Alcohols-buliding-blocks

On June 30, 1994, Bazylak, Grzegorz published an article.Quality Control of 2,2′-(tert-Butylazanediyl)diethanol The title of the article was Chemometric characterization of alkanolamines using molecular descriptors and planar chromatography data. And the article contained the following:

Twenty nine congeneric alkanolamines, mainly derivatives of ethanolamine and diethanolamine, were analyzed by reversed phase TLC on octadecyl silica layers using either methanol – water (9 + 1, volume/volume) or acetonitrile-water (9 + 1, volume/volume) as mobile phase. The capacity factors were compared with data, taken from the literature, obtained by paper chromatog. on cellulose, using three different mobile phase systems. Seven topol. indexes and other mol. descriptors, reflecting structural differences between the solutes, were calculated All the data were subjected to principal component anal. and hierarchical cluster anal. to determine the main factors affecting the observed physicochem. similarities and dissimilarities of alkanolamines or their chromatog. behavior. Multivariate classification of the alkanolamines revealed slight differences between the results obtained by principal component anal. and hierarchical cluster anal. The usefulness of the calculated abstract principal component (which accounted for 99% of the variance in the data) as the independent variable in quant. structure-retention relations (QSRR) was examined to determine whether it could be used to predict alkanolamine retention in planar chromatog. systems. The experimental process involved the reaction of 2,2′-(tert-Butylazanediyl)diethanol(cas: 2160-93-2).Quality Control of 2,2′-(tert-Butylazanediyl)diethanol

The Article related to chemometric characterization alkanolamine planar chromatog, alkanolamine planar chromatog retention structure relation, tlc reversed phase alkanolamine, thin layer chromatog alkanolamine and other aspects.Quality Control of 2,2′-(tert-Butylazanediyl)diethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 1, 2020, Tsochatzis, Emmanouil D.; Mieth, Anja; Alberto Lopes, Joao; Simoneau, Catherine published an article.Formula: C14H22O The title of the article was A Salting-out Liquid-Liquid extraction (SALLE) for the analysis of caprolactam and 2,4-di-tert butyl phenol in water and food simulants. Study of the salinity effect to specific migration from food contact materials. And the article contained the following:

Caprolactam and 2,4-di-tert-Bu phenol (2,4-DTBP) are substances typically found in some food contact materials (FCMs). They are known to often migrate into food, and are difficult to analyze in liquid food simulants using GC. In this work a simple salting-out Liquid-Liquid Extraction (SALLE) for the anal. of both substances in water and the official food simulant A (10% volume/volume ethanol, Regulation (EU) Number 10/2011) is presented. The method, which included anal. determination by GC-MS, was optimized and validated to ensure sufficient anal. quality. The method’s LOQs allowed the proper quantification of caprolactam at its EU legislative limit (15 mg kg-1). For 2,4-DTBP the method also revealed good sensitivity, although no official limits have been established yet. Linear regression coefficients (R2) were in all cases higher than 0.999, and recoveries ranged from 87% and 95% for caprolactam and 2,4-DTBP, resp. Precision was also acceptable, with the RSDs (%) below 12%. The method proved to be adequate to be used for routine anal. The presence of salt during migration of caprolactam and 2,4-DTBP was also investigated in this work. Polyamide/polyethylene FCM multilayer films have been tested with water and simulant A, containing different amounts of NaCl (up to 15% m/v), and applying different migration conditions (temperature and time). The results indicated that salinity plays an important effect on the migration of caprolactam, with the presence of salt reducing its migration in case of water and increasing it in case of simulant A. These preliminary results seem to indicate that migration testing should consider not only the well-known fatty content of a food, but also its salinity content, as it may end up affecting drastically the migration of polar substances. The experimental process involved the reaction of 2,4-Di-tert-butylphenol(cas: 96-76-4).Formula: C14H22O

The Article related to caprolactam 24 dtbp food contact material, food contact materials, gc-ms, method validation, migration testing and food simulants, salle – salt assisted liquid extraction, salinity effect and other aspects.Formula: C14H22O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 18, 2021, Huarte, Estibaliz; Serra, Gessica; Monteagudo-Mera, Andrea; Spencer, Jeremy; Cid, Concepcion; de Pena, Maria-Paz published an article.Quality Control of 3-Hydroxyphenylacetic acid The title of the article was Raw and sous-vide-cooked red cardoon stalks (Cynara cardunculus L. var. altilis DC): (Poly)phenol bioaccessibility, anti-inflammatory activity in the gastrointestinal tract, and prebiotic activity. And the article contained the following:

The in vitro anti-inflammatory and prebiotic activity and the content and profile of bioaccessible (poly)phenols and catabolites of raw and sous-vide-cooked red cardoon (Cynara cardunculus L. var. altilis DC) were investigated during gastrointestinal (GI) digestion. Raw cardoon after in vitro GI digestion had 0.7% bioaccessible (poly)phenols, which protected against lipopolysaccharide-induced inflammation by counteracting IL-8, IL-6, TNF-α, and IL-10 secretions in differentiated Caco-2 cells. Contrarily, GI-digested sous vide cardoon showed higher (poly)phenol bioaccessibility (59.8%) and exerted proinflammatory effects in Caco-2 cells. (Poly)phenols were highly metabolized during the first 8 h of in vitro fermentation, and nine catabolites were produced during 48 h of fermentation Colonic-fermented raw and sous-vide-cooked cardoon did not show anti-inflammatory activity in HT-29 cells but presented potential prebiotic activity, comparable to the com. prebiotic FOS, by stimulating health-promoting bacteria such as Bifidobacterium spp. and Lactobacillus/Enterococcus spp. and by increasing the production of total SCFAs, especially acetate. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Quality Control of 3-Hydroxyphenylacetic acid

The Article related to sous vide cooking cynara polyphenol bioaccessibility antiinflammatory digestibility prebiotic, (poly)phenols, cynara, cytokines, gastrointestinal digestion, gut microbiota, heat treatment and other aspects.Quality Control of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 29, 2020, Gatidou, Georgia; Vazaiou, Niki; Thomaidis, Nikolaos S.; Stasinakis, Athanasios S. published an article.Synthetic Route of 585-88-6 The title of the article was Biodegradability assessment of food additives using OECD 301F respirometric test. And the article contained the following:

The ready biodegradability of twenty food additives, belonging to the classes of artificial sweeteners, natural sweeteners, preservatives and colorings, was investigated using activated sludge as inoculum and OECD 301F respirometric test. According to the results, saccharin, aspartame, sodium cyclamate, xylitol, erythritol, maltitol, potassium sorbate, benzoic acid and sodium ascorbate are characterized as readily biodegradable compounds, partial biodegradation (<60% during the test) was noticed for steviol, inulin, alitame, curcumin, ponceau 4R and tartrazine, while no biodegradation was observed for the other five compounds The duration of lag phase before the start of biodegradation varied between the target compounds, while their ultimate biodegradation half-life values ranged between 0.7 ± 0.1 days (benzoic acid) and 24.6 ± 1.0 days (curcumin). The expected removal of target compounds due to ultimate biodegradation mechanism was estimated for a biol. wastewater treatment system operated at a retention time of one day and percentages higher than 40% were calculated for sodium cyclamate, potassium sorbate and benzoic acid. Higher removal percentages are expected in full-scale Sewage Treatment Plants (STPs) due to the contribution of other mechanisms such as sorption to suspended solids, (bio)transformation and co-metabolic phenomena. Further biodegradation experiments should be conducted under different exptl. conditions for the food additives that did not fulfill the requirements of the applied protocol. Future studies should also focus on the occurrence and fate of food colorants and natural sweeteners in full-scale STPs. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Synthetic Route of 585-88-6

The Article related to food additive biodegradability artificial sweetener preservative coloring, micropollutants, oecd protocol, ready biodegradability, sweeteners, ultimate biodegradation kinetics, wastewater and other aspects.Synthetic Route of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2020, Kim, Hanseol; Kim, Sinyeon; Kim, Dohyeon; Yoon, Sung Ho published an article.Application In Synthesis of 3-Hydroxyphenylacetic acid The title of the article was A single amino acid substitution in aromatic hydroxylase (HpaB) of Escherichia coli alters substrate specificity of the structural isomers of hydroxyphenylacetate. And the article contained the following:

A broad range of aromatic compounds can be degraded by enteric bacteria, and hydroxyphenylacetic acid (HPA) degrading bacteria are the most widespread. Majority of Escherichia coli strains can use both the structural isomers of HPA, 3HPA and 4HPA, as the sole carbon source, which are catabolized by the same pathway whose associated enzymes are encoded by hpa gene cluster. Previously, we observed that E. coli B REL606 grew only on 4HPA, while E. coli B BL21(DE3) grew on 3HPA as well as 4HPA. In this study, we report that a single amino acid in 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of E. coli determines the substrate specificity of HPA isomers. Alignment of protein sequences encoded in hpa gene clusters of BL21(DE3) and REL606 showed that there was a difference of only one amino acid (position 379 in HpaB) between the two, viz., Arg in BL21(DE3) and Cys in REL606. REL606 cells expressing HpaB having Arg379 could grow on 3HPA, whereas those expressing HpaB with Gly379 or Ser379 could not. Structural anal. suggested that the amino acid residue at position 379 of HpaB is located not in the active site, but in the vicinity of the 4HPA binding site, and that it plays an important role in mediating the entrance and stable binding of substrates to the active site. The arginine residue at position 379 of HpaB is critical for 3HPA recognition. Information regarding the effect of amino acid residues on the substrate specificity of structural isomers can facilitate in designing hydoxylases with high catalytic efficiency and versatility. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Application In Synthesis of 3-Hydroxyphenylacetic acid

The Article related to escherichia coli aromatic hydroxylase hydroxyphenylacetate amino acid substitution, 4-hydroxyphenylacetate 3-hydroxylase, hydroxyphenylacetic acid, structural isomer, substrate specificity and other aspects.Application In Synthesis of 3-Hydroxyphenylacetic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dimitrokalli, Evangelia; Fertaki, Stefani; Lykouras, Michail; Kokkinos, Petros; Orkoula, Malvina; Kontoyannis, Christos published an article in 2021, the title of the article was Warfarin Sodium Stability in Oral Formulations.Product Details of 585-88-6 And the article contains the following content:

Warfarin sodium is a low-dose pharmaceutical blood thinner that exists in two forms: the clathrate form and the amorphous form. In com. available warfarin sodium oral suspension, the active pharmaceutical ingredient (API) is added in the amorphous state. This study investigates the apparent instability of the com. available warfarin liquid oral formulation using Raman and IR spectroscopy, X-ray diffraction, differential scanning calorimetry, UV spectroscopy, and optical microscopy. Warfarin, not its sodium salt, was identified as the undissolved solid existing in the suspension. This was found to be due to the dissociation of sodium salt and the protonation of the warfarin ion in the liquid phase, which triggered the crystallization of the sparingly soluble unsalted form. The coexistence of protonated and unprotonated warfarin ions in the supernatant, as detected by Raman and UV spectroscopy, confirmed this assumption. Study of the dissolution of warfarin sodium amorphous salt and crystalline sodium clathrate in the placebo and pure water verified the results. The effect of pH and temperature on warfarin precipitation was also explored. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Product Details of 585-88-6

The Article related to warfarin sodium stability oral formulation, dsc, ir, raman spectroscopy, x-ray powder diffraction, crystallization, oral suspension, warfarin, warfarin clathrate, warfarin sodium amorphous and other aspects.Product Details of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On June 30, 2022, Toushik, Sazzad Hossen; Park, Jun-Ha; Kim, Kyeongjun; Ashrafudoulla, Md.; Senakpon Isaie Ulrich, Mevo; Mizan, Furkanur Rahman Md.; Roy, Pantu Kumar; Shim, Won-Bo; Kim, Young-Mog; Park, Si Hong; Ha, Sang-Do published an article.Category: alcohols-buliding-blocks The title of the article was Antibiofilm efficacy of Leuconostoc mesenteroides J.27-derived postbiotic and food-grade essential oils against Vibrio parahaemolyticus, Pseudomonas aeruginosa, and Escherichia coli alone and in combination, and their application as a green preservative in the seafood industry. And the article contained the following:

Foodborne pathogen-mediated biofilms in food processing environments are severe threats to human lives. In the interest of human and environmental safety, natural substances with antimicrobial properties and generally regarded as safe (GRAS) status are the futuristic disinfectants of the food industry. In this study, the efficacy of bioactive, soluble products (metabolic byproducts) from lactic acid bacteria (LAB) and plant-derived essential oils (EO) were investigated as biocidal agents. The postbiotic produced by kimchi-derived Leuconostoc mesenteroides J.27 isolate was analyzed for its metabolic components to reveal its antimicrobial potential against three pathogenic microorganisms (Vibrio parahaemolyticus, Pseudomonas aeruginosa, and Escherichia coli). Addnl., the efficacy of food-grade EO (eugenol and thymol, resp.) was also assessed in our study. Determination of the min. inhibitory concentration (MIC) of postbiotic and EO against three tested pathogens revealed that the sub-MIC (0.5 MIC) of postbiotic and EO could efficiently inhibit the biofilm formation on both seafood (squid) and seafood-processing surfaces (rubber and low-d. polyethylene plastic). Moreover, the polymerase chain reaction (PCR) anal. confirmed that the LAB J.27 isolate possesses bacteriocin- and enzyme-coding genes. The residual antibacterial activity of the produced postbiotic was maintained over a diverse pH range (pH 1-6) but was entirely abolished at neutral or higher pH values. However, the activity was unaffected by exposure to high temperatures (100 and 121 °C) and storage (30 days). Notably, the leakage of intracellular metabolites, damage to DNA, and the down-regulation of biofilm-associated gene expression in the pathogens increased significantly (p > 0.05) following the combination treatment of postbiotic with thymol compared to postbiotic with eugenol. Nonetheless, all in vitro results indicated the prospective use of combining Leu. mesenteroides J.27-derived postbiotic with both EO as a “green preservative” in the seafood industry to inhibit the formation of pathogenic microbial biofilms. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Category: alcohols-buliding-blocks

The Article related to leuconostoc thymol postbiotic antibiofilm preservative pseudomonas escherichia vibrio seafood, bacterial biofilm, bio-preservative, foodborne pathogen, lactic acid bacteria, seafood safety and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zhou; Cheng, Bizhen; Liu, Wei; Feng, Guangyan; Zhao, Junming; Zhang, Liquan; Peng, Yan published an article in 2022, the title of the article was Global Metabolites Reprogramming Induced by Spermine Contributing to Salt Tolerance in Creeping Bentgrass.Quality Control of 2,3-Dihydroxypropanoic acid And the article contains the following content:

Soil salinization has become a serious challenge to modern agriculture worldwide. The purpose of the study was to reveal salt tolerance induced by spermine (Spm) associated with alterations in water and redox homeostasis, photosynthetic performance, and global metabolites reprogramming based on analyses of physiol. responses and metabolomics in creeping bentgrass (Agrostis stolonifera). Plants pretreated with or without 0.5 mM Spm were subjected to salt stress induced by NaCl for 25 days in controlled growth chambers. Results showed that a prolonged period of salt stress caused a great deal of sodium (Na) accumulation, water loss, photoinhibition, and oxidative damage to plants. However, exogenous application of Spm significantly improved endogenous spermidine (Spd) and Spm contents, followed by significant enhancement of osmotic adjustment (OA), photosynthesis, and antioxidant capacity in leaves under salt stress. The Spm inhibited salt-induced Na accumulation but did not affect potassium (K) content. The anal. of metabolomics demonstrated that the Spm increased intermediate metabolites of γ-aminobutyric acid (GABA) shunt (GABA, glutamic acid, and alanine) and tricarboxylic acid (TCA) cycle (aconitic acid) under salt stress. In addition, the Spm also up-regulated the accumulation of multiple amino acids (glutamine, valine, isoleucine, methionine, serine, lysine, tyrosine, phenylalanine, and tryptophan), sugars (mannose, fructose, sucrose-6-phosphate, tagatose, and cellobiose), organic acid (gallic acid), and other metabolites (glycerol) in response to salt stress. These metabolites played important roles in OA, energy metabolism, signal transduction, and antioxidant defense under salt stress. More importantly, the Spm enhanced GABA shunt and the TCA cycle for energy supply in leaves. Current findings provide new evidence about the regulatory roles of the Spm in alleviating salt damage to plants associated with global metabolites reprogramming and metabolic homeostasis. The experimental process involved the reaction of 2,3-Dihydroxypropanoic acid(cas: 473-81-4).Quality Control of 2,3-Dihydroxypropanoic acid

The Article related to creeping bentgrass spermine salt tolerance metabolism metabolite reprogramming, antioxidant capacity, energy metabolism, ions homeostasis, metabolic pathway, osmotic adjustment, polyamines and other aspects.Quality Control of 2,3-Dihydroxypropanoic acid

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Malecki, Jan; Terpilowski, Konrad; Nastaj, Maciej; Solowiej, Bartosz G. published an article in 2022, the title of the article was Physicochemical, Nutritional, Microstructural, Surface and Sensory Properties of a Model High-Protein Bars Intended for Athletes Depending on the Type of Protein and Syrup Used.Application of 585-88-6 And the article contains the following content:

The main objective of this study was to investigate the possibility of using a combination of vegetable proteins from soybean (SOY), rice (RPC), and pea (PEA) with liquid syrups: tapioca fiber (TF), oligofructose (OF), and maltitol (ML) in the application of high-protein bars to determine the ability of these ingredients to modify the textural, physicochem., nutritional, surface properties, microstructure, sensory parameters, and technol. suitability. Ten variants of the samples were made, including the control sample made of whey protein concentrate (WPC) in combination with glucose syrup (GS). All combinations used had a pos. effect on the hardness reduction of the bars after the storage period. Microstructure and the contact angle showed a large influence on the proteins and syrups used on the features of the manufactured products, primarily on the increased hydrophobicity of the surface of samples made of RPC + ML, SOY + OF, and RPC + TF. The combination of proteins and syrups used significantly reduced the sugar content of the product. Water activity (<0.7), dynamic viscosity (<27 mPas•g/cm3), and sensory anal. (the highest final ratings) showed that bars made of RPC + OF, SOY + OF, and SOY + ML are characterized by a high potential for use in this type of products. The experimental process involved the reaction of SweetPearlR P300 DC Maltitol(cas: 585-88-6).Application of 585-88-6

The Article related to protein bar athlete syrup physicochem nutritional microstructure sensory property, contact angle, industrial application, liquid fiber, nutritional value, optical microscopy, plant protein and other aspects.Application of 585-88-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Yujia; Myojin, Takumi; Li, Kexin; Kurita, Ayuki; Seto, Masayuki; Motoyama, Ayano; Liu, Xiaoyang; Satoh, Ayano; Munemasa, Shintaro; Murata, Yoshiyuki; Nakamura, Toshiyuki; Nakamura, Yoshimasa published an article in 2022, the title of the article was A Major Intestinal Catabolite of Quercetin Glycosides, 3-Hydroxyphenylacetic Acid, Protects the Hepatocytes from the Acetaldehyde-Induced Cytotoxicity through the Enhancement of the Total Aldehyde Dehydrogenase Activity.Computed Properties of 621-37-4 And the article contains the following content:

Aldehyde dehydrogenases (ALDHs) are the major enzyme superfamily for the aldehyde metabolism Since the ALDH polymorphism leads to the accumulation of acetaldehyde, we considered that the enhancement of the liver ALDH activity by certain food ingredients could help prevent alc.-induced chronic diseases. Here, we evaluated the modulating effects of 3-hydroxyphenylacetic acid (OPAC), the major metabolite of quercetin glycosides, on the ALDH activity and acetaldehyde-induced cytotoxicity in the cultured cell models. OPAC significantly enhanced the total ALDH activity not only in mouse hepatoma Hepa1c1c7 cells, but also in human hepatoma HepG2 cells. OPAC significantly increased not only the nuclear level of aryl hydrocarbon receptor (AhR), but also the AhR-dependent reporter gene expression, though not the nuclear factor erythroid-2-related factor 2 (Nrf2)-dependent one. The pretreatment of OPAC at the concentration required for the ALDH upregulation completely inhibited the acetaldehyde-induced cytotoxicity. Silencing AhR impaired the resistant effect of OPAC against acetaldehyde. These results strongly suggested that OPAC protects the cells from the acetaldehyde-induced cytotoxicity, mainly through the AhR-dependent and Nrf2-independent enhancement of the total ALDH activity. Our findings suggest that OPAC has a protective potential in hepatocyte models and could offer a new preventive possibility of quercetin glycosides for targeting alc.-induced chronic diseases. The experimental process involved the reaction of 3-Hydroxyphenylacetic acid(cas: 621-37-4).Computed Properties of 621-37-4

The Article related to hepatocyte cytotoxicity 3hydroxyphenylacetic acid aldehyde dehydrogenase, 3-hydroxyphenylacetic acid, acetaldehyde, aldehyde dehydrogenase, aryl hydrocarbon receptor, quercetin metabolites and other aspects.Computed Properties of 621-37-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts