Alcohols-buliding-blocks

Non-covalent interactions of selected flavors with pea protein: Role of molecular structure of flavor compounds was written by Bi, Shuang;Pan, Xin;Zhang, Wentao;Ma, Zhuo;Lao, Fei;Shen, Qun;Wu, Jihong. And the article was included in Food Chemistry in 2022.Reference of 57-55-6 This article mentions the following:

The influence of the mol. structures of flavor compounds (specifically, variations in chain length and functional groups) on the binding of the flavor compounds (Z)-2-penten-1-ol, hexanal, and (E)-2-octenal to pea protein was investigated. The results showed that the mol. structures of the flavor compounds strongly influenced their binding affinity for pea protein. Specifically, (E)-2-octenal exhibited a higher binding affinity and a higher Stern-Volmer constant with pea protein than both hexanal and (Z)-2-penten-1-ol. Thermodn. anal. indicated that the flavor compound-pea protein interactions were spontaneous. Hydrophobic interactions were dominant in the non-covalent interactions between (E)-2-octenal/(Z)-2-penten-1-ol and pea protein, whereas hydrogen bonding was dominant in the non-covalent interactions between hexanal and pea protein. Surface hydrophobicity measurements, the use of bond-disrupting agents, and mol. docking further supported the hypothesis that hydrogen bonding, as well as hydrophobic interactions, occurred between the flavor compounds and pea protein. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Reference of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Highly soluble sulfur-rich [Ni(L)(^siS₃)] complexes containing the new ligand bis(2-mercapto-3-trimethylsilylphenyl) sulfide(2-) (^siS₃^2-) was written by Sellmann, Dieter;Prakash, Raju;Geipel, Franz;Heinemann, Frank W.. And the article was included in European Journal of Inorganic Chemistry in 2002.Recommanded Product: 29364-29-2 This article mentions the following:

The new organosulfur ligands ^siS₃-H₂ [^siS₃^2- = bis(2-mercapto-3-trimethylsilylphenyl) sulfide(2-)] and ^caS₃-H₂ [^caS₃^2- = bis(2-mercapto-3-carboxyphenyl) sulfide(2-)] were synthesized from ^HS₃-H₂ [^HS₃^2- = bis(2-mercaptophenyl) sulfide(2-)], BuLi, and Me₃SiCl or CO₂/H⁺. Reaction of ^siS₃-H₂ with Ni(acac)₂·4H₂O gave the air-stable and well-soluble trinuclear complex I, [Ni(^siS₃)]₃ (1), whose structure was determined by x-ray crystallog. Reactions of complex 1 with nucleophiles L [L = PR₃ (R = Pr, Ph, Cy), N₂H₄, S^tBu^–, and Cl^–] yielded the corresponding neutral or anionic complexes, which were isolated as [Ni(PR₃)(^siS₃)] [R = Pr (2), Ph (3), Cy (4)], Bu₄N[Ni(Cl)(^siS₃)] (5), Bu₄N[Ni(StBu)(^siS₃)] (6), and [Ni(N₂H₄)(^siS₃)] (8). The azido complex Et₄N[Ni(N₃)(^siS₃)] (7) was prepared from Me₃SiN₃ and the precursor chloro complex Et₄N[Ni(Cl)(^siS₃)] formed in situ. Reaction of 1 with NH₃ yielded labile [Ni(NH₃)(^siS₃)] (9), which was characterized in solution by ¹H and ¹³C NMR spectroscopy. Analogously, 1 reacts with nicotinamide (NA) or diethylnicotinamide (NAEt₂) to give, from equilibrium reactions, the corresponding mononuclear [Ni(L)(^siS₃)] complexes with L = NA, NAEt₂. X-ray structure determinations showed that 1, 3, 4, 5, and 7 all exhibit tetrahedrally distorted planar [Ni(L)(^siS₃)] fragments. Complex 7 is the first structurally characterized azidonickel complex with a coligand having exclusively S donors. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Recommanded Product: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Metal-free visible light-promoted synthesis of isothiazoles: a catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions was written by Cabrera-Afonso, Maria Jesus;Cembellin, Sara;Halima-Salem, Adnane;Berton, Mateo;Marzo, Leyre;Miloudi, Abdellah;Maestro, M. Carmen;Aleman, Jose. And the article was included in Green Chemistry in 2020.HPLC of Formula: 29364-29-2 This article mentions the following:

A sustainable synthesis of isothiazoles was developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance represented a new environmentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method was highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2HPLC of Formula: 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Passion fruit seed extract protects beta-amyloid-induced neuronal cell death in a differentiated human neuroblastoma SH-SY5Y cell model was written by Sato, Akira;Tagai, Nozomi;Ogino, Yoko;Uozumi, Haruka;Kawakami, Shinpei;Yamamoto, Takayuki;Tanuma, Sei-ichi;Maruki-Uchida, Hiroko;Mori, Sadao;Morita, Minoru. And the article was included in Food Science & Nutrition (Hoboken, NJ, United States) in 2022.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Alzheimers disease (AD) is a progressive neurodegenerative disease with accompanying perceptive disorder. We previously reported that decreasing levels of brain-derived neurotrophic factor (BDNF) promoted beta-amyloid (Aβ)-induced neuronal cell death in neuron-like differentiated SH-SY5Y (ndSH-SY5Y) human neuroblastoma cells in an AD mimic cell model. We investigated the neuroprotective effects of passion fruit seed extract (PFSE) and one of the main stilbene compounds, piceatannol, in an AD cell model using ndSH-SY5Y cells. Both PFSE and piceatannol were found to protect Aβ-induced neurite fragmentation in the cell model (protection efficacy; 34in PFSE and 36in piceatannol). In addition, both PFSE and piceatannol suppress Aβ-induced neuronal cell death in the cell model (inhibitory effect; 27in PFSE and 32in piceatannol). Our study is the first to report that piceatannol-rich PFSE can repress Aβ-induced neuronal cell death by protecting against neurite fragmentation in the AD human cell model. These findings suggest that piceatannol-rich PFSE can be considered a potentially neuroprotective functional food for both prevention and treatment of AD. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Universal strategy for sugar replacement in foods was written by van der Sman, R. G. M.;Jurgens, A.;Smith, A.;Renzetti, S.. And the article was included in Food Hydrocolloids in 2022.HPLC of Formula: 149-32-6 This article mentions the following:

In this paper we present a sugar replacements strategy, derived from phys. theory, which we think is applicable for a wide range of food categories. The strategy is based on the hypothesis that reformulated foods must mimic the values of two phys. characteristic numbers, related to the plasticizing and hygroscopic properties of sugar, to reproduce the texture of a sugar-rich product. We will show the validity of the strategy for reformulated biscuits, using exptl. determination of phys. properties of dough and baked biscuits, as well as sensorial evaluation by a trained panel. Our investigations shown that the majority of these phys. and sensorial attributes correlate with the two phys. characteristic numbers Furthermore, multiple reformulations can be defined which are close to the reference product (in terms of the two phys. characteristic numbers), which are indeed scored similar by the trained sensory panel. Hence, our strategy also leaves room for further optimization of the reformulated food towards dietary fiber content, laxative properties or sweetness. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6HPLC of Formula: 149-32-6).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 149-32-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration was written by Di Fruscia, Paolo;Carbone, Anna;Bottegoni, Giovanni;Berti, Francesco;Giacomina, Francesca;Ponzano, Stefano;Pagliuca, Chiara;Fiasella, Annalisa;Pizzirani, Daniela;Ortega, Jose Antonio;Nuzzi, Andrea;Tarozzo, Glauco;Mengatto, Luisa;Giampa, Roberta;Penna, Ilaria;Russo, Debora;Romeo, Elisa;Summa, Maria;Bertorelli, Rosalia;Armirotti, Andrea;Bertozzi, Sine Mandrup;Reggiani, Angelo;Bandiera, Tiziano;Bertozzi, Fabio. And the article was included in Journal of Medicinal Chemistry in 2021.Application In Synthesis of tert-Butyl (4-hydroxycyclohexyl)carbamate This article mentions the following:

Inhibition of intracellular N-acylethanolamine-hydrolyzing acid amidase (NAAA) activity is a promising approach to manage the inflammatory response under disabling conditions. In fact, NAAA inhibition preserves endogenous palmitoylethanolamide (PEA) from degradation, thus increasing and prolonging its anti-inflammatory and analgesic efficacy at the inflamed site. In the present work, we report the identification of a potent, systemically available, novel class of NAAA inhibitors, featuring a pyrazole azabicyclo[3.2.1]octane structural core. After an initial screening campaign, a careful structure-activity relationship study led to the discovery of endo-ethoxymethyl-pyrazinyloxy-8-azabicyclo[3.2.1]octane-pyrazole sulfonamide 50 (ARN19689), which was found to inhibit human NAAA in the low nanomolar range (IC₅₀ = 0.042μM) with a non-covalent mechanism of action. In light of its favorable biochem., in vitro and in vivo drug-like profile, sulfonamide 50 could be regarded as a promising pharmacol. tool to be further investigated in the field of inflammatory conditions. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2Application In Synthesis of tert-Butyl (4-hydroxycyclohexyl)carbamate).

tert-Butyl (4-hydroxycyclohexyl)carbamate (cas: 224309-64-2) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of tert-Butyl (4-hydroxycyclohexyl)carbamate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reactivity-based one-pot synthesis of the tumor-associated antigen N3 minor octasaccharide for the development of a photo-cleavable DIOS-MS sugar array was written by Lee, Jinq-Chyi;Wu, Chung-Yi;Apon, Junefredo V.;Siuzdak, Gary;Wong, Chi-Huey. And the article was included in Angewandte Chemie, International Edition in 2006.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol This article mentions the following:

Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one-pot strategy to synthesize the tumor-associated oligosaccharide antigen N3 minor. The target mol. was attached covalently to a porous silicon surface through a photo-cleavable linker for direct characterization in a mass spectrometer equipped with a laser source. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Quality Control of 3-(Hydroxymethyl)-4-nitrophenol).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 3-(Hydroxymethyl)-4-nitrophenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stereodynamic Chemosensor with Selective Circular Dichroism and Fluorescence Readout for in Situ Determination of Absolute Configuration, Enantiomeric Excess, and Concentration of Chiral Compounds was written by Bentley, Keith W.;Wolf, Christian. And the article was included in Journal of the American Chemical Society in 2013.Formula: C4H11NO This article mentions the following:

A stereodynamic chemosensor, 1-(4′-pyridyl)-8-(3′-formyl-4′-hydroxyphenyl)naphthalene N-oxide, having a parallel arrangement of a substrate-binding salicylaldehyde unit and an adjacent pyridyl N-oxide fluorophore undergoes rapid condensation with chiral amino alcs. and subsequent asym. transformation of the 1st kind toward a single rotamer. Crystallog. anal. shows that the concomitant central-to-axial chirality imprinting is controlled by minimization of steric repulsion and by intramol. hydrogen bonding between the bound amino alc. and the proximate N-oxide group. The substrate binding event results in strong CD effects and characteristic fluorescence changes which can be used for instantaneous in situ determination of the absolute configuration, enantiomeric composition and total concentration of a variety of chiral amino alcs. This chemosensing approach avoids time-consuming workup and purification steps, and it is applicable to minute sample amounts which reduces the use of solvents and limits waste production In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Formula: C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design of New Photoactivatable Amino Acids: Stereoselective Synthesis of N-Protected Phenylalanine Derivatives as Precursors of p-Diazocyclohexadienone-Containing Peptides was written by Dugave, C.. And the article was included in Journal of Organic Chemistry in 1995.Electric Literature of C7H7NO4 This article mentions the following:

4-Diazocyclohexa-2,5-dienone-based amino acids I were designed for building up photoactivatable peptides. Their stable precursors II [R = Me₃CO₂C (Boc), 9-fluorenylmethoxycarbonyl (Fmoc)] were synthesized by stereoselective alkylation of the corresponding benzyloxynitrobenzyl iodides by a chiral glycine equivalent Alkylation was carried out using either butyllithium in dry organic solvents or a phase transfer procedure. Alkylation, hydrolysis of the adduct, and protection as Boc and Fmoc derivatives were achieved in 57-73% overall yields and led to 97-99% optically pure material. II were inserted in model dipeptides by a homogeneous solution procedure and by solid-phase peptide synthesis. Deprotection and diazotization of the resulting p-hydroxyanilines gave the corresponding photoactivatable 4-diazocyclohexa-2,5-dienone-containing peptides in quant. yields. Such photoprobes are stable for several hours in the dark but are rapidly photolyzed at 350 nm or at 295 nm by a tryptophan-mediated energy transfer activation process. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Biogenesis of a bacterial metabolosome for propanediol utilization was written by Yang, Mengru;Wenner, Nicolas;Dykes, Gregory F.;Li, Yan;Zhu, Xiaojun;Sun, Yaqi;Huang, Fang;Hinton, Jay C. D.;Liu, Lu-Ning. And the article was included in Nature Communications in 2022.Related Products of 57-55-6 This article mentions the following:

Bacterial metabolosomes are a family of protein organelles in bacteria. Elucidating how thousands of proteins self-assemble to form functional metabolosomes is essential for understanding their significance in cellular metabolism and pathogenesis. Here we investigate the de novo biogenesis of propanediol-utilization (Pdu) metabolosomes and characterize the roles of the key constituents in generation and intracellular positioning of functional metabolosomes. Our results demonstrate that the Pdu metabolosome undertakes both “Shell first” and “Cargo first” assembly pathways, unlike the β-carboxysome structural analog which only involves the “Cargo first” strategy. Shell and cargo assemblies occur independently at the cell poles. The internal cargo core is formed through the ordered assembly of multiple enzyme complexes, and exhibits liquid-like properties within the metabolosome architecture. Our findings provide mechanistic insight into the mol. principles driving bacterial metabolosome assembly and expand our understanding of liquid-like organelle biogenesis. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts