Alcohols-buliding-blocks

Development of Water-Soluble Type I Photoinitiators for Hydrogel Synthesis was written by Aubry, Berengere;Dumur, Frederic;Lansalot, Muriel;Bourgeat-Lami, Elodie;Lacote, Emmanuel;Lalevee, Jacques. And the article was included in Macromol in 2022.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

In this work, two new water-soluble photoinitiators based on the α-alkoxy-arylketone scaffold have been synthesized and investigated for their ability to initiate photopolymerization for the preparation of hydrogels. The efficiency of these new Type I photoinitiators was compared to that of benchmark ones (2-hydroxy-4′-(2-hydroxyethoxy)-2-methylpropiophenone-Irgacure 2959 and 2-hydroxy-2-Me propiophenone-Irgacure 1173). In combination with additive (carbene-borane), a good initiating ability was found under air. Mech. properties of the prepared hydrogels were investigated by tensile tests and dynamic mech. anal. (DMA). Markedly, hydrogels could be prepared with the newly proposed initiating systems in mild conditions (i.e., under air, using low light intensity @405 or 395 nm and without specialized glassware) and exhibited similar properties to those prepared by harsher approaches (thermal treatment or UV light). In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel approach for the preparation of core-shell MOF/polymer composites as mixed-mode stationary phase was written by Si, Tiantian;Wang, Licheng;Zhang, Haixia;Liang, Xiaojing;Lu, Xiaofeng;Wang, Shuai;Guo, Yong. And the article was included in Talanta in 2021.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate This article mentions the following:

The nickel organic framework capped with polyvinylpyrrolidone was prepared and synergistically immobilized onto porous silica surface as the mixed-mode stationary phase for high-performance liquid chromatog. Here, polyvinylpyrrolidone firstly was chosen as functional mols. to change morphol. and size of the metal organic framework. The silica microspheres were then modified by them via a simple bonding method rather than in-situ growth method with the aid of electrostatic interaction commonly used before. The stationary phase showed flexible selectivity for separation of both hydrophilic and hydrophobic compounds, especially for hydrophilic compounds such as carbohydrates, alkaloids and sulfonamides etc. The chromatog. behaviors were evaluated by investigating various factors, and a typical mixed-mode retention feature of the column was observed The composites could be prepared repetitively, and relative standard deviations of retention time of objective compounds among different batches were less than 1.75%. It also showed excellent chromatog. reproducibility, stability and potentiality for application in real samples. In short, the composites can be used for a feasible option for anal. of multiple compounds as the mixed-mode stationary phase and it provides a general approach for preparing MOFs-based composites by changing morphol. and size of MOFs. In the experiment, the researchers used many compounds, for example, (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate).

(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate (cas: 10030-85-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal hydrate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A simple and efficient room temperature silylation of diverse functional groups with hexamethyldisilazane using CeO₂ nanoparticles as solid catalysts was written by Anbu, Nagaraj;Vijayan, Chellappa;Dhakshinamoorthy, Amarajothi. And the article was included in Molecular Catalysis in 2019.Reference of 1777-82-8 This article mentions the following:

In this study, a mild and efficient method is developed for the silylation of diverse functional groups using CeO₂ nanoparticles (n-CeO₂) as solid catalysts with hexamethyldisilazane (HMDS) as silylating agent at room temperature Alcs., phenols and acids are silylated to their resp. silyl derivatives with faster reaction rate while amines and thiols required relatively longer reaction time. Moreover, the solid catalyst is easily be separated from the reaction mixture and recycled more than five times without any noticeable decay in its activity. Powder X-ray diffraction (XRD), transmission electron microscope (TEM), UV-vis diffuse reflectance spectra (UV-DRS) and Raman analyses revealed identical structural integrity, particle size, absorption edge and valence state for the reused solid compared to the fresh solid catalyst. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Reference of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The Bark of the Spruce Picea jezoensis Is a Rich Source of Stilbenes was written by Suprun, Andrey R.;Dubrovina, Alexandra S.;Aleynova, Olga A.;Kiselev, Konstantin V.. And the article was included in Metabolites in 2021.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Stilbenes are plant phenolic secondary metabolites that show beneficial effects on human health and possess high antifungal activity against plant pathogens. Currently, a search for plant sources with high stilbene levels is relevant, since stilbene content in various plant species can vary substantially and is often at a low level. In this paper, the bark and wood of Picea jezoensis were analyzed for the content and composition of stilbenes and compared with other known stilbene sources. The HPLC-MS anal. of P. jezoensis bark and wood extracted with different solvents and at different temperatures revealed the presence of 11 and 5 stilbenes, resp. The highest number of stilbenes of 171 and 229 mg per g of the dry weight (mg/g DW) was extracted from the bark of P. jezoensis using methanol or ethanol at 60 °C for 2 h. Trans-astringin, trans-piceid, and trans-isorhapontin prevailed over other stilbenoids (99% of all detected stilbenes). The most abundant stilbene was trans-isorhapontin, reaching 217 mg/g DW or 87% of all stilbenes. An increase in the extraction time from 2 to 6 h did not considerably increase the detected level of stilbenes, while lower extraction temperatures (20 and 40 °C) significantly lowered stilbene yield. The content of stilbenes in the P. jezoensis bark considerably exceeded stilbene levels in other stilbene-producing plant species. The present data revealed that the bark of P. jezoensis is a rich source of stilbenes (primarily trans-isorhapontin) and provided effective stilbene extraction procedures. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Quality Control of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of ospemifene on the female reproductive and urinary tracts: translation from preclinical models into clinical evidence. was written by Archer, David F;Carr, Bruce R;Pinkerton, JoAnn V;Taylor, Hugh S;Constantine, Ginger D. And the article was included in Menopause (New York, N.Y.) in 2015.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

OBJECTIVE: Treatment of menopausal symptoms by compounds with tissue-selective estrogen agonist/antagonist effects, often called selective estrogen receptor modulators, has been researched as an alternative to the use of estrogen therapy. These structurally diverse molecules elicit tissue-dependent responses in hormone-responsive tissues and organs, exhibiting variations in estrogenic activity in preclinical models of postmenopausal reproductive tissues that may improve postmenopausal women’s health (eg, prevention and treatment of breast cancer, osteoporosis, and vulvar and vaginal atrophy). METHODS: This literature review investigates whether preclinical data predicted the clinical effects of ospemifene on female reproductive and urinary tract tissues and compares these findings with the specific vaginal effects of other estrogen receptor agonists/antagonists (tamoxifen, raloxifene, and bazedoxifene) in preclinical and clinical studies. Lasofoxifene, although not currently available, is included because of its unique effects on vaginal tissue. RESULTS: The response of endometrial and vaginal tissues to estrogen receptor agonists/antagonists can be differentiated using transvaginal ultrasound, endometrial histopathology, cytologic examination of vaginal smears, assessment of physical changes in the vagina, and relief of symptoms associated with vulvar and vaginal atrophy (such as dyspareunia). CONCLUSIONS: Available evidence indicates that ospemifene has unique effects on tissue, leading to a favorable long-term profile for the relief of vulvar and vaginal atrophy compared with other estrogen receptor agonists/antagonists (eg, tamoxifen, raloxifene, and bazedoxifene) with no short-term concerns about endometrial safety (based on endometrial hyperplasia, carcinoma, endometrial spotting, and endometrial bleeding). In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Quality Control of (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Soil VOC emissions of a Mediterranean woodland are sensitive to shrub invasion was written by Meischner, M.;Haberstroh, S.;Daber, L. E.;Kreuzwieser, J.;Caldeira, M. C.;Schnitzler, J.-P.;Werner, C.. And the article was included in Plant Biology (Berlin, Germany) in 2022.Related Products of 57-55-6 This article mentions the following:

Many belowground processes, such as soil respiration and soil-atm. VOC (volatile organic compounds) exchange, are closely linked to soil microbiol. processes. However, little is known about how changes in plant species cover, i.e. after plant invasion, alter these soil processes. In particular, the response of soil VOC emissions to plant invasion is not well understood. We analyzed soil VOC emissions and soil respiration of a Mediterranean cork oak (Quercus suber) ecosystem, comparing soil VOC emissions from a non-invaded Q. suber woodland to one invaded by the shrub Cistus ladanifer. Soil VOC emissions were determined under controlled conditions using online proton-transfer time-of-flight mass spectrometry. Net soil VOC emissions were measured by exposing soils with or without litter to different temperature and soil moisture conditions. Soil VOC emissions were sensitive to C. ladanifer invasion. Highest net emission rates were determined for oxygenated VOC (acetaldehyde, acetone, methanol, acetic acid), and high temperatures enhanced total VOC emissions. Invasion affected the relative contribution of various VOC. Methanol and acetaldehyde were emitted exclusively from litter and were associated with the non-invaded sites. In contrast, acetone emissions increased in response to shrub presence. Interestingly, low soil moisture enhanced the effect of shrub invasion on VOC emissions. Our results indicate that shrub invasion substantially influences important belowground processes in cork oak ecosystems, in particular soil VOC emissions. High soil moisture is suggested to diminish the invasion effect through a moisture-induced increase in microbial decomposition rates of soil VOC. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A novel polysaccharide from Boletus edulis: Extraction, purification, characterization and immunologic activity was written by Yu, Shasha;Ma, Rongjie;Dong, Xiaodan;Ji, Haiyu;Liu, Anjun. And the article was included in Industrial Crops and Products in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A novel polysaccharide (BEP) was extracted from Boletus edulis, and its structural characteristics and immunol. activity were evaluated. Our findings revealed that BEP (139 kDa) contained Man, Glc, and Gal in the molar ratio of 1:0.15:0.17 with typical characteristic absorption peaks of polysaccharides. Moreover, the results of methylation and 1D/2D NMR spectroscopy indicated that the backbone of BEP was (→6)-α-Manp-(1→ and →3,6)-α-Manp-(1→, with the side chain →3)-β-Manp-(1→, →3)-α-Galp-(1→ and α-Glcp-(1→)). The immunol. activity tests demonstrated that the BEP could enhance phagocytosis of peritoneal macrophages and secrete NO and cytokines in a dose-dependent by activated macrophage. It was noteworthy that the secretions of NO, IL-6 and TNF-α at 400 μg/mL concentration were increased by 25.50%, 191.67% and 196.05% compared with the control group, resp. The results illustrated that BEP was a novel polysaccharide, which may be marked as an immunol. agent in the food, pharmaceutical and cosmetic industries. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Category: alcohols-buliding-blocks).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel Synthesis of Nitrogen Heterocycles Using Zirconium-Promoted Reductive Cyclization was written by Mori, Miwako;Uesaka, Noriaki;Saitoh, Fumihiko;Shibasaki, Masakatsu. And the article was included in Journal of Organic Chemistry in 1994.COA of Formula: C13H19NO This article mentions the following:

Perhydroindole derivatives were prepared from enynes using zirconium-promoted reductive cyclization. The zirconacycles derived from enynes I (R¹ = benzyl, etc.; R² = TMS, Me, etc.) were treated with iodine, isonitriles, oxygen, and carbon monoxide to give various heterocycles. The carbon-zirconium bonds of the zirconacycle could be selectively cleaved by different reagents. For example, treatment of N-(2-butynyl)-N-(2-cyclohexenyl)benzenamine I (R¹ = benzyl; R₂ = Me) with bis(η⁵-2,4-cyclopentadien-1-yl)zirconium and subsequent carbonylation gave II (18% yield). In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6COA of Formula: C13H19NO).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.COA of Formula: C13H19NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enantioselective addition of methyl group to aldehydes catalyzed by titanium complex of fluorous ligand was written by Omote, Masaaki;Tanaka, Naoya;Tarui, Atsushi;Sato, Kazuyuki;Kumadaki, Itsumaro;Ando, Akira. And the article was included in Tetrahedron Letters in 2007.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol This article mentions the following:

Titanium complex of fluorous axially dissym. ligand (Ra*)-2,2′-bis[(R*)-perfluoro-1H-1-hydroxyoctyl]biphenyl (I) having perfluoroheptyl carbinol moieties catalyzed enantioselective addition of a Me group to aldehydes. Dimethylzinc prepared in situ by mixing ZnCl₂ and Me magnesium bromide without removal of magnesium salt was more reactive for addition of Me group than dimethylzinc without magnesium salt, and gave up to 99% ee of the products. The high fluorine content of I was recoverable by the selective extraction with perfluorohexane. In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of (S)-1-(2-Fluorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Construction of substituted pyrazolo[4,3-c]quinolines via [5+1] cyclization of pyrazole-arylamines with alcohols/amines in one pot was written by Tang, Dong;Mu, Yangxiu;Iqbal, Zafar;He, Lili;Jiang, Rui;Hou, Jing;Yang, Zhixiang;Yang, Minghua. And the article was included in Journal of Heterocyclic Chemistry in 2022.SDS of cas: 873-76-7 This article mentions the following:

An efficient protocol had been developed for the synthesis of pyrazolo[4,3-c]quinoline derivatives I [R¹ = Me, Ph, 3-pyridyl, etc.; R² = Ph, 4-MeC₆H₄, 4-ClC₆H₄, 4-BrC₆H₄, 4-NCC₆H₄; R³ = Ph, 1-naphthyl, 2-thienyl, etc.], by reacting (1H-pyrazol-5-yl)anilines and readily available alcs./amines. A wide range of substrates with diverse functional groups were smoothly converted to the corresponding products in moderate to good yields, under optimal reaction conditions. Furthermore, the strategy also proceeded well with thiol and amino acid to access pyrazolo[4,3-c]quinoline derivatives In the experiment, the researchers used many compounds, for example, (4-Chlorophenyl)methanol (cas: 873-76-7SDS of cas: 873-76-7).

(4-Chlorophenyl)methanol (cas: 873-76-7) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.SDS of cas: 873-76-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts