2, and tolerates a broad range of functional groups [e.g., I → II (95.5:4.5 e.r., 99% isolated yield)]. 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridines, which are found in numerous bioactive mols., were directly obtained by this method, and its applicability was demonstrated by the (formal) synthesis of several functional mols. In the experiment, the researchers used many compounds, for example, (6-Aminopyridin-2-yl)methanol (cas: 79651-64-2Quality Control of (6-Aminopyridin-2-yl)methanol).

(6-Aminopyridin-2-yl)methanol (cas: 79651-64-2) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Quality Control of (6-Aminopyridin-2-yl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Controlled multi-vinyl monomer homopolymerization through vinyl oligomer combination as a universal approach to hyperbranched architectures was written by Zhao, Tianyu;Zheng, Yu;Poly, Julien;Wang, Wenxin. And the article was included in Nature Communications in 2013.Safety of Diethyleneglycoldiacrylate This article mentions the following:

The three-dimensional structures of hyperbranched materials have made them attractive in many important applications. However, the preparation of hyperbranched materials remains challenging. The hyperbranched materials from addition polymerization have gained attention, but are still confined to only a low level of branching and often low yield. Moreover, the complication of synthesis only allows a few specialized monomers and inimers to be used. Here we report a ‘Vinyl Oligomer Combination’ strategy; a versatile approach that overcomes these difficulties and allows facile synthesis of highly branched polymeric materials from readily available multi-vinyl monomers, which have long been considered as formidable starting materials in addition polymerization We report the alteration of the growth manner of polymerization by controlling the kinetic chain length, together with the manipulation of chain growth conditions, to achieve veritable hyperbranched materials, which possess nearly 70% branch ratios as well as numerous vinyl functional groups. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Three component terpolymer and IPN hydrogels with response to stimuli was written by Alzari, Valeria;Ruiu, Andrea;Nuvoli, Daniele;Sanna, Roberta;Martinez, Javier Illescas;Appelhans, Dietmar;Voit, Brigitte;Zschoche, Stefan;Mariani, Alberto. And the article was included in Polymer in 2014.Related Products of 109-17-1 This article mentions the following:

Two different types of multi-stimuli-shrinking hydrogels were synthesized (IPNs and terpolymeric hydrogels) by properly polymerizing N-isopropylacrylamide, 2-hydroxyethyl methacrylate and 2-acrylamido-2-methylpropanesulfonic acid in various mutual ratios and different synthetic orders. Both classical (CP) and frontal (FP) polymerizations were used and the resulting material properties compared. The best compositions and synthetic routes were found and the swelling, morphol. and thermal material properties were studied. The results show that some IPNs exhibit marked stimuli-shrinking properties while some terpolymers present an opposite behavior. IPNs swell more than terpolymers and show a sharper stimuli-response, with a larger swelling ratio variation. In addition, FP allowed obtaining samples with the same characteristic of CP materials, but with significant preparation advantages. It has been demonstrated that by varying monomer mutual ratio, synthetic technique (FP or CP) and structural architecture (terpolymers or IPNs), different materials having peculiar properties and characteristics can be obtained. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Related Products of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Repurposing of tamoxifen ameliorates CLN3 and CLN7 disease phenotype was written by Soldati, Chiara;Lopez-Fabuel, Irene;Wanderlingh, Luca G.;Garcia-Macia, Marina;Monfregola, Jlenia;Esposito, Alessandra;Napolitano, Gennaro;Guevara-Ferrer, Marta;Scotto Rosato, Anna;Krogsaeter, Einar K.;Paquet, Dominik;Grimm, Christian M.;Montefusco, Sandro;Braulke, Thomas;Storch, Stephan;Mole, Sara E.;De Matteis, Maria A.;Ballabio, Andrea;Sampaio, Julio L.;McKay, Tristan;Johannes, Ludger;Bolanos, Juan P.;Medina, Diego L.. And the article was included in EMBO Molecular Medicine in 2021.Computed Properties of C24H23ClO2 This article mentions the following:

Batten diseases (BDs) are a group of lysosomal storage disorders characterized by seizure, visual loss, and cognitive and motor deterioration. We discovered increased levels of globotriaosylceramide (Gb3) in cellular and murine models of CLN3 and CLN7 diseases and used fluorescent-conjugated bacterial toxins to label Gb3 to develop a cell-based high content imaging (HCI) screening assay for the repurposing of FDA-approved compounds able to reduce this accumulation within BD cells. We found that tamoxifen reduced the lysosomal accumulation of Gb3 in CLN3 and CLN7 cell models, including neuronal progenitor cells (NPCs) from CLN7 patient-derived induced pluripotent stem cells (iPSC). Here, tamoxifen exerts its action through a mechanism that involves activation of the transcription factor EB (TFEB), a master gene of lysosomal function and autophagy. In vivo administration of tamoxifen to the CLN7^δex2 mouse model reduced the accumulation of Gb3 and SCMAS, decreased neuroinflammation, and improved motor coordination. These data strongly suggest that tamoxifen may be a suitable drug to treat some types of Batten disease. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Computed Properties of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation method of double-textured ZnO:B films deposited by MOCVD on plasma etched polymer buffer was written by Addonizio, M. L.;Fusco, L.. And the article was included in Journal of Alloys and Compounds in 2015.Formula: C16H26O7 This article mentions the following:

With the aim of enhancing light trapping phenomenon in PV thin film silicon devices, a method was developed to produce highly textured TCO surfaces by the growth of ZnO:B on a buffer layer consisting of UV-cured highly transparent acrylic polymer (IBA) whose surface had been modified by RIE process. Different RIE etching conditions, particularly RF-power and process duration, were used to obtain different polymer surface modifications. The effect of different treatment conditions on polymer surface was systematically studied and subsequently correlated to the properties of ZnO:B films deposited by MOCVD on these modified polymer surfaces. The surface morphol. of zinc oxide film, growth on IBA buffer layer, changed from conventional pyramid-like single-texture to cauliflower-like double-texture. The morphol. of double-textured ZnO strongly depended on the surface properties of the etched polymer. Excellent scattering properties were obtained and at the wavelength of 800 nm the haze value increased from 7.5% (pyramidal-like single-texture ZnO layer on glass) to 68% (double textured ZnO film obtained on etched IBA, treated for 20 min at RF-power of 80 W). The root-mean-square roughness showed similar behavior: it increased at the increasing of the etching time and the highest value of 160 nm was obtained for cauliflower-like ZnO:B film. Good elec. properties were maintained for double-textured ZnO:B films with excellent scattering properties. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

One-pot synthesis of pompon-like magnetic hollow SiO₂-supported Ag nanoparticles for catalytic application was written by Li, Zhuo-Rui;Jiang, Bo;Zhang, Xiao-Hui;Han, Guo-Zhi. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2022.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

In this paper, we develop a novel pompon-like magnetic hollow SiO₂-supported Ag (SiO₂@Ag) nanoparticles, in which small silver and magnetic nanoparticles were loaded on the hollow silica shell by one-pot solvothermal method. FT-IR, XRD, SEM, TEM and BET were applied to characterized the structure and morphol. of the magnetic hollow SiO₂@Ag nanoparticles. The synthesized material has not only high stability and monodispersity, but also uniform surface element distribution along with good magnetic response. On this basis, we studied the catalytic performance of this pompon-like magnetic hollow SiO₂@Ag nanoparticles for the reduction of aromatic nitro compounds, and further carried out extended researches on substrates scope. Research results indicate that the pompon-like magnetic hollow SiO₂@Ag nanoparticles have broad-spectrum catalytic activity for the reduction of aromatic nitro compounds After recycling for 8 times, it can still maintain 90% catalytic efficiency. This study provides a facile strategy for constructing hollow hierarchical structure, and expands the application of noble metal nanoparticles in organic transformation. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly enantioselective transfer hydrogenation of aromatic ketones was written by Pan, En-De;Li, Yan-Yun;Dong, Zhen-Rong;Chen, Jian-Shan;Li, Bao-Zhu;Zhang, Hui;Gao, Jing-Xing. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2003.Quality Control of (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Enantioselective reduction of prochiral ketones with 2-propanol or formic acid catalyzed by chiral metal complexes has been developed as a synthetic method complementary to asym. hydrogenation in the past decade. However, these processes are necessary to be improved for practical use in organic synthesis because of low catalytic activity and insufficient enantioselectivity. In this paper, we report an excellent catalytic system generated in situ from iridium complex IrCl(Ph₃P)₃ and chiral tetradentate diaminodiphosphine ligand for asym. transfer hydrogenation of various aromatic ketones. For isobutyrophenone transfer hydrogenation, the corresponding optically active alc. was obtained in 93% yield and with up to 99% e. e. after 5 h at 28 °C. Propiophenone was a better substrate with respect to catalytic activity and enantioselectivity in the presence of base as a co-catalyst. The conversion of propiophenone reached 95.8% and the turnover number as high as 3 193 h^-1. These results will provide a useful index for further designing practical chiral catalytic systems. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Quality Control of (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carbon (1s) NEXAFS spectroscopy of biogeochemically relevant reference organic compounds was written by Solomon, Dawit;Lehmann, Johannes;Kinyangi, James;Liang, Biqing;Heymann, Karen;Dathe, Lena;Hanley, Kelly;Wirick, Sue;Jacobsen, Chris. And the article was included in Soil Science Society of America Journal in 2009.Formula: C6H14O6 This article mentions the following:

Natural organic matter (NOM) is a highly active component of soils and sediments, and plays an important role in global C cycling. However, NOM has defied mol.-level structural characterization, owing to variations along the decomposition continuum and its existence as highly functionalized polyelectrolytes. We conducted a comprehensive systematic overview of spectral signatures and peak positions of major organic mols. that occur as part of NOM using near-edge x-ray absorption fine structure (NEXAFS) spectroscopy. The spectra of carbohydrates and amino sugars show resonances between 289.10 and 289.59 eV, attributed to 1s-3p/σ* transitions of O-alkyl (C-OH) moieties. They also exhibited distinct peaks between 288.42 and 288.74 eV, representing C1s-π*_C=O transition from COOH functionalities. Amino acids produced a strong signal around 288.70 eV, which can be identified as a C 1s-π*_C=O transition of carboxyl/carbonyl (COOH/COO-) structures. Spectral features near 285.29 eV were ascribed to C 1s-π*_C=C transition of ring structure of aromatic amino acids, while spectra between 287.14 and 287.86 eV were attributed to C 1s-π*_C-H and C 1s-σ*_C-H/3p Rydberg-like excitations from CH and CH₂ groups. Phenols and benzoquinone produced strong resonances between 285.08 and 285.37 eV, attributed to the π* orbital of C (C 1s-π*_C=C) atoms connected to either C or H (C-H) in the aromatic ring. The next higher excitation common to both phenols and quinone appeared between 286.05 and 286.35 eV, and could be associated with C 1s-π*_C=C transitions of aromatic C bonded to O atom in phenols, and to C 1s-π*_C=O transitions from aromatic C connected to O atom (C-OH) in phenols or to a C=O in p-benzoquinone and some phenols with carbonyl structures, resp. Nucleobases exhibited complex spectral features with pronounced resonances between 286.02 and 286.84 eV and between 288.01 and 288.70 eV. Mol. markers for black C (benzenecarboxylic acid and biphenyl-4,4′-dicarboxylic acid) exhibit sharp absorption bands between 285.01 and at 285.43 eV, possibly from C 1s-π*_C=C transition characteristic of C-H sites or unsaturated C (C=C) on aromatic ring structures. These aromatic carboxylic acids also exhibit broad peaks between 288.35 and 288.48 eV, reflecting C 1s-π*_C=O transition of carboxyl functional groups bonded to unsaturated C. This investigation provides a more comprehensive NEXAFS spectral library of biogeochem. relevant organic C compounds The spectra of these reference organic compounds reveal distinct spectral features and peak positions at the C K-edge that are characteristic of the MOs bonding C atoms. Detailed structural information can be derived from these distinctive spectral features that could be used to build robust peak assignment criteria to exploit the chem. sensitivity of NEXAFS spectroscopy for in situ mol.-level spatial investigation and fingerprinting of complex organic C compounds in environmental samples. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Formula: C6H14O6).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C6H14O6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of new mono-N-tosylated diamine ligands based on (R)-(+)-limonene and their application in asymmetric transfer hydrogenation of ketones and imines was written by Roszkowski, Piotr;Maurin, Jan K.;Czarnocki, Zbigniew. And the article was included in Tetrahedron: Asymmetry in 2013.HPLC of Formula: 120121-01-9 This article mentions the following:

A synthetic procedure leading to the preparation of a new family of enantiopure mono-N-tosylated-1,2-diamines derived from (R)-(+)-limonene is described. (+)-Limonene was transformed into the appropriate N-tosyl derivative using N-tosylaziridination based on chloramine-T trihydrate. Subsequent ring opening by sodium azide afforded the corresponding isomeric azides. Finally, reduction of the azide function gave enantiomerically pure mono-N-tosylated-1,2-diamines. The ligands obtained proved to be effective in the asym. transfer hydrogenation protocol on aromatic ketones and imines. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9HPLC of Formula: 120121-01-9).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 120121-01-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship was written by Vianello, Paola;Sartori, Luca;Amigoni, Federica;Cappa, Anna;Faga, Giovanni;Fattori, Raimondo;Legnaghi, Elena;Ciossani, Giuseppe;Mattevi, Andrea;Meroni, Giuseppe;Moretti, Loris;Cecatiello, Valentina;Pasqualato, Sebastiano;Romussi, Alessia;Thaler, Florian;Trifiro, Paolo;Villa, Manuela;Botrugno, Oronza A.;Dessanti, Paola;Minucci, Saverio;Vultaggio, Stefania;Zagarri, Elisa;Varasi, Mario;Mercurio, Ciro. And the article was included in Journal of Medicinal Chemistry in 2017.Reference of 142253-56-3 This article mentions the following:

The balance of methylation levels at histone H3 lysine 4 (H3K4) is regulated by KDM1A (LSD1). KDM1A is overexpressed in several tumor types, thus representing an emerging target for the development of novel cancer therapeutics. The authors have previously described the identification of thieno[3,2-b]pyrrole-5-carboxamides, as novel reversible inhibitors of KDM1A, whose preliminary exploration resulted in compound (I) with biochem. IC₅₀ = 160 nM. The authors now report the structure-guided optimization of this chem. series, based on multiple ligand/KDM1A-CoRest co-crystal structures, which led to several extremely potent inhibitors. In particular, compounds N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]- methoxy]phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]-pyrrole-5-carboxamide hydrochloride (46), 4-ethyl-N-[3-(methoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]-methoxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide (49) and N-[3-(ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]-phenoxy]methyl]phenyl]-4-methyl-thieno[3,2-b]pyrrole-5-carboxamide hydrochloride (50) showed single digit nanomolar IC₅₀ values for in vitro inhibition of KDM1A, with high selectivity in secondary assays. In THP-1 cells these compounds transcriptionally affected the expression of genes regulated by KDM1A, such as CD14, CD11b, and CD86. Moreover, 49 and 50 showed a remarkable anti-clonogenic cell growth effect on MLL-AF9 human leukemia cells. In the experiment, the researchers used many compounds, for example, 1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3Reference of 142253-56-3).

1-Boc-Azetidine-3-yl-methanol (cas: 142253-56-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 142253-56-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts